Sahin Lacin

Koc University

Hepatocellular carcinoma (HCC), the most prevalent liver tumor, is usually linked with chronic liver diseases, particularly cirrhosis. As per the 2020 statistics, this cancer ranks 6th in the list of most common cancers worldwide and is the third primary source of cancer-related deaths. Asia holds the record for the highest occurrence of HCC. HCC i...

Amaç: Lokal ileri gastrik/gastroözefageal bileşke kanseri(G/GÖB) olgularında perioperatif kemoterapi(KT)/kemoradyoterapi sağkalım oranlarında iyileşme sağlamasına rağmen halen 5 yıllık genel sağka- lım <%50’dir. Neoadjuvan immunoterapi(İT) sayesinde çeşitli kanser türlerinde oldukça iyi patolojik yanıtlar elde edilmiş olup, patolojik tam yanıt daha...

Simple Summary The aim of this study was to explore the utility of cascade family testing (CFT) in families of breast cancer patients who carry specific genetic variations. We conducted genetic analysis in a group of breast cancer patients and identified genetic variations in over 20% of them; thus, CFT was recommended to their first-degree relativ...

Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%-50% long-term complete response in relapsed or refractory diffuse large B-cell lymphoma (DLBCL) patients. However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cell therapy failure needs further investigation. A multi-center phase...

Objectives: Inflammatory indexes are shown to have clinical significance in cancer. We aimed to determine the prognostic significance of a novel scale index as combined inflammatory index (CII) including leukocyte/lymphocyte ratio(LLR) & prognostic nutritional index(PNI) in nodular lymphocyte predominant Hodgkin Lymphoma(NLPHL) comparing them with...

Özefagus Kanseri Epidemiyoloji, Etiyopatogenez ve Klinik Prezentasyon Ferit ASLAN Özefagus Kanserinde Patolojik Sınıflandırma Bermal HASBAY Özofagus Kanserinde Evreleme Sinan KOCA Özofagus Subepitelyal Lezyonların Karakterizasyonunda Endoskopik Ultrason Kullanımı Berrin YALINBAŞ KAYA Erken Evre Özefagus Kanseri’nde Minimal İnvaziv Cerrahi Tedaviler...

Background Positive effects of exercise in cancer patients have been reported.AimTo investigate whether intensity, duration, and timing of exercise affect disease relapse and mortality risk in patients with breast cancer (BC).Methods Patients with local or locally advanced stages of BC between January 2018 and January 2020 were recruited in the stu...

The aim of this study is to determine the power of he international prognostic scoring systems (IPS-7 and IPS-3) and to obtain indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) factors as prognostic indicators in cases with classical Hodgkin lymphoma (cHL). 1012 patients with cHL were evaluated with 2 di...

Purpose We aim to compare the efficiency and toxicity of three different 5-fluorouracil (5-FU) administration types in 5-FU, leucovorin, and oxaliplatin (FOLFOX) combination treatment for adjuvant therapy in colorectal cancer (CRC). Methods Five hundred and seventy patients with stage III colorectal carcinoma who received different FOLFOX regimens...

Purpose: We aimed to determine the COVID-19 infection rate and determine the factors that affect hospitalization and prognosis in patients receiving systemic chemotherapy (CT), immunotherapy (IT) and molecular-targeted therapies at our hospital within three months after the onset of COVID-19 pandemic. Materials and methods: The patients who rece...

The aim of this study is to validate the IPS-3 scoring system as a prognostic indicator in 1012 patients with advanced stage classical Hodgkin Lymphoma (cHL) treated by doxorubicin, bleomycin, vinblastine, dacarbazine (ABVD). According to the IPS-3 scoring system only 3.5% had high risk and 50.8% had low risk disease disease and 45.8% of the cases...

Objectives: The relationship between the microsatellite status (MS), tumor-infiltrating lymphocytes (TIL) and prognosis is unclear in en-dometrial cancer. We aim to examine the impact of MS and TILs on prognosis in patients with endometrioid type EC. Methods: The patients diagnosed with EC were retrospectively analyzed in the study. MS was evaluate...

OBJECTIVE: Numerous studies have been conducted on risk factors for meningioma, mostly investigating the relationship between meningioma tumor somatostatin receptor 2 status (SSTR2), tumor size, age at diagnosis, and tumor grade. This single-center study performed in patients undergoing meningioma resection was performed to investigate the relation...

Background Neovascularization plays a crucial pathogenic role in tumor development and vascular endothelial growth factor (VEGF-A) is a key signaling element that drives angiogenesis, thereby facilitating hepatocellular cancer (HCC) growth and metastasis. We aimed to define the relationship between serum VEGF-A levels and clinical outcomes in a coh...

32 Pazopanib is a tyrosine kinase inhibitor that is generally used for the treatment of metastatic 33 renal cell cancer and advanced soft tissue sarcoma. It can cause various degrees of 34 hepatotoxicity. Our study aimed to investigate the effect of taxifolin on pazopanib-induced liver 35 toxicity. A total of 18 rats were divided into three groups:...

Aim: To determine the power of the International Prognostic Scoring systems (IPS-7 and IPS-3) and to obtain more explanatory indexes by integrating LLR and PNI as prognostic indicators to IPS in cases with HL. Patients and Methods: 1,060 patients with HL were included in this study from 8 centers in Turkey. IPS-7 using seven parameters (age, sex, s...

Background: Liver reserve affects survival in hepatocellular carcinoma (HCC). Model for End-Stage Liver Disease (MELD) score is used to predict overall survival (OS) and to prioritize HCC patients on the transplantation waiting list, but more accurate models are needed. We hypothesized that integrating insulin-like growth factor 1 (IGF-1) levels i...

Background The Child–Turcotte–Pugh score (CTP) is the most commonly used tool to assess hepatic reserve and predict survival in hepatocellular cancer (HCC). The CTP stratification accuracy has been questioned and attempts have been made to improve the objectivity of the system. Serum insulin-like growth factor-1 (IGF-1)-CTP has been proposed to imp...

PurposeThe optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context.MethodsA...

Objective: 18-Fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) is one of the most valuable imaging types and tumor metabolic volume is another parameter that can be obtained from PET-CT. Our primary objective is to evaluate the effect of PET-CT metabolic parameters on survival in patients with malignant pleural m...

Background/aims: Gastric neuroendocrine tumors (G-NETs) are rare tumors, but their incidence is gradually increasing. Despite the existence of many classification systems, determining prognosis and planning treatment in patients with G-NETs remains a clinical challenge. In this study, the prognostic value of the World Health Organization (WHO) 201...

Objective: Bladder cancer (BC) is the most common malignancy of the urinary system and the incidence of BC varies regionally. Bladder cancer is more common in men than in women. Tumor stage and grade are the most important prognostic factors of BC. We aimed to describe the patterns of BC presentation and to examine the differences in the distributi...

Background The optimal chemotherapy regimen for concurrent chemoradiation in locally advanced non-small cell lung cancer (NSCLC) remains unclear. Cisplatin-etoposide regimen related toxicity is high, weekly regimens have been investigating. We aimed to compare the efficacy and safety of different concurrent chemotherapy regimens in the context. Me...

Worldwide, hepatocellular carcinoma (HCC) is the sixth most common cancer and the second most common cause of cancer mortality, with a very poor survival rate. Many factors increasing the risk of HCC are classified into two groups: preventable and non-preventable. Unfortunately, HCC incidence is steadily increasing throughout the world. Therefore,...

Renal cell carcinoma (RCC) is the most common type of kidney malignancy, and the clear-cell subtype represents the majority of RCCs. RCC is a heterogeneous disease in terms of genetic and histological features which determine the behavior of the disease. The von Hippel–Lindau (VHL) is a tumor suppressor gene and mutations of this gene are seen in 9...

Objective: The prognostic value of tumor location in patients with metastatic colorectal cancer (mCRC) was reported by recent analyses in RAS wild-type patients. However, there is no enough specific data regarding prognostic value of primary tumor location in RAS mutated mCRC patients. We aimed to find if there is any relation between tumor prognos...

e17107 Background: Endometrial cancer(EC) is a heterogeneous disease with diverse histological features and biological behaviour. Microsatellite instability (MSI) which occurs in cancerous tissue secondary to mismatch repair (MMR) defect of hereditary or somatic origin is a well-known feature further diversifying genetic tumor landscape. In this st...

Introduction We aimed to investigate the efficacy and side effects of bendamustine in relapsed/refractory lymphoma patients in Turkey. Material and methods In this retrospective study, we included relapsed/refractory Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) patients who underwent multiple lines of chemotherapy. The primary endpoint wa...

Background/aims: An organ preservation approach using chemoradiotherapy has been established for anal cancer. This retrospective cohort study aimed to define the clinico-demographic characteristics and outcomes of cases of human immunodeficiency virus (HIV)-negative anal carcinoma during a period of 20 years in a single comprehensive cancer instit...

Introduction: Pancreatic cancer (PC) demonstrates very poor prognosis and its incidence continues to increase, despite developments in chemotherapy, radiotherapy, and targeted therapies. Surgical resection is currently the only curative approach for PC. The role of radiotherapy in adjuvant and locally advanced PC continues to be increasingly contro...

Background: Hepatocellular carcinoma (HCC) prognosis depends on clinicopathological features in addition to the treatment provided. We aimed to assess the natural history of TNM stage I HCC tumors which received different treatment over a period of 20 years. Methods: Between 1992 and 2011, a total of 397 stage I HCC patients were included. Detai...

Background & Aims Environmental factors have been identified that affect risk of hepatocellular carcinoma (HCC), but little is known about the effects of sex hormones on liver cancer development or outcome. We investigated whether menopause hormone therapy (MHT) affects risk, age at onset, or outcome of HCC. Methods We performed a case–control stu...

e15660 Background: Erythropoietin (Epo) is a glycoprotein that stimulates cell proliferation and angiogenesis. Both, hypoxia and anemia are triggering factors that induce Epo overproduction. Although, previous studies reported that Epo induces angiogenesis in hepatocellular cancer (HCC), the relationship between Epo and HCC remains unclear .Our stu...

Purpose: The clinical significance of synchronous bilateral breast cancer (SBBC) is unclear and its influence on prognosis is controversial. Our study objective was to determine the epidemiological features, tumor characteristics, and prognosis of SBBC in comparison with those of unilateral breast cancer (UBC). Methods: A total of 3675 breast ca...

The epidemic of insulin resistance, obesity, and metabolic syndrome has led to the emergence of nonalcoholic steatohepatitis (NASH) as the most common cause of liver disease in the US. Patients with NASH are at an increased risk for hepatic disease-related morbidity and death, and chronic inflammation in NASH patients can lead to hepatocellular car...

289 Background: Alpha-1 Antitrypsin (A1AT) is a circulating liver derived protease inhibitor. There is an evolving evidence that elevated level of A1AT stimulate tumor cell proliferation, and invasion in different cancers. Despite A1AT well-known involvement in hepatic fibrosis, its role in hepatocellular carcinoma (HCC) pathogenesis is not well ch...

Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide. In patients with HCC, histopathogical differentiation is an important indicator of prognosis; however, because determination of HCC differentiation is difficult, the recently described immunohistochemical (IHC) marker glypican3 (GPC3) might assist in HCC prognostication.The...

Yusuf Karakas,1 Ece Esin,1 Sahin Lacin,1 Koray Ceyhan,2 Aylin Okcu Heper,2 Suayib Yalcin1 1Medical Oncology Department, Hacettepe University Cancer Institute, 2Department of Medical Pathology, Ankara University School of Medicine, Ankara, Turkey Abstract: A 55-year-old man presented with oral mucosal ulcers, blackening of both hands, and hyperpigme...

Background: Portal hypertension (PH) is the most common complication in cirrhotic hepatocellular carcinoma (HCC) patients. Although, several preclinical and clinical data have shown decreased portal pressure under sorafenib, clinical significance remains unclear. Our study aimed to evaluating changes in PH in HCC patients under Sorafenib treatment,...

Background: The status of the liver reserve in hepatocellular carcinoma (HCC) affects patient’s survival. In clinical practice, models for end-stage liver disease (MELD) score is used to predict overall survival (OS). Our aim is to evaluate whether integrating IGF-1 can provide additional value to MELD and sodium (Na)-MELD scoring systems in predic...

Background: Barcelona Clinic Liver Cancer (BCLC) and Cancer of the Liver Italian Program (CLIP) Staging are the only systems that include Child Tarcott Pugh score (CTP) to assess hepatic function. Recently, we developed and validated Insulin like growth factor-1 CTP (IGF-CTP) score which possessed a higher ability in predicting patients’ overall su...

Background: In the United States, the incidence of hepatocellular carcinoma (HCC) has been tripled over the last two decades. Despite the overwhelming effect of environmental risk factors of this cancer, the impact of physical activity on HCC is unclear. The current study aimed at addressing such association in USA. Methods: Under the IRB approval...

Background: Hepatocellular carcinoma (HCC) is one of the most deadly cancers worldwide and its histopathological differentiation is a main factor which may affect prognosis. Precise determination of HCC differentiation is difficult, and as recently described an immunohistochemistry (IHC) marker Glypican 3 might be useful for this purpose. The goal...

Purpose: Educational status may be an important parameter in assessing breast cancer risk and prognosis. The purpose of this study was to investigate the correlation between the level of education and clinicopathological characteristics of breast cancer, including tumor grade, HER-2 and estrogen receptor (ER) status, tumor size, axillary lymph nod...

A 40-year-old male patient presented with increasing serum levels of calcitonin and CEA. He underwent potential curative surgery for medullary thyroid carcinoma, 3 years ago and then 7 months later he had metastasectomy and cervical lymph node dissection for recurrent disease. On admission he had multiple metastatic skin nodules on the chest wall a...