Rana Abu-Huwaij

Amman Arab University

This study aimed to incorporate green-synthesized zinc oxide nanoparticles (ZnO NPs), functionalized with polyethylene glycol (PEG) and linked to doxorubicin (DOX), into various topical gel formulations (hydrogel, oleogel, and bigel) to enhance their dermal delivery. The ZnO NPs were produced using the aqueous extract of the root hair of Phoenix da...

A novel approach was devised to address the challenges in delivering cisplatin (CIS) for lung cancer treatment. This involved the development of a non-invasive hydrogel delivery system, aiming to minimize side effects associated with its administration. Using carbopol 971 (CP) and chitosan (CH) at varying ratios, the hydrogels were prepared and loa...

An innovative strategy was formulated to overcome the challenges in delivering doxorubicin (DOX) for breast cancer treatment. Transdermal patches were prepared using carbopol 971 (CP) and polyvinyl alcohol (PVA) loaded with starch-coated iron oxide nanoparticles conjugated to DOX (DOX@St-IONPs). The patches’ physicochemical properties, in vitro dru...

Background Miscarriages account for 20% of clinically confirmed pregnancies and up to 50% of all pregnancies and is considered one of the most heartbreaking events experienced by women. The current study aimed to explore participants’ perceptions and practices and how they link with the negative emotions of miscarriage. Methods In this cross-secti...

Green synthesis of zinc oxide (ZnO) nanoparticles (NPs) using various plant extracts as reducing and capping agents has gained attention in recent research. The green synthesis of ZnO NPs offers several advantages such as being simple, eco-friendly, safe, cost-effective, and reproducible approach with high stability. Hence, this article provides an...

Doxorubicin (DOX) is an anthracycline antineoplastic agents, which interacts with DNA and shows sever toxicity due to its lack of specificity. The cytotoxic effect of zinc oxide nanoparticles (ZnO NPs) is mainly concerned in changing the cytoskeleton and nucleoskeleton of proteins and/or producing reactive oxygen species (ROS) in cells exposed to Z...

Dermal drug delivery has emerged as a promising alternative to traditional methods of drug administration due to its non-invasive nature and ease of use. However, the stratum corneum, the outermost layer of the skin, presents a significant barrier to drug penetration. Niosomes, self-assembled vesicular structures composed of nonionic surfactants an...

Background: In a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery. Method: This review provides a comprehensive overview of the ethosomal system and assesses its potential as an effective nanocarrier for delivering active ingredients to the skin. The foc...

The aim of this study is to design and evaluate a transdermal delivery system for alendronate sodium (ALS) loaded with nanocarrier to improve its permeability and prolong its release. This is due to its low bioavailability, potential gastrointestinal side effects, and the special administration needed for the oral dosage form of ALS. When using the...

This study aimed to develop and evaluate thermoresponsive in situ microgels for the local ocular delivery of prednisolone (PRD) (PRD microgels) to improve drug bioavailability and prolong ocular drug residence time. Lipid nanosystems of PRD microemulsions (PRD-MEs) were prepared and evaluated at a drug concentration of 0.25–0.75%. PRD microgels wer...

Greenly synthesized iron oxide nanoparticles (IONPs) were prepared from Spinacia oleracea leaf extract. They were coated with 10% polyethylene glycol (PEG) and conjugated with doxorubicin (DOX). They were characterized by UV–Vis spectrophotometer, X-ray diffraction, and Fourier transforms infrared spectroscopy (FTIR). They exhibited a particle size...

Background Nanoemulsions (NEs) have been explored as nanocarriers for the delivery of many drugs and cosmeceuticals. The extraordinary expansion of using NEs is due to their capability to conquer the main challenges of conventional delivery systems such as short residence time with low patient acceptance, poor stability, low aqueous solubility, per...

The purpose of this study was to fabricate non-invasive transdermal patches loaded with promising greenly synthesized nanoparticles for breast cancer therapy. The half maximum inhibitory concentration (IC50) on triple negative breast cancer (TNBC) and human dermal fibroblast (HDF) cell lines were investigated. In addition, the migration inhibition...

Introduction Treating hair loss of Alopecia areata is a quite challenge. The treatment not only needs to be effective but must meet specific requirements in terms of accurate dose, sustain release, comfortable application with aesthetic appearance. Thus, the study was designed to develop sustained release topical patches releasing allicin using dif...

Background The qualified and paradigm jump in the formulation and production of cosmeceuticals refer in some way to the great revolution in nanotechnology. Nowadays, the industry of nano-formulated cosmeceuticals plays a significant and essential role in the evolution and growth of the pharmaceutical industries. This review manuscript focuses on th...

Zinc oxide nanoparticles (ZnO NPs) were produced using the root hair extract of Phoenix dactylifera, and characterized by UV–Vis absorbance spectrophotometer, X-ray diffraction, particle size analyzer, and Fourier-transform infrared spectroscopy. Their antimicrobial activity and anticancer cytotoxicity were studied. An optimal nano-size range of 30...

Abstract: During the second semester of the 2019/2020 academic year, universities and schools around the world switched to distance learning to comply with the strict lock-down conditions and assure the safety of staff and students. Thus a structured self-administered questionnaire was used on an undergraduate sample of students (n = 573) enrolled...

Atorvastatin (ATR) is frequently prescribed to lower plasma cholesterol levels. However, features such as marginal aqueous solubility, high protein binding (>95%), and low bioavailability (12–14%) have opposed its oral use. Therefore, unidirectional controlled-release mucoadhesive patches of ATR, using Carbopol® (CP) as a mucoadhesive polymer, Solu...

The aim of the present study is to synthesize a mesoporous silica MCM-48 and loading it with the poorly soluble drug valsartan. The MCM-48 was characterized by Brauner-Emmett-Teller surface area analyzer, scanning electron microscope, powder X-ray diffraction, thermal gravimetric analysis and Fourier transform infra-red (FTIR). The exact loading ca...

During past years, researchers have focused on developing a technique that can be applied in biomedical field. Ongoing research efforts focused on iron oxide nanoparticles (IONPs) as one of those developed techniques. They have been widely used because of their unique properties. They are biocompatible, biodegradable with unique non-toxic magnetic...

The aim of this study was to develop an ibuprofen microemulsion (IBU-ME) incorporated into in situ gels (microgels) for local delivery into periodontal pockets. The IBU-ME was prepared at a concentration of 1% w/v IBU. Various concentrations of the thermosensitive Pluronic® F127 (P127) solution and a series of combinations of the P127 solution and...

Purpose Conventional organogel and microemulsion-laden organogels (microemulsion organogels) were developed to deliver the lipophilic drug, lidocaine, topically. Methods Optimized formulations of lidocaine microemulsions of oil, water, and surfactant:cosurfactant (Tween® 20:ethanol), at ratios 4:1 and 2:1 v/v, were selected based on the droplet si...

The aim of the study was to develop and characterize mucoadhesive buccal patches of valsartan (VAL) in nanoemulsion (NE) form and to evaluate the impact of nano-formulation in improving its solubility, mucoadhesive strength and in-vitro permeation in comparison to the traditional mucoadhesive VAL patches. A thermodynamic stable VAL-loaded NE was de...

The objective of the present study was to develop buccal bilayered controlled release tablets in order to overcome the poor oral bioavailability of valsartan. They were prepared by direct compression. Various types and amounts of mucoadhesive polymers were investigated. The tablets were evaluated for weight variation, thickness, hardness, friabilit...

PurposeThe aim of this study was to investigate the effect of commonly used penetration enhancers on the viscoelastic properties and in vitro drug release from topical gel formulations. Methods Three penetration enhancers, diethylene glycol monoethyl ether (Transcutol®-P, TC), propylene glycol (PG), and 70 % ethanol were selected in this study. The...

Bilayer nicotine mucoadhesive patches were prepared and evaluated to determine the feasibility of the formulation as a nicotine replacement product to aid in smoking cessation. Nicotine patches were prepared using xanthan gum or carbopol 934 as a mucoadhesive polymers and ethyl cellulose as a backing layer. The patches were evaluated for their thic...

The aim of this study was to characterize a buccal mucoadhesive film using lidocaine and its hydrochloride salt (LDHCL) as a model drug. Buccal films were developed using carbopol 971P as a mucoadhesive polymer, and glycerol as a plasticizer. Scanning Electron Microscope, Differential Scanning Calorimetry, X-ray powder diffraction, and Fourier Tran...

The aim of this study was to develop a controlled release buccal mucoadhesive delivery system for systemic delivery of lidocaine hydrochloride as a model drug. In vitro release and buccal permeation as well as in vivo permeation of LDHCL patches were evaluated. The drug release and the permeability of the drug through porcine buccal mucosa were eva...