Shanmugampillai Jeyarajaguru Kabilan

Kalasalingam University · Faculty of Bio-Technology

The combination of natural and synthetic polymers for nanomedicine development had many advantages, including less toxicity, biocompatibility, prolonged circulation, higher stability, and ease of surface modification. Here, a novel folic acid-conjugated Camptothecin-loaded-poly (lactic-co-glycolic) acid-glutenin nanoparticles (FA-CPT-PLGA-Glu NPs)...

Boerhavia diffusa L., a flowering plant is traditionally used as a therapy for protecting against several diseases. The present study aims to identify the optimal extraction conditions for ultrasound-assisted solvent extraction (USAE) for retrieving highest amount of biologically important compounds from B. diffusa L. through RSM (Response Surface...

Plants produce many secondary metabolites that lead to defensive mechanisms and regulate signaling for defense against herbivores, pests, and diseases. The plant secondary metabolites are made of polyphenolic compounds, such as flavonoids, alkaloids, saponins, tannins, glycosides, etc., which are new lead molecules in drug discovery research of aph...

Male sexual dysfunction is considered one of the major consequences of diabetes mellitus. The medicinal plant, Mimosa pudica Linn. is believed to have numerous therapeutic effects, including anti-diabetic, anti-obesity, aphrodisiac, and a sexual behaviour-enhancing properties. In the present study, the significant effect of ethanolic extract of M....

Targeted delivery via surface receptors can significantly improve the therapeutic efficacy and reduce adverse drug reactions. The protein nanocarrier system offers many advantages, including encapsulation in various drugs and molecules and prolonged circulation. Here, the folate receptor-targeted folic acid-conjugated retinoic acid-loaded glutenin...

Targeted delivery via surface receptors can significantly improve the therapeutic efficacy and reduce the adverse drug reactions. The protein nanocarrier system offers many advantages, such as encapsulation in various drugs and molecules and prolonged circulation. Here, the folate receptor-targeted folic acid-conjugated retinoic acid-loaded gluteni...

The change in the education system to meet the needs of the students of every generation is inevitable. The education system is transforming towards technology catering to the requirements of Generation Y and Generation Alpha. The online teaching practice has many issues and concerns among students, like lack of interaction, inactiveness, incuriosi...

Irritable Bowel Syndrome (IBS) is a gastrointestinal disorder that affects 7-21% of the world’s population. People suffering from this illness can have a significant change in their quality of life and their productivity at work. Medicinal plants and their derived products have long been explored and used for their medicinal qualities throughout th...

This study was designed to optimize the ultrasound-assisted extraction (UAE) of bioactive chemicals from Hemidesmus indicus (L.) R.Br. through RSM (response surface methodology) and ANFIS (adaptive neuro-fuzzy inference system). The effect of four independent parameters, methanol concentration (X1: 55–65%), temperature (X2: 30–40 °C), time (X3: 15–...

Chronic kidney disease (CKD) is one of the most outgrowing diseases of all, and globally, about 10% of the world's population is affected. Chronic kidney disease (CKD) occurs when the kidney can no longer perform its function to full capacity. There are currently two treatment options for CKD: dialysis and transplantation. Both existing treatment o...

Receptor-mediated drug delivery systems are a promising tool for targeting malignant cells to suppress/inhibit the malignancy without disturbing healthy cells. Protein-based nanocarrier systems possess numerous advantages for the delivery of variety of chemotherapeutics, including therapeutic peptides and genes. In the present work, glucose-conjuga...

The present study aimed to produce a novel biocompatible, stable and biodegradable exopolysaccharide (EPS) from endophytic bacteria to deliver drugs into malignant cells effectively. EPS-producing endophytic bacteria, Pseudomonas otitidis was isolated and identified from the roots of the medicinal plant Tribulus terrestris L. The ice-cold ethanol p...

Context Lymphatic flariasis, generally called as elephantiasis, is a vector-borne infectious disease caused by the flarial nematodes, mainly Wuchereria bancrofti, Brugia malayi, and Brugia timori, which are transmitted through mosquitoes. The infection afects the normal fow of lymph leading to abnormal enlargement of body parts, severe pain, perma...

The present study aimed to produce a novel biocompatible, stable and biodegradable exopolysaccharide (EPS) from endophytic bacteria to deliver drugs into malignant cells effectively. EPS-producing endophytic bacteria, Pseudomonas otitidis was isolated and identified from the roots of the medicinal plant Tribulus terrestris L. The ice-cold ethanol p...

The Keap1-Nrf2 pathway plays a prominent role in activating cytoprotective genes, detoxification and antioxidative defense enzymes against oxidative stress and xenobiotics-induced damage. Oxidative stress is involved in the initiation and progression of numerous health complications. The present study investigated the antioxidant potential of aqueo...

Introduction: Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, the existence of intracytoplasmic inclusion bodies called Lewy bodies (LBs) and Lewy neurites (LNs) causes PD, w...

Plants and their derived molecules have been traditionally used to manage numerous pathological complications, including male erectile dysfunction (ED). Mimosa pudica Linn. commonly referred to as the touch-me-not plant, and its extract are important sources of new lead molecules in drug discovery research. The main goal of this study was to predic...

Background COVID-19 viral infection is a worldwide pandemic that created a major concern regarding the need for a suitable drug candidate for viral infections. The entire scientific community is putting up their entire efforts and research to find a proper cure for this. The traditional Indian Siddha system of medicine is one of the oldest forms of...

COVID-19 pandemic has created a need for adapting to online teaching, making this the era of Digital Pedagogy. The switch to the online mode makes tutors not use their usual chalk and board methods, creative flashcards, charts, models and creates urges to switch for online materials. Professional ethics is a common humanities course across all engi...

The objectives of the study were to assess the potential of herbal formulation made up of Wedeliachinensis leaves and Boerhaaviadiffusa roots in possessing activities like nephroprotectivity and hepatoprotectivity. Nephroprotective and hepatoprotective activity was evaluated using MTT cytotoxicity assay using mammalian cell culture. The results of...

The aim of the study were to perform nutritional, phytochemical and sensory analysis and assessing the potential of herbal formulation made up of Wedeliachinensis leaves and Boerhaaviadiffusa roots in possessing phytochemical contents and to be a part of herbal tea development. The phytochemical analysis were performed for each herb sample to deter...

The objectives of the study were to assess the potential of herbal formulation made up of Wedeliachinensis leaves and Boerhaaviadiffusa roots in possessing activities like antioxidant and antibacterial. The antioxidant potentials of the extracts were evaluated by performing DPPH radical scavenging assay and FRAP assay. The antibacterial activity wa...

Background: G-Immune Plus is a polyherbal formulated capsule made from the extracts of Wedelia calendulacea, Tinospora cordifolia, Withania somnifera, Centella asiatica, Emblica officinalis, Asparagus racemosus, and Tribulus terrestris. Materials and Methods: The antioxidant properties of the polyherbal formulation G-immune plus capsule were evalua...