Sheng-Hua Wu

National Museum of Natural Science · Department of Biology

Background Pain is often neglected in disabled older population, especially in Taiwan where the population of institutional residents is rapidly growing. Our study aimed to investigate pain prevalence and associated factors among institutional residents to improve pain assessment and management. Methods This nationwide study recruited 5,746 instit...

Species in Taiwan that are accepted in Inonotus or have been connected to the generic name are provided. Eight species are accepted in Inonotus, including I. chrysomarginatus, which is newly recorded in Taiwan. Twelve species that were previously associated with the genus Inonotus have now been reclassified and placed in various other genera, inclu...

Paclitaxel (PAC) results in long-term chemotherapy-induced peripheral neuropathy (CIPN). The coexpression of transient receptor potential vanilloid 1 (TRPV1) and Toll-like receptor 4 (TLR4) in the nervous system plays an essential role in mediating CIPN. In this study, we used a TLR4 agonist (lipopolysaccharide, LPS) and a TLR4 antagonist (TAK-242)...

Background Vulvovaginal laxity, atrophic vaginitis, and orgasmic dysfunction are not only aesthetic but also sexual problems. Autologous fat grafting (AFG) facilitates tissue rejuvenation through the effects of adipose-derived stem cells; the fat grafts serve as soft-tissue filler. However, few studies have reported the clinical outcomes of patient...

Muscle loss and weakness after a burn injury are typically the consequences of neuronal dysregulation and metabolic change. Hypermetabolism has been noted to cause muscle atrophy. However, the mechanism underlying the development of burn-induced motor neuropathy and its contribution to muscle atrophy warrant elucidation. Current therapeutic interve...

Background Inducing and reversing neuromuscular block is essential to a positive outcome of thyroid surgery, with intraoperative neuromonitoring (IONM) being used to decrease recurrent and superior laryngeal nerve injuries and improve vocal outcome. Neostigmine is a non-specific broad-spectrum and inexpensive reversal agent for neuromuscular blocki...

Dendrocorticiopsis orientalis is presented in this study as a new genus and new species based on morphological and phylogenetic evidence. This new taxon is characterized by resupinate, smooth and membranaceous basidiomata, monomitic hyphal system with clamps, colorless dendrohyphidia, variable presence of cystidia, and ellipsoid to ovoid basidiospo...

Three species of Aleurodiscus s.l. characterized in having effused basidiomata, clamped generative hyphae and quasi-binding hyphae, sulphuric positive reaction of gloeocystidia, hyphidia, acanthophyses, and smooth basidiospores are described. They are A. bicornis sp. nov., A. formosanus sp. nov., and A. parvisporus. Aleurodiscus bicornis was found...

Background Neuromuscular blocking agents provide muscular relaxation for tracheal intubation and surgery. However, the degree of neuromuscular block may disturb neuromuscular transmission and lead to weak electromyography during intraoperative neuromonitoring. This study aimed to investigate a surgeon-friendly neuromuscular block degree titrated su...

The phlebioid clade (Polyporales, Basidiomycota) accommodates numerous species of corticioid and polyporoid fungi of the Phanerochaetaceae, Irpicaceae, and Meruliaceae. The present study used morphological and phylogenetic approaches to revise the generic classification of the phlebioid clade and survey species diversity. The phylogenetic analyses...

Background and objectives Chemotherapy-induced peripheral neuropathy (CIPN) is considered one of the most common sequelae in patients with cancer who experience consistent abnormal sensations or pain symptoms during or after paclitaxel (PAC) chemotherapy. Transient receptor potential vanilloid 1 (TRPV1) and toll-like receptor 4 (TLR4) have been rep...

Background: Neuronal apoptosis and inflammation in the ventral horn of the spinal cord contribute to denervated muscle atrophy post-burn. Hyperbaric oxygen therapy (HBOT) exerts anti-inflammation and neuroprotection. Furthermore, hypoxia-inducible factor (HIF)-1α has been reported to promote inflammation and apoptosis. We investigated the therapeut...

Species of the corticioid genus Cylindrobasidium are saprophytes or parasites in forest ecosystems. This study presents three new species of Cylindrobasidium from East Asia, according to study of morphological characteristics, and phylogenetic analyses based on sequence data inferred from nuc rDNA internal transcribed spacer ITS1-5.8S-ITS2 (ITS) re...

Objective Proper position of an electromyographic (EMG) endotracheal tube within the larynx plays a key role in functional electrophysiologic intraoperative neural monitoring (IONM) in thyroid surgery. The purpose of this study was to determine the feasibility of a portable video‐assisted intubation device (UEScope) to verify the optimal placement...

Liver damage induced by paracetamol overdose is the main cause of acute liver failure worldwide. In order to study the hepatoprotective effect of Sanghuangporus sanghuang mycelium (SS) on paracetamol-induced liver injury, SS was administered orally every day for 6 days in mice before paracetamol treatment. SS decreased serum aminotransferase activi...

The new genus Schizocorticium (Hymenochaetales) of corticioid fungi is presented with three new species: Schizocorticium magnosporum, Schizocorticium mediosporum, and Schizocorticium parvisporum. Most collections of these three species were made from Taiwan, and only two specimens were collected from Yunnan Province of China. Generic status of Schi...

Phylloporia moricola is described as a new species based on collections from Sichuan Province, China. All studied basidiocarps grow on trunks of Morus sp. This new species is supported by morphological features and phylogenetic analyses of DNA sequences inferred from a dataset of nuc 28S rDNA. P. moricola is characterized by having effused-reflexed...

Three species of Aleurodiscus s.l. characterized in having effused basidiomata, clamped generative hyphae and quasi-binding hyphae, sulphuric positive reaction of gloeocystidia, hyphidia, acanthophyses and smooth basidiospores, are described. They are A . bicornis sp. nov., A . formosanus sp. nov. and A . parvisporus . Aleurodiscus bicornis was fou...

Background Patients often experience scar-related pruritus, which negatively affects quality of life. Triamcinolone acetonide (TAC) is widely used to treat pathological scars, and botulinum toxin type-A (BTX-A) reportedly improves scarring and associated discomfort. Objectives To investigate the clinical efficacy of the combined TAC and BTX-A (TAC...

Sanghuangporus vitexicola (Hymenochaetales) is described as a new species based on collections made from Pingtung County, tropical South Taiwan. All studied basidiocarps grew on living trunks of Vitex negundo. This new species is characterized by having perennial, pileate basidiocarps; pore surface yellowish brown, pores 6–8 per mm; context 0.7–1.5...

Three new Peniophorella species (Hymenochaetales) growing on dead wood, are described and illustrated. Peniophorella aspersa was collected in Taiwan and mainland China, and characterized by minutely warted hymenial surface, well-developed subiculum, rare stephanocysts and cylindrical-suballantoid spores. Peniophorella crystallifera collected in mai...

Burn-related neuropathy is common and often involves pain, paresthesia, or muscle weakness. Irisin, an exercise-induced myokine after cleavage from its membrane precursor fibronectin type III domain-containing 5 (FNDC5), exhibits neuroprotective and anti-inflammatory activities. A rat model of third-degree burn on the right hind paw was used to inv...

Two wood-inhabiting agarics, Cyptotrama glabra and Hymenopellis raphanipes, are newly recorded in Taiwan. Their detailed descriptions and illustrations are provided. Phylogenetic analyses using sequences of the internal transcribed spacer (ITS rDNA) were carried out to confirm our morphology-based determinations.

Ganoderma bambusicola sp. nov. is described and illustrated from tropical Taiwan; it is also found in Laos and Myamar. The species is recognized as new based on morphological study and phylogenetic analyses using three gene regions: ITS, rpb2 and tef1-α. Ganoderma bambusicola has been incorrectly identified as G. neojaponicum in Taiwan for several...

Introduction Titration of neuromuscular block (NMB) plays a key role in intraoperative recurrent laryngeal nerve monitoring during thyroid surgery. The combination of neuromuscular blocking agent and timely partial reversal of NMB was investigated in both animal experiments and clinical neuro-monitored thyroidectomy. Methods In animal experiments,...

Four new species of Phylloporia (Hymenochaetales) are presented based on collections made from subtropical-tropical southeastern Taiwan. They are P. alyxiae, P. mori, P. murrayae, and P. rubiacearum. These four species respectively grow on plant genera Alyxia, Morus, Murraya, and family Rubiaceae. Their status of new species in Phylloporia is suppo...

Diabetes mellitus (DM) causes impaired wound healing by affecting one or more of the biological mechanisms of hemostasis, inflammation, proliferation, and remodeling and a large number of cell types, extracellular components, growth factors, and cytokines. Interventions targeted toward these mechanisms might accelerate the wound healing process. To...

Dentipellis fimbriata sp. nov. is described and illustrated from Taiwan. This new species is characterized by odontoid to hydnoid hymenophore, margin with rhizomorphs, monomitic hyphal system with clamp connections, subiculum with yellowish brown hyphae, aculeal trama with numerous tubular gloeocystidia, and amyloid basidiospores. Morphological and...

Species of Ceriporia (Irpicaceae, Basidiomycota) are saprotrophs or endophytes in forest ecosystems. To evaluate the taxonomy and generic relationships of Ceriporia and other related taxa, we used morphology and multigene phylogenetic analyses based on sequence data from nuc rDNA internal transcribed spacer ITS1-5.8S-ITS2 (ITS) region, nuc 28S rDNA...

Background: Burn injury induces long-term skeletal muscle pathology. We hypothesized EPO could attenuate burn-induced muscle fiber atrophy. Methods: Rats were allocated into four groups: a sham burn group, an untreated burn group subjected to third degree hind paw burn, and two burn groups treated with weekly or daily EPO for four weeks. Gastrocnem...

Background and Objectives: The tie-over bolster technique has been conventionally used for skin graft fixation; however, long operative times and postoperative pain are the main disadvantages of this method. In this study, we introduce a new method using vacuum-assisted closure (VAC) with a silicon-based dressing as an alternative for skin graft fi...

This article reviews the literature on development of neuromuscular blockade management in thyroid surgery with intraoperative neural monitoring (IONM) in the past decade. Neuromuscular blockade management includes the choice of neuromuscular blocking agents (NMBAs) and reversal of neuromuscular blockade by sugammadex. A series of animal study and...

Paratrichaptum accuratum is a large conspicuous polypore fungus growing on dead or living angiosperm trees in subtropical-boreal areas of China, Indonesia, Japan, and Taiwan. The present study places P. accuratum in the family Gloeophyllaceae that belongs to the order Gloeophyllales within Agaricomycetes (Basidiomycota), based on evidence derived f...

Sanghuangporus toxicodendri (Hymenochaetales) is described as new based on collections made from Shennongjia Forestry District, Hubei Province, China. All studied basidiocarps grew on living trunks of Toxicodendron sp. This new species is characterized by having perennial, effused-reflexed to pileate basidiocarps; pore surface brownish yellow or ye...

Four new species of Aleurodiscus sensu lato with echinulate basidiospores are described from East Asia: A.alpinus, A.pinicola, A.senticosus, and A.sichuanensis. Aleurodiscusalpinus is from northwest Yunnan of China where it occurs on Rhododendron in montane habitats. Aleurodiscuspinicola occurs on Pinus in montane settings in Taiwan and northwest Y...

Two new ionone-type sesquiterpenoids, sanghuanglin (1) and (+)-(2E,4E)-5-((S)-2,2-dimethyl-6-methylenecyclohexyl)-3-methylpenta-2,4-dienoic acid (2), were isolated from the whole broth of Sanghuangporus sanghuang BCRC 38847. Their chemical structures, including absolute configuration, were determined based on various spectroscopic methods, such as...

Phanerochaete canobrunnea, P. cystidiata and P. fusca are presented as new species, supported by morphological studies and two sets of phylogenetic analyses. The 5.8S+nuc 28S+rpb1 dataset shows the generic placement of the three species within the phlebioid clade of Polyporales. The ITS+nuc 28S dataset displays relationships for the new taxa within...

Twelve wood-rotting polypores (basidiomycetes) are newly recorded in Taiwan, viz. Abundisporus pubertatis, Antella chinensis, Ceriporia purpurea, Luteoporia albomarginata, Megasporia yunnanensis, Megasporoporia bannaensis, Neodatronia sinensis, Obba rivulosa, Pseudowrightoporia crassihypha, P. japonica, P. oblongispora, and Tinctoporellus hinnuleus...

Two new genera with phylogenetic affinities to Phanerochaete s.l. are presented, namely Hydnophanerochaete and Odontoefibula . The generic type of Hydnophanerochaete is Phanerochaeteodontoidea . Odontoefibula is established based on a new species: O.orientalis (generic type). Both genera have effused basidiocarps with odontioid hymenial surface, si...

Inonotus taiwanensis (Hymenochaetales) is described as a new species collected from southern Taiwan, and all specimens grew on the trunk of Trema tomentosa. This new species is characterized by having resupinate, effuse-reflexed to pileate basidiocarps, bright yellow context, long setal hyphae in context and trama, setae in hymenium and trama, and...

A new corticioid species, Dacryobolus angiospermarum, is described and illustrated from southern China based on morphological and molecular evidence. The new species is similar to D. karstenii but differs in growing on angiosperm wood, having wider skeletal hyphae, and lacking hymenial cystidia. In the phylogenetic tree inferred from ITS and nrLSU...

Hyperbaric oxygen (HBO) treatment has been proven to decrease neuroinflammation in rats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effects of HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague-Dawley (SD) rats were randomly assigned to the following six groups (n = 6 p...

Hyperbaric oxygen (HBO) treatment has been proven to attenuate neuroinflammation in rats. This study aimed to determine the potential mechanism underlying the anti-inflammatory effects of HBO treatment on burn-induced neuroinflammation in rats. Thirty-six adult male Sprague–Dawley (SD) rats were randomly assigned to the following six groups (n = 6...

Four wood-rotting polypores are reported from Taiwan for the first time: Ceriporiopsis pseudogilvescens, Megasporia major, Phlebiopsis castanea, and Trametes maxima. ITS (internal transcribed spacer) sequences were obtained from each specimen to confirm the determinations.

Gloeoporus Mont. is characterized by an easily separated gelatinous hymenophore and a continuous hymenium over the pore mouth. Recent molecular taxonomic and phylogenetic research showed that morphological grouping of Gloeoporus is polyphyletic. The lack of comprehensive phylogenetic studies of Gloeoporus exacerbates confusion in determining the ta...

Xylodon subflaviporus (Hymenochaetales, Basidiomycota) is described as a new species collected from tropical and subtropical regions of East Asia. This new species is characterized by resupinate basidiocarps, a poroid hymenophore, pseudodimitic hyphal system, nodose-septate hyphae, four types of cystidia (capitate, acicular to cylindrical, subulate...

Eleven taxa of Lopharia s.s., Dendrodontia , Dentocorticium and Fuscocerrena in Polyporales are included in the phylogenetic analyses of nuc rDNA ITS1-5.8S-ITS2 (ITS), D1-D2 domains of nuc 28S rDNA (28S) and RNA polymerase II second-largest subunit ( rpb2 ) sequences. New species Lophariaresupinata and L.sinensis are described and illustrated. Loph...

Burn-induced neuromuscular dysfunction may contribute to long-term morbidity; therefore, it is imperative to develop novel treatments. The present study investigated whether erythropoietin (EPO) administration attenuates burn-induced motor neuron apoptosis and neuroinflammatory response. To validate our hypothesis, a third-degree hind paw burn rat...

Acute leukemia is one of the commonly diagnosed neoplasms and causes human death. However, the treatment for acute leukemia is not yet satisfactory. Studies have shown that mushroom-derived polysaccharides display low toxicity and have been used clinically for cancer therapy. Therefore, we set out to evaluate the anti-cancerous efficacy of a water-...

Objective: No effective treatments have yet been developed for burn-induced neuropathic pain. Platelet-rich plasma (PRP) has been reported to ameliorate various types of inflammation pain. However, the effect of PRP on burn-induced neuropathic pain is unclear. Methods: Burn-induced neuropathic pain Sprague-Dawley rat model was confirmed using a mec...

In the current study, the new species Phanerochaete bambucicola and P. incarnata, from subtropical Taiwan are presented, while P. robusta is redescribed. We amplified the 5.8 s and LSU ribosomal genes along with RPB1. We generated an ITS dataset and a concatenated 5.8 s + nLSU + RPB1 dataset, which we analyzed using Maximum Parsimony and Bayesian m...

Background: Burn scar pain is considered as neuropathic pain. The anti-inflammation and anti-neuroinflammation effects of adipose-derived stem cells (ASCs) were observed in several studies. We designed a study using a murine model involving the transplantation of autologous ASCs in rats subjected to burn injuries. The aim was to detect the anti-ne...

A corticioid fungal species found in mountainous Taiwan, and Yunnan Province of China, is described as a new genus and new species: Purpureocorticium microsporum (Agaricomycetes, Basidiomycota). Morphological study and phylogenetic analyses based on sequence data respectively derived from the large subunit nuclear ribosomal RNA gene (LSU nrDNA) alo...

The traditional medicinal fungus, Lingzhi, has long been considered to be Ganoderma lucidum, but was recently described as G. lingzhi based on both morphological and molecular data. Months earlier than this description, the species was identified as G. sichuanense by another research group. A sequenced epitype for G. sichuanense was selected that,...

Sanghuangporus sanghuang (SS) is a mushroom that belongs to the genus Sanghuangporus and it is commonly called “Sangwhang” in Taiwan. It is popular in oriental countries and has been traditionally used as food and medicine. The mystery surrounding it was solved in 2012, when it was discovered. However, existing research has not extensively investig...

Three species of Hyphodontia (Schizoporaceae) with poroid or raduloid hymenial surface are described as new to science. Hyphodontia chinensis sp. nov. was found in southwest and northeast China, having raduloid hymenophore, ventricose to subulate cystidia, and slightly thickened-walled, ellipsoid basidiospores; H. reticulata sp. nov. was found in c...

Aleurodiscus tenuissimus and A. tropicus, on dead bamboo, are new species from tropical Asia. Both species have effused basidiocarps and simple-septate generative hyphae. Aleurodiscus tenuissimus, from southern China, lacks acanthophyses and possesses echinulate basidiospores, whereas A. tropicus, from southern China and Vietnam, has abundant acant...

Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract...

Sanghuangporus sanghuang (S. sanghuang) is a rare fungal species that grows on wild mulberry trees, and its yield is much lower than that of valuable medicinal herbs such as saffron and other fungal species such as Cordyceps sinensis and Antrodia cinnamomea. The annual production of Sanghuangporus vaninii (S. vaninii) is approximately 40 tons. Sang...

Acute lung injury (ALI) is characterized by inflammation of the lung tissue and oxidative injury caused by excessive accumulation of reactive oxygen species. Studies have suggested that anti-inflammatory or antioxidant agents could be used for the treatment of ALI with a good outcome. Therefore, our study aimed to test whether the mycelium extract...

Background: Non-replantable fingertip amputation is still a clinical challenge. We performed modified composite grafting with pulp adipofascial advancement flap for Hirase IIA fingertip amputations. Results from a series of patients are presented and achieved better outcome than traditional composite grafting. Patients and methods: From Septembe...

A dichotomous key to all currently accepted species of Hyphodontia in the broad sense is presented. It consists of a key to genera (Alutaceodontia, Botryodontia, Chaetoporellus, Deviodontia, Hastodontia, Hyphodontia s. str., Kneiffiella, Lagarobasidium, Lyomyces, Palifer, Rogersella, Schizopora, Xylodon) and detailed keys to species level within ge...

Background: Stromal vascular fraction (SVF) cells were used to increase the efficacy of a newly formed adipose tissue in a collagen gel in vitro. However, the outcome of the seeded cells in the collagen gel in vivo remains unknown. We traced the SVF cells in the host tissue and evaluated the efficacy of SVF for fat tissue engineering. Methods: T...

Burn-induced neuropathic pain is complex, and fat grafting has reportedly improved neuropathic pain. However, the mechanism of fat grafting in improving neuropathic pain is unclear. Previous investigations have found that neuroinflammation causes neuropathic pain, and anti-inflammatory targeting may provide potential therapeutic opportunities in ne...

Although Inonotus linteus complex is placed in the genus Inonotus, its perennial basidiocarps with a dimitic hyphal system, at least in the trama, distinguish the complex from other species in the genus, which have an annual habit and a monomitic hyphal system. The species number of Inonotus linteus complex has been increased in China and tropical...

Traumatic wounds inflict small- and large-fiber sensory nerve damage, causing neuropathic pain in scar tissue, thus impairing patients' quality of life and leading to the development of psychological disorders. Autologous fat grafting has been clinically shown to improve scar quality, but few studies have explored the effects of this technique on p...

Background: Severe burns result in hypercatabolic state and concomitant muscle atrophy that persists for several months, thereby limiting patient recovery. However, the effects of burns on the corresponding spinal dermatome remain unknown. This study aimed to investigate whether burns induce apoptosis of spinal cord ventral horn motor neurons (VHM...

Hyphoderma setigerum (Fr.) Donk is a white-rot wood-decaying corticoid fungal species. It occurs worldwide from tropical to temperate regions. However, taxonomic studies in recent decades showed that H. setigerum is a species complex with four separate species, before this study. Hyphoderma pinicola sp. nov. was collected on dead wood of Pinus yun...

Fibrodontia alba sp. nov. is described from central Taiwan. Its major diagnostic features are white, minutely and densely aculeate hymenial surface, colorless generative hyphae, colorless, in mass pale colored, narrow, moderately encrusted skeletal-like hyphae in aculeal trama and ellipsoid basidiospores. Bayesian inference of the phylogeny based o...

Megasporia guangdongensis and Megasporoporiella subcavernulosa, members of Megasporoporia s.l., are newly recorded from Taiwan. Description and illustrations of these two species are provided.

Hyphoderma formosanum (Meruliaceae, Polyporales) is proposed as a new species. It was collected in central Taiwan, from mixed forests at the altitudes 1200-1300 m, and grows saprobically on wood of gymnosperms and angiosperms. The species is characterized by odontioid hymenial surface, partly encrusted capitate cystidia, encrusted projecting hyphal...

Background: The management of neuropathic pain after burn injury is a critical clinical issue. Autologous fat grafting has been shown to alleviate neuropathic pain in certain cases, but has not been shown to alleviate the pain associated with burn-induced scars. The authors assessed the effectiveness of autologous fat grafting for the management o...