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The Brazilian Research and Teaching Center in Biomedicine and Aerospace Biomedical Engineering

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The recent engagement of Brazil in the construction and utilization of the International Space Station has motivated several Brazilian research institutions and universities to establish study centers related to Space Sciences. The Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS) is no exception. The University initiated in 1993 the first degree course training students to operate commercial aircraft in South America (the School of Aeronautical Sciences. A further step was the decision to build the first Brazilian laboratory dedicated to the conduct of experiments in ground-based microgravity simulation. Established in 1998, the Microgravity Laboratory, which was located in the Instituto de Pesquisas Cientificas e Tecnologicas (IPCT), was supported by the Schools of Medicine, Aeronautical Sciences and Electrical Engineering/Biomedical Engineering. At the end of 2006, the Microgravity Laboratory became a Center and was transferred to the School of Engineering. The principal activities of the Microgravity Centre are the development of research projects related to human physiology before, during and after ground-based microgravity simulation and parabolic flights, to aviation medicine in the 21st century and to aerospace biomedical engineering. The history of Brazilian, and why not say worldwide, space science should unquestionably go through PUCRS. As time passes, the pioneering spirit of our University in the aerospace area has become undeniable. This is due to the group of professionals, students, technicians and staff in general that have once worked or are still working in the Center of Microgravity, a group of faculty and students that excel in their undeniable technical-scientific qualifications.
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HIPPOKRATIA 2008, 12 (Suppl 1): 32-36
ORIGINAL ARTICLE
The Establishment of MicroG at PUCRS
The participation of Brazil in the construction and uti-
lization of the International Space Station has motivated
various Brazilian research institutions and universities to
establish centers of study related to Aerospace Science.
The Pontical Catholic University of Rio Grande do Sul
(PUCRS) is no exception. With more than 50 years of
tradition, PUCRS today is a leading and pioneering Bra-
zilian University in the areas of Aeronautics and Astro-
nautics, which is demonstrated by the creation of the rst
university course in South America dedicated to the qual-
ication of commercial pilots, the School of Aeronautical
Sciences, in 1993.The decision to build the rst Brazilian
laboratory aimed at the study of human physiology in the
aerospace environment and in simulations of micrograv-
ity on earth constituted a step further.
Established in 1999, the Laboratory of Micrograv-
ity, initially located in the Institute of Scientific and
Technological Research – (ISTR) – was the result of
a joint effort of the School of Medicine, School of
Aeronautical Sciences and the School of Engineering/
Master’s Program in Electrical Engineering (Area of
Concentration: Information Technology; Research on
DSP & Biomedical Engineering)1.
With its expansion, and the international acknowl-
edgement for the pioneering and highly qualied work,
in 2006 the Laboratory of Microgravity became the Cen-
ter of Microgravity, and ofcially integrated the research
of the Academic Units of PUCRS. It is currently located
in Building 30 together with the School of Engineering,
Block F, Room 283.
Today, the Center of Microgravity is, par excellence,
a research center with both undergraduate and graduate
courses in various areas of knowledge.
The objectives
The principal activity of the Center of Micrograv-
ity/FENG-PUCRS, as of now Center of MicroG, is the
development of research projects relative to biomedicine
before, during and after the simulations of microgravity2
and parabolic ights3, for aviation medicine of the 21st
century and aerospace biomedical engineering4.
In its creation, some directives were established for
the design of the research projects and for the develop-
ment of academic relations between this Center and the
national and international scientic community.
The Brazilian Research and Teaching Center in Biomedicine and
Aerospace Biomedical Engineering
Russomano T, Falcao PF, Dalmarco G, Martinelli L, Cardoso R, Santos MA, Sparenberg A
Microgravity Center, PUCRS, Porto Alegre, RS, Brazil
Abstract
The recent engagement of Brazil in the construction and utilization of the International Space Station has motivated
several Brazilian research institutions and universities to establish study centers related to Space Sciences. The Ponticia
Universidade Catolica do Rio Grande do Sul (PUCRS) is no exception.
Method: The University initiated in 1993 the rst degree course training students to operate commercial aircraft in
South America (the School of Aeronautical Sciences. A further step was the decision to build the rst Brazilian labora-
tory dedicated to the conduct of experiments in ground-based microgravity simulation. Established in 1998, the Micro-
gravity Laboratory, which was located in the Instituto de Pesquisas Cienticas e Tecnologicas (IPCT), was supported by
the Schools of Medicine, Aeronautical Sciences and Electrical Engineering/Biomedical Engineering. At the end of 2006,
the Microgravity Laboratory became a Center and was transferred to the School of Engineering.
Results: The principal activities of the Microgravity Centre are the development of research projects related to human
physiology before, during and after ground-based microgravity simulation and parabolic ights, to aviation medicine in
the 21st century and to aerospace biomedical engineering.
Conclusion: The history of Brazilian, and why not say worldwide, space science should unquestionably go through
PUCRS. As time passes, the pioneering spirit of our University in the aerospace area has become undeniable. This is due
to the group of professionals, students, technicians and staff in general that have once worked or are still working in the
Center of Microgravity, a group of faculty and students that excel in their undeniable technical-scientic qualications.
Hippokratia 2008; 12 (Suppl 1): 32-36
Key words: Microgravity, space life sciences, research center, space biomedicine
Corresponding author: Thais Russomano, Head, Microgravity Centre/FENG-PUCRS, Predio 30, Bloco F, Sala 283, Av Ipiranga 6681, Porto
Alegre, RS, 90619-900, Brazil, e-mail: trussomano@hotmail.com
33
HIPPOKRATIA 2008, 12 (Suppl 1)
Gustavo Dalmarco, both engineers, graduated in Engi-
neering of Control and Automation from PUCRS, and
hired by the School of Engineering.
The Center of Microgravity counts on the collabora-
tion of various professors from different Academic Units
of PUCRS, as indicated in Figure 1. The staff of collabo-
rating Schools, however, is dynamic and is altered every
year, as research projects are included or completed6. In
general, each study carried out by MicroG counts on at
least 4 professors from diverse but complementary areas.
The Academic Units of PUCRS commonly involved in
MicroG researches are listed below:
Academic Units of PUCRS members of the Center of
Microgravity
(alphabetic order)
School of Biosciences
School of Aeronautical Sciences
School of Physical Education
School of Nursing, Nutrition and Physiotherapy
School of Engineering
• Department of Medicine and Mechatronics
• Department of Electric
• Master’s in Electric Engineering/DSP &
Biomedical Engineering
School of Pharmacy
School of Philosophy and the Humanities
• Department of Sociology
• Department of History
School of Physics
School of Information Science
School of Medicine
National and international consultants are ofcially
invited to contribute to research projects, through con-
sulting provided gratuitously in form of video-conferenc-
es. This support has been fundamental for publicizing,
especially international, of works realized in MicroG.
Among the international consultants, Prof. John Ernst-
ing is a renowned professor and researcher in Aerospace
Medicine of King’s College London and Vice-Marshal
(retired) of the British Royal Air Force, Prof. Rupert Ger-
zer, director of the Institute of Aerospace Medicine of the
German Aerospace Center (DLR) and the ex-director of
the Division of “Space Life Sciences” of NASA, Dr. Joan
Vernikos.
The student body is divided in undergraduate students
(interns, monitors and grant winners of scientic initia-
tion – BPA/PUCRS, FAPERGS, CNPq) and graduate stu-
dents (Master’s in Electrical Engineering/Technology of
Information/Line of Research DSP & Biomedical En-
gineering), as indicated in Figure 2. In both cases, one
clearly perceives the inclusion of various areas of knowl-
edge in the works developed. In the same way that was
made explicit in Figure 1, the staff of the undergraduate
and graduate student body is dynamic and also is altered
every year with the inclusion of new projects or with the
conclusion of studies.
Accordingly, the following rules were set:
1. To be short-term (suggested 1 to 6 months), since
prolonged studies tend to jeopardize the development of
the new center;
2. To be low cost, so that nancial difculties do not
hinder research activities;
3. To be a motivating source for researchers, profes-
sors and students, so they:
a) Participate in the development of protocols, exper-
imental techniques, collection and analysis of research
data;
b) Present results of their studies in national and inter-
national scientic conferences;
c) Publish work in scientic journals.
4. To motivate the cooperation between Brazilian
and International Universities / Institutions, aiming at
researcher, student, material resource and nancial ex-
changes;
5. To contribute to aerospace science, resulting in
clear scientic, technological, social and economic ben-
ets for society.
This last objective has brought extensive publicity for
the Center of MircoG as a center of excellence in Latin
America in the areas to which it is dedicated, since the
publications concerning research results and achieve-
ments realized have systematically been announced by
the national and international media5.
Administrative Structure of the Center
of Microgravity
Administration of PUCRS – President’s and
Vice Presidents’ Ofces
School of Engineering
Center of Microgravity
Coordination
Research Assistants
Professors/Researchers – National and
International Consultants
Undergraduate/graduate students –
Interns/Monitors/Grant winners - Technicians
The Center of Microgravity is directly subordinate to
the School of Engineering. There is a general coordinator
of the MicroG, a position that is currently occupied by
Professor Thais Russomano. The direct support of more
than 50 interdisciplinary research projects of MicroG is
given by two research assistants, Felipe P. Falcγo and
34 RUSSOMANO T
Figure 1: Distribution of the collaborating staff in projects of MicroG (updated to May, 2007).
Table 1 identies the areas of study of MicroG and
its corresponding research areas, within which profes-
sors, researchers, national and international consultants,
as well as PUCRS undergraduate and graduate students
perform in an interdisciplinary way.
Table 1: Area of study and lines of research of MicroG
Areas of Study Research Areas
Aerospace Physiology
Simulation of microG and hyperG
Hypoxia
Experiments in parabolic ights
Aerospace Medicine Commercial aviation in the 21st
century
Biomedical
Engineering Aerospace Biomedical Eng.
Aerospace
Pharmacology
Aerospace Pharmacological
Techniques
Computation & Tele-
communication
Telemedicine
Virtual Reality
Physics & Astrophysics Hyper gravity
Radiations
Sociology & History Aerospace History
Physiotherapy Aerospace Physiotherapy
Science of Sports &
Biomechanics Aerospace Biomechanics
Thanks to a series of ofcial accords and the infor-
mal support, settled from the beginning (Figure 3) with
renowned international teaching and research institu-
tions in the areas of biomedicine and aerospace biomed-
ical engineering, there has always been an important
exchange between students, professors and research-
ers. To be mentioned are the Department of Applied
Human Physiology & Aerospace Medicine of King’s
College London7, the Institute of Aerospace Medicine
of the German Aerospace Center8, the European Space
Agency (ESA) – through campaigns of parabolic ights
and the North American Space Agency (NASA). In
the same way, experts from other countries and students
from foreign teaching institutions visit MicroG periodi-
cally (Figure 4).
The success of the work developed by MicroG can
be clearly identied by the number of annual publica-
tions, both nationally and internationally. Figure 5 clearly
shows the quantitative and qualitative scientic develop-
ment, as the results obtained in the projects of MicroG
have been made public. The number of international pub-
lications is today the mark of excellence of this genuinely
interdisciplinary research center.
Figure 2. Distribution of the staff of PUCRS graduate students who develop projects in MicroG (updated to May, 2007).
35
HIPPOKRATIA 2008, 12 (Suppl 1)
Figure 4: Researcher exchange, including students, between PUCRS and international centers of excellence in biomedicine
and aerospace biomedical engineering.
Figure 3: National and international accords between MicroG and national and international centers of excellence in biomedi-
cine and aerospace biomedical engineering.
Figure 5: Number of annual scientic publications (national and international) of MicroG.
36 RUSSOMANO T
Conclusion
In national and international conferences, as well as
in interviews for the local and national media, it has
been repeatedly stated that the history of Brazilian, and
why not say worldwide, space science should unques-
tionably go through PUCRS. As time passes, the pio-
neering spirit of our University in the aerospace area
has become undeniable. This is due to the group of pro-
fessionals, students, technicians and staff in general that
have once worked or are still working in the Center of
Microgravity, a group of faculty and students that excel
in their undeniable technical-scientic qualications.
References
1. Russomano T. The microgravity laboratory/IPCT-PUCRS. The
rst Brazilian space life sciences center. Aviat Space Environ
Med 2002; 73: 521
2. Russomano T, Santos M, Andrade L, et al. O efeito da escopolam-
ina na performance mental durante simulaηγo de microgravidade
. Scientia Medica 2005; 15: 90 - 97
3. Evetts S, Evetts L, Russomano T, Castro J, Ernsting J. An Assess-
ment of the Feasibility and Effectiviness of a Method of Perform-
ing Cardiopulmonary Resuscitation during Microgravity. In: 75th
Annual Scientif Meeting Aerospace Medicine Association, An-
chorage, Alaska, 2004, pp 130
4. Russomano T, Evetts S, Castro J, et al. A device for sampling
arterialized earlobe blood in austere environments. Aviat Space
Environ Med 2006; 77: 453 – 455
5. Russomano T. Editorial: Nova recomendaηγo mιdica da NASA ι
baseada em estudo publicado na Revista Scientia Mιdica. Scien-
tia Medica 2005; 15: 88 – 89
6. Leγes R, Cambraia R, Bacim F, et al. Development of walking
pattern evaluation system for hypogravity simulation. In: IEEE
2006 International Conference of the Engineering in Medicine
and Biology Society, New York, 2006.
7. Santos M, Bosquillon C, Falcγo F, et al. Development of a
Diffusion Chamber to Evaluate In Vitro Respiratory Epithe-
lial Cell Layer Permeability in Microgravity. In: 54th Interna-
tional Congress of Aviation and Space Medicine, Bangalore,
2006.
8. Russomano T, Allan J, Beck L, et al. Development of a lower body
negative pressure box with an environmental control system for
physiological studies. Adv Space Res 2006; 38: 1233 – 1239
ResearchGate has not been able to resolve any citations for this publication.
Article
Full-text available
There is currently no effective method of measuring arterial blood gas tensions in austere environments such as in space or at high altitude. An alternative to direct arterial measurement is the sampling of arterialized earlobe blood, an accurate technique that has been in use in clinical medicine and physiology for more than 50 yr. We, therefore, developed an earlobe arterialized blood (EAB) collector for practical use in extreme environments. The results from the EAB collector were compared with simultaneous samples of blood drawn from the radial artery. Six healthy subjects breathed a gas mixture of 12.8% O2 in N2 during 15 min of 8 degree head-down tilt. The blood samples were analyzed immediately. The mean differences in Po2 between arterialized earlobe and radial artery samples were 0.25 +/- 1.25 mmHg for Po2 and 1.0 +/- 0.75 mmHg for Pco2; neither difference was significant. There was no difference between the pH values obtained by the two techniques. This study suggests that arterialized blood sampled from the earlobe using the EAB collector may provide sufficiently accurate measurements of the Po2, Pco2 and pH of arterial blood for clinical or research use in extreme environments.
Article
Full-text available
A headward fluid shift occurs during microgravity exposure, which causes the cardiovascular adaptive syndrome. Different countermeasures have been proposed to decrease its symptomatology, like the application of lower body negative pressure (LBNP). A LBNP box with an environment control system was developed, aiming to improve features of LBNP boxes used worldwide. It consists of five carbon steel ribs in the shape of a cylinder, which is wrapped with high pressure resistant and transparent vinyl. Inner and outer-wheeled trolleys can comfortably and easily move the subject in and out of the box. A custom-made skirt is secured around the subject's waist by an adjustable belt. The other end is secured between two window-type wooden structures, which seal the LBNP box. Inlet and an outlet valves connect the external to the internal environment of the chamber and tube system allows air to circulate gently. Electronic sensors are used to adjust the airflow keeping a pre-set negative pressure without changing humidity and temperature inside the box. Structural, pressure profile and leaking tests were performed with successful results. The improvements of the present LBNP box have substantially decreased the undesirable side effects of uncontrolled environment conditions during rapid pressure changes, and increased test subjects' comfort.
Article
Full-text available
This study aimed to develop a Walking Pattern Evaluation System during Hypogravity Simulation (SAMSH), which included the adaptation of a body suspension device, the instrumentation of a treadmill and the development of a virtual environment. SAMSH was developed using one subject. Kinematic analyses were performed whilst one individual was walking on the treadmill during body weight reduction simulating the gravitational forces of the Moon (reduction of 60%) and Mars (reduction of 30%) with and without virtual reality glasses (Head Mounted Display, HMD). The walking pattern was evaluated by means of knee and ankle electrogoniometers, foot switches placed on the front and back part of the plantar region, and five video cameras. Results showed that the body weight reduction during Moon simulation alter the walking pattern, including the increase in step time, contact time, step length and aerial time, and the decrease of walking cadence time (steps per minute). The findings of this study also suggested that hypogravity simulation reduces walking effort. The utilization of the HMD allowed the evaluation of the head position three-dimensionally during hypogravity simulation. The virtual environment reduced postural balance, due to the absence of visual input, which was evidenced by a protective extension reaction.
Article
IntroductionA headward fluid shift occurs in microgravity due to the absence of hydrostatic gradients. Different countermeasures have been proposed to decrease related cardiovascular symptoms, like the application of lower body negative pressure (LBNP) in-flight. We have developed an LBNP box with an environmental control system. It aims at improving features of LBNP boxes currently used worldwide.MethodThe LBNP box is a cylindrical structure consisting of five carbon steel ribs wrapped with high pressure resistant and transparent vinyl. Inner and outer-wheeled trolleys were developed to safely, comfortably, and easily move the subject in and out of the box. A leather skirt is secured around the subject’s waist by an adjustable belt. The other end is secured between two wooden structures, which seal the open area of the LBNP box. An inlet and an outlet valves connect the external to the internal environments of the chamber. A tube system allows air to circulate gently in the box. Electronic sensors linked to a computer program are used to adjust the airflow keeping a pre-set negative pressure without changing humidity and temperature inside the box.ResultsThe LBNP box structure supported −100 mmHg for periods of 10 min. The trolley apparatus proved comfortable and improved the displacement and instrumentation of the subject. The sealing system was leakage-proof. The development of the micro-controller and the software interfaces was completed successfully. Air-pressure controller efficiently maintained the desired differential pressure.ConclusionThe improvements of the present LBNP box – comfortable and easy way of moving subjects in and out the box, the sealing mechanism, the well distributed airflow, and the computerized internal environment control system secondary to the input of electronic sensors – have substantially decreased the undesirable side-effects of uncontrolled environment conditions during rapid pressure changes, and increase test subjects’ comfort.
O efeito da escopolamina na performance mental durante simulaηγo de microgravidade
  • T Russomano
  • M Santos
  • L Andrade
Russomano T, Santos M, Andrade L, et al. O efeito da escopolamina na performance mental durante simulaηγo de microgravidade . Scientia Medica 2005; 15: 90 -97
Development of a Diffusion Chamber to Evaluate In Vitro Respiratory Epithelial Cell Layer Permeability in Microgravity
  • M Santos
  • C Bosquillon
  • F Falcγo
Santos M, Bosquillon C, Falcγo F, et al. Development of a Diffusion Chamber to Evaluate In Vitro Respiratory Epithelial Cell Layer Permeability in Microgravity. In: 54 th International Congress of Aviation and Space Medicine, Bangalore, 2006.
An Assessment of the Feasibility and Effectiviness of a Method of Performing Cardiopulmonary Resuscitation during Microgravity
  • S Evetts
  • L Evetts
  • T Russomano
  • J Castro
  • J Ernsting
Evetts S, Evetts L, Russomano T, Castro J, Ernsting J. An Assessment of the Feasibility and Effectiviness of a Method of Performing Cardiopulmonary Resuscitation during Microgravity. In: 75 th Annual Scientifif Meeting Aerospace Medicine Association, Anchorage, Alaska, 2004, pp 130
Editorial: Nova recomendaηγo mιdica da NASA ι baseada em estudo publicado na
  • T Russomano
Russomano T. Editorial: Nova recomendaηγo mιdica da NASA ι baseada em estudo publicado na Revista Scientia Mιdica. Scientia Medica 2005; 15: 88 -89