Sabine Plancoulaine

French Institute of Health and Medical Research | Inserm · Sorbonne Paris Cité Research Center in Epidemiology and Statistics - CRESS

Objective: To assess the association between sleep irregularity, anxiety, and depression while controlling for other sleep dimensions and using a longitudinal design. Methods: Longitudinal cohort study which started in April 2020 during the first French lockdown in the general population. Follow-up questionnaires were completed in June 2020, a p...

Objective We investigated maternal and paternal sleep evolution from 3 to 36 months postpartum, their interrelations and predictors in the SEPAGES cohort. Methods Sleep information (night sleep duration [NSD], weekend daytime sleep duration [DSD] and subjective sleep loss [SSL]) was collected by self-administered questionnaires at 3, 18, 24 and 36...

Study objectives: To identify sleep multi-trajectories in children from age 1 to 5.5 years and their early correlates. Methods: We collected early family, maternal, and child characteristics, including children's nighttime (NSD) and daytime (DSD) sleep duration, night waking (NW), and sleep onset difficulties (SOD), by parental phone interviews...

Aims To compare the children's sleep electroencephalogram according to their intellectual profile. Methods Children were grouped according to their Wechsler Intelligence Scale for Children (WISC) scores (17 with normal intelligence quotient [IQ, NIQ] and 24 with high IQ [HIQ]). Comparisons of spectral power between groups and its relationship with...

Introduction Parents reported degraded sleep outcomes up to several years after child birth. Most published studies were cross-sectional, in early post-partum and focusing on maternal-child dyads. We aimed at identifying sleep multi-trajectories (SMT) including night (NSD) and daytime (DSD) sleep duration and subjective sleep loss (SSL) between 3 a...

Study objectives: To determine the prevalence of metabolic syndrome (MS) in children with narcolepsy and to evaluate their clinical and sleep characteristics according to the different components of MS. Methods: This retrospective study consisted of 58 de novo children with narcolepsy (median age: 12.7 y, 48.3% of boys). The recently published M...

Aims To investigate associations between outdoor and screen time and changes in sleep patterns in children from two nationwide birth‐cohorts in the SAPRIS project. Methods During the first French COVID‐19 pandemic lockdown, volunteer parents of children enrolled in the ELFE and EPIPAGE2 birth‐cohorts completed online questions about their child's...

Short sleep duration has been linked to adverse behavioral and cognitive outcomes in schoolchildren, but few studies examined this relation in preschoolers. We aimed to investigate the association between parent-reported sleep duration at 3.5 years and behavioral and cognitive outcomes at 5 years in European children. We used harmonized data from f...

Sleep complaints and cannabis use are common among University students and are related to detrimental effects on health. The aim of this study was to explore their association. This cross-sectional study based on the i-Share e-cohort included French students between 18 and 30 years old (n = 14,787). Frequency of cannabis use was categorized into da...

The objective of the present study was to validate the Short Version of French Sleepiness Scale for Adolescents (FSSA) with eight items (FSSA8). Methods: A total of 384 adolescents, aged between 12 and 18 years, completed the FSSA8. These included 269 nonclinical adolescents and 115 adolescents admitted for overnight polysomnography and Multiple...

Objectives Sleepiness is associated with decreased cognitive abilities and remains one of the main causes of fatal road accidents. The tools currently available to assess sleepiness, such as questionnaires, are subject to intra- and inter-individual variability, while multiple sleep latency tests are only feasible in few sleep laboratories. The mai...

Obstructive sleep apnea syndrome (OSAS) treatment has been shown to improve cardiac behavioral and cognitive functions in typically developing children. Early OSAS diagnosis in children with Down syndrome (DS) would be important to prevent its complications, especially cognitive ones, but remains overlooked. The main objective of our study was to a...

Background Sleep is important for healthy functioning in children. Numerous genetic and environmental factors, from conception onwards, may influence this phenotype. Epigenetic mechanisms such as DNA methylation have been proposed to underlie variation in sleep or may be an early-life marker of sleep disturbances. We examined if DNA methylation at...

Résumé Une faible exposition à la lumière naturelle extérieure et une forte exposition aux écrans sont des perturbateurs du sommeil et des rythmes circadiens. Lors du premier confinement en mars-mai 2020 en France, certains comportements ont pu être modifiés. Nous avons voulu décrire et étudier les relations entre l'exposition à la lumière (naturel...

Introduction: Sleepiness is associated with a decrease in cognitive abilities with effects comparable to those of alcohol. It remains one of the main causes of fatal road accidents. Various tools are available to assess sleepiness subjectively and objectively, such as questionnaires and multiple sleep latency test. However, the former are subject t...

Introduction There has been little focus on sleep and its relation to behavior and cognition in preschool-aged children. We aimed to investigate the association between sleep duration in early preschoolers (» 3.5 years of age) and later behavioral and cognitive outcomes (» 5 years of age) in European children. Methods We used harmonized data from...

Introduction Sleepiness is associated with a decrease in cognitive abilities with effects comparable to those of alcohol. It remains one of the main causes of fatal road accidents. Various tools are available to assess sleepiness subjectively and objectively, such as questionnaires and multiple sleep latency test. However, the former are subject to...

Background Screen media use in early childhood has largely increased in recent years, even more so during the COVID-19 epidemic, and there is much discussion regarding its influence on neurodevelopment, including Autism Spectrum Disorder (ASD). Methods We examined the relationship between use of TV, computer, tablet and smartphone at age 2 years a...

Background Early childhood may represent an opportune time to commence primordial prevention of cardiovascular disease (CVD, i.e., prevention of risk factors onset), but epidemiological evidence is scarce. We aimed to examine the distribution and parental and early life determinants of ideal cardiovascular health (CVH) in children up to 5 years and...

Objective A defect of the waking systems could constitute a factor of vulnerability for sudden infant death syndrome (SIDS). A decrease in orexin levels, which promotes wakefulness and activates histaminergic neurons (another hypothalamic wake-promoting system) has already been demonstrated between 2 and 6 months. This work aims to study the levels...

Background Integrated patterns of energy balance-related behaviours of preschool children in Asia are sparse, with few comparative analyses. Purpose Using cohorts in Singapore (GUSTO) and France (EDEN), we characterized lifestyle patterns of children and investigated their associations with family-focused contextual factors. Methods Ten behaviour...

Objectif Caractériser la prise de poids rapide (PPR) associée à l’apparition de narcolepsie chez l’enfant et déterminer si elle constitue un marqueur de sévérité de la maladie. Méthodes Quatre-vingt-quatre enfants narcoleptiques, d’âge médian 12 ans au diagnostic : 60 % garçons, 91 % cataplexie, 99 % positivité HLA-DQB1*06 :02. La PPR est défini à...

Objectif Nous avons cherché à identifier des trajectoires de sommeil (durée nocturne (DN), réveils nocturnes (RN), difficultés à s’endormir (DE)) chez les enfants entre 1 et 5,5 ans et les facteurs précoces associés à chacune d’elles. Méthodes Des trajectoires de DN, RN et DE ont été modélisées à partir des données collectées par questionnaires pa...

Objectif Exploration de différents marqueurs permettant d’évaluer la somnolence dans un contexte de prévention routière. Méthodes Au total, 185 conducteurs (âge médian 44 ans, 72 % hommes, 15 % obèses) ont été inclus pendant une pause sur une aire d’autoroute lors d’un départ en vacances. Des questionnaires sur la somnolence, le sommeil la veille...

Objectives To characterize the rapid weight gain (RWG) phenotype associated with the onset of childhood narcolepsy and to determine whether it could constitute a marker of severity of the disease. Methods RWG was defined using the BMI z‐score slope reported to one year (>0.67 SD) from symptom onset to disease diagnosis. We compared the clinical, m...

The objective of this study was to compare the maturation of spontaneous arousals during day and night sleep in preterm and term infants. From the Autonomic Baby Evaluation study, the sleep and arousal characteristics of 12 preterm (35.1 ± 2.1 weeks’ gestational age, GA) and 21 term (39.8 ± 0.8 weeks GA) newborns were compared between diurnal and n...

Sleep is essential for optimal child development and health during the life course. However, sleep disturbances are common in early childhood and increase the risk of cognitive, metabolic and inflammatory disorders throughout life. Sleep and immunity are mutually linked, and cytokines secreted by immune cells could mediate this interaction. The sle...

Objectif : L’objectif était d’explorer les différents marqueurs subjectifs et objectifs (biologiques, neurocognitifs) permettant d’évaluer la somnolence chez les conducteurs dans un contexte de prévention routière. Méthode : 185 conducteurs (âge médian 44 ans, 72% hommes, 15% obèses) ont été inclus un samedi matin, au cours de leur pause sur une a...

COVID-19 limitation strategies have led to widespread school closures around the world. The present study reports children’s mental health and associated factors during the COVID-19 school closure in France in the spring of 2020. We conducted a cross-sectional analysis using data from the SAPRIS project set up during the COVID-19 pandemic in France...

Energy balance-related behaviors (EBRBs), i.e., diet, sedentary behavior, physical activity, and sleep, combine into lifestyle patterns, which we aim to identify in French preschoolers and analyze their family correlates within the framework of a comprehensive socioecological model. Parental questionnaires provided information about family characte...

Studies in children have reported associations of screen time and background TV on language skills as measured by their parents. However, few large, longitudinal studies have examined language skills assessed by trained psychologists, which is less prone to social desirability. We assessed screen time and exposure to TV during family meals at ages...

Background: COVID-19 limitation strategies have led to widespread school closures around the world. The present study reports children’s mental health and associated factors during the COVID-19 school closure in France in the spring of 2020. Methods: We conducted a cross-sectional analysis using data from the SAPRIS project set up during the COVID-...

Introduction There is a reciprocal interaction between sleep and the immune system. Activation of the immune system changes the quality of sleep, and sleep regulates innate and adaptive immune responses. While these interactions have been studied in adults and adolescents, only a few studies have focused on school age children and none on preschool...

Introduction Refractive errors are very common, in particular in children and adolescents, leading to global health issues, academic implications and economic costs. The process of emmetropization in child development is a multifactorial and active mechanism, and is yet to be fully understood. Light exposure and endogenous circadian rhythmicity are...

Refractive errors are common, especially in children and adolescents, leading to global health issues, academic implications and economic costs. Circadian rhythm and sleep habits may play a role. The study included 1130 children from the EDEN birth-cohort. Data were collected through parental questionnaires at age 2 and 5 for sleep duration and tim...

Objectif Les troubles de la réfraction sont très courants. Le sommeil et les rythmes circadiens pourraient être impliqués dans leur développement. Méthodes L’étude inclus 1133 enfants d’une cohorte de naissance ayant des données sur le sommeil à 2 ans et les troubles de la réfraction à 5 ans (myopie, hypermétropie et prescription de lunettes). La...

Objectif Le sommeil et le système immunitaire interagissent y compris hors contexte pathologique. Les relations entre durées de sommeil et niveaux sériques de cytokines inflammatoires ont été essentiellement étudiées chez les adultes, très peu chez les enfants et jamais chez les enfants d’âge préscolaire. Méthodes L’étude inclus 687 enfants d’une...

High cognitive functioning could be a protective factor for school difficulties, behavioral and mood impairments in children with narcolepsy. To investigate this factor, we studied the intellectual abilities of 74 children with narcolepsy (43 boys, 11.7 years old at diagnosis, 91% of cataplexies, 64% obese, 100% HLA positive for DR-DQB1*06:02). All...

Résumé Le sommeil et le système immunitaire interagissent notamment via les cytokines. Chez l’adulte, il a été montré que le manque de sommeil chronique conduisait à une activation des marqueurs de l’inflammation (comme l’IL-6 et la CRP, les plus étudiés), constituant une inflammation chronique de bas grade, avec cependant des différences selon le...

The involvement of sleep in cognitive functioning is well known, but only a few studies have examined objective sleep parameters in children with high intellectual potential (HP). The main objective of this study was to compare sleep characteristics of 33 children with high intellectual potentialities (HP) (median 10 years old, 64% of boys) compare...

Aims : Describe the cognitive profile in a large group of narcoleptic children and investigate whether the cognitive profile is a protective factor for school difficulties, behavioral and mood impairments.

Sleep problems reported by parents affect 20% to 30% of infants. Few studies focused on the longitudinal association between infant feeding practices and sleep, especially in France. Analyses were based on 8,696 infants from the French national birth cohort ELFE. Collection of feeding practices from birth to 10 months allowed for the identification...

Background Short sleep duration is associated with concomitant behavioral difficulties, but the longitudinal association between sleep duration and later behavior in early childhood remains unclear. The aim was to study the association between sleep duration trajectories throughout preschool and behavior at age 5–6 years. Participants 1021 childre...

Objectif Les enfants à haut potentiel intellectuel (HPI) représentent 2,3 % de la population pédiatrique générale et présentent fréquemment des troubles de l’humeur, du comportement et/ou du sommeil. L’objectif était de comparer l’architecture du sommeil de 33 enfants HPI à celle de 25 enfants contrôles appariés pour l’âge (M = 10,5 ans) et le sexe...

Objectif Identifier les pratiques alimentaires associées à la durée totale de sommeil (DTS), aux réveils nocturnes (RN) et aux difficultés d’endormissement (DE) à 1 an. Méthodes Au total, 8340 enfants avec des données disponibles sur le sommeil (DTS, RN, DE) et les pratiques alimentaires ont été incluses. Les pratiques alimentaires étudiées étaien...

Objectif Explorer les relations entre l’exposition fœtale à certains phénols et phtalates et le sommeil de l’enfant à 2 ans. Méthodes Au total, 4456 dyades mère–fils d’une cohorte de naissance avec des dosages de métabolites urinaires maternels de 9 phénols et 11 phtalates et des données sur le sommeil de 2 ans (durée de sommeil, réveils nocturnes...

Objectif Notre objectif était d’évaluer les facteurs influençant l’efficience intellectuelle chez les enfants narcoleptiques de type 1. Méthodes Une étude rétrospective a été faite dans notre CRMR narcolepsie sur 75 enfants âgés respectivement de 11,8 ans (5,5 à 17,6 ans) lors du diagnostic, 9,5 ans (4,5 à 15,8 ans) lors du début des symptômes (67...

Background: Despite the growing interest in the relation between adiposity in children and different lifestyle clusters, few studies used a longitudinal design to examine a large range of behaviors in various contexts, in particular eating- and sleep-related routines, and few studies have examined these factors in young children. The objectives of...

Sleep occupies a substantial proportion of life. Sleep modifications parallel brain development during childhood. Sex and gender differences have been reported in brain development and many clinical and psychosocial conditions. This narrative review provides insight into the differences between girls and boys in terms of brain maturation and plasti...

Objective: Infant sleep plays a critical role in normal development. Sleep problems, including sleep onset difficulties (SODs) and night waking (NW), range from 20% to 30% in infants and young children and can be persistent over time up to adulthood. Young French children seem to have longer sleep durations and less sleep troubles than their count...

Infant sleep plays a critical role in his/her normal development. Sleep problems, including sleep onset difficulties (SOD) and night waking (NW), ranges from 20% to 30% in infants and young children and are partially persistent over time up to adulthood. French young children seem to have longer sleep durations and less sleep troubles than their co...

Background: Few studies on the relationship between sleep quantity and/or quality and cognition have been conducted among preschoolers from the healthy general population. We aimed to identify, among 3-year-old children, early polysomnography (PSG) sleep factors associated with estimated intelligence quotient (IQ) using the Weschler Preschool and...

Introduction Preterm birth is associated with increased risks for several pathologies including neurodevelopmental ones. Studies on sleep patterns among preterm versus non-preterm children provide discordant results. We aimed at describing sleep patterns (i.e. sleep onset difficulties (SOD), night-waking (NW), insomnia symptoms (IS)) and identifyin...

Introduction The association between sleep and behavior has been extensively studied in adolescents and school-aged children, but very little attention has been given to preschoolers. A systematic review of the literature allowed us to identify 10 articles describing the link between sleep duration and behavior in preschool aged children, with only...

Introduction Infant sleep plays a critical role in his/her normal development. Sleep problems, including sleep onset difficulties (SOD) and night waking (NW), in infants and young children ranges from 20% to 30% and were found to be partially persistent over time up to adulthood. In USA and UK, lower incomes and educational level as well as some ra...

Sleep problems affect 20%–30% of toddlers and preschoolers. Few longitudinal studies focused on the impact of infant feeding practices on sleep. We aimed to study the associations between feeding practices up to 8 months and trajectories of sleep quantity or quality from 2 to 5–6 years. Analyses included 1,028 children from the EDEN mother–child co...

Objectif Peu d’études rapportent le lien entre la quantité et/ou la qualité du sommeil et la cognition chez l’enfant pré-scolaire. Le but était donc d’étudier les relations entre le sommeil des premiers mois de vie et les caractéristiques neurocognitives à 3 ans. Méthodes Les enfants inclus dans cette étude faisaient partie de la cohorte AuBE. Ces...

Objectif Identifier les facteurs précoces associés aux difficultés d’endormissement (DE), réveils nocturnes (RN) et insomnie (IS) à 1 an chez les enfants nés prématurés ≤ 34SA. Méthodes Au total, 3151 enfants de la cohorte EPIPAGE2 ont été inclus. Les facteurs étudiés sont familiaux (éducation, revenus, situation familiale, pays de naissance), mat...

Objectif Afin de déterminer si l’histamine cérébrale (HA) est impliquée dans la narcolepsie, nous avons quantifié les niveaux d’HA et de son métabolite direct (télé-méthylhistamine, t-MeHA) dans le liquide céphalorachidien (LCR) chez l’enfant narcoleptique de type1 (NT1). Méthodes L’étude inclut 24 enfants NT1 et 21 témoins appariés en sexe et âge...

Abstract The objective was to study the longitudinal associations between inattention/hyperactivity symptoms and night-waking in preschool-years, in light of their joint evolution. Within the French birth-cohort study EDEN, repeated measures of 1342 children’s night-waking and inattention/hyperactivity symptoms were collected at age 2, 3 and 5–6 th...

Objective: Deficiency in 25-hydroxyvitamin D (25OHD) has been associated with sleep disorders in adults. Only three cross-sectional studies were performed in children; which showed an association between 25OHD deficiency and both obstructive sleep apnea syndrome and primary snoring. No longitudinal study has been performed in children from the gen...

Objective Narcolepsy is a sleep disorder characterized in humans by excessive daytime sleepiness and cataplexy. Greater than fifty percent of narcoleptic patients have an onset of symptoms prior to the age of 18. Current general agreement considers the loss of hypothalamic hypocretin (orexin) neurons as the direct cause of narcolepsy notably catapl...

Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadian behaviours and cancer is not...

Introduction Sleep disorders and short sleep duration have been associated with 25-hydroxyvitamin D (25OHD) deficiency in adults and short sleep duration in the elderly has been improved by supplementation. Only two cross-sectional studies have been performed among children and showed a positive association between 25OHD deficiency, obstructive sle...

Objective: Sleep duration may vary both interindividually and intraindividually over time. We aimed to identify night-sleep duration (NSD) trajectories among preschoolers and to study associated factors. Methods: NSD was collected within the French birth-cohort study EDEN at ages 2, 3, and 5-6 years through parental questionnaires, and were used...

Objectif Étudier les relations entre pratiques alimentaires de la naissance à 8 mois et trajectoires de sommeil (difficultés d’endormissement [DE], réveils nocturnes [RN] et durée du sommeil nocturne [DSN]) entre 2 et 5–6 ans dans la cohorte EDEN. Méthodes Les analyses concernent 1034 enfants avec des données complètes collectées par questionnaire...

This is the first systematic review of the literature on sleep and its relation to cognition and behaviour in preschool-aged children. In comparison with the literature focused on school-aged children, knowledge involving preschoolers is rather sparse. A total of 26 studies was included in this review, which revealed a high degree of heterogeneity...

Objective The aim was to study, with a developmental approach, the longitudinal association between night-waking from age 2 to 5–6 years and behavior at age 5–6 years. Methods Within the French birth cohort study EDEN, repeated measures of children’s night-waking were collected at age 2, 3 and 5–6 through parental questionnaires and were used to m...

Background and objectives: Circadian disruption, resulting from shiftwork, has been classified as probably carcinogenic to humans by the International Agency for Research on Cancer. The biological circadian clock is subject to environmental effects, particularly light exposure and rhythmic food intake. However, the association between circadian nut...

Objectives Sleep problems and deprivation are common during pregnancy, particularly in the third trimester. Previous studies are mostly descriptive or focused on specific clinical groups and late pregnancy. We aimed to identify sleep duration trajectories during the pregnancy period, their associated factors, and impact on pregnancy and birth outco...

Objective This preliminary study investigated electrophysiological and microstructural features of sleep in children and adolescents 4–18 years of age who were born to depressed mothers. Methods A total of 31 healthy subjects (15 male and 16 female) participated in the study. In this sample, 20 children born to mothers diagnosed with Major Depress...

Introduction Short sleep duration and/or poor sleep quality in childhood have been associated with later poorer health outcomes. Breastfeeding has been associated with frequent night-waking and inconsistently with short sleep duration up to 18 months. Besides mothers may introduce complementary feeding before the recommended age when children prese...

Objectif Etudier les trajectoires de développement jointes de réveils nocturnes et des difficultés d’attention (DA) chez l’enfant de 2 et 5 ans. Méthodes Des mesures répétées de réveils nocturnes ainsi que de DA ont été collectées chez 1342 enfants de la cohorte EDEN à 2, 3 et 5 ans. Les réveils nocturnes ont été définis comme fréquents si, selon...

Objectif Etudier l’impact des trajectoires de durees de sommeil nocturne (TDS) entre 2 et 5 ans sur la masse grasse ( %MG) et la masse maigre ( %MM) mesurees par impedance a 5 ans au sein de la cohorte de naissance EDEN. Nous avons egalement etudie les relations entre TDS et le z-score d’IMC et le rapport standardise du tour de taille sur taille (s...

Objectif Etudier la relation entre trajectoires de duree de sommeil (TDS) entre 2 et 5 ans et la taille mesuree a 5 ans dans la cohorte de naissance EDEN. En effet, tres peu d’etudes se sont interessees specifiquement a cette relation alors que l’enfance est la periode de la vie avec la plus forte croissance en taille sous la dependance de l’hormon...

Objective: This study investigated sleep architecture in newborn and six-month-old infants who were born to depressed mothers. Method: Sixty-four healthy full-term infants (32 males and 32 females) participated in the study. Of these, 32 were high-risk infants who were born to mothers diagnosed with depression, and 32 were low-risk infants born...

Background: Few studies on the relations between sleep quantity and/or quality and cognition have been conducted among preschoolers from healthy general population. We aimed at identifying, among 36 months old children, early factors associated with intelligence quotient (IQ) estimated through the Weschler Preschool and Primary Scale Intelligence-...

Objectif : Etudier les trajectoires de développement jointes de réveils nocturnes et des difficultés d’attention (DA) chez l’enfant de 2 et 5 ans. Méthode : Des mesures répétées de réveils nocturnes ainsi que de DA ont été collectées chez 1342 enfants de la cohorte EDEN à 2, 3 et 5 ans. Les réveils nocturnes ont été définis comme fréquents si, sel...

FULL TEXT AVAILABLE UPON REQUEST. Night waking in preschoolers has been associated with adverse health outcomes in cross-sectional studies, but has rarely been analyzed in a longitudinal setting. Therefore, little is known about the evolution of night waking in early childhood. The objectives of the present study were: to identify night-waking traj...

State of the art : The association between sleep, cognition and behavior has been extensively studied in adolescents and school-aged children, but very little attention has been given to preschoolers. A systematic review of the literature allowed us to identify 26 articles describing the link between naturally occurring sleep and behavior or cognit...

Objectif Étudier l’association entre les 2 trajectoires de réveils nocturnes entre 2 et 5 ans (trajectoire de réveils nocturnes fréquents versus rares) [1] et le comportement de l’enfant à 5 ans. Méthodes Nous disposions pour 1103 enfants de l’évolution de leurs réveils nocturnes entre 2 et 5 ans (modélisée par 2 trajectoires) et des scores de l’é...