Shumaila Jan

Quaid-i-Azam University | QAU · Department of Biochemistry

Introduction: Alpha-Cypermethrin is a synthetic pyrethroid insecticide. Pyrethroids are derived from pyrethrins, which are toxic components found in the Chrysanthemum cinerariaefolium flowers. They have been employed in agriculture, home and veterinary formulations to control the insect vectors of disease, agricultural insects and topically applied...

Introduction: Alpha-cypermethrin (Pyrethroid insecticide) is widely used in disease vector control, agriculture, home pest control and protection of foodstuff across the world. Due to its unchecked and widespread use, non-target organisms are also getting affected by its toxic effects. Objectives: This investigation was aimed to determine the preve...

Introduction: Hemostasis mechanism involves blood coagulation as one of the step which is responsible for blood clot formation that restricts blood flow at site of injury. By inhibiting coagulation cascade and reducing thrombus formation, several cardiovascular diseases (CVD) and atherosclerosis can be prevented. Traditionally, Fagonia olivieri (zy...

Introduction: Periploca aphylla Decne. (Asclepiadoideae) locally named as “Bata”, is a medicinally important plant. The milky juice of P. aphylla is externally applied to tumors and swellings, for cerebral fever treatment and as stomachic. The flowers are used as vegetables, emetic purposes, expectorant, laxative, diuretic and for wart removal. Obj...

Purpose: Cypermethrin (class II) belongs to pyrethroid insecticides which have been in wide use to control various pests including moth pests of cotton, fruit and vegetable crops. This study was aimed to investigate the effects of cypermethrin on haematology of female rats and their modulation by co-administration of sodium selenite. Methodology: F...

Introduction: Plants have been utilized for the cure of different diseases since ancient times. Medicinal importance of the plants is due to presence of phytochemicals having specific physiological action on the human body. A wide variety of activities have been found in these phytochemicals which might help in preventing chronic disorders. Periplo...

New era of Asian Oncology Challenge, Cure, Care June 16-18, 2022

Background Oxidative stress is believed to be a root cause of various degenerative and fibrotic disorders. Dietary foods enrich in antioxidants can cure or curtail the progression of oxidative stress induced disorders. Fruit of Monotheca buxifolia is used locally for digestive and urinary tract disorders. We have evaluated the protective potential...

Ethnopharmacological relevance: Branched cancerwort, Kickxia ramosissima (Wall.) Janchen (Scrophulariaceae) is traditionally used for the treatment of inflammatory disorders such as rheumatism, diabetes, jaundice and for activation of immune system. Local communities also used this plant for the treatment of spleen enlargement, as febrifuge and in...

This study was conducted to investigate the antioxidant potential of methanol extract and its derived fractions (hexane, ethyl acetate, butanol, and aqueous) of fruits of Monotheca buxifolia (Falc.) Dc., a locally used fruit in Pakistan. Dried powder of the fruit of M. buxifolia was extracted with methanol and the resultant was fractionated with so...

In Pakistan Fagonia olivieri (Zygophyllaceae) is commonly used in the indigenous system of medicine for treatment of conditions like diabetes, cancer, fever, asthma, toothache, stomach troubles and kidney disorders. This study evaluated the crude methanol extract of F. olivieri (FOM) and its derived fractions for their antimicrobial and cytotoxic a...

Methanol extract and its n-hexane, ethyl acetate, butanol and aqueous fraction of Galium aparine L. (Rubiacea) were evaluated in vitro for their antioxidant capacity (DPPH, superoxide radical, phosphomolybdate assay); reducing power (ABTS, hydroxyl, hydrogen peroxide, to reduce Fe(3+) to Fe(2+) ions) and to estimate total flavonoid and phenolic con...

In Pakistan Fagonia olivieri (Zygophyllaceae) is commonly used for the treatment of diabetes, cancer, fever, asthma, urinary discharges, toothache, stomach troubles and kidney diseases. Therefore the crude methanolic extract and various fractions of Fagonia olivieri are evaluated for phytochemical composition and in vitro various biological activit...

Background Launaea procumbens (Asteraceae) is used as a folk medicine to treat hepatic disorders in Pakistan. The effect of a chloroform extract of Launaea procumbens (LPCE) was evaluated against carbon-tetrachloride (CCl4)-induced liver damage in rats. Methods To evaluate the hepatoprotective effects of LPCE, 36 male Sprague–Dawley rats were equa...

Allelopathic screening of various fractions of Launaea procumbens, collected from Wah Cantt (Punjab) Pakistan, was conceded to identify potent allelopathic fraction for future phytochemical analyses. For this purpose, radish root inhibition method was used to test allelopathic potential. Two different concentrations of 100 ppm and 1000 ppm of Launa...

The protective effects of Sonchus asper butanol extract against KBrO3- induced oxidative damage in kidney of rat were determined in this study. 24 Sprague-Dawley male rats (180 to 200 g) were divided into 4 groups. Group I was given saline (1 ml/kg b.w., 0.85% NaCl) and DMSO (1 ml/kg b.w.); group II was treated with KBrO3 (20 mg/kg b.w., i.p.); gro...

Launaea procumbens is traditionally used in the treatment of renal dysfunction. In the present study, protective effects of L. procumbens against KBrO 3 -induced nephrotoxicity in rat were determined. In this study, 24 male albino rats (195 to 200 g) were equally divided into 4 groups. Group I was given saline (1 ml/kg b.w., 0.85% NaCl) and DMSO (1...

Launaea procumbens is traditionally used in the treatment of liver dysfunction and hepatitis. In the present study, protective effects of L. procumbens against potassium bromate (KBrO 3)-induced hepatotoxicity of rat were determined. However, 36 male albino rats (180 to 200 g) were equally divided into 6 groups. Group I was given saline (1 ml/kg b....

Molecular markers; DNA, argyrophilic nucleolar organiser regions (AgNORs) and telomerase enzymes play important role in diagnosis of nephrotoxicity induced by potassium bromate (KBrO3). In the present study, the effects of Launaea procumbens against KBrO3 induced molecular changes in male rats are determined. 36 male albino rats (180 to 200 g) were...

The protective effects of Sonchus asper butanol extract against KBrO 3 -induced oxidative damage in kidney of rat were determined in this study. 24 Sprague-Dawley male rats (180 to 200 g) were divided into 4 groups. Group I was given saline (1 ml/kg b.w., 0.85% NaCl) and DMSO (1 ml/kg b.w.); group II was treated with KBrO 3 (20 mg/kg b.w., i.p.); g...

Launaea procumbens is traditionally used in the treatment of liver dysfunction and hepatitis. In the present study, protective effects of L. procumbens against potassium bromate (KBrO 3)-induced hepatotoxicity of rat were determined. However, 36 male albino rats (180 to 200 g) were equally divided into 6 groups. Group I was given saline (1 ml/kg b....

Launaea nudicaulis is a local medicinal plant of District Bannu, KPK, Pakistan, used traditionally for various diseases and having the phytotoxic ability. In the present study, allelopathic activity of the various fractions of Launaea nudicaulis was studied against radish growth. Two concentrations of the extract: 100 and 1000 ppm were used. Methan...

Molecular markers; DNA, argyrophilic nucleolar organiser regions (AgNORs) and telomerase enzymes play important role in diagnosis of nephrotoxicity induced by potassium bromate (KBrO 3). In the present study, the effects of Launaea procumbens against KBrO 3 induced molecular changes in male rats are determined. 36 male albino rats (180 to 200 g) we...

Launaea procumbens is traditionally used in the treatment of renal dysfunction. In the present study, protective effects of L. procumbens against KBrO 3 -induced nephrotoxicity in rat were determined. In this study, 24 male albino rats (195 to 200 g) were equally divided into 4 groups. Group I was given saline (1 ml/kg b.w., 0.85% NaCl) and DMSO (1...

Sonchus arvensis is used as salad, vegetable and as a human diet in Pakistan, traditionally used in the treatment of various ailments. This study was designed to investigate the mathanol extract of S. arvensis was evaluated against CCl 4-induced adrenal oxidative stress in rat. The extract was administered to rats after 48 h of CCl 4 treatment (3 m...

Allelopathic screening of various fractions of Launaea procumbens, collected from Wah Cantt (Punjab) Pakistan, was conceded to identify potent allelopathic fraction for future phytochemical analyses. For this purpose, radish root inhibition method was used to test allelopathic potential. Two different concentrations of 100 ppm and 1000 ppm of Launa...