Rownock Afruza

National Institutes of Health | NIH · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Cell-free RNAs (cfRNAs) are promising analytes as non-invasive biomarkers and have even greater potential if tied in with metabolomics. Plasma is an optimal source for cfRNAs but is often derived from a variety of anticoagulants. Plasma obtained in heparin is suitable for metabolomics but is difficult to utilize for qPCR-based downstream analysis....

Non-alcoholic fatty liver disease (NAFLD) covers a broad spectrum of liver diseases ranging from steatosis to cirrhosis. There are limited data on prevention of hepatic steatosis or its progression to liver disease. Here, we tested if either transgenic (Tg) doxycycline-induced expression in adipose tissue of E4orf1 (E4), an adenoviral protein, or d...

Obesity and hyperlipidemia are independent risk factors of chronic kidney disease (CKD). In mice, diet induced obesity accelerates lipogenesis, lipid accumulation, and injury in kidneys. Expression of adenoviral protein, E4orf1, improves glucose clearance and reduces endogenous insulin secretion to glucose challenge in mice. Therefore, in this pilo...

Background Prevalence of chronic kidney disease (CKD) is increasing along with obesity. Hyperinsulinemia is often associated with obesity and in turn linked with CKD. Rodent studies show that a high fat diet induces hyperinsulinemia, accelerates renal lipogenesis (as determined by the expressions of fatty acid synthase (FAS) and Acetyl CoA Carboxyl...

Adipose: TOS Late Breaking Poster Session Track 1: Metabolism and Integrative Physiology

Objective: Linkages of renin gene polymorphisms with hypertension have been implicated in several populations with contrasting results. Present study aims to assess the pattern of renin gene polymorphisms in Bangladeshi hypertensive individuals. Methodology: Introns 1, 9 of renin gene and 4063 bases upstream of promoter sequence of renin gene were...

Recurrence is a great problem in cancer treatment. A proportion of cancer patients develop recurrence, even after curative resection. In the present study, data of a total 315 cancer patients, age between 22 to 60 years were analyzed, among them 130 patients were male and 185 were female. Patients were diagnosed with primary stage of cancer (72%) a...