Sourav Biswas

Clemson University | CU · Department of Chemistry

This study aims to investigate the potential therapeutic application of Ixeridium dentatum (ID) in treating atopic dermatitis (AD) through network pharmacology, molecular docking, and molecular dynamic simulation. We employed GC-MS techniques and identified 40 bioactive compounds present in the ID and determined their targets by accessing public da...

Saprolegnia parasitica is an oomycete responsible for a fish disease called saprolegniosis, which poses an economic and environmental burden on aquaculture production. In Saprolegnia, CHS5 of S. parasitica (SpCHS5) contains an N-terminal domain, a catalytic domain of the glycosyltransferase −2 family containing a GT-A fold, and a C-terminal transme...

Objective Colorectal cancer (CRC) is the third leading cause of cancer-related deaths in both men and women. Toll-like receptor 5 (TLR5), an autoimmune signaling receptor that plays a role in cancer, can be exploited for the suppression of human colon cancer. Salmonella flagellin protein, a novel agonist of TLR5 activating downstream signaling, cou...

Saprolegnia parasitica is an oomycete responsible for fish disease called saprolegniosis, which poses economic and environmental burden on aquaculture production. Chitin is an essential cell wall component of S. parasitica synthesized by chitin synthase (CHS) enzyme. CHSs are large membrane-integrated enzymes with multiple domains responsible for c...

Dengue, a mosquito-borne disease, has appeared as a major infectious disease globally. The virus requires its proteins to replicate and reproduce in the host cell. The NS3 protease converts the polyprotein to functional proteins with the help of the NS2B cofactor. Thus, NS3 protease is a promising target to develop antiviral inhibitors against the...

The “1st BSMIAB-COB International Conference on COVID-19 Pandemic”, a fully virtual conference hosted by Bangladesh Society for Microbiology, Immunology and Advanced Biotechnology (BSMIAB) and Community of Biotechnology (COB) brings together the global basic translation as well as applied researchers in order to showcase their findings regarding th...

Computer-aided drug screening by molecular docking, molecular dynamics (MD) and structural–activity relationship (SAR) can offer an efficient approach to identify promising drug repurposing candidates for COVID-19 treatment. In this study, computational screening is performed by molecular docking of 1615 Food and Drug Administration (FDA) approved...