Renata Soćko

Nofer Institute of Occupational Medicine · Department of Chemical Safety

4-Toliloamina (p-toluidyna) ma postać białych, połyskujących płatków. Substancja ta jest wytwarzana i/lub importowana do Europejskiego Obszaru Gospodarczego w ilości 1 000 ÷ 10 000 t/rok. Związek jest używany jako półprodukt w syntezach substancji organicznych, m.in. przy produkcji barwników, żywic jonowymiennych, pestycydów oraz farmaceutyków. Oko...

Etoposide at room temperature is a solid present in the form of a white or yellow-brown crystalline powder. It is an anticancer drug with cytotoxic and anti-mitotic activity, used to treat patients with testicular cancer, acute myelogenous leukemia, lung cancer, non-small-cell lung cancer, adrenal cortex cancer, gastric cancer, hepatoblastoma, acut...

Wood is the raw material of the wood industry, which is used in the form of solid wood or in the processed form. Occupational exposure to wood dusts occur during processing and woodworking. The highest levels of wood dust concentrations in the work environment were recorded in the furniture and carpentry industries. The number of workers exposed to...

Background: Electronic cigarettes are currently in common use. However, in Poland there is no specific legislation governing the sale of these products. At the same time, no information has been made public about the hazards e-cigarettes pose to the users and bystanders - passive smokers. The aim of the study was to determine the qualitative compo...

Based on the literature, current legislation and the European Union (EU) directives, the rules to protect the health of workers in Poland and the countries of the former Eastern Bloc were analyzed. Since 2002, the activities in the field of hygiene standards in the countries of the former Eastern Bloc have been correlated with the EU policy. The fu...

In 2007, a new maximum admissible concentration value of 88 mg/m3 was specified for dichloromethane (DCM) in the Polish list of admissible concentrations of harmful chemicals and dusts in the work environment atmosphere. The new value is four times higher than the former one (20 mg/m3), valid in Poland for 20 past years. At the same time, it was de...

Dichloromethane (DCM) has been widely used in Poland and worldwide as a pesticide fumigant to preserve seed and fruit, in the manufacture of polyurethane, in the cosmetic, pharmaceutical and food-processing industry. It isalso used as an ingredient of fire extinguishing formulations and as a cooling agent in refrigerators. Because of dichloromethan...

Sevoflurane and isoflurane are polyfluorinated anesthetics used during surgical treatment of both adults and children. They are usually applied as mixtures with oxygen or dinitrogen monoxide. An assessment of health risk of exposure to these inhalant anesthetics poses a serious problem for employers, mostly due to the fact that maximum admissible c...

The aim of this work is to analyse Maximum Admissible Concentration (MAC) values proposed for irritants by the Group of Experts for Chemical Agents in Poland, based on the RD50 value. In 1994-2004, MAC values for irritants based on the RD50 value were set for 17 chemicals. For the purpose of the analysis, 1/10 RD50, 1/100 RD50 and the MAC/RD50 rati...

The aim of the present study was to investigate persistent neurobehavioural effects of repeated low-level exposure to chlorphenvinphos ((2-chloro-1-(2,4-dichlorophenyl) vinyl diethyl phosphate-CVP) in rats. The rats received 10 i.p. injections of CVP at daily doses of 0.5 mg/kg or 1.0 mg/kg (one injection/day, five days/week) which corresponded to...

Organophosphorous compounds (OPs) constitute a large proportion of insecticides used all over the world. Their insecticidal properties and acute toxicity in nontarget species derive from the inhibition of acetylcholinesterase (AChE) which disturbs the cholinergically mediated neurotransmission. OPs do not accumulate in living organisms and the acut...

The purpose of this study was to find out whether chlorphenvinphos (CVP), an organophosphorous pesticide, interacts with the muscarinic cholinergic receptors in CNS. To attain this goal, the effects of intrahypothalamic injections of oxotremorine (Ox), a muscarinic agonist, and physostigmine (Phys), a carbamate anticholinesterase, were compared wit...

Effects of repetitive exposure (ten times in a period of two weeks) to chlorphenvinphos (CVP), at daily doses of 0.5 and 1.0 mg/kg, i.p., were studied in adult male Wistar rats of imp-DaK stock. It was found that 3 hrs after the last exposure, the cholinesterase (ChE) activity in the blood and brain was close to 50% of the control value in the 0.5...

Cholinesterase (ChE) activity in blood and brain as well as the hippocampal and cortical EEG were investigated in rabbits exposed once a day for a period of two weeks to an organophosphate insecticide, chlorphenvinphos (CVP). The daily dose of CVP was 14.0 mg/kg i.p. ChE activity in plasma and erythrocytes decreased by 60 and 48%, respectively, by...

Effect of a single i.p. exposure to an organophosphate insecticide, chlorphenvinphos (CVP), in doses of 1.0 and 3.0 mg/kg (one third and one tenth LD50, respectively), on the latency of the paw-lick response (hot plate test) was investigated in rats before and after a short inescapable footshock. The test was repeated twice on the 18th and 19th day...

In order to evaluate some of the central effects of an organophosphorus pesticide--chlorphenvinphos (CVP), the time course of changes in the activity of blood cholinesterase (ChE), body temperature and hippocampal EEG were compared in rabbits after acute i.p. exposure. The pesticide was administered twice at an interval of 80-90 days. The Deichmann...

Cholinesterase (ChE) activity in blood (plasma and erythrocytes) and in different parts of the brain, open field behavior and response-to-change in a "T" maze were investigated in separate groups of rats after a single intraperitoneal exposure to an organophosphorus pesticide - chlorphenvinphos. The doses used were 3.0 mg/kg or 1.0 mg/kg which amou...

The effect of a single exposure to an agricultural insecticide, chlorphenvinphos (CVP), an organophosphorus anticholinesterase, on neocortical seizure activity induced or promoted by cardiazol, and on hippocampal and neocortical EEG was studied in rats. It was found that CVP, given intraperitoneally in doses of 1.0 and 3.0 mg/kg, resulted in no cha...

The circadian rhythm of the level of histamine (HI) and histidine decarboxylase (HD) and histamine-methyltransferase (HMT) activity in 6 brain and 5 ocular structures of the rabbit was studied. Clear circadian variations of the histaminergic parameters in two brain (hypothalamus and lateral geniculate body) and two ocular (retina and iris-ciliary b...

Iris, ciliary body, choroid and retina of the cow, rabbit and man contain histamine; the retinas are less rich in histamine (55-135 ng/g tissue) than the uvea (209-3073 ng/g tissue). The tissues show no diamine oxidase activity, no or marginal histidine decarboxylase activity, and well expressed histamine-N-methyltransferase activity. The killing o...