Sachin Goyal

Everyone today wants to detect disease early on, but because there aren't many patterns for the many diseases available, it's hard to do so. Because DNA sequences contain all the genetic data about organisms, which can be utilised by researchers to discover or treat diseases early on by developing new medications, using DNA sequences to extract pat...

The utilization of drones with their specific features, such as energy efficiency, dynamic structure, and mobility in Flying Ad-hoc Networks (FANET), has found extensive applications in various fields like disaster management, rescue operations, medical services, and military operations. However, the efficiency and effectiveness of FANET communicat...

Increasing connections of Inverter Based Renewable (IBR) plants have presented a new challenge of managing control interactions amongst multiple IBR plants and between IBR and synchronous plants. Wide area power system modelling in the EMT domain with vendor and site specific models have successfully helped in identifying and resolving control inte...

In biological science, the study of DNA sequences is considered an important factor because it carries the genomic details that can be used by researchers and doctors for the early prediction of disease using DNA classification. The NCBI has the world's largest database of genetic sequences, but the security of this massive amount of data is curren...

Everyone today wants to detect disease early on, but because there aren't many patterns for the many diseases available, it's hard to do so. Because DNA sequences contain all the genetic data about organisms, which can be utilised by researchers to discover or treat diseases early on by developing new medications, using DNA sequences to extract pat...

In today’s Internet environment, copyright protection of digital multimedia material is a major concern. Digital image watermarking provides the concept of secured copyright protection—the strength and quality of the watermark image loss due to geometrical attacks. However, minimization of the impact of geometrical attacks is a major challenge. Thi...

The active use of the Internet and multimedia content has recently escalated copyright violations. Digital content, especially images and videos are subject to vulnerable attacks. It is also possible that an attacker might remove the watermark from the original image. Therefore, the copyright of digital images must be secured to prevent them from b...

Background The study was aimed at encapsulating the evidence of in vitro and in vivo antiviral activities of molnupiravir and its active form against highly pathogenic SARS-CoV-2, the pathogen responsible for COVID-19, and finding out the efficacy and safety of molnupiravir in clinical trials. Main body Information on publications was explored on...

Background Matteuccia struthiopteris (L.) Todaro is a popular edible wild fern found in the subtropical Himalayas. It is widely used in folk medicine to treat several ailments and known for its antioxidant, anti-inflammatory, antibacterial, antiviral and antidiabetic activities. Due to its multidimensional nutritional, pharmacological and therapeut...

The connection of large inverter based resources (IBR) in transmission systems is often located geographically and electrically far away from load centers. This, coupled with the displacement of synchronous machine plants, results in a reduction of the network short circuit strength at the point of connection. Under these conditions, state-of-the-a...

The power and competence of drones are exploited in numerous areas of applications like surveillance, healthcare, and disaster management in Flying Ad-hoc Network (FANET). The incongruous routing and incompetent flight period are major issues in drones due to minimum stability and a small amount of battery capability. Then, the communication is unp...

Customer Data analysis is a significant part of different ventures utilizing figuring applications, for example, E-business and online shopping. Enormous information is utilized for advancing items which gives better availability among retailers and customers. These days, individuals consistently utilize online advancements to think about the best...

Machine learning has transformed the world by giving it a wide variety of applications in the field of manufacturing, and now it has proved itself in the field of healthcare too. Its application ranges from cardiac arrest prediction to body organ recognition from images, lung disease detection, etc. Machine learning application has increased the re...

Introduction Traditional healers' assertions that Quercus leucotrichophora A. Camus is a plant that has been used in traditional medicine to treat various urinary and renal diseases, thus the present study aims to investigate the diuretic activity of the methanolic extract of seeds in rats. Methods Dried course powder was extracted with methanol u...

Breast cancer is a leading cause of death among women. The death rate is reduced when this disease is detected early with the help of mammography. Deep learning is a method that radiologists use and request to help them make more accurate diagnoses and enhance their outcome predictions. This work presents a novel strategy comprising a pre-processin...

Introduction: Immediate Release Tablets are those tablets which are designed to disintegrate and release their medication with no special rate controlling features, such as special coatings and other techniques. Recently immediate release tablets have started gaining popularity and acceptance as a drug delivery system, mainly because of their quick...

Jasminum mesnyi hance also known as primrose jasmine is one of the well- known plant in the eld of herbal medicine. It belongs to the family called Oleaceae. It is found in China, Nepal, and India. The drug can be prepared either from whole plant, or from leaves, stem, bark, root, ower, seed etc. The phytochemical derived from Jasminum mesnyi han...

The Aim of this research work was to develop sustained release bilayer dosage form by using Metformin Hydrochloride and Glimepiride that can help to provide synergistic effect for the therapeutic management of Diabetes. Bilayer dosages form was developed and determines the sustained release effect of both Metformin Hydrochloride and Glimepiride by...

Formulation, standardization and evaluation of a polyherbal tablet for managing osteoporosis, was the goal of this study.Methods: Aqueous root extract powders were used to produce polyherbal tablets by wet granulation method of selected plant Nigella sativa, Gingiberofficinale, Curcuma longa, Termania chebula and Kukkutantatwak bhasma with the help...

The use of social media has increased tremendously during the past few decades and is considered one of the major sources of news. Social media don’t have the authority to verify the authenticity of the news and because of this, it is considered as a significant reason behind the spread of fake news. Many existing methods have been applied to detec...

Quinoline has recently become an important heterocyclic compound due to its diverse applications in industrial and synthetic organic chemistry. It is an important scaffold for leads in drug discovery and plays an important role in medicinal chemistry. There are numerous articles now reporting on its functionalization for biological and pharmaceutic...

In the current pandemic situation where the coronavirus is spreading very fast that can jump from one human to another. Along with this, there are millions of viruses for example Ebola, SARS, etc. that can spread as fast as the coronavirus due to the mobilization and globalization of the population and are equally deadly. Earlier identification of...

Karkatasringi, whose botanical name is Pistacia integerrima and belongs to the Anacardiaceae family, is a well-known medicinal plant. This plant is native to India and is distributed along the Northwest Himalayan region at about 500–2500 m above the sea level. Various parts of the plant including roots, bark galls, and leaves contain a number of se...

The specific features of UAV like energy efficiency, dynamic structure and mobility in Flying Ad-hoc Network (FANET) is good utilized for the selection of UAV in a vast variety of applications like disaster management, rescue management, medical, and military. So, the effectiveness of FANET is reduced by enhancing the packet transmission expenses d...

This review gives information about some new discovered imidazole derivatives and the activities of these imidazole derivatives. In this review, summarized imidazole derivative which have been proved to exhibit various pharmacological activities as antimicrobial, anti-inflammatory, anti-tubercular, anti-depressant, antiviral and analgesic. Many stu...

Automatic traffic sign recognition is essential for autonomous driving, assisted driving, and driver safety. Convolutional neural networks (CNNs) are the most widely used deep learning algorithm for traffic signs recognition. This research presents an effective technique for automatically recognizing traffic signs images. This technique mainly uses...

The silver nanoparticles were successfully synthesized by using Oxalis griffithii's methanolic leaf extract as a reducing agent and aqueous silver nitrate as the precursor. Nowadays, physical and chemical methods are widely used for the synthesis of nanoparticles, but unfortunately, these methods are expensive and not at all eco-friendly. This stud...

Digital Image Watermarking (DIW) has recently gained attention due to the increase in copyright issues. The robustness, imperceptibility, and security in the prevailing techniques are not efficient because of the poor selection of embedding parameters. Therefore, we make use of the benefits from some techniques like Human Visual System (HVS), Fuzzy...

Drymaria cordata is one of the most important medicinal plants used by the different tribes of India and different parts of the world from the very long period of time. It is one of the traditional herbal medicines used as one of the ingredients in many native poly herbal formulations. In different countries it has different uses such as the plant...

Nature is the main source of supplements that one human needs. Some of the traditional medicines systems such as Ayurveda, Siddha, Unani, and Chinese belong to the medicines that obtained from natural sources and all human may depend upon that medicines from the ancient times. Murraya koenigii is herbal plant belongs to the family Rutaceae. It is c...

Traffic signs are important parts of modern transportation systems because they keep roads safe and help drivers. There are two types of traffic signs: symbol-based and text-based. It is very important for real-world applications like autonomous driving, traffic monitoring, and driver safety to be able to read traffic signs. Therefore, traffic sign...

DNA sequences can be considered as a pool of genetic information mostly used for reproduction, classification, and detection of disease. FASTA is the commonly used DNA sequence in a textual format whose size is too large which makes it difficult to store and manage; also securing this data is a big issue. Compression techniques that can reduce the...

In digestive system of human beings the colon and rectum are two important parts. Cancer attacking either of these organs may said to be colorectal cancers. The effect of Conventional cancer chemotherapy is not very satisfactory for treatment of colorectal cancer, as the drug molecule does not reach the target site at effective therapeutic concentr...

NOVEL CONCEPT IN VAGINAL DRUG DELIVERY SYSTEM: AN OVERVIEW

FANET (flying ad-hoc network) has provided broad area for research and deployment due to efficient use of the capabilities of drones and UAVs (unmanned ariel vehicles) in several military and rescue applications. Drones have high mobility in 3D (3 dimensional) environment and low battery power, which produce various problems such as small journey t...

Biomimetics in dentistry is a very useful concept and further and firmer multidisciplinary scientific and technical research is needed in this field. Regeneration of the lost dental tissue rather than mild replacement with dental materials ensures better prognosis, excellent biocompatibility, and high success rate. The scope of biomimetic dentistry...

The outbreak of coronavirus disease 2019 (COVID-19) rapidly escalated into a worldwide pandemic, creating a global health and economic crisis. It is a novel virus which is distinct from SARS-CoV and MERS-CoV, with Chinese horseshoe bats being the most probable origin. Transmission occurs primarily through droplet spread or contact routes. Due to th...

Integration of renewable generators into the power system is crucial to successfully transition the world’s power supply to sustainable sources. Increasing the penetration of Inverter Based Renewable (IBR) plants into power systems comes with new challenges that need to be understood and considered carefully to allow stable and efficient operation....

Background: Bacteria and their products play the main role in the initiation and exacerbation of pulp and periapical diseases. Previous authors established that mechanical instrumentation alone is inefficient and supporting actions of disinfectants such as NaOCl are still necessary. Hence; the present study was conducted for evaluating and comparin...

Atorvastatin calcium is a HMG-CoA reductase inhibitor used for the treatment of hyperlipidaemia. It has oral bioavailability of ≤12 %. It also undergoes high first pass metabolism. It is highly soluble in acidic pH and absorbed more in the upper part of the gastrointestinal tract. In order, to improve the absorption and its oral bioavailability, ni...

Many regions worldwide are experiencing a rapid uptake of inverter-based resources (IBR) concurrent with the retirement of conventional synchronous generation. New IBR, such as wind and solar farms, are often situated in remote locations with limited network capacity. Also, they are often far from large synchronous generators which have traditional...

This chapter provides an overview of the e-commerce business model, the history of e-commerce, the scope of e-commerce, the difference between e-commerce and traditional commerce, issues related to e-commerce, electronic data interchange, value chain, and supply chain, and the pros and cons and limitations of e-commerce.

Among the female population, breast cancer has been the most common fatal disease. Breast density, a risk factor for breast cancer, is a radiologic feature that represents the content of fibro glandular tissue relative to the area or volume of the breast. Breast density is one of the key attributes for breast cancer diagnosis to suggest screening a...

The current decade of technology trends adopted the utilization of wireless sensors network. The wireless sensors network integrates with cloud based services and facilitate in every field of social engineering. The success story of sensors based network is utilization of energy. The sensor devices occupied tiny battery for energy. If the energy ut...

ABSTRACT: The present study describes simple, accurate, precise and cost Clomiphene citrate, effective UV-spectroscopic method for the estimation of clomiphene citrate Methanol, Method development in methanol as per ICH guidelines. The absorption maxima for clomiphene citrate in methanol was found to be 235nm and 294 nm. The drug follows linearity...

Psidium guajava known as Guava is a medicinal plant belonging to the family Myrtaceae. P. guajava is a well-known traditional medicinal plant used in various indigenous systems of medicine. P. guajava leaves are green to dull green colour with characteristic taste and having ovate-elliptic shape. The chief constituents like essential oil, poly phen...

Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and β-CD. Mouth dissolving Tablets also called as Orodispersible tablets. Formulated Levocetirizine β-CD complex was characterized by infrared spectroscopy, thermal analysis and X-ray diffraction pattern....

Network is a connection of devices in either a wired or wireless manner. Networking has become a part and parcel of computing in the present world. They form the backbone of the modern-day computing business. Hence, it is important for networks to remain alive, up, and reliable all the time. A way to ensure that is network traffic analysis. Network...

Review on novel approach in pharmaceutical gel explains about gels and its novel development as hydrogel. Gel which is defined as intermediate state of matter consists of liquid and solid components. Hydrogels are also briefly discussed in the review that is defined as three dimensional structures which has capacity to retain bulk amount of water a...

The aim of this work to formulate a sustained release matrix tablet of Simvastatin. In this study, the release of Simvastatin examined from polymer matrices Polyvinyl pyrrolidone K-30 and Polyethylene glycol 4000. Simvastatin is an antihyperlipidemic drug and short half-life and usually taken to 4 times a day. Sustained release matrix tablets of Si...

Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. It is characterized by hyperandrogenism, polycystic ovaries, and chronic anovulation along with insulin resistance, hyperinsulinemia, abdominal obesity, hypertension, and dyslipidemia as frequent metabolic traits (metabolic syndrome) that culminate in s...

Genetic switches frequently include DNA loops secured by proteins. Recent studies of the lambda bacteriophage repressor (CI), showed that this arrangement in which the protein links two sets of three operators separated by approximately 2.3 kbp, optimizes both the stability and dynamics of DNA loops, compared to an arrangement with just two sets of...

Finding the optimal DNA and salt concentration for FCS measurements. (DOCX)

Fitting strategy of FCS data with a two-stage, two-component diffusion model. (DOCX)

Representative autocorrelation functions and the residuals for their fitting with one or two components with no protein (left), 250 nM (middle), or 500 nM CI (right). (PPTX)

Representative autocorrelation functions and the residuals for their fitting with one or two components in the presence of 150 (left) or 350 (right) nM CI. (PPTX)

Dissociation constants for the WT CI and D197G mutant with operator DNAs were obtained by fitting the data to the Hill equation. Note that the activities of the protein preparations were not determined but were likely to be 50% or higher. In addition, previously measured specific and non-specific affinities of repressor proteins were shown to decre...

Names and schematic compositions of DNA constructs used in FCS measurements. In the descriptions, “ALEX488” indicates the fluorophore label, “5” indicates the number of base pairs separating ALEX-488 from the specific lambda repressor operator (OL3, OR3, or OL1), NS38 indicates a sequence of 38 base pairs of non-specific DNA with the wild type (WIL...

The dependence on protein concentration of the diffusion time of OL1wild DNA. (a) Data (black squares) were fit (red curve) using a single-phase binding model (between A and B, top left panel) or a bi-phasic binding model (among A, B and C, bottom left panel). The fitting which assumes bi-phasic behavior best captures the trend of the data. Analysi...

A schematic diagram of the components required to fit the auto-correlation data accurately enough to avoid non-random error fluctuations. (PPTX)

Representative nanographs of wild-type CI complexes securing 400 bp DNA loops. The CI complexes increased in size as the CI concentration was raised. (PPTX)

Diffusion times of the protein-DNA complexes for both the WT and mutant CI proteins. (DOC)

FCS data for OL1wild DNA fragments in the absence (black) or presence (red) of 500 nM mutant (D197G) CI protein. The autocorrelation function without protein was well fit by a single diffusing species (labeled DNA) but that in the presence of protein displayed extremely fast diffusion and was well fit by a single exponential component. Residual dif...

Data with which to determine the optimal DNA (a, c) and salt (KCl) concentrations (b, d) from measurements of the number of particles in the focal volume and the counts per particle. (PPTX)

Change in diffusion time for the OL1wild DNA in presence of increasing concentrations of D197G mutant protein. (PPTX)

The relative, first component amplitude in two-component plots (fraction of DNA with a single bound protein) displayed Hill-equation responses when DNA fragments containing the OL1 (black), OL3 (red) and OR3 (blue) operators were titrated with WT (left) and mutant (right) lambda repressors. The data in the right panel were taken directly from Fig 2...

This chapter provides an overview of the e-commerce business model, the history of e-commerce, the scope of e-commerce, the difference between e-commerce and traditional commerce, issues related to e-commerce, electronic data interchange, value chain, and supply chain, and the pros and cons and limitations of e-commerce.

Mouth dissolving tablet is an innovative solid unit dosage form that overcome the problem of swallowing and provide rapid disintegration and dissolution to release the drug as soon as they come in contact with saliva, hence provide quick onset action. The aim of this study was to formulate and evaluate mouth dissolving tablets of Ondansetron hydroc...

Losartan potassium is used as an antihypertensive drug but it goes under first pass metabolism due do which it has low bioavailability. Fast onset of action is major concern in the management of hypertension. Therefore the aim of this study is to formulate mouth dissolving tablet of losartan potassium to improve its bioavailability, to achieve fast...

Communication is a very important area of research in the present era. Expansion of globalization and reduction in the cost of electronic devices has made communication very effective. A large number of researchers from academics and industries are involved in the research on communication and networks. Any novel idea has to be verified on the simu...

MANET is an infrastructure fewer network, here each node acts as à router and so capable to forwards data packets to all other neighboring nodes. Hence, the routing packet overhead has been reduced. Routing in MANETs is challenging since the network topology is dynamic, self-organized, self-administrated and low transmission range. Due to the above...

MANETs) Mobile Ad-hoc Networks is a group of mobile nodes that are connected dynamically, in which each node acts as a router to all other nodes. Due to the absence of centralized administration and dynamic nature, MANETs are vulnerable to various kinds of attacks from malicious nodes. Several secure routing protocols like AODV, DSR, TSR, and OLSR...

Colorants are mainly used to impart a distinctive appearance to each step of our lives. They are present everywhere in the nature. In mainly edible things like vegetables, fruits and animals also. Pigments can also be prepared synthetically in the laboratory. Both natural and synthetic pigments are used in food, cosmetics and pharmaceutical product...

Colorants are mainly used to impart a distinctive appearance to the pharmaceutical dosage forms. The present study was carried out to develop aluminium lake color of a dye obtained from red cabbageusing different adsorbent (s) (Aluminium oxide or aluminium hydroxide or combination of both) in different ratio by simply mixing them to get dye adsorbe...

Colorants are mainly used to impart a distinctive appearance to the pharmaceutical dosage forms. The present study was carried out to develop aluminium lake color of a dye obtained from red cabbageusing different adsorbent (s) (Aluminium oxide or aluminium hydroxide or combination of both) in different ratio by simply mixing them to get dye adsorbe...

To protect digital content from illegal copy or reproduction, digital watermarking techniques are used which embed watermark into digital content and extract the same from the digital content to help in digital media protection. As techniques based on spatial and frequency domain are reported to have several limitations due to unsatisfactory values...

Organizations focuses IDPSes for respective purposes, e.g. identifying problems with security strategies, manually presented threats and deterring individuals from violating security policies. IDPSes have become a necessary technique to the security infrastructure of approximate each association. IDPSes typical record information interrelated to pr...

Wireless sensor network consists of hundreds or thousands of low cost, low power, and self-organizing tiny sensor nodes that are deployed within the sensor network. Sensor network is susceptible to physical attacks due to deprived power and restricted resource capability and is exposed to external environment for transmitting and receiving data. No...

This paper is mainly concern about how network monitoring, using software tools can be helpful for protection of our communication network, how different kind of network attacks is perform. Now these days network security is main concern for each organization due to this, network monitoring has become an important part of computer security to preve...