Si Jiarui

Tianjin Medical University | TIJMU · computer

Diabetes Mellitus (DM) is a chronic condition that affects the blood glucose metabolism of various organs and tissues throughout the body. It can result in microvascular disorders such as coronary heart disease and cerebral hemorrhage. One significant complication is retinopathy, which, in severe cases, can lead to blindness. Early screening and de...

Glucose management for people with type 2 diabetes mellitus is essential but challenging due to the multi-factored and chronic disease nature of diabetes. To control glucose levels in a safe range and lessen abnormal glucose variability efficiently and economically, an intelligent prediction of glucose is demanding. A glucose trajectory prediction...

In this paper, we aim to identify the best ratio of training set, and to evaluate the diagnostic performance of eight classical machine learning methods for chronic diseases. The five categories of chronic disease datasets were collected from UCI and GitHub database include heart disease, breast cancer, diabetic retinopathy, Parkinson’s disease and...

Background: Hodgkin Lymphoma (HL) is a type of aggressive malignancy in lymphoma that has high incidence in young adults and elderly patients. Identification of reliable diagnostic markers and efficient therapeutic targets are especially important for the diagnosis and treatment of HL. Although many HL-related molecules have been identified, our u...

Increasing evidence shows that Aβ oligomers are key pathogenic molecules in Alzheimer’s disease. Among Aβ oligomers, dimer is the smallest aggregate and toxic unit. Therefore, understanding its structural and dynamic properties is quite useful to prevent the formation and toxicity of the Aβ oligomers. In this study, we performed molecular dynamic s...

Comparison of APL for both the top and bottom leaflets between the DPPC membranes inserted with four Aβ42 dimers during the extended 150 ns MD simulation. (TIF)

RMSF values for all the backbone atoms of four Aβ42 dimers. The 400 ns MD simulation was used in the calculations. The N-terminal polar and C-terminal apolar regions of Aβ42 peptide are shown in blue and gray bar under X-axis, respectively. (TIF)

Comparison of average secondary structure content, β-strand, turn and coil, for four aβ42 dimers. (TIF)

Comparison of the mass density profiles for water (black), head-group of DPPC (red) and three Aβ42 dimers, CNNC, NCNC and NCCN, during the fist and last 100 ns of simulation. (TIF)

Comparsion of the final snapshot of four Aβ42 dimers from MD simulation. The Aβ42 peptide is shown in carton. The polar and apolar regions of Aβ42 peptide are colored in blue and red, respectively. The water molecules and phosphorus atoms are shown as Van der Waals spheres of different colors and sizes. The water molecules on the surface of DPPC bi...

RMSD of all backbone atoms in the four Aβ42 dimers within the DPPC membrabe throughout the 400 ns simulation. The RMSD values are plotted with respect to the structure after equilibration. (TIF)

Average SCD as function of the carbon atom along the lipid tails for the membranes inserted with four Aβ42 dimers, pure DPPC membrane and the experimental values. (TIF)

Radical distribution functions (RDF) for DPPC molecules with respect to Aβ42 dimers. (TIF)

The objective of this paper is to analyze the relationship among the interrelated gene sequences of Alzheimer's disease (AD). Further this paper will provide a study on genetic factor of the occurrence about Alzheimer's disease, so as to provide more information on the prevention of Alzheimer's disease, the clinical diagnosis and gene therapy for A...

Stochastic search algorithms are often robust, scalable problem solvers. In this paper, we carefully study the Iterative Sampling(IS), Heuristic-Biased Stochastic Sampling(HBSS) and Value-Biased Stochastic Sampling(VBSS) algorithm, and present an approach for enhancing such multi-start algorithms. This paper shows that given some heuristic informat...