Rodolphe Thuret

Centre Hospitalier Universitaire de Montpellier | CHU Montpellier · Urology

Systematic screening for prostate cancer is widely recommended in candidates for renal transplant at the time of listing. There are concerns that overdiagnosis of low-risk prostate cancer may result in reducing access to transplant without demonstrated oncological benefits. The objective of the study was to assess the outcome of newly diagnosed pro...

Objective: To analyze de novo graft carcinoma characteristics from our updated national multicentric retrospective cohort. Methods: Thirty-two transplant centers have retrospectively completed the database. This database concerns all kidney graft tumors including urothelial, and others type but excludes renal lymphomas over 31 years. Results:...

Objective Compare different imaging scenarios in the diagnosis of uncomplicated renal colic due to urolithiasis (URCU).Materials and methodsA total of 206 prospectively included patients had been admitted with suspected URCU and had undergone abdominal plain film (APF), US and unenhanced CT after clinical STONE score evaluation. CT was the referenc...

Purpose The objective of this study was to compare living-donor kidney transplantation (LDKT) performed either sequentially, in one operating room, leading to extended cold ischemia time (CIT) or simultaneously, in two different operating room, with shorter CIT. Methods We retrospectively included all living-donor nephrectomies and kidney transpla...

Background: Renal insufficiency can occur in patients with congenital lower urinary tract malformations (LUTM) even when managed during infancy. Data in the current literature concerning this subject remain sparse. The aim of this study was to report the feasibility and long-term results of renal transplantation during adulthood in patients with a...

Epidemiological studies have suggested that prostatitis may increase the risk of prostate cancer due to chronic inflammation. We studied the association between several genitourinary infections and the risk of prostate cancer based on data from the EPICAP study. EPICAP is a population‐based case‐control study conducted in the département of Hérault...

Purpose: Postoperative serum C-reactive protein (CRP) can be measured after major abdominal surgery to predict of complications at postoperative day (POD) 4. However, in urology, no studies have been conduced to analyze the role of CRP after radical cystectomy. The present study aims to analyze the relationship between a high postoperative level o...

Although renal graft percutaneous embolization was introduced to avoid the risk associated with graft nephrectomy, there is no universal consensus about its indications and results. Evaluate the efficacy of graft embolization in the treatment of graft intolerance syndrome as well as its safety compared to surgical removal with respect to complicati...

Résumé Objectif Rapporter la nature, l’incidence, les outils diagnostiques et les moyens thérapeutiques des complications chirurgicales de la transplantation rénale. Matériels et méthodes Une recherche bibliographique exhaustive à partir de Medline (http://www.ncbi.nlm.nih.gov/) et Embase (http://www.embase.com/) a été réalisée entre 1960 et 2016...

OBJECTIVES To describe kidney transplantation surgical techniques and to propose strategies in high-risk recipients. MATERIAL AND METHODS Relevant publications were identified through Medline (http://www.ncbi.nlm.nih.gov/) and Embase (http://www.embase.com/) database using the following keywords, alone or in association, "renal transplantation; pe...

Résumé Objectif Réaliser une mise au point des connaissances sur l’épidémiologie de l’insuffisance rénale chronique et son traitement de choix qu’est la transplantation rénale avec une analyse des coûts et des résultats de ce traitement ainsi que de ses inégalités d’accès. Matériel et méthodes Une recherche bibliographique exhaustive à partir de...

Résumé Objectif Décrire les symptômes du bas appareil urinaire et leur traitement dans la population des candidats et receveurs d’une transplantation rénale. Matériels et méthodes Une recherche bibliographique à partir de Medline (http://www.ncbi.nlm.nih.gov) et Embase (http://www.embase.com) a été réalisée en utilisant les mots clés (MeSH) suiva...

OBJECTIVES To perform a State of The Art about the different aspects of pancreas transplantation such as indications, technical features, immunosuppressive strategies and outcomes of simultaneous pancreas-kidney transplantation. MATERIAL AND METHODS An exhaustive systematic review of the scientific literature was performed in the Medline database...

Résumé Objectif Réaliser une mise au point sur les aspects éthiques, réglementaires et techniques de la chirurgie du donneur vivant de rein. Matériel et méthodes Une recherche bibliographique exhaustive à partir de Medline (http://www.ncbi.nlm.nih.gov) et Embase (http://www.embase.com) a été réalisée en utilisant les mots clés suivants seuls ou e...

Résumé Objectif Proposer une revue des connaissances épidémiologiques et médicales du donneur décédé dans le cadre de la transplantation rénale. Matériels et méthodes Une recherche bibliographique à partir de Medline (http://www.ncbi.nlm.nih.gov) et Embase (http://www.embase.com) a été réalisée en utilisant les mots clés (MeSH) suivants seuls ou...

OBJECTIVES To perform a state of the art about the history of kidney transplantation. MATERIAL AND METHODS An exhaustive systematic review of the scientific literature was performed in the Medline database (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) using different associations of the following keywords (MESH): kidney transpla...

Résumé Objectif Décrire l’état de l’art des connaissances actuelles des conséquences gonadique de la maladie rénale chronique (MRC) terminale et de la transplantation rénale. Matériel et méthode Une recherche bibliographique a été conduite à partir des bases de données bibliographiques Medline (NLM outil Pubmed) et Embase à partir des mots clés s...

Résumé Objectif Réaliser une mise au point des connaissances de la maladie lithiasique et de la prise en charge des calculs de l’appareil urinaire du transplant au moment du prélèvement rénal ou après transplantation rénale. Matériel et méthodes Une recherche bibliographique exhaustive à partir de Medline (http://www.ncbi.nlm.nih.gov) et Embase (...

Numerous therapeutic options are possible in the treatment of renal carcinomas including radical nephrectomy, partial nephrectomy, cryoablation, radiofrequency, active follow-up and among surgical treatments, different approaches may be used such as laparotomy, laparoscopy, robotic-assisted intervention. The choice between these different procedure...

Background Extracorporeal membranous oxygenation is proposed for abdominal organ procurement from donation after circulatory determination of death (DCD). In France, the national Agency of Biomedicine supervises the procurement of kidneys from DCD, specifying the durations of tolerated warm and cold ischemia. However, no study has determined the op...

Introduction la conservation hypothermique des greffons en transplantation a atteint ses limites en particulier pour les greffons à issu de donneurs à critères élargis et décédés après arrêt cardiaque. Les résultats et les perspectives récentes en conservation normothermique pour la préservation des greffons rénaux sont discutés dans cet article....

Nephron sparing surgery (NSS) results in the transplanted population remain unknown because they are only presented in small series or case reports. Our objective was to study renal sparing surgery for kidney graft renal cell carcinomas (RCC) in a multicenter cohort. Data were collected from 32 French transplantation centers. Cases of renal graft d...

To determine the impact of renal graft nephrectomy on second kidney transplantation survival. We carried out a retrospective single-center study by analyzing cases performed from January 2000 to December 2011. Retransplanted patients who underwent previous allograft nephrectomy more than 3 months post-transplantation (group 1) were compared with th...

Les cancers primitifs de l’urètre sont rares. Les données de la littérature sont limitées, et les recommandations sont de grades B et C. Un traitement conservateur peut être proposé pour les lésions localisées de l’urètre antérieur. Les lésions localement évoluées et celles de l’urètre postérieur relèvent d’une thérapie multimodale qui doit être di...

Prostate cancer is the most common cancer in male in most Western countries, including France. Despite a significant morbidity and mortality to a lesser extent, the etiology of prostate cancer remains largely unknown. Indeed, the only well-established risk factors to date are age, ethnicity and a family history of prostate cancer. We present, here,...

Local recurrence (LR) after radical nephrectomy (RN) for kidney cancer is uncommon. Our objectives were to analyse characteristics and therapeutic options of LR after RN and to identify survival prognostic factors. From a multi-institutional retrospective database, we identified 72 patients who experienced LR after RN. Mean time to LR was 26.5 ± 3....

105 Background: Thirteen hundred prostate cancer patients have been treated with Intensity modulated radiotherapy (IMRT) since 2001. We present the final results of the pilot study concerning the first 373 patients with a median follow-up of 72.7 months (range 0 to 130). Methods: All patients received the entire treatment course to a prescribed tot...

To compare postoperative complications in patients with or without preoperative immunonutrition before cystectomy. A prospective, multicenter, pilot, case-control study was conducted during 6 months. Patients with 7-day preoperative immunonutrition were prospectively included and compared with a retrospective, matched control group without immunonu...

The present study assessed the incidence and histopathological features of incidentally diagnosed prostate cancer (PCa) in specimens from radical cystoprostatectomy (RCP) for bladder cancer. The patient outcomes also were evaluated. We retrospectively reviewed the histopathological features and survival data of 4,299 male patients who underwent a R...

Purpose: To examine the overall and stage-specific age-adjusted incidence, 5-year survival and mortality rates of bladder cancer (BCa) in the United States, between 1973 and 2009. Materials and methods: A total of 148,315 BCa patients were identified in the Surveillance, Epidemiology and End Results database, between years 1973 and 2009. Inciden...

150 Background: Everolimus is able to stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor. Giving everolimus together with hormonotherapy and radiation therapy may kill more tumor cells. Methods: We conducted a phase I trial to evaluate the impact of everolimus (RAD001), an m...

Purpose We determined the accuracy of renal biopsy in predicting histological subtype and final Fuhrman nuclear grade in small (4 cm or smaller) renal cancers, and evaluated the concordance between renal biopsy and surgery for these 2 criteria. Materials and Methods A total of 187 percutaneous needle biopsies of small renal tumors, guided by compu...

Purpose: The association between marital status and tumor stage and grade, as well as overall mortality (OM) and cancer-specific mortality (CSM) received little attention in patients with squamous cell carcinoma of the penis (SCCP). Methods: We relied on the surveillance, epidemiology, and end results (SEER) 17 database to identify patients diag...

Objective: To quantify and compare cancer-specific mortality (CSM) and other-cause mortality (OCM) in individuals with stage T1G1-3 clinically node-negative (cN0) squamous cell carcinoma of the penis (SCCP) since there is no consensus regarding the need for an inguinal lymph node dissection (ILND) in patients with T1G2-3 cN0 SCCP. Methods: Relyi...

Introduction Transplantation Committee of the French Association of Urology (CTAFU) conducted a review of the complication of kidney transplantation in obese recipients. Material and methods A bibliographic research in French and English using Medline with the keywords “obesity”, “body mass index”, “kidney transplantation”, “graft function”, “surv...

De novo tumors in renal allografts are rare and their prevalence is underestimated. We therefore analyzed renal cell carcinomas arising in renal allografts through a retrospective French renal transplant cohort. We performed a retrospective, multicentric survey by sending questionnaires to all French kidney transplantation centers. All graft tumors...

Study Type – Prognosis (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Patients with end-stage renal disease (ESRD) have an increased risk of developing RCC in their native kidneys. The prevalence of RCC is 3–4% in cases of ESRD in dialyzed and/or transplanted patients, which corresponds to a rate 100-tim...

The benefit of active treatment for prostate cancer is a subject of continuous debate. We assessed the relationship between treatment type (radical prostatectomy vs observation) and cancer specific mortality in a large, population based cohort. We examined the records of 44,694 patients treated with radical prostatectomy or observation between 1992...

To test the relationship between the extent of pelvic lymph node dissection at radical prostatectomy and the rate of lymph node metastases, and to identify the ideal number of lymph nodes that should be removed to achieve an optimal staging. We assessed 20 789 prostate cancer patients treated with radical prostatectomy and pelvic lymph node dissect...

Contemporary patients with localized prostate cancer (PCa) are more frequently treated with radiotherapy. However, there are limited data on the effect of this treatment on cancer-specific mortality (CSM). Our objective was to test the relationship between radiotherapy and survival in men with localized PCa and compare it with those treated with ob...

Partial (PN) or radical nephrectomy (RN) represents the standard of care for patients with small renal masses. Active surveillance (AS) also may be considered. We examined the rates of PN, RN, and AS within a contemporary population-based cohort. Using the surveillance, epidemiology and end results database, we identified 26,468 patients diagnosed...

A formal validation and head-to-head comparison of the National Comprehensive Cancer Network (NCCN) practice guideline lymph node invasion (LNI) nomogram, Partin tables, and D'Amico risk-classification was conducted for prediction of LNI at radical prostatectomy (RP). We focused on 20,877 patients treated with RP and pelvic lymph node dissection (P...

The purpose of this study was to evaluate the diagnostic performance of CT in determining whether a small solid renal enhancing mass is benign or malignant. Ninety-nine biopsies of enhancing solid renal masses 4 cm or smaller without fat on CT scans were performed under CT fluoroscopic guidance. The growth pattern, interface with parenchyma, presen...

Previous reports indicated that African-American men with testicular germ cell tumors (TGCTs) have more aggressive tumor characteristics and less favorable outcomes than other men. The authors of this report evaluated the effects of race and socioeconomic status (SES) on stage distribution, overall mortality (OM), and cancer-specific mortality (CSM...

In patients with nonmetastatic muscle invasive bladder cancer, radical cystectomy and pelvic lymph node dissection represent a comprehensive surgical treatment. We tested the hypothesis that radical cystectomy performed at a high caseload hospital and/or by a high caseload surgeon is more likely to include pelvic lymph node dissection. We identifie...

Conditional survival (CS) implies that, on average, long-term cancer survivors have a better prognosis than newly diagnosed individuals. The objective of the current study was to devise an accurate predictive tool that accounts for CS in men diagnosed with penile cancer. Overall, 1245 patients treated with primary tumor excision (PTE) for pT(1-3)M0...

•  To test the effect of histological subtype (NBSCC vs UC) on cancer-specific mortality (CSM), after adjusting for other-cause mortality (OCM). •  In Western countries, non-bilharzial squamous cell carcinoma (NBSCC) is the second most common histological subtype in bladder cancer (BCa) after urothelial carcinoma (UC). •  We identified 12,311 patie...

The existing literature suggests that the postoperative mortality (POM) rate in radical cystectomy (RC) patients does not exceed 3%. We sought to develop and externally validate a reference table that quantifies POM after RC. We identified 12,274 patients treated with RC, between 1998 and 2007, within the Nationwide Inpatient Sample database. A tot...

The detrimental effect of unmarried marital status on stage and survival has been confirmed in several malignancies. We set to test whether this applied to patients diagnosed with prostate cancer (PCa) treated with radical prostatectomy (RP). We identified 163,697 non-metastatic PCa patients treated with RP, within 17 Surveillance, Epidemiology, an...

On average, patients remain hospitalized no more than 2 days after MIRP. The aim of our study was to examine the temporal trends in length of stay ≥ 3 days and to test the relationship between annual surgical volume (ASV) and annual hospital volume (AHV) and length of stay ≥ 3 days in patients undergoing MIRP. Within the Florida Hospital Inpatient...

What's known on the subject? and What does the study add? Lymphadenectomy is the most accurate lymph node staging procedure in patients with prostate cancer. We presented the first formal validation of the 2010 European Association of Urology guidelines for lymphadenectomy in prostate cancer patients. • To assess the 2010 European Association of Ur...

To test whether the rates of in-hospital mortality, complications, and transfusions are higher in patients treated with cytoreductive nephrectomy (CNT) for metastatic renal cell carcinoma (mRCC) relative to patients treated with nephrectomy (NT) for non-mRCC. We assessed 17,688 patients treated with a NT between years 1999 and 2008, within the Flor...

The median survival of patients with metastatic renal cell carcinoma (mRCC) increased from 10 to more than 40 months since the advent of targeted therapy. The transformation of mRCC from an initially lethal disease to a more favorable entity, albeit incurable, occurred with the transition from best supportive care, to cytokines, to finally sequenti...

• To examine cancer-specific mortality (CSM) in patients with pT4N₀₋₃ M₀ urothelial carcinoma of the urinary bladder (UCUB) and to compare it to patients with pT3N₀₋₃ M₀, in a population-based cohort treated with radical cystectomy (RC). • RCs were performed in 5625 pT3-T4b₀₋₃ M₀ patients with UCUB within 17 Surveillance, Epidemiology and End Resul...

We tested the relationship between caseload and total hospital charges after stratifying by minimally invasive and open radical prostatectomy. We evaluated 1,188 vs 3,354 men treated with minimally invasive vs open radical prostatectomy in the Florida Hospital Inpatients data file in 2008. Caseload was defined as the count of procedures performed b...

To revisit whether the perioperative mortality differs between septuagenarian and octogenarian patients and younger patients in a large contemporary population-based cohort. The data from tertiary care centers have suggested that perioperative mortality after radical cystectomy is not considerably different in septuagenarian or octogenarian patient...

The adherence rate to National Cancer Institute (NCI) recommendations regarding inguinal lymph nodes dissection (ILND) in high grade T1 (G3T1) and T2-4 squamous cell carcinoma of the penis (SCCP) is not known. We assessed ILND rates in a North American cohort. The 17 registries of the Surveillance, Epidemiology, and End Results (SEER) database incl...

Penile cancer is rare. Thus, predicting cancer specific mortality may be difficult. We devised an accurate and yet easily applicable predictive rule that compares favorably with 2 previous models (73.8% and 74.7% accuracy, respectively). We identified patients treated with primary tumor excision for all stages of penile squamous cell carcinoma betw...

At radical cystectomy (RC), continent urinary diversion (CUD) provides functional outcomes that most closely approximate that of a native bladder. We tested the hypothesis that patients treated at high RC caseload hospitals and/or by high RC caseload surgeons have higher CUD rates. We identified 9,493 bladder cancer patients treated with RC between...

Patients treated with radical cystectomy represent a very heterogeneous group with respect to cancer-specific and other-cause mortality. Comorbidities and comorbidity-associated events represent very important causes of mortality in those individuals. The authors examined the rates of cancer-specific and other-cause mortality in a population-based...

Upper urinary tract urothelial carcinoma (UTUC) is relatively uncommon. In this article, we review prognostic factors, criteria and indications for treatment with the available modalities using contemporary data. A systematic search on PubMed was performed using the keywords 'upper tract urothelial carcinoma', 'upper tract transitional cell carcino...

• To evaluate the relationship between surgical volume (SV) and total hospital charges in patients undergoing minimally invasive radical prostatectomy (MIRP) for treatment of localized prostate cancer. • Within the Florida Hospital Inpatient Datafile, 2666 men who were treated with MIRP for prostate cancer between 2002-2008 were identified. • The S...

Radical prostatectomy is the standard of care for localized prostate cancer. Numerous previous reports show the relationship between surgical experience and various outcomes. We examined the effect of surgical experience on complications and transfusion rates, and determined individual surgeon annual caseload trends in a contemporary radical prosta...

The relationship between provider volume and complication and transfusion rates in patients undergoing minimally invasive prostatectomy (MIRP) for prostate cancer has not been assessed. Temporal trends in MIRP annual surgical caseload (AC), impact of MIRP surgical experience (SE), and in-hospital complication and transfusion rates were evaluated. B...

The efficacy of prostate cancer (PCa) treatment modalities is a subject of continuous debate. We tested the hypothesis that significant differences in survival rates may exist among PCa patients treated with radical prostatectomy (RP), radiation therapy (RT), and observation. We focused on 404,604 patients with clinically localized PCa within 17 Su...

The rising incidence of renal cell carcinoma (RCC) has been largely attributed to the increasing use of imaging procedures. Our aim was to examine stage-specific incidence, mortality, and survival trends of RCC in North America. We computed age-adjusted incidence, survival, and mortality rates using the Surveillance Epidemiology and End Results dat...

At radical prostatectomy (RP), pelvic lymph node dissection (PLND) represents the most accurate staging procedure for the presence of lymph node (LN) metastases. We evaluated the rate of PLND use and its lymph node count (LNC) over the last two decades. We also tested the relationship between LNC and the rate of pN1 stage. Between 1988 and 2006, 13...