Shahid Akbar

University of Electronic Science and Technology of China | UESTC · Institute of Fundamental and Frontier Sciences

Motivation Despite the extensive manufacturing of antiviral drugs and vaccination, viral infections continue to be a major human ailment. Antiviral peptides (AVPs) have emerged as potential candidates in the pursuit of novel antiviral drugs. These peptides show vigorous antiviral activity against a diverse range of viruses by targeting different ph...

Background Viral infections have been the main health issue in the last decade. Antiviral peptides (AVPs) are a subclass of antimicrobial peptides (AMPs) with substantial potential to protect the human body against various viral diseases. However, there has been significant production of antiviral vaccines and medications. Recently, the development...

Inflammation is a biological resistant response to harmful stimuli, such as infection, damaged cells, toxic chemicals, or tissue injuries. Inflammation eradicates pathogenic microorganisms or irritants and facilitates tissue repair. Prolonged inflammation can result in chronic inflammatory diseases. In the last decade, peptide therapeutics have gai...

Inflammation is a biologically resistant response to harmful stimuli, such as infection, damaged cells, toxic chemicals, or tissue injuries. Its purpose is to eradicate pathogenic micro-organisms or irritants and facilitate tissue repair. Prolonged inflammation can result in chronic inflammatory diseases. However, wet-laboratory-based treatments ar...

Mycobacterium tuberculosis, a highly perilous pathogen in humans, serves as the causative agent of tuberculosis (TB), affecting nearly 33% of the global population. With the increasing prevalence of multidrug-resistant TB, there is a needs for novel and efficacious alternative therapies. Peptide therapies have emerged as a favorable alternative due...

Amyloid proteins (AMYs) are usually an aggregate of insoluble fibrous that have major pathogenic effects on various tissues. However, its abnormal deposition may lead to several diseases i.e., Parkinson’s, Alzheimer’s, and type 2 diabetes. In addition, AMYs form amyloid aggregates when they are in a misfolded state. Therefore, it is crucial to accu...

Neuropeptides (NPs) are a kind of neuromodulator/ neurotransmitter that works as signaling molecules in the central nervous system, and perform major roles in physiological and hormone regulation activities. Recently, machine learning-based therapeutic agents have gained the attention of researchers due to their high and reliable prediction results...

IoT-based remote health monitoring is a promising technology to support patients who are unable to travel to medical facilities. Due to the sensitivity of health data, it is important to secure it against all possible threats. While a great deal of work has been done to secure IoT device-cloud communication and health records on the cloud, insider...

Viral diseases are a major health concern in the last few years. Antiviral peptides (AVPs) belong to a type of antimicrobial peptides (AMPs) that have the high potential to defend the human body from various viral diseases. Despite the large production of antiviral vaccination and drugs, viral infections are still a prominent human disease. The dis...

Cancer is a Toxic health concern worldwide, it happens when cellular modifications cause the irregular growth and division of human cells. Several traditional approaches such as therapies and wet laboratory-based methods have been applied to treat cancer cells. However, these methods are considered less effective due to their high cost and diverse...

Fungal infections have become a serious health concern for human beings worldwide. Fungal infections usually occur when the invading fungus appear on a particular part of the body and become hard for the human immune system to resist. The existing antifungal treatments are considered inappropriate because of their severe side effects. With the rapi...

In extremely cold environments, living organisms like plants, animals, fishes, and microbes can die due to the intracellular ice formation in their bodies. To sustain life in such cold environments, some cold-blooded species produced Antifreeze proteins (AFPs), also called ice-binding proteins. AFPs are not only limited to the medical field but als...

Tuberculosis (TB) is a worldwide illness caused by the bacteria Mycobacterium tuberculosis. Owing to the high prevalence of multidrug-resistant tuberculosis, numerous traditional strategies for developing novel alternative therapies have been presented. The effectiveness and dependability of these procedures are not always consistent. Peptide-based...

Antioxidant proteins have been discovered closely associated with disease control due to its capability to eradicate excess free radicals. The accurate identification of antioxidant proteins is on the upsurge owing to their therapeutic significance. However, observing the rapid increases of this toxic disease in the human body, several machine lear...

World widely, Fungal infections have become a serious issue for human beings. Fungal infections normally happen once invading fungus appear on a specific area of the body and become difficult for the human immune system to control. Current antifungal based therapies and drugs are deemed unsatisfactory due to their harmful side effects. Due to the r...

Cancer is a leading killer disease globally, it occurs when the cellular changes cause the abnormal growth and division of the cells. Conventional treatment such as therapies and wet experimental methods are deemed unsatisfactory and worthless because of its huge cost and laborious nature. However, the recent innovation of anticancer peptides (ACPs...

Hormone binding proteins (HBPs) are soluble carrier proteins that can non-covalently and selectively interact with the human hormone. HBPs plays a significant role in human life, but its functions are still unclear. Conventional experimental approaches are deemed ineffective due to its high time processing time and cost. Due to the rapid increases...

Please cite this article as: S. Akbar, A.U. Rahman, M. Hayat, M. Sohail, cACP: Classifying anticancer peptides using discriminative intelligent model via Chou's 5-step rules and general pseudo components, Chemometrics and Intelligent Laboratory Systems (2020), doi: https://doi. Abstract World widely, cancer is considered a fatal disease and remains...

World widely, cancer is considered a fatal disease and remains the major cause of death. Conventional medication approaches using therapies and anticancer drugs are deemed ineffective due to its high cost and harmful impacts on the normal cells. However, the innovation of anticancer peptides (ACPs) provides an effective way how to deals with cancer...

DNA-binding proteins (DBPs) participate in various biological processes including DNA replication, recombination, and repair. In the human genome, about 6–7% of these proteins are utilized for genes encoding. DBPs shape the DNA into a compact structure known chromatin while some of these proteins regulate the chromosome packaging and transcription...

Antifreeze proteins (AFPs) perform distinguishable roles in maintaining homeostatic conditions of living organisms and protect their cell and body from freezing in extremely cold conditions. Owing to high diversity in protein sequences and structures, the discrimination of AFPs from non-AFPs through experimental approaches is expensive and lengthy....

RNA 5-methylcytosine (m5C) sites perform a major role in numerous biological processes and commonly reported in both DNA and RNA cellular. The enzymatic mechanism and biological functions of m5C sites in DNA remain the focusing area of researchers for last few decades. Likewise, the investigators also targeted m5C sites in RNA due to its ce...

Cancer is a serious disease and occurs the cause of death around the world. Various traditional methods i.e. targeted therapy chemotherapy and radiation based therapies have been extensively used by the investigators but still it is considered ineffective due to its high cost, side effects and Vulnerability towards finding errors. Therefore; an aut...

Face detection and recognition on the basis of local structure pattern has become an attention area of researchers from past few decades due to its persistent and reliable features. In this paper, we propose an intelligent and stable computational model for face detection. Local binary pattern (LBP) operator is used to collect local information fro...

Face recognition is one of the highly focused area for the researchers due to its persistent and reliable features. In this paper, we propose a reliable and computational efficient model for face recognition. Principal component analysis (PCA) is used to collect statistical based features from sub region of the face images. Different nature classif...

Face recognition is one of the challenging problems in the area of pattern detection and recognition. It is practically applicable in different automated systems for security purpose, access control, public security, desktop login and many more. Due to vagueness and intricacy in face pattern, there need more exercise in order to enhance the quality...

The significance of Iris detection and recognition has been increased from last few decades. Looking at the importance of Iris detection and recognition, we propose a robust, stable and reliable computational model. Three Feature extraction strategies including Discrete Sine Transform (DST), Hilbert transform and Fast wavelet Hadamard Transform are...

Fingerprint recognition is mostly used in biometric and security system that are practically applicable in different fields of national defense organization for various safety measures. Looking at the importance of biometric system, a lot of efforts have been carried out for recognition of fingerprint, but still there exist some issues, which deman...