Stephen Majekodunmi

University of Uyo | UNIUYO · Faculty of Pharmacy

Objective: This work was aimed at formulating omeprazole tablets using afzelia gum as a binder that is capable of inhibiting the gastric degradation of the drug. Methods: Afzelia gum at different concentrations of 0, 5, 10, 15, 20 and 30% was used as a binder to formulate omeprazole tablets. The tablets were formulated by direct compression and the...

Purpose: To develop an extended-release formulation of domperidone using a blend of Raphia hookeri gum and hydroxypropyl methylcellulose as tablet matrix. Methods: Tablets (400 mg) containing 30 mg domperidone (DPD) were formulated using binary mixtures of hydroxypropyl methylcellulose (HPMC) and Raphia hookeri gum (RHG) as matrix former; and micro...

This work is an attempt at converting waste products from food, peels of Musa sapientum into useful pharmaceutical excipient. The gum from the peels was extracted, dried and pulverized by an already established method. A similar process was carried out with M. acuminata peels. Interaction studies were carried out using differential scanning calorim...

Antimalarial drug resistance has emerged as one of the greatest challenges facing malarial control. The aim of this investigation is to enhance the antimalarial effect of mefloquine (MQ) by combining it with chlorpheniramine (CPM) using Plasmodium berghei-infected wistar rat model. P. berghei parasites (10 6) were administered intraperitoneally int...

Solid lipid microparticles of erythromycin ethyl succinate were prepared using solvent evaporation method to improve its bioavailability and efficacy. The solvent was allowed to evaporate after which the various entrapments were determined; the best entrapment was used in the in vivo studies to determine the bioavailability and efficacy. This study...

Objective: Afzelia africana gum has been shown to possess surface activity. It is a good alternative to sodium carboxy methylcellulose in terms of suspending properties. This work was aimed at evaluating the emulsifying properties of the gum in liquid paraffin emulsion. Methods: Liquid paraffin emulsions (200 ml each) were prepared with different c...

An efficient and beneficial waste disposal mechanism is highly desired. This study was carried out to extract and characterize a potential multifunctional pharmaceutical excipient from crab shell wastes. Shells of Pachygrapsus mamoratus were obtained from Oron, a coastal town in Akwa Ibom State of Nigeria. Chitin was extracted from the powdered she...

Objective: To explore the antifungal and antibacterial activity of methanolic extract of Cassia alata (C. alata) and its formulations for skin diseases. Methods: Sundried leaves of C. alata Linn. were extracted using different solvents as follows: water, methanol, ethanol, n-hexane and lastly with acetone. The crude extract was investigated for...

To explore the antidiabetic properties of Mucuna pruriens(M. pruriens). Diabetes was induced in Wistar rats by single intravenous injection of 120 mg/kg of alloxan monohydrate and different doses of the extract were administered to diabetic rats. The blood glucose level was determined using a glucometer and results were compared with normal and unt...

The quantitative effects of formulation and processing variables on the mechanical and disintegration properties of Alstonia boonei tablets have been studied using a 23 factorial experimental design. Alstonia boonei tablets were prepared by direct compression using Emcompress® and Avicel® as direct compression excipients, and by wet granulation usi...

Purpose: To formulate the extracts of the stem bark of Alstonia boonei , an important antimalarial herb, into tablet dosage form. Methods: Tablets were formulated using direct compression and wet granulation methods. The mechanical properties of the tablets were assessed using crushing strength and friability and the crushing strength:friability ra...