Sahar Rostamian

Boston Children's Hospital ·  Department of Neurology

Background: Epilepsy is one of the most common in all age groups and disabling neurologic disorders around the world. Objectives: This systematic review was to explore whether berberine (BBR) has any anti-seizure or anti-epileptic effects and also reviewed this possible mechanism. Methods: The EMBASE, Scopus, Cochrane Library, PubMed, and Web of...

Background and aims: Paraoxonase 1 (PON1) is related to high-density lipoprotein (HDL) in serum and protects against low-density lipoprotein (LDL) oxidation. This study aimed to investigate the effects of Terminalia chebula on PON1 in hyperlipidemic rats and the molecular docking effects of some compounds of this medical plant on PON1 activity. Met...

Background Ischemia-reperfusion injury (IRI) is a well-known ailment that can disturb organ function. Objectives This systematic review study investigated fisetin's effects and possible mechanisms in attenuating myocardial, cerebral, renal, and hepatic IRIs. Methods This systematic review included studies earlier than Sep 2023 by following the PR...

Background Depression and anxiety are the most common mental disorders worldwide. Objective We aimed to review silymarin and silibinin effects and underlying mechanisms in the central nervous system (CNS) for depression and anxiety treatment. Methods The research protocol was prepared based on following the PRISMA statement. An extensive search w...

Background: Esophageal cancer is a cancerous tumor that develops in the esophagus. It is the 10th most common cancer and has a low survival rate. Esophageal adenocarcinoma (EAC) is increasing in incidence globally. Those with EAC are affected by Barrett's esophagus metaplasia, which is attributed to genetic predisposition and is more common in men...

Deep learning-enabled smartphone-based image processing has significant advantages in the development of point-of-care diagnostics. Conventionally, most deep-learning applications require task specific large scale expertly annotated datasets. Therefore, these algorithms are oftentimes limited only to applications that have large retrospective datas...

Background Contrast-induced nephropathy (CIN) is nephrotoxicity due to contrast media characterized by elevated serum creatinine levels. The formation of oxygen free radicals is one of the causes of CIN. Objective Given the antioxidant properties of Pimpinella anisum L and Dracocephalum moldavica L, this study aimed to investigate the effects of t...

Alzheimer's disease (AD) as an advanced brain disorder may cause damage to the memory and tissue loss in the brain. Since AD is a mostly costly disease, various deep learning-based models have been presented to achieve a high accuracy classifier to Alzheimer's diagnosis. While a model with high discriminative features is required to obtain a high p...