Sena Cenesiz

Ondokuz Mayıs Üniversitesi · Unit for Biochemistry

Tuberculosis (TB) is a contagious and zoonotic disease that adversely affects human and animal health, caused by the formation of tubercules in a caseous character in the lungs, other tissues and organs. The causative of the disease is Mycobacterium bovis. An increase or decrease in acute phase protein (APP) levels is observed in various bacterial,...

Background The causative agent of Chlamydiosis, also called enzootic abortion of sheep, is an obligate intracellular Gram-negative bacterium called Chlamydia abortus. Purpose The aim of this study is to determine the prevalence of Chlamydiosis and changes in oxidative stress levels in sheep abortions in the Black Sea Region. Method PCR analysis m...

Brucellosis is a chronic zoonotic disease caused by brucella strains that adversely affects human and animal health. Increases or decreases in acute phase protein (APP) levels are observed in various infective diseases in cattle. In our study, it was aimed to investigate how the change in APP levels in cattle infected with Brucella abortus and whic...

Antioxidants provide protection against free radicals formed as a result of increased metabolism in living organisms and the damage these radicals cause to the cell. For this reason, determining the antioxidant levels can help eco-physiologists in the field in understanding the physiological state of the animal at that moment and in conservation bi...

Aim: The investigation of serum leptin, ghrelin, insulin, seratonin hormones, NO, total oxidant/antioxidant status and brain cannaboid 1 receptor protein and apoptotic cell levels in atorvastatin and Lactobacillus acidophilus administrated experimental hypercholesterolemia was aimed in the project. Methods: In the study, 5 experimental groups we...

Hypercholesterolemia is a very common health problem in the world. In this study, it was aimed to investigate the effects of administering atorvastatin and Lactobacillus acidophilus probiotic on cholesterol metabolism, and formation of neurosterides and myelin. Five groups were formed in the study. Group-1 was fed with standard rat chow as a contro...

In aquaculture, biochemical and hematological analyzes are frequently performed for scientific research, health screening and diagnosis of diseases. Biochemical and hematological parameters in fish as in other vertebrates varies nutrition, water quality, pathogens and various environmental factors that can create stress. Caudal vascular blood colle...

In aquaculture, biochemical and hematological analyses are frequently performed for scientific research, health screening and disease diagnosis. In fish, as in other vertebrates, biochemical and hematological parameters vary due to diet, water quality, pathogens and various environmental factors that may cause stress. Blood sampling via caudal veni...

Astaxanthin is an oxidized carotenoid component responsible for pigmentation, protecting essential polyunsaturated fatty acids from oxidation, immune response, communication, reproductive behavior, and improved reproduction in aquatic animals. In aquaculture, astaxanthin is a pigment used to give rainbow trout flesh its distinctive pinkish tint. Si...

Aim The purpose of the study is to research the effect of quercetin, which has a good antioxidant characteristic in rats exposed to sodium fluoride (NaF) toxication, on oxidant and antioxidant activity in liver tissue and erythrocyte. Material and method 40 Swiss albino male rats with a weight of approximately 20–25 gr were used in the study. The...

Since heavy metal dirtiness, which we frequently encounter in environmental pollution causes harmful effects on the organism through biochemical enzyme reactions, in this study, the effects of mercury (Hg+2), copper (Cu+2), and zinc (Zn+2) heavy metal ions, which are common in environmental pollution, on PON (paraoxonase) enzyme activity in muscle...

Animal Physiology-Ecophysiology, Bird Thyroid Physiology

The world population is increasing exponentially every year. The United Nations estimates that there is a 95 % chance that the world's population will be between 8.4 and 8.7 billion by 2030, and between 9.4 and 10.2 billion by 2050. Rapid growth in the world's population has begun to drive demand for food be a problem. This growth has triggered the...

PurposeCanine ehrlichiosis is an important tick-borne disease of dogs worldwide. In the present study, we aimed to determine the serum total antioxidant capacity (TAC), malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase, (SOD), glutathione peroxidase (GSH-Px), adenosine deaminase (ADA) activity and serum protein profiles in dogs affecte...

The formation of reactive oxygen species is a physiological event in aerobic life. In case of infection, if the increased oxidant substances cannot be cleaned sufficiently by antioxidants, oxidative stress occurs. As a result, a number of pathological problems occur by damaging DNA, protein, carbohydrate and lipids. In biological systems, the balan...

Paratuberculosis leads to economic losses due to loses body weight, decrease in milk yield and fertility problems. Diagnosis of this disease is of great importance for both economic and public health. However, there is a definite method for the diagnosis of this disease. In this study, serologically in tagged paratuberculosis in cattle detection of...

Background: Cutaneous papillomas are benign proliferative neoplasms. The aetiology and pathogenesis of the disease are very complex. Papillomatosis lesions can be detected anywhere on the body, frequently appearing on the surface of the head, neck, teats, udder, external genital mucosa and upper part of the gastrointestinal tract. The disease is no...

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Objective The aim of this study was to evaluate the protective effects of cornelian cherry fruit extract against cisplatin-induced nephrotoxicity in vitro. Materials and methods African green monkey kidney epithelial cells (Vero) were incubated with 100 mg/mL of cornelian cherry fruit extract, 50 μmol/L of cisplatin or 50 μmol/L of cisplatin plus...

Amaç: Paratüberküloz, sığırlarda vücut ağırlığında azalma, süt üretiminde düşme, gebelik oranında azalma gibi birçok neden ile ekonomik kayıplar meydana getirmektedir. Bu hastalığın teşhisi hem ekonomik hem de halk sağlığı açısından önem arz etmektedir. Ancak bu hastalığın teşhisinde kesin bir yöntem bulunmamaktadır. Bu çalışmada, serolojik olarak...

Oxidative stress has been defined as an imbalance between higher cellular levels of reactive oxygen species (ROS). If ROS are not controlled by enzymatic and non-enzymatic antioxidants, they can cause oxidative injury. Brains are protected by antioxidants from nitro-oxidative and peroxidative damage. The antioxidant enzymes are superoxide dismutase...

The aim of this study is to determine the oxidant and antioxidant parameters in paratuberculosis positive cattle sera. Paratuberculosis is a zoonotic disease in cattle infected with Mycobacterium avium. The analysis did not show any significant difference in serum superoxide dismutase (SOD) and glutathione perioxidase (GSH-Px) activities of paratub...

Background: There is increasing evidence that insulin-like growth factor-2 (IGF-2) levels are altered in skin injury; there are no data evaluating the serum concentration and skin tissue expression of IGF-2 in canine generalized demodicosis. Hypothesis/objectives: To assess serum concentrations of IGF-2 collected from dogs with generalized demod...

Purpose: Formaldehyde is a common environmental contaminant that causes oxidative DNA damage in cells by increasing the production of reactive oxygen species. The aim of this study was to investigate the amount of 8-hydroxy-deoxyguanosine (8-OhdG), tumor pro- tein 53(TP53), beta-amyloid[Aß(1-42), Aß (1-40)], total antioxidant capacity (TAC) and mal...

The aim of the present study is to investigate the effects of L-carnitine usage on weight loss, performance value and plasma biochemical parameters of the obesity induced rats during swimming exercise. A total of 40 male Sprague-Dawley rats were allocated randomly to four treatment groups (negative control, placebo group, Group 3 and Group 4 were f...

Canine generalised demodicosis (CGD) is a challenging disease to treat effectively. Inactivated parapoxvirus ovis (iPPVO) could help to accelerate treatment with acaricidial therapy by altering the immune response. This study was designed to investigate the effects of treating CGD with amitraz plus iPPVO in terms of clinical outcomes and blood para...

The aim of this study was to investigate the effects of aging on the central nervous system steroid and myelin basic protein (MBP) profiles. Forty-seven male Sprague-Dawley rats (newborn, 1, 6, 12 and 24-monthsold) were studied. Tissues were obtained from the cerebellum and parietal, frontal, temporal cortex of the central nervous system of the rat...

Objective: The purpose of this study is to investigate effects of the geographic diversity and plant species on the mineral levels of the honey and honey bee tissues. Furthermore we investigated the effectiveness of honey bees and honey bee products to use as bioindicators for the determination of minerals and heavy metals which carry risk for the...

The aim of the study was to investigate and compare the effects of N-acetyl cysteine (NAC) and resveratrol on acute phase response in rats with experimentally induced arthritis. In this study, 30 Sprague-Dawley mature rats were inoculated with two doses of Freund's Complete Adjuvant (FCA) by means of intradermal injections into the left hind claws...

Aim: Determination of age-related changes in levels of some non-enzymatic antioxidants such as serum haptoglobin, haemoglobin and albumin, serum haptoglobin phenotype and serum protein profile was aimed with this study. Methods and results: Fifty Sprague-Dawley male rats were divided equally into five groups as 1 (one-month old), 2 (six-months old)...

The aim of this study was to demonstrate the total serum malondialdehyde (MDA) levels for lipid peroxidation status, total serum sialic acid (SA) levels for cell destruction level, serum ceruloplasmin (CP), albumin and uric acid (UA) for the antioxidant capacity in foals with lower respiratory tract disease. The material of the study was consisted...

The aim of this study was to investigate the effects of aging on the central nervous system steroid and myelin basic protein (MBP) profiles. Forty-seven male Sprague-Dawley rats (newborn, 1, 6, 12 and 24-monthsold) were studied. Tissues were obtained from the cerebellum and parietal, frontal, temporal cortex of the central nervous system of the rat...

In this study, the effects of florfenicol and tulathromycin on clinical recovery and acute-phase proteins in bovine respiratory diseases (BRD) were evaluated under the field conditions. A total of 30 local race feedlot cattle were used in the study. Twenty naturally infected beef and 10 healthy beef were used for the experimental and control groups...

This study aimed to investigate serum total sialic acid (TSA) and ceruloplasmin (CP) levels and their possible correlation in Toxoplasma gondii seropositive dogs. The study was conducted on the dogs that had been kept in doghouses located in the province of Istanbul. Based upon indirect fluorescence antibody test (IFAT) results, 15 T. gondii serone...

This study describes the effects of fluoride exposure on the protein profile, glycoprotein pattern, and total sialic acid concentration of serum in rabbits. For this aim; 20 healthy New Zealand rabbits were used. The rabbits were divided into two equal groups each with ten animals according to their weighing: control group and experimental group. T...

Ozcan, A., Kaya, N., Atakisi, O., Karapehlivan, M., Atakisi, E. and Cenesiz, S. 2009. Effect of kefir on the oxidative stress due to lead in rats. J. Appl. Anim. Res., 35: 91–93.To study the effect of kefir given to the rats, which have been developed oxidative stress through administration of lead, 36 rats were divided into 4 groups, the control g...

The effect of varied amounts of kefir applied in drinking water was investigated in relation to changes in total cholesterol serum, total lipid, aspartate amino transferase (AST) and alanine amino transferase (ALT) activities in broiler chicks. Ninety broiler chicks (one-day old) with an average weight of 37 g were divided into 3 groups including o...

In this study, it is aimed to investigate the effects of different amounts of oak leaves (Quercus hartwissiana) consumed with or without polyethylene glycol (PEG) on the levels of reduced glutathione (GSH), malondialdehyde (MDA), β-carotene and retinol. Fourty two lambs with the average body weight 33.0±0.7 kg were used as the animal material in th...

In this study we investigated the effect of kefir on the levels of glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO) in the liver, stomach, spleen and colon of mice with colonic aberrant crypts formed by azoxymethane (AOM). Thirty 12 weeks old Swiss Albino mice averaging 31.5 g weight were used as experimental animals. The mice were separ...

We conducted this study to describe the serum electrophoretic pattern in dogs associated with the infection of Toxoplasma gondii (T. gondii). The serum protein pattern of 25 dogs with confirmed T. gondii infection and 15 clinically healthy dogs were evaluated using native polyacrylamide gel electrophoresis. Albumin, alpha-1 globulin, alpha-2 globul...

The aim of this study was to evaluate the role of antioxidant enzyme activity and nitric oxide levels induced by 28 day biliary obstruction in the rat. A total of 21 young Swiss albino rats were divided in to 3 groups. Bile duct ligations, bile duct ligations plus resveratrol, sham operated. Bile duct ligations plus resveratrol group received 10 mg...

Trichophytosis which caused by Trichophyton spp. is an enzootic skin disease. In this study, effects of trichophytosis on serum adenozine deaminase (ADA) and nitric oxide (NO) activities were investigated. Thirty cattles with thrichophytosis and 10 healthy cattles were used in the study. Average ages of the cattle were 1-3 and average body weight w...

The objective of this study was to determine serum nitric oxide (NO) and malondialdehyde (MDA) levels in cattle infected with Brucella abortus (B. abortus). Study cohort was comprised of 30 cattle aged between 2-3 years; 20 infected with B. abortus and 10 healthy cattle. B. abortus infection was determined in the animals by Serum Agglutination Test...

The changes in serum haptoglobin (Hp) and amyloid A (SAA) concentrations in sheep with peste des petits ruminants (PPR) were investigated. Additionally, the relationships between these acute phase proteins and clinical symptoms were studied. Twenty sheep showing PPR virus antibodies in c-ELISA and 10 sheep PPR virus negative were used as the experi...

The effects of levamisole, as an anthelmintic or immunomodulator, on pregnancy were investigated in ewes. Immunomodulatory and anthelmintic doses of levamisole and physiologic saline were injected on days 0 (oestrus), 7, 14, and 21 in group I (immunomodulatory dose; n=7), group II (anthelmintic dose; n=6), and group III (control; n=6), respectively...

: Twenty healthy yearling Tuj ewe-lambs with a mean body weight of 31±2 kg were divided into two equal groups. Each group of ten sheep was provided with hay and water ad libitum throughout the study. The water for the control group contained 0.49 mg F/L, whereas the water for the experimental group contained 13.8 mg F/L, equivalent for the latter g...

The present study was conducted to investigate whether vitamin C or kefir (a milk-based fermentation product) protected Swiss albino mice from azoxymethane (AOM) toxicity. We also investigated the effect of AOM administration on the induction of metallothionein (MT) expression in mice tissues. 40 12-week-old male/female (20:20) Swiss albino mice wi...

: Twenty healthy 6-month-old male and female New Zealand rabbits with a mean body weight of 3.5±0.5 kg were fed a standard commercial rabbit diet and provided with water ad libitum containing 40 mg F/L for 70 days. Blood samples were obtained from each rabbit, and sera adenosine deaminase (ADA) activity and C-reactive protein (CRP) and ceruloplasmi...

In this study, malondialdehyde (MDA), ceruloplasmine (CER) and adenozine deaminase (ADA) concentrations were investigated in cattle with cystic echinococcosis. Group I consisted of 15 cattle with cystic echinococcosis whereas Group II consisted of 10 clinically healthy cattle aged 2-3 years. Venous blood samples were taken from the animals before b...