Séverine Lannoy

Séverine Lannoy
Virginia Commonwealth University | VCU · Virginia Institute for Psychiatric and Behavioral Genetics

PhD

About

76
Publications
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888
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Publications

Publications (76)
Preprint
Background: Genetic risk factors, impulsivity, and exposure to painful and provocative events (PPEs) have each been linked with risk for suicide attempt (SA). However, the degree to which genetic associations with SA are mediated by dimensions of impulsivity and PPEs remains unexplored, particularly in early adolescence. Methods: Participants were...
Article
Full-text available
Background Alcohol use disorder (AUD) is a highly impairing condition with important public health impacts. Despite the availability of treatment options for AUD, research shows that few people receive treatment, and even fewer can maintain abstinence/low‐drinking levels. This study investigated the role of personality traits in past‐year alcohol u...
Article
Introduction Resting heart rate has been distinctly related to both internalizing (high pulse) and externalizing (low pulse) disorders. We aimed to explore the associations between resting heart rate and suicidal behavior (nonfatal suicide attempt [SA] and suicide death [SD]) and evaluate if such associations exist beyond the effects of internalizi...
Article
Full-text available
Background Alcohol consumption contributes to excess morbidity and mortality in part through the development of alcohol-related medical conditions (AMCs, including alcoholic cardiomyopathy, hepatitis, cirrhosis, etc.). The current study aimed to clarify the extent to which risk for these outcomes differs as a function of socioeconomic position (SEP...
Article
Introduction The Interpersonal‐Psychological Theory of Suicide proposes that capability for suicide is acquired through exposure to painful and provocative events (PPEs). Although there is robust evidence for a positive association between aggregate measures of PPEs and risk for suicidal behavior, little is known about the contributions of physical...
Preprint
Background: Alcohol Use Disorder (AUD) is a highly impairing condition with important public health impacts. Despite the availability of treatment options for AUD, research shows that few people receive treatment, and even fewer can maintain abstinence/low drinking levels. This study investigated the role of personality traits in current alcohol us...
Article
Despite recent progress in the genetics of suicidal behavior, the pathway by which genetic liability increases suicide attempt risk is unclear. We investigated the mediational pathways from family/genetic risk for suicide attempt (FGRS SA ) to suicide attempt by considering the roles of psychiatric illnesses. In a Swedish cohort, we evaluated time...
Article
Full-text available
Background and aims: Alcohol use disorder (AUD) is one of the strongest predictors of suicidal behavior. Here, we measured risk of suicide attempt and death as a function of AUD typologies. Design: We used AUD typologies from previous latent class analysis: (i) externalizing subtype (characterized by externalizing symptomatology and early age of...
Article
Studies on the genetic factors involved in binge drinking (BD) and its associated traits are very rare. The aim of this cross-sectional study was to investigate differences in the association between impulsivity, emotion regulation and BD in a sample of young adults according to the rs6265/Val66Met variant in the brain-derived neurotrophic factor (...
Article
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Background Greater alcohol accessibility, for example in the form of a high density of alcohol outlets or low alcohol taxation rates, may be associated with increased risk of suicidal behavior. However, most studies have been conducted at the aggregate level, and some have not accounted for potential confounders such as socioeconomic position or ne...
Article
Full-text available
Heavy drinking and diagnosis with alcohol use disorder (AUD) are consistently associated with risk for suicide attempt (SA). Though the shared genetic architecture among alcohol consumption and problems (ACP) and SA remains largely uncharacterized, impulsivity has been proposed as a heritable, intermediate phenotype for both alcohol problems and su...
Article
Objective: Binge drinking is characterized by excessive alcohol use and is widespread in youth. We explore the relationship between binge drinking's risk factors by considering (i) aggregate genetic liability (polygenic risk score [PGS]) for alcohol use and problems and (ii) impulsivity-related processes. We examined whether the associations betwe...
Article
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This study examined the extent to which the genetic and environmental characteristics of having a first versus a second suicide attempt (SA) are common or specific. We evaluated the direct pathway between these phenotypes and the role of specific risk factors. From Swedish national registries, two subsamples of individuals born between 1960 and 198...
Article
Background and aims: Substance use disorder (SUD) is related to widespread adverse consequences including higher suicidality. Shared genetic liability has been demonstrated between SUD and suicidality. Here, we measured the factors that contribute to increased risk of non-fatal suicide attempt among individuals with SUD by focusing on aggregate ge...
Article
The COVID-19 pandemic led to unprecedented restrictions to mitigate disease spread, leading to consequences affecting mental health. Many studies examining COVID-19 pandemic effects on well-being and mental health initiated inquiry after the pandemic onset, whereas we used self-report questionnaires obtained before the pandemic to re-assess the sam...
Article
Full-text available
Background: Suicidal thoughts and behaviors (STB) constitute a central public health concern in adolescence. Previous studies emphasized the difficulty to cope with negative life events during adolescence as a risk factor for STB. Familial and genetic liability has also been documented to explain STB risk. Nevertheless, less is known about aggrega...
Article
Introduction: The exploration of cognitive impairments associated with tobacco use disorder has expanded during the last decades, centrally showing working memory and executive deficits among smokers. Despite their critical role in everyday life and in the smoking cessation process, attentional abilities have seldom been explored. Previous studies...
Article
Background The aim of this study was to clarify the possible causal associations between education phenotypes and non-fatal suicide attempts. In particular, we evaluated the roles of academic achievement (school grades), cognitive performance (IQ), and educational attainment (education level). Methods Based on longitudinal Swedish registry data, w...
Article
Introduction Alcohol use disorder (AUD) has been identified as a strong risk factor for suicide attempt. However, few studies have considered protective factors that may moderate this association, such as resilience. Methods We used longitudinal nationwide Swedish data of 903,333 males born 1960–1980 and 48,285 males born 1949–1951. We performed C...
Article
Full-text available
Objective: Executive control continues to develop throughout adolescence and is vulnerable to alcohol use. Although longitudinal assessment is ideal for tracking executive function development and onset of alcohol use, prior testing experience must be distinguished from developmental trajectories. Method: We used the Stroop Match-to-Sample task...
Article
Background Previous studies have demonstrated substantial associations between substance use disorders (SUD) and suicidal behavior. The current study empirically assesses the extent to which shared genetic and/or environmental factors contribute to associations between alcohol use disorders (AUD) or drug use disorders (DUD) and suicidal behavior, i...
Chapter
Alcohol use disorder (AUD) is recognized as harmful for the developing brain. Numerous studies have sought environmental and genetic risk factors that predict the development of AUD, but recently identified resilience factors have emerged as protective. This chapter reviews normal processes of brain development in adolescence and emerging adulthood...
Article
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Despite the large-scale dissemination of mindfulness-based interventions, debates persist about the very nature of mindfulness. To date, one of the dominant views is the five-facet approach, which suggests that mindfulness includes five facets (i.e., Observing, Describing, Nonjudging, Nonreactivity, and Acting with Awareness). However, uncertainty...
Article
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Aims Negative and Positive urgency are emotion-related impulsivity traits that are thought to be transdiagnostic factors in psychopathology. However, it has recently been claimed that these two traits are closely related to each other and that considering them separately might have limited conceptual and methodological value. The present study aime...
Article
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Rationale: Attitudes towards alcohol constitute a central factor to predict future consumption. Previous studies showed that young adults with risky alcohol consumption present positive implicit and explicit attitudes towards alcohol. Objectives: It appears crucial to disentangle the relationship between specific consumption patterns (e.g., binge...
Preprint
Full-text available
Despite the large-scale dissemination of mindfulness-based interventions, debates persist about the very nature of mindfulness. To date, one of the dominant views is the five-facet approach, which suggests that mindfulness includes five facets (i.e., Observing, Describing, Nonjudging, Nonreactivity, and Acting with Awareness). However, uncertainty...
Article
Multiple sclerosis (MS) is associated with deficits in social cognition, the process underlying social interaction and cognitive function. However, the relationships between executive impairment and social cognition remain unclear in MS. Previous studies exclusively focused on group comparisons between healthy controls and patients with MS, treatin...
Article
This study aimed to delineate the specific characteristics of binge drinking habits by capitalizing on data-driven network analysis. Such an approach allowed us to consider binge drinking as a network system of interacting elements, thus identifying the key variables involved in this phenomenon. A total of 1,455 university students with excessive d...
Article
Background: Severe alcohol use disorder (SAUD) is associated with social cognition deficits. Patients with SAUD are impaired for the recognition of emotional facial expressions, particularly at early stages of abstinence. These deficits damage interpersonal relations and increase relapse risk. However, uncertainties still abound on their variation...
Article
Binge drinking is a widespread alcohol consumption pattern commonly engaged by youth. Here, we present the first systematic review focusing on emotional processes related to binge drinking. Capitalizing on a theoretical model describing three emotional processing steps (emotional appraisal/identification, emotional response, emotional regulation) a...
Article
Rationale: Severe alcohol use disorder (SAUD) is a psychiatric condition linked to cerebral and cognitive consequences. SAUD is notably characterized by an over-activation of the reflexive/reward system when confronted with alcohol-related cues. Such over-reactivity generates a preferential allocation of attentional resources towards these cues, la...
Article
Full-text available
Background There is a need for empirical studies assessing the psychometric properties of self-reported alcohol use as measures of excessive chronic drinking (ECD) compared to those of objective measures, such as ethyl glucuronide (EtG). Objectives To test the quality of self-reported measures of alcohol use and of risky single-occasion drinking (...
Article
The global outbreak of coronavirus disease 2019 (COVID-19) and the resulting lockdown measures have raised concerns regarding their effect on alcohol consumption. We investigated alcohol use during lockdown in a population of college students, usually characterized by social and heavy drinking. We also tested the predictive role of pre-lockdown dri...
Poster
Full-text available
Introduction. La drunkorexie, se caractérisant par l’association entre troubles des conduites alimentaires (TCA) et consommation excessive d’alcool (TUAL), constitue un phénomène récent chez les jeunes, en particulier chez les étudiant·e·s [1]. Ses manifestations comportementales et les motivations sous-jacentes sont multiples et en font un phénomè...
Article
Alcohol use disorder (AUD) has been associated with impairments in social and emotional cognition that play a crucial role in the development and maintenance of addiction. Repeated alcohol intoxications trigger inflammatory processes and sensitize the immune system. In addition, emerging data points to perturbations in the gut microbiome as a key r...
Article
Full-text available
Mobile phone use and misuse have become a pressing challenge in today's society. Dangerous mobile phone use, such as the use of a mobile phone while driving, is widely practiced, though banned in several jurisdictions. Research aiming at unfolding the psychological predictors of dangerous mobile phone use have so far been scarce. Especially, resear...
Article
Aims: Emotional processing is a crucial ability in human and impairments in the processing of emotions are considered as transdiagnostic processes in psychopathology. In alcohol use disorder, numerous studies have investigated emotional processing and showed emotional deficits related to the perpetuation of alcohol use. Recent studies have also ex...
Article
Full-text available
Substance use in youth is a central public health concern, related to deleterious consequences at psychological, social, and cognitive/cerebral levels. Previous research has identified impulsivity and consumption motives as key factors in the emergence of excessive substance use among college students. However, most studies have focused on a specif...
Article
Full-text available
Rationale. Binge drinking (i.e., excessive episodic alcohol consumption) among young adults has been associated with deleterious consequences, notably at the cognitive and brain levels. These behavioural impairments and brain alterations have a direct impact on psychological and interpersonal functioning, but they might also be involved in the tran...
Article
Full-text available
Rationale: Binge drinking (BD), characterized by recurring alternations between intense intoxication episodes and abstinence periods, is the most frequent alcohol consumption pattern in youth and is growing in prevalence among older adults. Many studies have underlined the specific harmful impact of this habit by showing impaired abilities in a wid...
Article
Aims: Investigation of the relationship between self-esteem and alcohol use among college students has yielded discrepant results. We hypothesized that these discrepancies could originate from a potential heterogeneity of self-esteem patterns among young adult with an alcohol use disorder (AUD). Methods: A community sample of 343 college student...
Article
Background: Executive deficits have widely been reported in young binge drinkers over the last decade, but uncertainty remains regarding the specificity of these deficits and their variation across executive subcomponents. The current study aimed to offer a theoretically grounded and specific exploration of the differential deficits observed across...
Article
Excessive alcohol use among adolescents has become a pressing challenge among Western societies. Accordingly, one of the current research objectives is to identify the processes associated with this harmful habit. Although numerous studies have underlined the role of executive and motivational processes, few have explored emotional and interpersona...
Article
Background: Binge drinking is a harmful pattern of alcohol consumption, associated with cognitive and cerebral impairments. Indeed, various cognitive processes have been identified as disrupted in binge drinking, ranging from perceptive to executive functions, but emotional processes have conversely been little investigated. Particularly, it is un...
Article
Background: Binge drinking, characterized by alternations between intense alcohol intakes and abstinence periods, is the most frequent alcohol-consumption pattern among adolescents and is associated with cognitive impairments. Objectives: It appears crucial to disentangle the psychological factors involved in the emergence of binge drinking in adol...
Article
Full-text available
Background Each year, more than 300,000 university students take part in European exchange programs. Besides their positive educational and cultural impacts, these programs are also reputed to immerse students in a high‐risk festive context where excessive alcohol consumption is strongly present. There is thus a crucial need to evaluate the actual...
Article
Full-text available
Binge drinking is a widespread alcohol consumption pattern in youth that is linked to important behavioral and cerebral impairments, in both the short and the long term. From a critical review of the current literature on this topic, we conclude that binge drinkers display executive impairments, cerebral modifications, and problems with emotion-rel...
Article
Binge drinking is an excessive pattern of alcohol use, highly prevalent in adolescents and young adults. Several studies have explored the cognitive impairments associated with binge drinking, and Carbia et al. (2018) recently proposed a systematic review of these impairments. Although this review offers an insightful and up-to-date synthesis of th...
Chapter
• This chapter reviews current data measuring the links between impulsivity and BD. • BD is usually described as being related to strong impulsivity leading to uncontrolled alcohol-use; however, impulsivity has been explored using a large range of conceptual frameworks and techniques, leading to scattered data. • We capitalized on the UPPS model, d...
Article
Full-text available
Emotional crossmodal integration (i.e., multisensorial decoding of emotions) is a crucial process that ensures adaptive social behaviors and responses to the environment. Recent evidence suggests that in binge drinking—an excessive alcohol consumption pattern associated with psychological and cerebral deficits—crossmodal integration is preserved at...
Article
Background: Binge drinking (BD) is frequently observed in youth, with psychological and cognitive consequences, but its specific negative impact on quality of life has been scarcely explored. Methods: This study measured the relationship between BD and self-perceived quality of life among European students. Sociodemographic and alcohol consumption...
Article
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This study evaluated inhibition and performance monitoring abilities through the explicit processing of alcohol cues. Twenty-two binge drinkers and 22 control participants performed a speeded Go/No-Go task using pictures of alcohol and soft cans as Go and No-Go targets. This task measures inhibitory control and performance monitoring (i.e. task adj...
Article
OBJECTIVE: Excessive alcohol drinking, particularly among college students, is a major health concern worldwide. The implicit associations between alcohol-related concepts and affective attributes has been repeatedly postulated as a reliable predictor of these drinking behaviors. The Implicit Association Test (IAT) is considered as one of the most...
Article
Background: Alcohol-dependent individuals (ALC) simultaneously present decreased inhibitory control and increased attention towards alcohol-related cues. The dual-process models have proposed that these symptoms reflect an imbalance between prefrontal/reflective and limbic/automatic systems, respectively leading to cognitive dysfunctions in executi...
Article
Full-text available
Introduction: Decoding emotional information from faces and voices is crucial for efficient interpersonal communication. Emotional decoding deficits have been found in alcohol-dependence (ALC), particularly in crossmodal situations (with simultaneous stimulations from different modalities), but are still underexplored in Korsakoff syndrome (KS). T...
Article
Objective: Performance monitoring, which allows efficient behavioral regulation using either internal (error processing) or external (feedback processing) cues, has not yet been explored in binge drinking despite its adaptive importance in everyday life, particularly in the regulation of alcohol consumption. Capitalizing on a theoretical model of r...
Article
Full-text available
Binge drinking is an alcohol consumption pattern with various psychological and cognitive consequences. As binge drinking showed qualitatively comparable cognitive impairments to those reported in alcohol-dependence, a continuum hypothesis suggests that this habit would be a first step toward alcohol-related disorders. Besides these cognitive impai...
Article
Full-text available
RationaleThe cognitive deficits observed in young binge drinkers have been largely documented during the last decade. Yet, these earlier studies have mainly focused on high-level cognitive abilities (particularly memory and executive functions), and uncertainty thus still abounds regarding the integrity of less complex cognitive processes in binge...
Article
This study explored the involvement of two key psychological factors, drinking motives and impulsivity traits, in binge drinking. On the basis of a large screening phase (N=4,424), 867 binge drinkers were selected and were first compared with 924 non-binge drinkers. Then, a cluster analysis was performed, focusing on the binge drinker sample, to ex...
Article
Full-text available
Binge drinking is a widespread alcohol-consumption pattern in youth and is linked to cognitive consequences, mostly for executive functions. However, other crucial factors remain less explored in binge drinking and notably the emotional-automatic processes. Dual-process model postulates that addictive disorders are not only due to impaired reflecti...

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