Shamundeeswari Anandan

University of Bergen | UiB · Department of Clinical Science

Simple Summary High-grade serous ovarian cancer (HGSOC) has a dismal prognosis, but its tumor microenvironment (TME), which impacts disease progression and prognosis, is inadequately mapped. A better understanding of the complexity of the TME requires its characterization with multidimensional approaches that allow for simultaneous identification a...

Brain segmentation in magnetic resonance imaging (MRI) images is the process of isolating the brain from non-brain tissues to simplify the further analysis, such as detecting pathology or calculating volumes. This paper proposes a Graph-based Unsupervised Brain Segmentation (GUBS) that processes 3D MRI images and segments them into brain, non-brain...

In this paper, we propose a minimum spanning tree-based method for segmenting brain tumors. The proposed method performs interactive segmentation based on the minimum spanning tree without tuning parameters. The steps involve preprocessing, making a graph, constructing a minimum spanning tree, and a newly implemented way of interactively segmenting...

Simple Summary High-grade serous ovarian cancer (HGSOC) is the deadliest gynecological malignancy. Despite increasing research on HGSOC, biomarkers for individualized selection of therapy are scarce. In this study, we develop a multiparametric mass cytometry antibody panel to identify differences in the cellular composition of the microenvironment...

Background: The survival rate of patients with advanced high-grade serous ovarian carcinoma (HGSOC) remains disappointing. Clinically translatable orthotopic cell line xenograft models and patient-derived xenografts (PDXs) may aid the implementation of more personalised treatment approaches. Although orthotopic PDX reflecting heterogeneous molecul...

During evolution plants have evolved a multitude of adaptations to harsh environments lacking liquid water. Selectively advantageous structural adaptations include the storage of water in the parenchymatous tissues of diverse succulent plant organs, the formation of effective evaporation barriers and the minimization of water loss by rapid sealing...

In drug discovery, the role of multiple receptors based therapeutics is found to be a highly critical approach in producing high efficacy with reduced side effects drug molecules. Hepatitis-C is found to be a threatful chronic disease, even ending up in death in many cases. In the present study, we have selected a few drugs which are found highly p...