Sikiru Olaitan Balogun

UFGD - Universidade Federal da Grande Dourados | ufgd · Faculty of Health Sciences (FCS)

Ethnopharmacological relevance: Helicteres sacarolha, popularly known in Brazil as 'rosquinha', 'sacarolhas', 'semente-de-macaco', is widely distributed in different phytogeographic zones in Brazil. Preparations from its roots and leaves are employed in popular Brazilian medicine in the treatments of ailments such as peptic ulcer, hypertension amo...

Ellagic acid (EA), a plant-derived polyphenol, exhibits antioxidant, anti-inflammatory, and gastroprotective effects. Its gastroprotective mechanisms have not been fully elucidated nor have its effects on chronic ulcer previously been described. Toward these ends, the antiulcer activities of EA were evaluated in acute (ethanol and indomethacin) and...

Ethnopharmacological relevance: Lafoensia pacari St.-Hil. is a tree native to the Brazilian Cerrado. Its bark macerate is popularly used in Brazilian folk medicine for the treatment of peptic ulcer, wound healing and inflammation. Aim of the study: To evaluate the antiulcer activities of the methanol extract of Lafoensia pacari (MELP) and possib...

Ethnopharmacological relevance: Dilodendron bipinnatum Radlk., Sapindaceae, is popularly known as 'mulher-pobre'. Its stem bark macerate or decoction is popularly used mainly to treat uterine inflammation and bone fractures. Acute oral and subchronic toxicities of the hydroethanolic extract of Dilodendron bipinnatum (HEDb) were investigated as wel...

Senna rugosa is a species found in the Cerrado and used in folk medicine as a vermifuge and in the treatment of poisonous snakebites accidents. In this work, we identified the main secondary metabolites present in ethanolic extracts of the leaves (ELSR) and roots (ERSR) of S. rugosa and evaluated the potential cytoprotective effect against cellular...

Cancer is a heterogeneous disease that includes a complex ecosystem of different cell types. In the development of anti-cancer drugs, including those aimed at treating breast cancer, one of the major obstacles is establishing a model that reproduces the complexity of human cancer. In the present study, we will use organoids to study anti-tumour pha...

In this study, a novel compound was isolated, identified, and its chemical structure was determined from the extract of the roots of Senna velutina. In addition, we sought to evaluate the anticancer potential of this molecule against melanoma and leukemic cell lines and identify the pathways of cell death involved. To this end, a novel anthraquinon...

Cancer is a complex disease, considered a major public health problem worldwide. Among the types of cancer, melanoma, and leukemias present high mortality rates in Brazil and worldwide. Currently, conventional cytotoxic treatments cause severe side effects by the non-selectivity between normal cells and cancer cells. Therefore, molecules of natural...

Objetivo: Verificar a intensidade do basquete em cadeira de rodas (BCR) em pessoas com deficiência (PCD) durante 8 semanas de intervenção. Métodos: Estudo experimental longitudinal com 13 PCD foi avaliado o monitoramento da FC, freqüência cardíaca média (FCMéd) para cálculo da frequência cardíaca mínima (FCMin) e % frequência cardíaca de treinament...

Preparations of Helicteres sacarolha (Malvaceae) leaves and roots are used in the form of decoction, infusion or maceration, to treat gastrointestinal disturbances, among others. Studies supporting some of its ethnomedicinal uses are still incipient. The present study aimed to investigate it potential effect on chronic ulcer, colitis and possible p...

Introduction Eucalyptus tereticornis Smith. is used in the Green Pharmacies Project in the state of Ceará, Brazil, in for the treatment of respiratory ailments. Its major essential oil content is 1,8-cineole. Until the present time, there is no phytochemical standardization. Therefore, the present study was aimed at standardization by phytochemical...

Objective: Few studies on physical medicine and rehabilitation analyze the benefit of wheelchair basketball in people with motor disabilities. Given these, this study aimed to investigate the effect of the intervention of wheelchair basketball on urinary tract infection in people with motor disabilities. Methods: A 12-month experimental follow-u...

Ocimum gratissimum L. has attracted substantial consideration from researchers because of its anti-inflammatory uses in ethnomedicine in Sub-Saharan Africa and Asia. This study investigated the effect of flavonoid-rich ethylacetate fraction of O. gratissimum (EAFOg) in apoptosis induction of activated macrophages and inflammatory response in LPS-in...

Ocimum gratissimum L. has attracted substantial consideration from researchers because of its anti-inflammatory uses in ethnomedicine in Sub-Saharan Africa and Asia. This study investigated the effect of flavonoid-rich ethylacetate fraction of O. gratissimum (EAFOg) in apoptosis induction of activated macrophages and inflammatory response in LPS-in...

Objectives: To evaluate the effect of a probiotic supplement containing two genera and five species of bacteria versus placebo on the quality of life (QoL) in female university students with intestinal constipation (IC). Design: A randomized, double-blind placebo-controlled study was conducted on female university students in a single study center...

Introduction: Momordica charanthia L., Curcubitaceae, is a pantropical food and medicinal plant. The plant is included in the Official List of Brazilian Medicinal Plants of interest to the Brazilian Unified Health System. The study aimed to perfom microbiological studies with extracts of Momordica charanthia L. including chemical characterizatio...

Ethnopharmacological relevance Virola elongata is a tree species belonging to the Myristicaceae family, distributed in the North and Midwest regions of Brazil, in the phytogeographic domain of the Amazon. The aqueous infusion or the hydroethanolic macerate of the stem bark of V. elongata are used in Brazilian and Ecuadorian indigenous folk medicine...

Ethnopharmacological importance: The Caatinga (semi-arid region), is an exclusively Brazilian biome. Considering the scarcity of ethnobotanical and ethnopharmacological studies in this region before the year 2000, this study presents data from ethnobotanical expeditions carried out between 1980 and 1990, by the late professor Francisco José de Abre...

Ethnopharmacological relevance Cochlospermum regium (Bixaceae) is a native shrub of Brazil and its xylopodium (infusion/decoction) is being used for the treatment of gastritis, ulcers, arthritis, intestinal infections, gynaecological infections, skin diseases, among others. The aim of the present study was to evaluate the gastroprotective/antiulcer...

Objective The aim of this study was to screen a group of medicinal plants’ extracts used in the treatment of ailments related to infections in the Brazilian popular medicine. And to carry out in vivo toxicity and antibacterial studies on Conyza bonariensis (Asteraceae) leaves and roots methanolic extracts selected based on the screening. Methods: E...

Ethnopharmacological relevance: Simaba ferruginea A. St.-Hil., Simaroubaceae, popularly known as "calunga" is a typical subtropical shrub used in Central Brazil mainly for infection, anti-inflammatory, analgesic and gastric duodenal-ulcers. It presents in its composition the alkaloid canthin-6-one, an alkaloid indole β-carboxylic. Aim: This stud...

Ethnopharmacological importance: Lafoensia pacari A. St.-Hil., (Lythraceae) is a native tree of Brazilian Cerrado and commonly known in Brazil as "mangava-brava". Its leaves are used in Brazilian folk medicine in wound healing, cutaneous mycoses, and in the treatment of gastritis and ulcers. Aim of the study: The present study was designed to ev...

Vitexin is an important component of various medicinal plants frequently used to treat asthma, such as Crataegus spp., Vitex spp., Passiflora spp., and Echinodorus spp. However, there is no information about the vitexin potential itself as anti-asthmatic. The aim of the present work was to evaluate the anti-hypersensitive activity of vitexin in a m...

Vitexin is an important component of various medicinal plants frequently used to treat asthma, such as Crataegus spp., Vitex spp., Passiflora spp., and Echinodorus spp. However, there is no information about the vitexin potential itself as anti-asthmatic. The aim of the present work was to evaluate the anti-hypersensitive activity of vitexin in a m...

NIPRISAN ® is a polyherbal formulation developed for the prophylactic management of sickle cell disease. This study was aimed to evaluate the cytotoxicity of NIPRISAN ® in our continued effort to generate useful data for its safe and efficacious use. The fingerprints profile of NIPRISAN® was first analysed using a HPLC to establish constituents' ma...

Background: The constant pursuit of improved athletic performance characterizes high-performance sport and the use of medicinal plants as dietary supplements is becoming widespread among athletes to enhance long-term endurance performance. Aim: The present study evaluated the toxicity of Heteropterys tomentosa (HEHt) and its acute adaptogenic effec...

Gallesia integrifolia is a Brazilian Amazon tree whose bark decoction is popularly used to treat peptic ulcer. The essential oil from the inner stem bark of G. integrifolia (EOGi) was chemically characterized by GC/MS. The in vitro cytotoxicity and genotoxicity were evaluated in CHO-K1 cells, while the in vivo oral acute toxicity was performed in m...

Ethnopharmacological relevance: Copaifera malmei Harms (Fabaceae), known mainly as óleo-mirim, is a native and endemic plant found in the states of Mato Grosso and Goiás of Brazil. The plant's leaves infusion is popularly used by riverine communities of the northern Araguaia microregion, Mato Grosso, Brazil, for the treatment of gastric ulcers and...

Objective: The purpose of this study is to evaluate selected Brazilian plants, Juruena valley region of Mato Grosso, for their in vitro antimicrobial and antioxidant activities. Methods: The plants (26) were extracted with hydroethanolic solution by maceration. The extracts were tested for their in vitro antimicrobial activity was determined by MI...

Ethnopharmacological importance: Currently, in many traditional communities, such as the riverine community in the North Araguaia microregion (Mato Grosso, Brazil), plant knowledge and use represent the main, if not the only, therapeutic resource for the maintenance of health and/or treatment of diseases. This study aimed to identify and document s...

Ethnopharmacological importance: Currently, in many traditional communities, such as the riverine community in the North Araguaia microregion (Mato Grosso, Brazil), plant knowledge and use represent the main, if not the only, therapeutic resource for the maintenance of health and/or treatment of diseases. This study aimed to identify and document...

Ethnopharmacological relevance: Ocimum gratissimum L. is a herbaceous plant that has been reported in several ethnopharmacological surveys as a plant readily accessible to the communities and widely used for the treatment of inflammatory diseases. The main goal of this study was to investigate the in vitro and in vivo anti-inflammatory activity an...

Ethnopharmacological relevance: Echinodorus scaber, Alismataceae, is popularly known in Brazil as "chapéu-de-couro". The plant leaves are used by the population as decoction, infusion, or maceration in bottled spirits, to treat inflammatory respiratory diseases. Aim of the study: To investigate the anti-inflammatory mechanism of the hydroethanol...

Ethnopharmacological relevance: Piper umbellatum L. (Piperaceae) is a shrub found in the Amazon, Savannah and Atlantic Forest region of Brazil. It is widely used in folk medicine in many countries primarily for the treatment of gastric disorders. The aim of this study was to evaluate the gastroprotective and anti-ulcer effects of hydroethanolic ex...

Ethnopharmacological relevance: Gallesia integrifolia (Phytolaccaceae) is commonly known as "pau-d'alho" in Brazil or "garlic plant" due to the strong scent of garlic peculiar to all parts of the plant. The bark decoction is used for the treatment of microbial infections among other diseases by different ethnic groups in Brazil, Peruvian Amazonian...

Ethnopharmacological relevance: Copaifera malmei Harms (Fabaceae) is a plant that occurs in the central region of Brazil, where the plant's leaves infusion is popularly used to treat gastric ulcer and inflammatory diseases. This study was aimed to investigate the gastroprotective activity and mode of action of the plants' leaves infusion in order...

Ethnopharmacological importance The use of medicinal plants for treatment, cure and prevention of diseases has been described by many people since time immemorial. Because of this use, commercial and scientific interests have emerged, making it necessary to realize ethnobotanical surveys of medicinal plants species, which is important for subseque...

The use of medicinal plants for treatment, cure and prevention of diseases has been described by many people since time immemorial. Because of this use, commercial and scientific interests have emerged, making it necessary to realize ethnobotanical surveys of medicinal plants species, which is important for subsequent chemical and pharmacological b...

Helicteres sacarolha A. St.- Hil. et al., popularly known in Brazil as 'semente-de-macaco', is widely employed in the popular medicine in many of parts of Brazil in the alleviation of symptoms of ailments such as peptic ulcer and inflammation. Up to the present, there is no study addressing the gastroprotective activity of the hydroethanolic extrac...

Ethnopharmacological relevance: Helicteres sacarolha A. St.- Hil. et al.popularly knowninBrazilas ‘semente- de-macaco’, is widely employed in the popular medicine in many of parts of Brazil in the alleviation of symptoms of ailments such as peptic ulcer and inflammation. Up to the present, there is no study addressing the gastroprotective activity...

Cedrela odorata L. (Meliaceae) is a native plant of the Amazon region and its inner stem bark is used in the treatment of diabetes in the form of maceration in Brazilian popular medicine. Until now, there is no scientific study on this activity. The present study was aimed at evaluating the anti-hyperglycemic activity, anti-diabetic, toxicity, anti...

Ethnopharmacological relevance: Dilodendron bipinnatum Radlk. (Sapindaceae), popularly known as "mulher-pobre", is a native tree of the Pantanal of Mato Grosso, Brazil. The stem bark of Dilodendron bipinnatum is used by the population, in the forms of decoction and maceration in the treatment of inflammatory conditions. There is no information in...

Bidens pilosa, a member of the Asteraceae family, is one of the dominant medicinal plant species worldwide including Uganda. This study aimed at assessing both acute and sub-chronic toxicities of Bidens pilosa Leaves Extract (BPLE). Phytochemical tests were done on BPLE to detect the presence of secondary metabolites. In acute toxicity test, a sing...

Simaba ferruginea A. St-Hil. (Simaroubaceae) is a subshrub typical of the Brazilian Cerrado, whose rhizomes are popularly used as infusion or decoction for the treatment of gastric ulcers, diarrhea and fever. To evaluate the pharmacological mechanism(s) of action of the antiulcer effects of the methanol extract of Simaba ferruginea and its alkaloid...

Introduction: Ficus trichopoda is a ficus species growing in wet places - swamp forest, river banks and swamp grassland. It is well used in the management of inflammation - related conditions locally. This present work was undertaken to investigate anti-inflammatory and analgesic properties of aqueous ethanolic extract of Ficus trichopoda bark in r...

Ficus trichopoda, Baker, is a medicinal plant belonging to the Moraceae family used popularly as a 'multi-purpose' herb in Uganda. The aim of this study was to evaluate the anti-diarrheal, ulcer protective effects of 70% ethanolic extract of Ficus trichopoda stem bark (FTE) and its acute toxicity. The anti-diarrheal effect was evaluated using casto...

A total of 40 consecutive isolates of Klebsiella species obtained from clinical specimens were analyzed for susceptibility pattern to common antibiotics used in Nigeria, plasmid profiles, and β-lactamase production and assay. Six different species of Klebsiella were detected in all strains. 20 strains (50%) were K. pneumoniae, 9 strains (23%) were...