Roshan Dhruv Patel

Smt. C. V. Gajera Pharmacy Mahila College, Amreli, Gujarat, India · Pharmacognosy

Background: Epilobium hirsutum Linn. (Onagraceae) is used widely as traditional medicine for its various medicinal values. Despite the popular utilization of this plant, still no conclusive study has been reported so far regarding the pharmacognostical standardization. Aim: Thus, the present study was aimed to scientifically establish a standard mo...

Background: Melilotus officinalis Linn. (Fabaceae) historically has been used for a variety of medicinal purposes. Despite the popular medicinal utilization, still no conclusive study has been reported so far regarding the pharmacognostical standardization. Aim: Thus, the present study was focused to scientifically establish a standard monograph of...

Lychee is an evergreen tree reaching 10–28 metres tall, the lychee bears fleshy fruits that are up to 5 cm (2.0 in) long and 4 cm (1.6 in) wide. The outside of the fruit is covered by a pink-red, roughly textured rind that is inedible but easily removed to expose a layer of sweet, translucent white flesh. Lychees are eaten in many different dessert...

Quantitative structure activity relationship is study of relationship between physiochemical (independent) properties and biological (dependent) activity of bioactive molecules. Some amides and ureas reported in the literature as a CCR5 receptor (binding) antagonist were selected for the present study in order to establish structure activity relati...

Disorders of the nail unit range from relatively innocuous conditions such as pigmentation in heavy smokers, to painful and debilitating states where the nail unit can be dystrophied, hypertrophied, inflamed, infected etc. The human nail forms a resistant barrier to the topical penetration of drugs. Thus, treatment of nail disorders, such as fungal...

The plant Cassia fistula Linn. belonging to family leguminosae, known as Cassia in English, Amaltas in Hindi. The methanolic extract of plant pod showed the presence of glycoside, steroids, amino acids, flavanoids. The present study was focused to evaluate antipyretic activity of pod of Cassia fistula Linn. The methanolic extract showed antipyretic...

INTRODUCTION Solid lipid nanoparticles (SLN) have been developed as potential carriers for a number of drugs (reviewed in) 1,2 . SLNs have been reported as an alternative drug delivery system to traditional polymeric nanoparticles 3 . A clear advan-tage of solid lipid nanoparticles (SLNs) over polymeric nanoparticles is the fact that the lipid matr...

Household pharmaceuticals include household prescription, over-the-counter and illegal drugs. These are in the form of pills, ointments, liquids, sprays, pre-filled syringes, injection vials, cosmetics, sunscreen agents, diagnostic agents, contact lens solutions, nutraceuticals, etc. The traditional ways of managing unwanted household pharmaceutica...

From ancient time Acacia catechu Willd. (AC) is used as a potent medicinal. Preliminary phytochemical tests were conducted with the crude extract obtained from the leaves of AC reveals the presence of carbohydrates, steroids, alkaloids, glycosides, tannins, saponins, flavones, and phenolic. Anthelmintic activity of petroleum ether, ethanolic and et...

The plant Annona reticulata is also referred as custard apple which is widely cultivated in India for its edible fruit belongs to family Annonaceae. The seed bark contains useful tannins and astringents. The seed of Annona reticulata swells and form gelatinous mass when it comes in contact with water due to its hydrophilic nature. In present study...

Fagonia arabica L., belonging to the family Zygophyallaceae, commonly known as Dhamaso in Gujarati, Ustarkar in Hindi, Dhanvyas in Sanskrit is a wildly grown perennial plant. The plant is globally distributed in Africa, Arabia, Pakistan and India. It contains several triterpenoid saponins and mainly used in skin diseases. The present study deals wi...

INTRODUCTION The method of wet chemistry such as titrimetric analysis and gravimetry still has an important role in modern analytical chemistry. There are many areas in which titrimetric procedures are invaluable. The term titrimetric analysis refer to quantitative chemical analysis carried out by determining the volume of solution of accurately kn...

INTRODUCTION The method of wet chemistry such as titrimetric analysis and gravimetry still has an important role in modern analytical chemistry. There are many areas in which titrimetric procedures are invaluable. The term titrimetric analysis refer to quantitative chemical analysis carried out by determining the volume of solution of accurately kn...

Indicators used in titrations show well-marked changes of color in certain intervals of pH. Most of these indicators are organic dyes and are of synthetic origins. The present study was designated to evaluate the extracted flower petals of some easily available plants. A comparative study of Delonix regia Raf. and Caesalpina pulcherrima Swartz Obs....

Indicators used in titrations show well-marked changes of color in certain intervals of pH. Most of these indicators are organic dyes and are of synthetic origins. The present study was designated to evaluate the extracted flower petals of some easily available plants. A comparative study of Delonix regia Raf. and Caesalpina pulcherrima Swartz Obs....

The most superficial and least permeable skin layer, the stratum corneum, both from structural and compositional viewpoint, provides a uniquely impressive resistance to molecular transport both from and into the body. Studies have been carried out to find safe and suitable permeation enhancers to promote the percutaneous absorption of a number of d...

Anti-inflammatory activity of the methanolic extracts of the root of Indigofera oblongifolia Forsk was studied in Wistar rats using the carrageenan induced left hind paw edema. The methanolic extracts at the dose of 250 mg/kg and 500 mg/kg body weight shows moderate to significant anti-inflammatory activity. The methanolic extracts of Indigofera ob...

Berberis aristata DC (Berberidaceae) is used in Indian traditional medicine for treating antibacterial, antiperiodic, antidiarrhoeal, ophthalmic, skin diseases and diabetes mellitus. Objective of this study is to induce experimental diabetes mellitus using streptozotocin in normal adult male wistar rats and to study the Antidiabetic activity of met...

The ethanolic extract of bark of Dalbergia sissoo Roxb. was investigated for its activity against Indian earthworms Pheretima posthuma and nematode Ascardi galli. Various concentrations (10, 20, 50 mg/ml) of ethanolic extract were tested, which involved determination of time of paralysis and time of death of the worms. It was compared with Piperazi...

Alcohoilc extract from the seeds of Brassica nigra Linn. were investigated for their anthelmintic activity against Pheretima posthuma and Ascardia galli. Various concentrations (10-100 mg/ml) of extract were tested in bioassay, which involved determination of time of paralysis and time of death of the worms. Alcoholic extracts exhibited significant...

The shade-dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the solvents, pet. ether, chloroform, ethanol and water, in the increasing order of polarity. A preliminary phytochemical analysis was carried out for all the extracts. It was found that the leaves revealed the presence of alkaloid...

Plectranthus amboinicus (Lour) Spreng belongs to family Lamiaceae, known as country borage in English. It is large succulent aromatic perennial herb, shrubby below, hispidly villous or tomentose. It is found throughout India, Ceylon and Moluccas. The leaves of the plant are bitter, acrid and were being widely used traditionally for various purposes...

Stem of Berberis aristata DC (Berberidaceae) is used in Indian traditional medicine for treating antibacterial, antiperiodic, antidiarrhoeal, ophthalmic, skin diseases and diabetes mellitus. It is an important commodity in folklore medicine of India for as laxative, ophthalmia and other eye diseases so far there no record on detailed pharmacognosti...

Natural gums and mucilages have been extensively explored as pharmaceutical excipients. These gums are biocompatible, cheap and easily available. Mucoadhesives are agents which adhere to the mucous membrane due to specific properties and release the drug at the site of action in controlled manner. Since the biodegradability of the synthetic polymer...

Today synthetic indicators are the choice of acid-base titrations. But due to environmental pollution, availability and cost, the search for natural compounds as an acid-base indicator was started. The present vocation highlights the exploit of the acidified ethanolic extract of the flowers of few medicinal plants as an acid-base indicator in acid-...

Plant Momordica charantia Linn. belongs to family Cucurbitaceae. It is known as bitter gourd in English and karela in Hindi. Earlier claims show that the plant is used in stomachic ailments as a carminative tonic; as an antipyretic and antidiabetic agent; and in rheumatoid arthritis and gout. The fruit has been claimed to contain charantin, steroid...

Extending the residence time of a dosage form at a particular site and controlling the release of drug from the dosage form are useful especially for achieving controlled plasma level of the drug as well as improving bioavailability. The objective of this study was to extend the GI residence time of the dosage form and control the release of Tramad...

Cassia tora (Cassia obstusifolia L) is a common herbaceous annual occurring as a weed throughout India and belongs to the family of Caesalpiniaceae. Seeds of plant contain gluco-mannose hence attempt to evaluate the seeds for suitability as tablet binder is considered and the present investigation repots the isolation of mucilage of Cassia tora see...

Plectranthus amboinicus (Lour) Spreng belongs to family Lamiaceae and known as country borage in English. It is large succulent aromatic perennial herb, shrubby below, hispidly villous or tomentose. It is found throughout India, Sri Lanka and Moluccas. The leaves of the plant are bitter, acrid and were being widely used traditionally for various pu...

Sodium alginate beads were evaluated as sustained release vehicles for the delivery of Riboflavin. It has been shown that the structure of the cross-linked calcium alginate network is of primary importance in the retention and/or release of the Riboflavin. The Riboflavin bead formulations were prepared by dispersing Riboflavin together with a mixtu...

The leaves of Plectranthus amboinicus (Lour) Spreng were traditionally used for the treatment of pyrexia and acute pains. The present study was carried out using acetic acid-induced writhing and tail immersion tests in mice while, yeast-induced pyrexia in rats. The leaves were subjected to successive extraction using the various solvents (petroleum...

Plectranthus amboinicus (Lour) Spreng belongs to family Lamiaceae, known as country borage in English. It is large succulent aromatic perennial herb, shrubby below, hispidly villous or tomentose. It is found throughout India, Ceylon and Moluccas. The leaves of the plant are bitter, acrid and were being widely used traditionally for various purposes...

The shade-dried powder of leaves of Plectranthus amboinicus (Lour) Spreng was subjected to successive extraction using the various solvents (petroleum ether, chloroform, ethanol and water) in increasing order of polarity. The preliminary phytochemical analyses were carried out for all the extracts. The analyses of the leaves revealed the presence o...

The present work reports isolation of seed mucilage of Zizyphus jujuba. Physiochemical characterization such as swelling index, hydration capacity, powder porosity, loss on drying, pH and viscosity were studied. The seed mucilage of Zizyphus jujuba has been evaluated for its granulating and binding properties in tablets, using paracetamol as a mode...

The plant Plectranthus amboinicus (Lour.) Spreng belongs to family Lamiaceae, known as country borage in English. The anti-oxidant potential of aqueous and ethanolic extract of leaves of Plectranthus amboinicus (Lour) Spreng was investigated by DPPH assay, reducing power assay and nitric acid screening methods. The preliminary phytochemical analysi...

The ethyl alcohol (EA) extract of the stem of Berberis aristata DC (BA) (Berberidaceae) was analysed for its anti-diarrhoeal activity. Like loperamide (3 mg/Kg body weight), a single oral dose of Berberis aristata ethyl alcohol extract (BA-EA) (250, 500 mg/Kg body weight) produced a significant decrease in the severity of diarrhoea. To understand t...

The present study was designed to investigate analgesic activity of Cassia fistula methyl alcohol extract (CF-MA), using hot plate method and tail clip method. CF-MA was administered intraperitoneal at doses of 250 mg/kg and 500 mg/kg to Wister albino rats and Swiss Albino mice. CF-MA showed significant (p<0.01) inhibition in pain response induced...

The roots of Clitoria ternatea Linn are used in traditional medicine for the treatment of diarrhoea. Thus the alcoholic extract of Clitoria ternatea Linn (Fabaceae) root was investigated for its anti-diarrhoeal property in Wister albino rats to substantiate Ayurvedic claim. Alcoholic extract of the root of this plant, at graded doses (100, 200 & 40...

The objective of this work was to develop sustained release tablets of highly water soluble Tramadol HCl using polymers (HPMC K100M, HPMC K15M, HPMC K 4M) as cost effective, non toxic easily available and suitable hydrophilic matrix system. Sustained release tablet of Tramadol HCl (dose 50mg) were produced by wet granulation method. After the evalu...

Quantitative structure activity relationship is study of relationship between physiochemical (independent) properties and biological (dependent) activity of bioactive molecules. It plays an important role in the drug discovery and development and involves steps including data preparation, data analysis, and model validation. Validation is important...

Gastroesophageal reflux is very common in youth. If conservative procedures fail to relieve it, the use of a potent antiemetic agent that facilitates gastric motility and emptying, such as Domperidone, is vindicated. Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Its localization outside the blood-...

Ulcerative colitis is a disease of the intestine, explicitly the large intestine or colon that includes characteristic ulcers, or open sores, in the colon. For eradication of Ulcerative colitis, there are various methods among that delivery of drug to colon is one of them. Colon specific delivery can achieve by using polymer, which will release the...

Ulcerative colitis is a disease of the intestine, explicitly the large intestine or colon that includes characteristic ulcers, or open sores, in the colon. For eradication of Ulcerative colitis, there are various methods among that delivery of drug to colon is one of them. Colon specific delivery can achieve by using polymer, which will release the...

Gastroesophageal reflux is very common in youth. If conservative procedures fail to relieve it, the use of a potent antiemetic agent that facilitates gastric motility and emptying, such as Domperidone, is vindicated. Domperidone is a synthetic benzimidazole compound that acts as a dopamine D2 receptor antagonist. Its localization outside the blood-...

Natural products are gaining increased applications in drug discovery and development. Being chemically diverse they are able to modulate several targets simultaneously in a complex system. Analysis of gene expression becomes necessary for better understanding of molecular mechanisms. Conventional strategies for expression profiling are optimized f...

The aim of the present cram was to investigate the potential of a tranfersomes formulation for transdermal delivery of Curcumin. Curcumin is widely used in potent anti-inflammatory herbal drug. Its activity is similar to the NSAIDs in inflammatory pain management but main problem with curcumin when given orally is its poor bioavailability due to le...

The plant Corallocarpus epigeous (Rottl. & Willd.) belongs to family Cucurbitaceae, known as ‘akasgaddah’ in Hindi. It is a plant with prostrate or climbing nature, monoecious, root large and turnip shaped. It is distributed throughout Punjab, Sindh, Gujarat, Rajputana, Mysore, Deccan and Ceylon. Earlier claim shows that the plant is used as bitter...

A keloid is a benign, well-demarcated area of fibrous tissue overgrowth that extends beyond the original defect. A hypertrophic scar is similar but remains confined to the initial defect and tends to resolve with time. An imbalance of matrix degradation and collagen biosynthesis resulting in excess accumulation of collagen in the wound has been pos...

Space weather refers to condition in the solar wind, magnetosphere, ionosphere, and atmosphere that can influence the reliability of space and ground -based technological systems. Space weather plays an ever increasing role in our society as human beings develop more and more delicate technologies in space and on the Earth. In the present paper the...