Suhaili Shamsi

Universiti Putra Malaysia | UPM · Department of Biochemistry

Arabica, Robusta, and Liberica are the three main coffee species cultivated globally. Liberica coffee is a minor species, accounting for less than 1% of global cultivation. Due to favorable climatic conditions in Malaysia, Liberica coffee dominates coffee production, accounting for 73%, while Robusta makes up the remaining 27%. Nevertheless, the su...

Vibriosis is one of the most common diseases in marine aquaculture, caused by bacteria belonging to the genus Vibrio, that has been affecting many species of economically significant aquatic organisms around the world. The prevention of vibriosis in aquaculture is difficult, and the various treatments for vibriosis have their limitations. Therefore...

The bone morphogenic protein (BMP) family is a member of the TGF-beta superfamily and plays a crucial role during the onset of gut inflammation and arthritis diseases. Recent studies have reported a connection with the gut–joint axis; however, the genetic players are still less explored. Meanwhile, BDMC33 is a newly synthesized anti-inflammatory dr...

Acute Toxicity Assessment and Behavioral Response of Curcumin Derivative, BDMC33 in Zebrafish (Danio rerio) Larvae

Infectious diseases are major threat due to it being the main cause of enormous morbidity and mortality in the world. Multidrug-resistant (MDR) bacteria put an additional burden of infection leading to inferior treatment by the antibiotics of the latest generations. The emergence and spread of MDR bacteria (so-called “superbugs”), due to mutations...

Curcumin (CUR) has been studied for its biomedical applications due to its active biological properties. However, CUR has limitations such as poor solubility, low bioavailability, and rapid degradation. Thus, CUR was nanoformulated with the application of polymeric micelle. Previous studies of CUR-loaded Pluronic F127 nanoformulation (NanoCUR) were...

Background The impetuous usage of antibiotics has led to the perpetual rise of methicillin-resistant Staphylococcus aureus (MRSA), which has garnered the interest of potential drug alternatives, including nanomaterials. Purpose The present study investigates the stability, toxicity, and antibacterial potential of gallic acid-loaded graphene oxide...

Excessive use of synthetic larvicide has led to resistant strains of mosquito vectors and adverse ecological concerns globally. Hence, bioactive compounds from the plant have become a promising alternative to synthetic larvicide. Collectively, there is adequate evidence on the larvicidal effect of Piper sarmentosum (Kaduk). However, its leaves extr...

Background In the current literature, there are ongoing debates on the toxicity of graphene oxide (GO) that demonstrate contradictory findings regarding its toxicity profile. As a potential drug carrier, these findings are very concerning due to the safety concerns in humans, as well as the dramatic rise of GO being excreted into the environment. T...

Gallic acid (GA) is a phenolic compound found in almost all plants and has been reported to possess powerful health benefits such as anti-oxidant, anti-inflammatory, anti-cancer, and anti-diabetic properties. However, GA suffers a short half-life when administered in vivo. Recent studies have employed graphene oxide (GO), a biocompatible and cost-e...

An increased awareness on consuming healthy food and beverages worldwide has led to an upsurge of interest in functional food, which includes the use of natural sweetener, the Stevia rebaudiana Bertoni extract. Nevertheless, limited data has been available on the biological activities of commercial Stevia extract available in Malaysia. Hence, the p...

Since the 15 th century, essential oils (EO) were having a strong interest as therapeutic agents and recently EO has been widely used in pharmaceutical, cosmetic, food and agricultural industries. The previous study showed that EOs from Stevia rebaudiana Bertoni (SrB) possess high antioxidant, anti-inflammatory, and antimicrobial properties. In thi...

Extracts from leaves of Stevia rebaudiana Bertoni, steviol glycosides are used to sweeten food and beverages. It has been approved as sweeteners in many countries all over the world. The majority findings show there is no toxicity in steviol glycosides. However, the complex purification process on commercial stevia has caused its authenticity to be...

Apart from being well known to the world as herb-based sweetening additive, Stevia rebaudiana (S. rebaudiana) and its phenolic compounds are considered as a natural antidiabetic alternative to replace synthetic drugs that possess numbers of side effects. Therefore, this study was aimed to evaluate the solvent effects on the extraction of phenolic c...

In spite of its prominence as a natural non-calorific sweetener used to replace table sugar, Stevia rebaudiana contains a variety of valuable phytoconstituents functioning as natural food-derived antioxidants with a protective effect against oxidative damage. In this study, leave extracts were screened for their phytochemical compounds and quantifi...

Staphylococcus aureus (SA) is the most common occurring bacterial pathogen that caused skin and soft tissue infections. However, the emergence of multi-drug resistant strains such as methicillin-resistant SA (MRSA) compromises therapy and poses a serious challenge to human health. Therefore, the need to develop alternative novel anti-bacterial agen...

Inhibition of the cytochrome P450 (CYP) enzymes has been shown to enhance the metabolism of drugs that are CYP substrates, and to consequently alter their pharmacokinetic profiles. Curcumin (CUR), piperine (PIP) and capsaicin (CAP) are spice components (SC) that inhibit the activities of a range of CYP enzymes, but the selection of which SC to be p...

Curcumin (CUR) has been formulated into a host of nano-sized formulations in a bid to improve its in vivo solubility, stability and bioavailability. The aim of this study was to investigate whether the encapsulation of CUR in nanocarriers would impede its biological interactivity, specifically its potential anti-cancer adjuvant activity via the mod...