S.M.Ali DadfarUniversity Hospital RWTH Aachen · Department of Nanomedicine and Theranostics
S.M.Ali Dadfar
Dr. rer. medic.
Senior Scientist/ Process R&D in Nanomedicine at ARDENA
About
38
Publications
21,274
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Introduction
I completed my PhD in nanomedicine at RWTH Aachen University Clinic with a Magna cum laude grade, under the guidance of Prof. Dr. Dr. Twan Lammers at the Institute for Experimental Molecular Imaging (ExMI). Following my PhD, I pursued my passion for science as a researcher at Ardena pharmaceutical company in the Netherlands. With over a decade of experience in nanomedicine and polymer chemistry, I have worked at universities and pharmaceutical companies in Germany, the Netherlands, and Iran.
Additional affiliations
September 2007 - December 2009
September 2002 - June 2006
Education
February 2016 - September 2021
Publications
Publications (38)
In this study, the properties of poly (vinyl alcohol) (PVA) films incorporated with Zataria multiflora essential oil (ZMO) as a potential antioxidant/antibacterial material was investigated. PVA films were prepared from PVA solutions (2% w/v) containing different concentrations of ZMO. Water solubility, moisture absorption, water swelling, and wate...
Gelatin composite films were prepared from gelatin solutions (10% w/v) containing multi-walled carbon nanotubes (MWCNT, 0.5, 1, 1.5, and 2% w/w gelatin) as nanofiller. The water solubility, water swelling, water uptake, water vapor permeability (WVP), mechanical, and antibacterial properties of the films were examined. Water solubility, water swell...
Polyvinyl alcohol (PVA) thin films were reinforced by glutaraldehyde and multiwalled carbon nanotubes (MWCNTs) and then mechanical, water solubility, water swelling, water uptake, water vapor permeability, and antibacterial properties of the films were examined. Cross-linking by glutaraldehyde or incorporation of MWCNT caused a significant increase...
In this article, oxygen barrier properties of nanocomposite films composed of organoclay (OC), high-density polyethylene (HDPE), and ethylene vinyl acetate (EVA) copolymer have been investigated. The nanocomposite films whose EVA forms a dominant fraction were prepared using the solution method. The dispersion of the OC in the HDPE/EVA blend was im...
Nanocomposite films based on low density polyethylene (LDPE), containing of 2, 3, and 4 wt.% organoclay (OC) and ethylene vinyl acetate (EVA) copolymer as a new compatibilizer were prepared and characterized using rheological tests, X-ray diffraction, differential scanning calorimetry, oxygen permeation measurements, and tensile tests. There was no...
Based on the nature of accumulated foulants, fouling is classified into organic, inorganic, particulate,
and biological categories. Among these categories, the last one, i.e., biofouling, is considered the most
problematic, posing numerous challenges in industry, medicine, and other fields. Biofouling is the
accumulation of micro and/or macro biolo...
Objective:
Magnetic particle imaging (MPI) visualizes the spatial distribution of magnetic nanoparticles. MPI already provides excellent temporal and good spatial resolution, however, to achieve translation into clinics, further advances in the fields of sensitivity, image reconstruction and tracer performance are needed. In this work, we propose...
Aims:
(Ultra) Small superparamagnetic iron oxide nanoparticles, (U)SPIO, are widely used as magnetic resonance imaging contrast media and assumed to be safe for clinical applications in cardiovascular disease. As safety tests largely relied on normolipidemic models, not fully representative of the clinical setting, we investigated the impact of (U...
Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integri...
Microbubbles (MB) are used as ultrasound (US) contrast agents and can be efficiently targeted against markers of angiogenesis and inflammation. Due to their gas core, MB locally alter susceptibilities in magnetic resonance imaging (MRI), but unfortunately, the resulting contrast is low and not sufficient to generate powerful molecular MRI probes. T...
Introduction:
Aim of this study is to evaluate whether magnetic particle imaging (MPI) is capable of measuring velocities occurring in the coronary arteries and to compute coronary flow reserve (CFR) in a canonical phantom as a preliminary study.
Methods:
For basic velocity measurements, a circulation phantom was designed containing replaceable...
Over the last decade, superparamagnetic iron oxide nanoparticles (SPION) have been extensively tested for magnetic particle imaging (MPI). MPI is an emerging tomographic imaging technique -currently in the preclinical stage- that enables direct spatial and temporal tracking of SPION in vivo. In MPI, the magnetic moments of SPION are probed directly...
Riboflavin carrier protein (RCP) and riboflavin transporters (RFVTs) have been reported to be highly overexpressed in various cancer cells. Hence, targeting RCP and RFVTs using riboflavin may enhance tumor accumulation and internalization of drug delivery systems. To test this hypothesis, butyl-based 3-arm peptostar polymers were synthesized consis...
Superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by co-precipitation method, functionalized respectively with tetraethyl orthosilicate (TEOS) and 3-(trimethoxysilyl)propyl methacrylate (TMSPM), and monodispersed by filtration and centrifugation. The vinyl-functionalized monodispersed SPIONs were then coated with a shell of the nove...
Superparamagnetic iron oxide nanoparticles (SPION) are extensively used for magnetic resonance imaging (MRI) and magnetic particle imaging (MPI), as well as for magnetic fluid hyperthermia (MFH). We here describe a sequential centrifugation protocol to obtain SPION with well-defined sizes from a polydisperse SPION starting formulation, synthesized...
Superparamagnetic iron oxide nanoparticles (SPION) are widely used for biomedical applications, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI), magnetic fluid hyperthermia (MFH), separation of biomolecules, and targeted drug and gene delivery. These applications not only results from the magnetic properties of SPION, bu...
Novel dual responsive hydrogels of semi‐interpenetrating polymer networks (semi‐IPN) based on temperature‐sensitive N‐isopropylacrylamide (NIPAA) and pH‐sensitive N‐ethylmaleamic acid (NEMA) monomers and sodium alginate (Alg‐Na) polymer were synthesized using free‐radical polymerization in the presence of N,N′‐methylenebisacrylamide (MBA) as a cros...
MPI has the potential to be a meaningful alternative to PCI especially for difficult interventions and special patient groups. In this work, we showed that SPION infused PCL could be a viable material for MPI visible scaffolds. However, the right sample for the system matrix measurement has to be chosen. In this work we presented which sample is mo...
MPI has the ability to non-invasively detect pathologic hemodynamics in coronary blood vessels without using radiation. A valid velocity computation under physiologic as well as pathologic conditions would greatly illustrate MPI’s applicability in cardiovascular imaging. Therefore, further studies should address flow quantification including high f...
Many different iron oxide nanoparticles have been evaluated over the years, for many different biomedical applications. We here summarize the synthesis, surface functionalization and characterization of iron oxide nanoparticles, as well as their (pre-) clinical use in diagnostic, therapeutic and theranostic settings. Diagnostic applications include...
we synthesized an amphiphilic block copolymer via RAFT polymerization and amidic bond formation. Deferoxamine along with phenethylamine moieties were successfully grafted on the polymer backbone. The obtained product is able to self assemble in water into nanostructured entities potentially exploitable for hydrophobic drugs entrapment. Furthermore,...
MPI represents a promising modality for cardiovascular imaging. The chance to depict vessels in high resolution in addition to flow pattern analysis without using radiation could make MPI a strong alternative to clinically established methods. Though, it still remains unclear to what extent MPI is feasible of making its contribution. An important s...
While the idea of bioresorbable scaffolds is intriguing, we have only limited resources to monitor them from the outside. MPI might be a solution to this problem. In this work, we showed that it is possible to infuse PCL with SPIONs. The polyester that we created generated a concentration dependent signal and could be further processed. As next ste...
Superparamagnetic iron oxide nanoparticles (SPION) are widely used for biomedical applications, including magnetic resonance imaging (MRI), magnetic particle imaging (MPI) and magnetic fluid hyperthermia (MFH). Various methods are used to prepare SPION. The co-precipitation technique is among the most simple and efficient synthetic procedures, but...
This study was performed to evaluate the properties of poly(vinyl alcohol) (PVA), gelatin, and PVA-gelatin dispersions and films enriched with Zataria multiflora essential oil (ZO). The results reveal that the ζ potential, particle size, and viscosity values and the antioxidant and antibacterial activities of the dispersions changed significantly w...
We developed a simple and straightforward method for preparing monodispersed SPION with optimized sizes and properties for MRI, MPI and hyperthermia applications.
We investigated several operational parameters including reaction time, reaction temperature, pH, stirring speed, sonication and centrifuge speed on particle size and size distribution of magnetic nanoparticles. We obtained SPION with small size, low polydispersity index and excellent MR imaging properties.
In this study, the properties of poly (vinyl alcohol) (PVA) films incorporated with Zataria multiflora essential oil (ZMO) as a potential antioxidant/antibacterial material was investigated. PVA films were prepared from PVA solutions (2% w/v) containing different concentrations of ZMO. Water solubility, moisture absorption, water swelling, and wate...
Questions
Questions (24)
Dear Researchers,
I have to speed up the sedimentation time of a suspension including microparticles. I am looking for a non-toxic additive that can increase the precipitation time. It could be any materials for instance charge-neutralising agent. I really appreciate your help regarding the discussed issue.
Best regards
Ali Dadfar
Dear all,
Does anyone have experience with the pancreatin enzyme? It seems the solubility of pancreatin in water is very poor and I am looking for a way to increase its solubility (e.g. adding solvent or surfactants, etc?). Could anyone help me with that?
Best regards,
Dadfar
Dear all,
Does anyone have experience with the pancreatin enzyme? It seems the solubility of pancreatin in water is very poor and I am looking for a way to increase its solubility (e.g. adding solvent or surfactants, etc?). Could anyone help me with that?
Best regards,
Dadfar
Dear Scientists,
I have recently faced an issue and need your help and suggestions. I tried to pass a sample solved in DMF via a polyacrylonitrile (PAN) membrane. But, the membrane shrank and I am afraid that a part of the PAN has been dissolved in DMF and moved to the sample. Would you please tell me how I can prove the presence or non-presence of PAN in the final product? Also, is PAN, FDA-approved?
I really appreciate any help and suggestions.
Best regards,
Dadfar
Dear Scientists,
I would like to consult you about the issue that I recently faced with that. I am planning to do 0.2 µm filtration of silica nanoparticles in water with a size of around 50 nm. I tried different filter types (cellulose, PTFE, PES, Nylon, hydrophilic, etc), but unfortunately, non of them worked out. Could you please recommend to me which filter type (material) I have to select to easily pass the sample through it without issue?
Best regards,
Ali
Dear Scientists,
I have a question regarding the preparation of "ammonium phosphate buffer" and would be great to help me with that. I prepared some ammonium phosphate buffer at pH around 5 which was a very transparent liquid. But, after filtration with a 200 nm filter, I noticed that the color of the filter changed to "brownish" which was very weird. Does anyone know the reason for the brownish color of the filter?
Best regards,
Ali
Dear scientists,
I am looking for any synthetic or real RNA or DNA with a negative charge and large molecular weight (around 1M Dalton) and a reasonable price for optimization of a reaction. There is some RNA from yeast available on Sigma, but, I couldn't find the molecular weight. I would appreciate any help or suggestion.
Best regards,
Ali
