Sam-Gyu Mr. LEE

Chonnam National University · Department of Physical Medicine and Rehabilitation

Background This study investigated the impact of physical frailty on the development of disabilities in mobility, activities of daily living (ADL), and instrumental activities of daily living (IADL) according to sex among community-dwelling Korean older adults. Methods We used data of 2,905 older adults aged 70-84 years from the Korean Frailty and...

[This corrects the article e4 in vol. 9.].

Background: This study investigated the impact of physical frailty on the development of disabilities in mobility, activities of daily living (ADL), and instrumental activities of daily living (IADL) according to sex among community-dwelling Korean older adults. Methods: We used data of 2,905 older adults aged 70-84 years from the Korean Frailty an...

Background: Sarcopenia is an age-related chronic condition that can lead to mobility disabilities. This study aimed to evaluate the risk factors for incident sarcopenia in older Korean adults. Methods: The Korean Frailty and Aging Cohort Study (KFACS) is a multicentre prospective study with a baseline examination in 2016-2017. A prospective foll...

Background and aimsDespite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study.MethodsA total of 1595 community-dwelling...

Objective: To investigate long-term and serial functional outcomes in ischemic stroke patients without diabetes with post-stroke hyperglycemia. Methods: The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) is a large, multi-center, prospective cohort study of stroke patients admitted to participating hospitals in nine areas of Kor...

Background despite of the beneficial effects of fibroblast growth factor (FGF) 21 in several metabolic diseases, the association of plasma FGF21 with muscle mass and muscle strength is still unclear. Methods a total of 386 community-dwelling older adults aged 70–84 years were analysed. Appendicular skeletal muscle mass was measured using dual-ener...

Aims/Introduction We aimed to examine the prevalence of sarcopenia and frailty in Korean older adults with diabetes compared with subjects without diabetes. Materials and Methods We analyzed the data of 2,403 participants aged 70–84 years enrolled in the Korean Frailty and Aging Cohort Study. Sarcopenia was defined using the Asian Working Group fo...

The aim of this study is to investigate the changes in functional independence and their associated factors during the first 6 months to 1 year after stroke onset. This study is the interim results of the Korean Stroke Cohort for Functioning and Rehabilitation. A total of 1,011 participants were included and classified into 3 subgroups according to...

This paper shows the simultaneous clustering and classification that is done in order to discover internal grouping on an unlabeled data set. Moreover, it simultaneously classifies the data using clusters discovered as class labels. During the simultaneous clustering and classification, silhouette and F1 scores were calculated for clustering and cl...

Highlights • For setting the therapeutic goals for patients with Parkinson's disease (PD), rehabilitation specialist should confirm the disease diagnosis and progression of individual patients with PD. • It is recommended for clinicians to assess the motor (gait, mobility, or balance), cognition, speech and swallowing function in patients with PD a...

Exercise therapy plays key roles in functional improvements during neurorehabilitation. However, it may be difficult for some people to properly perform exercise because mobility and endurance might be restricted by neurological deficits due to stroke. Additionally, there is little evidence detailing the biological mechanisms underlying the most ef...

Purpose The purpose of the Korean Frailty and Aging Cohort Study (KFACS) is to initiate a nationwide, population-based prospective cohort study of older adults living in the community to assess their frailty status and explore transitions between frailty states over time in Korea. Participants The KFACS is a multicentre longitudinal study with the...

Assessment of functional independence and residual disability is very important for measuring treatment outcome after stroke. The modified Rankin Scale (mRS) and the modified Barthel Index (MBI) are commonly used scales to measure disability or dependence in activities of daily living (ADL) of stroke survivors. Lack of consensus regarding MBI score...

Background: Previous studies have investigated the predictors for home discharge without considering stroke severity. Objectives: To develop a practical assessment tool that predicts home discharge for moderate stroke patients after subacute rehabilitation therapy in the tertiary hospitals. Methods: Stroke patients with National Institutes of Healt...

The objective of this study was to investigate factors affecting the return home one year after a stroke. The subjects of this study consisted of patients who participated in a large-scale multi-objective cohort study of initial stage stroke patients who were admitted to 9 representative hospitals in Korea. We analyzed the distribution of the subje...

Background and Purpose— The theory of cognitive reserve (CR) was introduced to account for individual differences in the clinical manifestation of neuropathology. This study investigated whether CR has a modulating effect on cognitive impairment and recovery after stroke. Methods— This study is an interim analysis of the Korean Stroke Cohort for F...

This corrects the article on p. 54 in vol. 15, PMID: 30618217.

Objective To investigate the rate of return to work and identify key factors associated with return to work between 3 months and 2 years after stroke. Design Prospective cohort study. Setting The Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) in Korea. Participants A total of 193 persons with first-ever stroke who reported worki...

Objectives: To determine whether hearing loss is associated with social frailty in older adults. Methods: Cross-sectional analysis of cohort study data. Hearing was measured using of Pure-tone audiometry. Hearing loss was determined based on the average of hearing thresholds at 0.5, 1, and 2 kHz in the ear that had better hearing. Social frailty...

Objective: The objective of this study was to apply the clustering approach of multi-facet functional recovery pattern with big data of in the Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) using artificial intelligence, and to provide valuable prediction models for clinically use. Methods: This study was an interim analysis of the...

Objective: The objective of this study was to investigate differences of functional recovery pattern and the factors associated with recovery pattern between male and female stroke patients. Methods: This study was an interim analysis of the Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) designed as 10 years long-term follow-up stu...

Background and Purpose Few studies have investigated the relationship between the specific functional factors potentially associated with functional level and stroke recurrence. We conducted a study of patients with noncardioembolic ischemic stroke (NCIS) to determine the functional factors affecting recurrence within the first year. Methods In to...

Clinical characteristics and functional status assessed at discharge of the patients who were not followed up

Objective: This study investigated the effect of regular swimming exercise according to the duration-intensity on neurocognitive function in a cerebral infarction rat model. Methods: Forty male Sprague–Dawley 10-week-old rats, weighing 300 ± 50 g, were subjected to photothrombotic cerebral infarction. The remaining 36 rats were randomly divided int...

Objective: To identify contributing factors that can be used to predict which patients with first-ever stroke will return to driving during 1 year after stroke. Design: Multicentre cohort study. Subjects: A total of 620 first-ever stroke patients who drove before stroke. Methods: The Stroke Cohort for Functioning and Rehabilitation is a larg...

Objectives This study was conducted to determine the cutoff value and efficacy of the EuroQol Visual Analogue Scale (EQ-VAS) for predicting frailty. DesignThe EQ-VAS medians (Interquartile Range) were compared and analyzed against the FFI. ParticipantsThe subjects were 1471 older adults aged 70 to 84 years who had completed both EQ-VAS and Fried Fr...

Introduction/Background The aim of this study was to investigate the correlations between the modified Rankin Scale (mRS) grades and Korean versions of the MBI (K-MBI) scores in assessing the residual functional status of stroke survivors. Material and method The Korean versions of the MBI and mRS scales were administered to 5759 ischemic stroke p...

Objective: To investigate the correlation between spasticity severity and functional outcomes during the first year after stroke. Design: The Korean Stroke Cohort for Functioning and Rehabilitation is a large, multicenter, prospective cohort study of all patients with acute first-ever stroke admitted to participating hospitals in nine Korean are...

Objective To determine the incidence and risk factors for medical complications in Korean patients suffering from stroke and the impact of such complications on post-stroke functional outcomes. Methods We assessed patients enrolled in a prospective cohort study. All recruited patients had suffered a first acute stroke episode and been admitted to...

Background We conducted a prospective cohort study to investigate prevalence of poststroke cognitive impairment at 3 and 12 months after stroke onset and identify clinical and demographic factors associated with improvement or decline in cognitive function between 3 months and 12 months. Methods We analyzed the cognitive assessments of total patie...

“Clinical Practice Guideline for Stroke Rehabilitation in Korea 2016” is the 3rd edition of clinical practice guideline (CPG) for stroke rehabilitation in Korea, which updates the 2nd edition published in 2014. Forty-two specialists in stroke rehabilitation from 21 universities and 4 rehabilitation hospitals and 4 consultants participated in this u...

Aberrant expression of urokinase-type plasminogen activator receptor (uPAR) has been observed in human gastric cancers. Prostaglandin E2 (PGE2 ), whose biosynthesis is catalyzed by cyclooxygenase-2 (COX-2), is implicated in cancer metastasis; however, the cellular and molecular mechanisms of PGE2 -driven uPAR expression are yet to be elucidated in...

Background: There are a few reports on the impact of central facial palsy and dysarthria on quality of life (QOL) in stroke patients. Objective: To investigate the impact of central facial palsy on QOL compared with dysarthria during the chronic phase in patients with first-ever strokes. Methods: This study represents an interim analysis of th...

Purpose: To explore the long-term functional outcomes of stroke patients with very mild severity at 6 months after stroke. Methods: This study presents the interim results of the Korean Stroke Cohort for Functioning and Rehabilitation. On day 7, stroke evaluation was performed using the functional assessment battery including the National Instit...

Predicting functional outcome and quality of life (QOL) is critical to the treatment of patients with stroke. The purpose of this study was to analyze the factors influencing functional status and QOL of stroke patients 6 months after a first-ever stroke. This study was an interim analysis of the Korean Stroke Cohort for Functioning and Rehabilitat...

Purpose: This study investigated whether (-)-epigallocatechin-3-gallate (EGCG) can enhance cognition by a neurorestorative effect in a rat model of bilateral common carotid artery occlusion (BCCAO). Methods: Forty-eight male, 8-week-old Sprague-Dawley rats were randomly allocated to four groups 6 weeks after BCCAO or sham operation: EGCG-single...

Objective: To investigate the return to work status of patients with first-ever stroke with functional independence 6 months post-stroke. Design: Prospective cohort study Participants: Nine hundred and thirty-three patients with functional independence at 6 months after stroke onset. Methods: A complete post-enumeration survey was performed th...

Objective: This study aimed to analyze the incidence of vascular cognitive impairment (VCI) and factors influencing on VCI after the first-ever stroke. Materials and Methods: This is the interim result of the Korean Stroke Cohort for Functioning and Rehabilitation (KOSCO) designed as 10 years long-term follow-up investigating functions and quality...

Development of a long-term stroke care plan requires serial assessment of long-term patient function and consideration of caregiver mood. However, to date, few comprehensive cohort studies have included both stroke patients and caregivers. KOSCO is a large, multi-centre prospective cohort study for all acute first-ever stroke patients admitted to p...

Since aggressive cancer cells highly express the CD44 receptor compared to normal cells, hyaluronic acid (HA) can be used for CD44 targeting molecule. Since glutathione (GSH) level is normally elevated in the intracellular compartment and in the tumor cell, the fact that disulfide bond can be cleaved by GSH is widely used for intracellular drug del...

Objectives We examined whether obesity based on body mass index (BMI) was a predictor of functional independence measure (FIM) at 6 months after ischaemic stroke onset while adjusting for stroke risk factors and covariates and stratifying by age group. Design This is an interim report of the Korean Stroke Cohort for Functioning and Rehabilitation t...

Background: The aim of this study was to investigate whether chronic kidney disease (CKD) predicts the outcome of the Functional Independence Measure (FIM) and the Korean version of the modified Barthel Index (K-MBI) 6 months after stroke with adjustment for age, gender, education, smoking, drinking, obesity, hypertension, diabetes mellitus, dysli...

Background Since cancer cells are normally over-expressed cathepsin B, we synthesized dendrimer-methoxy poly(ethylene glycol) (MPEG)-doxorubicin (DOX) conjugates using a cathepsin B-cleavable peptide for anticancer drug targeting. Methods Gly-Phe-Leu-Gly peptide was conjugated with the carboxylic acid end groups of a dendrimer, which was then conj...

1H nuclear magnetic resonance spectra for the dendrimer molecule. Note: Peaks of a and b was indicated methylene protons of dendrimer core.

1H nuclear magnetic resonance spectra for the dendrimer-GFLG-mPEG conjugate. Note: Peaks of a and b was indicated methylene protons of dendrimer core. Abbreviations: GFLG, Gly-Phe-Leu-Gly; EDAC, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride; NHS, N-hydroxysuccinimide; PEG, poly(ethylene glycol); MPEG, methoxy poly(ethylene glycol).

1H nuclear magnetic resonance spectra for dendrimer-GFLG conjugate. Note: Peaks of a and b was indicated methylene protons of dendrimer core. Abbreviations: GFLG, Gly-Phe-Leu-Gly; EDAC, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride; NHS, N-hydroxysuccinimide.

Synthesis scheme for DendDP conjugate. Abbreviations: DendDP, dendrimer-MPEG-DOX conjugate; EDAC, N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride; DOX, doxorubicin; NHS, N-hydroxysuccinimide; MPEG, methoxy poly(ethylene glycol); TEA, triethylamine.

1H nuclear magnetic resonance spectra for DendGDP nanoparticles in double-distilled water. Abbreviations: DendGDP, dendrimer-MPEG-DOX conjugate with GFLG peptide linkage; DOX, doxorubicin; MPEG, methoxy poly(ethylene glycol); GFLG, Gly-Phe-Leu-Gly; ppm, part per million.

1H nuclear magnetic resonance spectra for the Gly-Phe-Leu-Gly peptide.

The purpose of this report was to provide information for patients receiving inpatient rehabilitation after stroke and to identify the possible factors influencing functional outcome after inpatient rehabilitation. Stroke patients (n = 5,212) who were discharged from the Departments of Rehabilitation Medicine (RM) of university hospitals and rehabi...

Introduction: Few studies investigated the diabetes mellitus (DM) as a predictable factor of 6 months K-Modified Barthel Index (KMBI) outcome after stroke. Aims: The aim of this study is to investigate whether DM predicts the outcome of KMBI at 6-month after stroke with adjustment for cardiovascular disease risk factors, socioeconomic position and...

Introduction: Previously, association between body mass index (BMI) and K-Modified Barthel Index (KMBI) score was reported. However, few studies investigated the value of obesity as a predictive factor of 6 months functional outcome after stroke. Aims: The aim of this study is to examine whether BMI predicts the 6-month KMBI after stroke onset with...

Introduction: Few studies investigated the relationship between the normal fasting blood sugar (FBS) level at onset and functional outcome (K-Modified Barthel Index; KMBI) at 6 months after stroke. Aims: The aim of this study is to investigate whether normal FBS level predicts 6-Month KBMI after adjustment for cardiovascular disease risk factors so...

The purpose of this study was to analyze the status of inpatient care for acute first-ever stroke at three general hospitals in Korea to provide basic data and useful information on the development of comprehensive and systematic rehabilitation care for stroke patients. This study conducted a retrospective complete enumeration survey of all acute f...

Objective To obtain information on the socioeconomic, medical, and functional status of polio survivors, and to use these results as the preliminary data for establishing the middle-aged cohort of polio survivors. Methods The subjects were recruited based on the medical records of multiple hospitals and centers. They were assessed through a struct...

Background: Walking-related disability is the most frequent reason for inpatient stroke rehabilitation. Task-related practice is a critical component for improving patient outcomes. Objective: To test the feasibility of providing quantitative feedback about daily walking performance and motivating greater skills practice via remote sensing. Met...

Spontaneous cervical epidural hematoma (SCEH) is an uncommon cause of acute nontraumatic myelopathy. SCEH presenting as Brown-Sequard syndrome is extremely rare. A 65-year-old man had motor weakness in the left extremities right after his mother's funeral. He received thrombolytic therapy under the impression of acute cerebral infarction at a local...

The aim of this study was to evaluate the effect of chronic formaldehyde (FA) exposure on the hippocampus in the chronic cerebral hypoperfusion rat model. Seventy-two male Sprague-Dawley rats were randomly divided into four groups: (A) sham-operated bilateral common carotid artery occlusion (BCCAO) with room air inhalation, (B) BCCAO with room air...

This first annual report provides a description of patients discharged from rehabilitation facilities in Korea based on secondary data analysis of Korean Brain Rehabilitation Registry V1.0 subscribed in 2009. The analysis included 1,697 records of patients with brain disorders including stroke, traumatic brain injury, brain tumor and other disorder...

To investigate the effect of combined therapy of exercise and nootropic agent on cognitive function in a focal cerebral infarction rat model. Forty 10-week old male Sprague-Dawley rats were subjected to photothrombotic cerebral infarction of the left parietal lobe. All rats were randomly divided into 4 groups: group A was photothrombotic cerebral i...

Simultaneous pulmonary thromboembolism (PTE) and hemopericardium is a rare but life-threatening condition. As hemopericardium is a contraindication to anticoagulation treatment, it is challenging to handle both conditions together. The objective of the study was to report a rare case of a man with thoracic spinal cord injury presenting with simulta...

A 53-year-old man abruptly developed headache and unconsciousness. Brain computed tomography (CT) and CT angiography showed subarachnoid hemorrhage, intraventricular hemorrhage, and multiple tortuous vascular structures on the brain stem and upper cervical spinal cord. Four-vessel angiography displayed intradural ventral arteriovenous fistula, supp...

A 49-year-old man received prolotherapy in the upper cervical region at a local medical clinic. Immediately after the procedure, he felt a sensation resembling an electric shock in his right upper and lower extremities, and continuously complained of numbness and discomfort in the right hemibody. He visited our clinic a week later. Upon physical ex...

Age is one of the many factors that can influence functional improvement and activities of daily living (ADL) after a stroke. We looked at the effects of functional improvement of hemiplegic upper extremity (HUE) on ADL according to age in stroke patients.

To investigate the effect of regular exercise program on cognitive function in chronic cerebral hypoperfused rat.

By using a functional magnetic resonance imaging (fMRI) technique we assessed brain activation patterns while subjects were viewing the living environments representing natural and urban scenery. A total of 28 healthy right-handed subjects underwent an fMRI on a 3.0 Tesla MRI scanner. The stimulation paradigm consisted of three times the rest condi...

We report here on analyzing 3,128 subjects with stroke and who were discharged from the Departments of Rehabilitation Medicine of secondary or tertiary hospitals, and all the hospitals subscribed to the Online Database System developed by the Korean Society of Neurorehabilitation.

To investigate the influence of the initial readings of blood pressure (BP) components on functional outcome in acute ischemic stroke patients stratified by age.

A 25-year-old male underwent allogenic peripheral blood stem cell transplantation and developed sclerodermoid chronic graft versus host disease. He complained of limitation of motion of major joints and some difficulties with activities of daily living (ADL) performances. He had been treated with physical and occupational therapies. After the rehab...

This study was performed to evaluate the effect of C-reactive protein (CRP) measured within 24 hr after stroke onset on functional outcome in ischemic stroke patients. The medical records of 28 first-ever hemiplegic ischemic stroke patients with the lesions on the middle cerebral arterial territory were reviewed. Subjects were classified into exper...

This study aimed to investigate the effect of serum albumin at admission, measured within 24 h after stroke onset, on the functional outcome in ischaemic stroke patients. The medical records of 76 first-ever hemiplegic ischaemic stroke patients were reviewed. Collected data included age, sex, initial stroke severity, cerebrovascular risk factors, l...

The aim of this study was to report on nine dysphagic patients with medullary infarction and to evaluate swallowing characteristics based on the location of the lesions.We retrospectively reviewed the medical records of these nine patients. The medullary lesions were midlateral (three patients), dorsolateral (one patient), inferodorsolateral (four...

Heterotopic ossification (HO) is the abnormal development of bone within soft tissue. It is frequently encountered after traumatic brain injury or spinal cord injury, rather than lower motoneuron disease. It has been reported as a rare complication in Guillain-Barré syndrome (GBS). We present the case of a 31-year-old woman who suffered from pain a...

This study measured the prevalence of complementary and alternative medicine (CAM) use among Korean stroke patients. Questionnaire-based 20-min interviews were conducted at the hospitals by a trained nurse after an outpatient visit. It included questions on demographic information, clinical information and the utilization of CAM. Of 304 stroke-pati...