Sertac Esin

Baskent University · Department of Perinatology

The aim of the study is to compare the perinatal outcomes of twin pregnancies resulting from assisted reproductive technology (ART) treatment in which granulocyte colony-stimulating factor (G-CSF) was used with those in which it was not. In this retrospective study, the clinical data of 122 dichorionic diamniotic twin pregnancies were reviewed. Pre...

Aim: Increasing cesarean section (C/S) rates have become a growing public health issue. Turkey ranked among the top countries in the world for the highest cesarean rates. Why women desire CS instead of vaginal birth may be the key to avoiding unnecessary C/Ss. In this study, we performed a questionnaire to evaluate the possible reasons for maternal...

Background To evaluate the relationship between IL-1α -889C/T (rs1800587), IL-1β -511C > T (rs16944), TNFα -308G > A (rs1800629), TNFα -238G > A (rs361525), IL-6 -174G > C (rs1800795), and IL-6 -572G > C (rs1800796) polymorphisms and the susceptibility to transposition of the great arteries (TGA). Methods A prospective analysis was performed on mo...

Objectives Total aortic occlusion is a severe complication of Takayasu arteritis (TAK). Pregnancy follow-up in the state of total aortic occlusion due to TAK has not been reported before. Case presentation A 35 year-old nulliparous woman with total aortic occlusion in the distal aorta due to TAK, admitted with pregnancy desire. She had developed a...

Purpose: To evaluate the results of the Kurjak antenatal neurodevelopmental test (KANET) in multicentric studies. Materials and methods: In KANET, normal, borderline, and abnormal fetuses postnatal development was followed. The Chi-square was considered significant if p < 0.05 was used in the statistical analysis. Specificity, sensitivity, prevalen...

Objective: The aim of this study was to compare the cervical ripening double balloon and hygroscopic dilator in labor induction. Material and Methods: This is a retrospective single-center study conducted in a tertiary center. Pregnant women at or after 37 weeks with induction indication were included in this study. A total of 113 patients were inc...

Covid outbreak has been getting worse and spread affected all over the world. Pregnant patients are also vulnerable to respiratory diseases. We aimed to evaluate the awareness, emotional status, and behavior of pregnant during the COVID outbreak. This study's main benefit is to analyze the knowledge and understanding of pregnant women about the pan...

Objectives Absence of fetal breathing movements (FBM) has been found to be a good predictor of preterm delivery in symptomatic patients. However, analysis of FBM patterns and Doppler measurement of them for preterm birth prediction have not been performed before. In this study, we aimed to investigate and analyze FBM patterns in symptomatic preterm...

In this study, we aimed to compare the clinical outcomes of Premature Preterm Rupture of Membranes (PPROM) cases diagnosed by classical speculum examination and by placental alpha microglobulin-1 protein (PAMG-1) assay. The medical records of all patients with singleton pregnancies that were diagnosed with PPROM were retrospectively reviewed. Singl...

n this review, we reviewed current literature on COVID-19 infection during pregnancy and provided up-to-date information and community/society recommendations. Although it has previous examples such as SARS and MERS and the infection findings appeared at an earlier period and have become known in China, the infection could not be limited and spread...

These guidelines follow the mission of the World Association of Perinatal Medicine, which brings together groups and individuals throughout the world with the goal of improving outcomes of maternal, fetal and neonatal (perinatal) patients. Guidelines for auditing, evaluation, and clinical care in perinatal medicine enable physicians diagnose, treat...

Purpose: In this study, we aimed to determine the frequency of different intestinal microorganisms of patients with normal pregnancies and HG and to compare these frequencies between the two groups. Materials and methods: This case-control study was carried out in Baskent University Department of Obstetrics and Gynecology and included 20 patients;...

An extensive review of the literature on the diagnostic and clinical accuracy of Kurjak’s antenatal neurodevelopmental test (KANET) and the summarized results of the multi-center study involving 10 centers revealed that four-dimensional ultrasonography (4D US) has become a powerful tool and KANET a valuable test that empowers the clinicians worldwi...

Background: In the literature, there is no detailed analysis on the prediction factors for premalignancy/malignancy within endometrial polyps (EPs) in infertile patients. In this study, we aimed to determine the frequency of endometrial premalignancy/malignancy within EPs in infertile patients undergoing office hysteroscopic polypectomy and identi...

Purpose: We aimed to investigate the association of vitamin D receptor (VDR) gene TaqI single nucleotide polymorphism (SNPs) with serum lead (Pb) levels in maternal and umbilical cord blood. Materials and methods: Eighty-one patients who lived in Konya, Turkey for the last 3 years and had delivery at Başkent University Konya Hospital in 2016 were i...

PIK3CA-related overgrowth spectrum, caused by mosaic mutations in the PIK3CA gene, is associated with regional or generalized asymmetric overgrowth of the body or a body part in addition to other clinical findings. Three-dimensional ultrasonography (3-D US) has the capability to display structural abnormalities in soft tissues or other organs, ther...

Objective: To compare translabial three-dimensional (3D) power Doppler ultrasound with Bishop score and transvaginal ultrasound measurements for cervical assessment before induction of labor with dinoprostone or cervical ripening balloon. Materials and methods: Translabial cervical volume and length, vascularization indices and transvaginal cerv...

p> Objective: Parenteral iron therapy for iron deficiency anemia is gaining popularity due to its fast and impressing action. However, effectiveness and safety of iron sucrose in pregnant patient population is less clear. In this study, we aimed to review our intravenous iron sucrose use in pregnant patients. Study Design: The medical records of a...

p>Separation between amniotic and chorionic membranes is a normal sonographic finding before 14th weeks of gestation. As pregnancy progresses, these membranes fuse and chorionic cavity becomes obliterated. Chorioamniotic membrane separation may occur spontaneously or as a complication of invasive intrauterine procedures. Following invasive fetal in...

Objective: To evaluate fetal cardiac ventricular disproportion as a marker of cardiac anomalies. Methods: A retrospective case series included data from all patients who had a fetus diagnosed subjectively with ventricular disproportion by routine obstetric ultrasonography between January 1, 2007 and December 31, 2013 at a single tertiary center...

Aim: To assess clinical and functional efficacy of implanted biological prosthesis “ASPIRE” (manufactured by Vascutek) for correction of mitral valve disease.Materials and methods: From October 2008 to December 2013, biological prostheses “ASPIRE” (Vascutek) were implanted to 34 patients with mitral valve disease (mean age 63.59 ± 4.96 years, 79.4%...

Objective To compare different ultrasonographic fetal weight estimation formulas in predicting the fetal birth weight of preterm premature rupture of membrane (PPROM) fetuses. Methods Based on the ultrasonographic measurements, the estimated fetal weight (EFW) was calculated according to the published formulas. The comparisons used estimated birth...

To compare the accuracy of 18 formulas in predicting fetal weight and also to make a comparison of these formulas in low-birth-weight fetuses (<2,500 g) and in fetuses weighing >4,000 g. Four-hundred-and-ninety-five pregnant patients were enrolled. The estimated fetal weight was calculated using 18 different formulas. The mean percentage error, the...

Objective: The aim of this study was to investigate the effect of parity on cervical ripening and labor induction with intra-vaginal slow-release dinoprostone and to determine the safety and efficacy of this medication in a tertiary referral center. Methods: The medical records of 2090 pregnant women who underwent cervical ripening and induction of...

Our objective was to compare the latency periods after preterm premature rupture of membranes (PPROM) and determine its subsequent impact on maternal and fetal outcomes for singleton and twin gestations > 24 weeks' and ≤ 34 weeks' gestation. Delivery in the first 72 h after the rupture of membranes was observed to be more frequent in the twin group...

Increased echogenicity of fetal bowel in the second trimester obstetrical ultrasound has been described in association with several pathologic conditions, such as growth restriction, aneuploidy, cystic fibrosis, congenital infections, and gastrointestinal malformations. Zellweger syndrome (ZS) is the prototype of peroxisomal disorders characterized...

To investigate first trimester maternal characteristics of women with impaired glucose tolerance that deliver large for gestational age (LGA) infants. Nested analysis from a prospective study of singleton pregnancies enrolled at first trimester. We studied women with an abnormal 1 h glucose challenge test that had normal follow-up oral glucose tole...

The most common method of antepartum fetal surveillance is the nonstress test (NST). Although it has satisfactory false-negative rates, dubious nonreactive results may challenge the physician. Any method or factor increasing the reactive NST results or shortening the time to attain a reactive test may be considerably useful. Most of the studies hav...

The impact of maternal body mass index (BMI) on cervical cerclage outcomes is not clear in the literature. We sought to investigate the impact of BMI on history-indicated cervical cerclage outcomes in our unit. We retrospectively reviewed 196 history-indicated cervical cerclage procedures. The results were analysed according to the BMI groups <25,...

Ectopia cordis is a very rare congenital anomaly with an incidence of 5.5-7.9 per million live births. In this manuscript we report an ectopia cordis diagnosed in a fetus at 12 weeks.

Abstract We read the article by Tranquilli et al with great interest(1). Female fetuses were found to be more reactive when the mother ate chocolate and the investigators speculated about the innate gender difference for the effects of chocolate. While we believe the results have important consequences, there are some aspects which may be criticize...

OBJECTIVE: To investigate whether the 3rd hour value of 100 g oral glucose tolerance test (OGTT) can be ignored when diagnosing gestational diabetes. STUDY DESIGN: During the first 8 months of 2010, 6909 patients between 24 and 28 weeks’ of gestation were screened with 50 g glucose challenge test and 140 mg/dl or higher plasma glucose levels were f...

To compare the effect of obesity on perioperative outcomes in women undergoing laparoscopic hysterectomy. In this retrospective cohort study, perioperative outcomes of all women who underwent laparoscopic supracervical hysterectomy (LSH) or total laparoscopic hysterectomy (TLH) for benign conditions were compared between obese (body mass index > or...

Aim: To determine clinical and diagnostic value of elastosonography (ES) in women with stress urinary incontinence (SUI). Methods: Thirty subjects with SUI and 30 subjects without SUI were compared in terms of elastosonographic suburethral tissue elasticity. SUI and bladder neck hypermobility was determined by Pad test, Q-tip and stress tests. Mea...

Abstract Objective: To predict histological chorioamnionitis (CA) in the cases of preterm premature rupture of membranes by using fetal thymus transverse and anteroposterior diameters and areal measurements. Methods: Fifty healthy and 50 patients diagnosed with preterm premature rupture of membranes (PPROM) between 24 to 37 weeks of gestation were...

To outline and discuss the clinical features and outcomes of adnexal masses that were treated during cesarean delivery at a tertiary referral hospital located in Ankara, Turkey. The operating room and pathology department databases for 2007-2012 were retrospectively reviewed for surgically managed adnexal masses during cesarean delivery. Clinicopat...

To compare the effectiveness of sublingual misoprostol with lidocaine pump spray for office hysteroscopy. Premenopausal women who had an indication for office hysteroscopy were included in this randomized, double-blind, placebo-controlled study. Eighty-two patients were evaluable for the final analysis. A tertiary referral center. Premenopausal wom...

Mutations in the SRY gene prevent the differentiation of the fetal gonads to testes and cause development of a female phenotype, and as a result sex reversal and pure gonadal dysgenesis (Swyer syndrome) can be developed. Different types of mutations identified in the SRY gene are responsible for 15% of the gonadal dysgenesis cases. In this study, w...

Study question Hysteroscopic metroplasty (HM) reported to improve pregnancy wastage associated with uterine septum. Different hysteroscopic approaches are possible and effectiveness, safety and advantages of one hysteroscopic technique to other are yet to be determined. Summary answer HM is shown to improve obstetric outcome in uterine septum pati...

Abstract Objective: The objective of the study was to compare bitter chocolate and orange juice with control group for non-reactive non-stress test (NST) patterns and for maternal perception of fetal movements. Study Design: Pregnant women who were followed-up on an outpatient basis and admitted for anon-stress test and had a non-reactive result we...

The objective of this study was to assess the impact of body mass index (BMI) on transobturator tape (TOT) success rates, patient acceptability and complications 1 year following surgery. The medical records of stress urinary incontinence (SUI) and mixed urinary incontinence (MUI) patients who underwent the TOT operation were retrospectively review...

To present a challenging case of hCG positivity in a young patient and to review similar cases reported in the literature. Literature search of gonadoblastoma cases with pure 46, XX karyotype using PubMed database. A 15-year-old girl with hCG positivity was investigated for the source and the initial diagnosis was an ectopic pregnancy. An ovarian t...

Burch colposuspension remains one of the successful operations performed for stress incontinence. Accidental suturing of the bladder wall during the procedure or subsequent erosion may lead to lower urinary tract symptoms. Diagnosis and management of these sutures indicate precise evaluation for which a 70 degree cystoscope is used. In selected cas...

To evaluate whether surgical volume has an impact on short-term outcomes of laparoscopic hysterectomy. This is a retrospective analysis of 1016 laparoscopic hysterectomies. The surgeons were divided into 2 groups based on a cutoff of 30 cases. Patient characteristics, the rates of laparotomy (4.5% vs 6.7%), and serious complications (3.6% vs 5.5%)...

The purpose of this study was to compare perioperative outcome measures of laparoscopic supracervical (LSH) and total hysterectomies (TLH). This is a retrospective analysis of 1016 LSHs and TLHs at a tertiary medical center between November 1999 and August 2008 in a multivariate logistic regression model. Overall, the groups were similar. Most of t...

To describe the successful laparoscopic management of a primary omental pregnancy. Case report. Department of Obstetrics and Gynecology, Dr. Sami Ulus Obstetrics, Gynecology and Children's Hospital, Ankara, Turkey. A 22-year-old patient with an omental pregnancy. Laparoscopic partial omentectomy. Successful laparoscopic management of an omental pre...

To analyze prognostic factors, the role of lymphadenectomy and postoperative adjuvant treatments in patients with uterine leiomyosarcomas (LMS). Sixty-three patients with uterine LMS are retrospectively analyzed with respect to both DFS and OS. Multivariate DFS analysis revealed percentage necrosis to be the unique factor to be significant (median...

Successful repair of large vesicovaginal fistulas poses a significant challenge in surgically unfit older women with pelvic organ prolapse. Two women, at ages of 85 and 93, referred for involuntary urine loss were found to have neglected pessaries resulting in large vesicovaginal fistulas. After the removal of the pessary, fistula repair and LeFort...

Von Willebrand disease is the most common inherited bleeding disorder caused by quantitative or qualitative defects of von Willebrand factor, which may lead to postpartum bleeding problems. In such patients, resistant postpartum hemorrhage may be treated effectively by using transcatheter arterial embolization. Life-threatening late postpartum blee...

To evaluate the clinical characteristics, complications, and satisfaction scores of patients who underwent the Manchester operation. This retrospective observational study evaluated data from 204 women who underwent the Manchester operation at the Department of Obstetrics and Gynecology of Hacettepe University School of Medicine, Ankara, Turkey, fr...

Primary extragenital leiomyosarcoma is rarely found in pelvic localization. A 33-year-old multiparous woman who had recurrent low-grade leiomyosarcoma presented with the complaints of dyspareunia, pelvic pain and gait disturbance. Her past medical history revealed she had been subjected to maximal excision of a paravaginal mass by using vaginal and...