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Publications (5)
Background:
This study evaluated whether the apolipoprotein ɛ4 (APOE4) allele, a genetic marker associated with increased risk of developing late-onset Alzheimer's disease (AD), was associated with differences in evoked pain responsiveness in cognitively healthy subjects.
Objective:
The aim was to determine whether individuals at increased risk...
Early recognition of Alzheimer’s disease (AD) in the prodromal period has not been robust yet will be necessary if effective disease-modifying drugs are to be useful in preventing or delaying the condition. The objective of this narrative review was to describe the current, evidenced based understanding of alterations in sensory data as potential b...
Background and purpose:
The incidence of Alzheimer disease (AD) is increasing in the United States, yet more than half of the people with AD are diagnosed late in the course of the disease. Most are identified outside primary care. New approaches to prevention and treatment means that early detection of AD may improve the quality of life of those...
Background:
Sex differences in pain have been shown to exist in older adults with normal cognition and people with Alzheimer's disease. It is unknown if sex differences in pain in older adults exist in a range of communicative older adults with varying cognitive ability from no impairment to moderately severe cognitive impairment.
Objective:
Thi...
Sex-differences in pain have been shown to exist in older adults with normal cognition. It is not known if sex-differences extend throughout a range of cognitive impairment in Alzheimer’s disease. We conducted a secondary analysis on data from a cross-sectional parent study of sex differences in the associations of cognitive function (MMSE) with se...
