Sirvan Abbasbeigi

Islamic Azad University Tehran Science and Research Branch | SRBIAU · Department of Biology

Protein aggregation is a complex phenomenon underlying various diseases, including neurodegenerative disorders, metabolic diseases, and systemic amyloidoses. This mini-review aims to provide an overview of the mechanisms governing protein aggregation, its implications in disease pathogenesis, and potential therapeutic strategies. A comprehensive li...

COVID-19 is a respiratory infection caused by SARS-CoV-2 that can also have neurological manifestations and complications. There is growing evidence that COVID-19 may be associated with an increased risk of neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis. The mechanisms underlying thi...

COVID-19 is a respiratory infection caused by SARS-CoV-2 that can also have neurological manifestations and complications. There is growing evidence that COVID-19 may be associated with an increased risk of neurodegenerative disorders, such as Alzheimer’s disease, Parkinson’s disease, and Amyotrophic lateral sclerosis. The mechanisms underlying thi...

Students often recognize biochemistry as a research-oriented system. It is effortless to see the spread of this view because everyday students pay more attention to what their instructors concentrate on and witness professors’ basic research in the laboratory. Meanwhile, biochemistry science depends on research activities that are fundamental and t...

Backgrounds: Is it possible to consider an absolute end to this pandemic? It has been almost four years since people tried to find an ultimate treatment for a well-known disease (Covid-19), and still, we are asking what is happening next. However, it is not fair to ignore those remarkable successes of scientists in restricting the complications cau...

About half a century ago, perhaps few people thought that the development of a particular type of viral disease and the vaccination process would take nearly a year; however, it happened (successful or unsuccessful). The best tool to help researchers in this direction is the subsequent development of computer-based science and proprietary processes...

Alzheimer's disease has been identified as a protein misfolding disease, a proteopathy, caused by the accumulation of abnormally folded amyloid beta protein into amyloid plaques, and tau protein into neurofibrillary tangles in the brain. Plaques are made up of small peptides, 39–43 amino acids in length, called amyloid-beta (Aβ). Amyloid beta is a...

Due to the increasing spread of the Coronavirus 2019 (COVID-19), the competition for the most successful possible solution has become very popular among different countries. Therefore, addressing the issue of which is the next most likely candidate to enter the global market; It is a question that sooner or later every country must answer. This stu...

About half a century ago, perhaps few thought that the development and vaccination process for a particular type of viral disease would take place almost a year; however, it is happened (either successful or unsuccessful). The most remarkable tool that has helped researchers in this direction has been the development of computer-based science and p...

Diseases resulting from protein accumulations can be described mainly by improper folding and aggregation of endogenous proteins in affected tissues such as the brain or the heart. During misfolding and aggregation, the affected protein often loses its normal function, becomes more resistant to degradation, and often acquires toxic functions that c...

Students often recognize biochemistry as a research-oriented system. It is effortless to see the spread of this view because everyday students pay more attention to what their professor concentrated on, and witness the work of professors' basic research in the laboratory. Meanwhile, biochemistry science depends on research activities that are funda...

It is displayed an oral presentation of my study, entitled "COVID-19 treatments | A glance at the most recent reported drugs, which may close to the operational phase," in the 4th International Congress on Biomedicine (ICB2020), held on November 9th - 16th, 2020.

Aurones are the secondary metabolites of natural compounds belonging to the flavonoids family. The family also includes flavones, flavonols, flavanones, flavanonols, catechins, anthocyanins, and chalcones, and widely presents in fruits and flowers where they play a significant role in the pigmentation of the plant. Structurally, aurones are a benzo...

Diseases resulting from protein accumulations can be described mainly by improper folding and aggregation of endogenous proteins in affected tissues such as the brain or the heart. During misfolding and aggregation, the affected protein often loses its normal function, becomes more resistant to degradation, and often acquires toxic functions that c...

Much of the existing treatment methods have resulted out from an understanding of the previous 2 outbreaks, particularly the SARS-CoV outbreak which shares similarities with the novel strain of the Coronavirus. However, to generate treatments with high efficacy, the unique features of SARS-CoV-2 must be understood to a greater extent, especially it...

The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread so rapidly and severely affected the people of almost every country in the world. The highly contagious nature of this virus makes it difficult to take control of the present pandemic situation.

Due to the increasing spread of the Coronavirus, 2019 (COVID-19), the competition for the most successful possible solution has become very popular among different countries. Therefore, addressing the issue of which is the next most likely candidate to enter the global market; It is a question that sooner or later every country must answer. This st...

In 1854, the term “amyloid” was used for the first time by Virchow. To describe an aggregated substance found in the liver of a deceased patient. Despite the misleading association to starch, the term is still used and currently, 27 diseases are associated with amyloid fibril deposits of normally soluble proteins. Early detection of amyloid deposit...

Introduction: An aurone is a heterocyclic chemical compound which is a type of flavonoid structure that provides yellow color to the flowers of some popular ornamental plants such as snapdragon and cosmos; in addition to possessing antifungal properties for plants. A novel series of aurone derivatives for in vivo imaging of β-amyloid plaques in the...

The development of drugs against SARS-CoV-2 has become an urgent necessity to combat the COVID-19 pandemic. With about 15% of COVID-19 patients suffering from severe disease and hospitals being overwhelmed, treatments are desperately needed in this situation. Although there is no specific drug or vaccine available which can be used to treat COVID-1...

In the study, we have inquired five types of synthetic compounds in the two different protein conditions. Protein conditions divided between amyloid/amorphous aggregates due to a comprehensive assessment for the selectivity and sensitivity parameters. Meanwhile, it has tried to answer this statement of how different and specific rates of synthetic...

Vegetable polyphones might be represented as serious candidates for a large group of antioxidants in the diet of vegetables and also fruits. All phenols contain either the derivatives of intermediate phenylalanines or precursors close to shikimic acid, divided into at least ten different classes based on chemical structure, aromatic ring structure,...

The aurone derivatives are a class of polyphenols family, which assumed that could bind to neurofibrillary tangle structures in-vivo in contrast with other probes incapability such as ThT and ThS. Therefore it is required to examine alternative synthetic compounds in-vitro first and then expand the experimental strategy to in-vivo circumstances. In...

β-Lactogluboline was purified via fractionation method (As an all β secondary structure) and bovine serum albumin (As an α/β secondary structure) was purchased from Sigma Aldrich. For more precision, their qualities were evaluated by SDS-PAGE and Bradford protein assay. Furthermore, the spectrophotometric analysis of synthetic compounds such as UV-...

Neurodegenerative diseases are characterized by the presence of amyloid deposition. Thioflavin T (ThT) has been one of the molecules of choice to attempt the detection of the amyloid deposits, but ThT is unable to cross the blood-brain barrier, due to its low lipophilicity. Therefore, there is strong motivation to design and develop new compounds f...

Introduction: As it was mentioned in our previous report, aurone derivatives originated from polyphenols cluster, and due to its natural features such as neutral load and proper lipophilicity coefficient, there is a good candidate to work on it as a suitable alternative instead of ThT compound which may well be known as amyloid plaques probe. we ha...

Objective: In 1854, the term “amyloid” was used for the first time by Virchow. To describe an aggregated substance found in the liver of a deceased patient. Despite the misleading association to starch, the term is still used a currently 27 diseases are associated with amyloid fibril deposits of normally soluble proteins. Early detection of amyloid...

Neurodegenerative diseases are characterized by the presence of amyloid deposition. Thioflavin T (ThT) has been one of the molecules of choice to attempt the detection of the amyloid deposits, but ThT is unable to cross the blood-brain barrier, due to its low lipophilicity. Therefore, there is strong motivation to design and develop new compounds f...