Rita Marleta Dewi

National Institute of Health Research and Development · Department of Parasitology

Objective To identify circulating HPV types among urban Indonesian women and their specific co-infection patterns in bid to curb HPV infection in the general population and minimize its complications. Methods Urban Indonesian women from general population were selected as sample framework. Sample size and distribution across regions were determine...

Indonesia needs to lower its high infectious disease rate. This requires reliable data and following their temporal changes across provinces. We investigated the benefits of surveying the epidemiological situation with the imax biclustering algorithm using secondary data from a recent national scale survey of main infectious diseases from the Natio...

Background Hepatitis B is a viral infection that has a high prevalence in Indonesia. The Ministry of Health of Indonesia has conducted a national vaccination program for hepatitis B. In order to evaluate the success of the hepatitis B vaccination in Indonesia, a community study based on basic health research (Riskesdas) was performed nationwide sin...

Novaria Sari Dewi Panjaitan, Sarwo Handayani, Rita Marleta Dewi Center for Biomedical Research, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong Science Center, Bogor, West Java, IndonesiaCorrespondence: Novaria Sari Dewi Panjaitan, Center for Biomedical Research, Research Organization for Health, National...

Human invasion in the forest domain results in close contact between humans and macaques which may increase the potential transmission of zoonotic diseases, including malaria. Primate-to-human cross-species transmission of infectious agents has become a focus of significant scientific interest over the years. This present study aims to identify mal...

Human Papilloma Virus is a major cause of cervical cancer. Recently more than 170 HPV genotypes have been identified. Therefore, the identification of HPV genotype is important for screening, therapy, and management of cervical cancer cases. As part of the national study of cervical cancer in Indonesia, the objective of this study is to identify HP...

Cancer is considered a leading cause of death worldwide due to its high morbidity and mortality rate. Conventional treatments for cancer therapy, such as chemotherapy, and radiotherapy, have been hampered by their side effects. Natural product-derived plants have been used for decades to treat diseases. Compared to conventional therapy, natural pro...

Host genetic factors, such as the genes for various cytokines and adhesion molecules, play a significant role in determining susceptibility to malaria infection. Polymorphisms in host genes have been correlated with malaria infection in both African and Asian regions. The purpose of this study was to investigate the association between both cytokin...

Diabetes mellitus is the most common chronic metabolic disorder and is considered one of the leading causes of morbidity and mortality. The improperly-treated chronic hyperglycemia of diabetes has been related to several long-term complications and multiple organ failures, including nephropathy, which can lead to kidney failure, retinopathy with th...

Silymarin is a standardized extract obtained from the seeds and fruits of Silybum marianum L., or commonly called milk thistle, a member of Carduus marianum family that contains mix of flavonolignans. Some epidemiological and preclinical studies revealed that S. marianum L. has been used for herbal remedies for centuries for its pharmacological act...

Leaves of Lannea coromandelica (Houtt.) Merr. is one of the plants found in Aceh. This study aims to determine the effect of giving water extract of Lannea coromandellica (Houtt.) Merr. against STZ-induced blood sugar levels of wistar rats. The experimental study used a sample of 25 male and 15 female Wistar rats. This research is experimental with...

Over the past decades, epidemiological studies have concluded that a diet rich in plant-derived products plays a pivotal role in human health. Fisetin (3,3’,4’,7-tetrahydroxyflavone) is a hydrophobic polyphenolic compound primarily found in edible plants (e.g. strawberry, blueberry, apple, grape, persimmon, kiwi, and cucumber). Various preclinical...

Background: Based on Basic Health Research (RISKESDAS) conducted by Ministry of Health, Indonesia, prediabetes prevalence tends to increase from 2007 until 2018. The numbers are relatively higher in rural than those in urban area despite of small discrepancies between the two (~ 2-4%). The purpose of this study was to identify urban-rural differen...

Abstract Cerebral malaria is a complication of Plasmodium falciparum infection and can cause death in humans. Plasmodium berghei ANKA (PbA) infection in C57BL/6 strain is widely used for cerebral malaria research. However, research to assess differences in brain histopathology, TNFα levels and the degree of parasitemia in Swiss websters infected...

Mass treatment and evaluation surveys of filariasis transmission were strategies in the control of lymphatic filariasis. Mass Drug Administration (MDA) stop period surveillance is required for five years before obtaining a lymphatic filariasis elimination certificate. The aim of conducting the study was to evaluate the activities of lymphatic filar...

Background The Global Programme to Eliminate Lymphatic Filariasis recommends the transmission assessment survey (TAS) as the preferred methodology for determining whether mass drug administration can be stopped in an endemic area. Because of the limited experience available globally with the use of Brugia Rapid™ tests in conducting TAS in Brugia sp...

Background: Sympatric existence of Plasmodium falciparum and Plasmodium vivax, and the practice of malaria treatment without microscopic confirmation suggest that the accidental treatment of vivax malaria with sulfadoxine-pyrimethamine (SP) is common. Methods: In this study, the frequency distribution of alleles associated with SP resistance wer...

Until 2012, four Plasmodium knowlesi malaria cases had been found in South Kalimantan. Objectives of this study were to determine the proporsion of P. knowlesi among microscopically positive malaria cases, clinical symptoms and morphology of P. knowlesi. This study is conducted in Central Kalimantan and South Kalimantan in 2013-2014. Samples were m...

Objective: To evaluate ethanolic extracts of phytochemical screening, in vitro and in vivo antiplasmodial activities of 15 plants used as antimalarial in Sei Kepayang, North Sumatra. Methods: Extraction was done through maceration with 70% ethanol and screened against chemical content, in vitro test anti-plasmodium against Plasmodium falciparum 3D7...

Kasus Japanese Encephalitis pada manusia di Indonesia telah ditemukan di beberapa provinsi.Penelitian ini bertujuan untuk mengetahui besarnya angka infeksi JE pada babi sebagai reservoirutama. Penelitian dilakukan di 12 provinsi yang meliputi 15 kabupaten/kota pada tahun 2012. Jumlahseluruh babi yang diperiksa adalah 726 ekor yang terdiri dari 59-6...

anaemia (Hb ≤9 g/dL); [RR 2.2 (95% CI 1.7-2.9) P. vivax RR 0.5 (0.3-0.9)] whereas with sub-microscopic infections both species were associated with increased risk of moderate to severe anaemia [P. falciparum: RR 2.1 (95% CI 1.6-2.8) and P. vivax: RR 1.9 (95% CI 1.3-2.7)]. The prevalence of placental malaria was 4.8% (72/1632) by PCR and 3.3% sub-mi...

Positive control of Plasmodium spp. is needed in identification of malaria species using Polymerase Chain Reaction (PCR) method. The limitedness of malaria positive control encourages us to develop the cloning method to multiply Plasmodium spp. DNA particularly P.vivax, P. malariae, and P. ovale that are still unable to be cultured continuously. DN...

Malaria remains a public health problem in several areas of Banjarnegara regency. Drug resistance or treatment failure is one of the main obstacles in controlling the disease in this area. To support The Malaria Control Program, since July 2001 up to June 2002 monitoring of the efficacy of chloroquine as a first line drug for uncomplicated falcipar...

Drug resistant malaria poses an increasing public health problem in Indonesia, especially eastern Indonesia, where malaria is highly endemic. Widespread chloroquine (CQ) resistance and increasing sulphadoxine-pyrimethamine (SP) resistance prompted Indonesia to adopt artemisinin-based combination therapy (ACT) as first-line therapy in 2004. To help...

Reports on treatment failures associated with the use of first-and second-line antimalarial drugs chloroquine and sulfadoxine-pyrimethamine have recently increased in many parts of Indonesia. The present study evaluated artemisinin-based combination therapy for treatment of persons with uncomplicated Plasmodium falciparum malaria in West Sumba Dist...

Problem statement: Malaria caused by various species of prozoan parasites, Plasmodium. The exact mechanism of humoral immunity in eliminating Plasmodium is not completely understood. However, an antimalarial antibody is strongly suspected to play important role in immunity. The purpose of this research was to evaluate the immunomodulator and antipl...

Accurate information about the burden of malaria infection at the district or provincial level is required both to plan and assess local malaria control efforts. Although many studies of malaria epidemiology, immunology, and drug resistance have been conducted at many sites in Indonesia, there is little published literature describing malaria preva...

Background: The Nias district of the North Sumatra Province of Indonesia has long been known to be endemic for malaria. Following the economic crisis at the end of 1998 and the subsequent tsunami and earthquake, in December 2004 and March 2005, respectively, the malaria control programme in the area deteriorated. The present study aims to provide...

The testing of inhibiton of Plasmodium falciparum by Artemisia annua, ,4,cina and A vulgaris isolate and artemisinin content each of plants was conducted . Artemisia leaves extracted from n-hexane and then separated by column chromatography with n-hexane,'ethylacetate as eluent. The column result tested to P.falciparum protozoa. The concentrations...

Evaluation of the in vivo antiplasmodial activity of the stem bark extract of Garcinia parvifolia Miq has been conducted. The in vivo antiplasmodial assay was performed on Plasmodium yoelii infected mice. Results showed that the ethanolic extract displayed ED 50 value less than 100 mg/kgBB/day.