Ramesh KUMAR Gupta

Moradabad Institute of Technology · Pharmacology

Present study was aimed to formulate a stable w/o herbal cream wherein light liquid paraffin constituted the oily phase and Aloe vera gel and turmeric extract were incorporated in the aqueous phase and were mixed together with continuous stirring to form a homogeneous polyherbal cream. The cream was evaluated for a spectrum of pharmaceutical parame...

Fumaria indica Linn. (Syn: Fumaria parviflora, Fumariaceae), commonly known as fumitory, that has been traditionally used for a number of ailments. The plant is indigenously used as anthelmintic, antidyspeptic, blood purifier, cholagogue, diaphoretic, diuretic, laxative, stomachic, hepatoprotective and anti-inflammatory. The aim of present study to...

Objective: The present study investigated the antidiabetic outcome of ethanolic extract of Cordia sebestena fruit (EECSF) in streptozotocin (STZ)-induced diabetogenic rodents and evaluated its consequence to improve the level of biochemical parameters, serum electrolytes level, and hematological indices along with its impact on body weight. Materia...

Background The present research reported isolation, characterization of protopine from Hedyotis corymbosa and investigation of in-vivo hepatoprotective activity of protopine against simvastatin induced hepatotoxicity in experimental rodents. Methods Protopine was isolated from H. coryambosa by column chromatography using chloroform: methanol: diet...

Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investigated for anthelmintic, antibacterial, and antifungal activity.Methods: All the compounds were characterized by infrared (IR) and1H...

Objective: A novel series of substituted 3,3-diphenyl propanamide derivatives (I-VIII) were synthesized by reacting 3,3-diphenyl propanoyl chloride with different amines/amino acids, and all the derivatives were investigated for anthelmintic, antibacterial, and antifungal activity.Methods: All the compounds were characterized by infrared (IR) and1H...

Objective:To evaluate hepatoprotective activity along with hematological and defensive recital of Trichosanthes dioica Roxb against simvastatin induced hepatotoxicity in experimental rodents. Methods: In the present study, in- vivo hepatoprotective effect of 50% methanolic fruit extract of Trichosanthes dioica Roxb (TME 200 and 400 mg/kg body weigh...

Introduction: Assessment of indoor air quality has become important as the bacteria and fungi are omnipresent. Human diseases caused by microorganisms can be classified as bacterial, fungal and viral infection and infection type is determined by the source of infection which can be air, food, water and soil via which the infection transmits in immu...

Context: Nyctanthes arbor-tristis L. (Oleaceae) leaf are used in treatment of malaria, rheumatoid arthritis, chronic fever and enlargement of spleen; however, there is paucity of information on its hepatoprotective and antioxidant potential. Aims: To evaluate hepatoprotective and antioxidant potentials of ethanolic leaf extract of Nyctanthes arbor-...

Objective: To investigated the hematological, antioxidant and protective performance of Usnea longissima (U. longissima) on CCl4 induced hepatotoxicity in experimental animals. Methods: Hepatotoxicity was induced by CCl4 (1 mL/kg body weigt 1:1 CCl4 i.p.), ethanolic U. longissima extracts at a doses (200 and 400 mg/kg body weigt) were administered...

Present study was aimed to formulate a stable w/o herbal cream wherein light liquid paraffin constituted the oily phase and Aloe vera gel and turmeric extract were incorporated in the aqueous phase and were mixed together with continuous stirring to form a homogeneous polyherbal cream. The cream was evaluated for a spectrum of pharmaceutical parame...

The purpose of this study is to evaluate nephroprotective potential of Trichosanthes dioica leaves extract against Gentamicin (GM) induced nephrotoxicity and renal dysfunction. Twenty-four Wistar rats were divided into four groups (n = 6). Control rats that received normal saline (i.p.) and 0.5% carboxymethyl cellulose (p.o.) per day for 8 days. Ne...

Objective: To evaluate the anti-inflammatory effect of Nardostachys jatamansi (N. jatamansi) rhizome against acute, subacute and chronic models of inflammation in experimental animals. Methods: N. jatamansi rhizome extract (150 and 300 mg/kg, p.o.) and the reference drugs phenylbutazone (100 mg/kg, p.o.) and acetylsalicylic acid (300 mg/kg, p.o.) w...

Objective: To assess the hepatoprotective effect of Ipomoea carnea (I. carnea) extract against antitubercular drug-induced liver toxicity in experimental animals. Methods: I. carnea extracts (125, 250 and 500 mg/kg, p.o. body weight) were administered daily for 35 d in experimental animals. Liver toxicity was induced by combination of three antitub...

Objective To evaluate hepatoprotective potential of the methanolic extract of Hedyotis corymbosa against D–galactosamine–induced hepatopathy in experimental animals.Methods In the present study, in-vivo hepatoprotective effect of 50% methanolic extract of Hedyotis corymbosa (HCE, 100 and 200 mg/kg body weight) was evaluated using experimental model...

The present study was undertaken to investigate the hepatoprotective potential of Ipomoea carnea leaves in experimental rats. The aqueous extract of Ipomoea carnea leaves (ICAE, 125, 250 and 500 mg/kg body weight) was administered daily for 14 days in experimental animals. Liver injury was induced chemically, by CCl4 administration (1 ml/kg i.p.)....

To evaluate nephroprotective potential of Solanum xanthocarpum (S. xanthocarpum) fruit extract(SXE) against gentamicin (GM) induced nephrotoxicity and renal dysfunction. Twenty-four Wistar rats were divided into four groups (n=6). Control rats that received normal saline (i.p.) and 0.5% carboxymethyl cellulose (p.o.) per day for 8 d. Nephrotoxicity...

To assess the hepatoprotective effect of Solanum xanthocarpum (S. xanthocarpum) fruit extract against antitubercular drug-induced liver toxicity in experimental animals. Ethanolic (50%) fruit extract of S. xanthocarpum (100, 200 and 400 mg/kg bw) was administered daily for 35 days in experimental animals. Liver toxicity was induced by combination o...

Compound named 2-hydroxy-5-(6-iodo-2-methyl-4-oxoquinazolin-3(4H)-YL) benzoic acid (S1) was synthesized by reaction of 6-iodo-2-methylbenzoxazin-4-one with 5-amino salicylic acid (5-ASA). Coupling of compound S1 with different amino acid ester hydrochlorides, dipeptide/tripeptide methyl esters yielded novel quinazolino peptide derivatives S1a-e. Th...

The aim of this study was to prepare and evaluate the anti-ulcer potential of ethyl cellulose floating microspheres containing Ranitidine hydrochloride. Microspheres were prepared by non-aqueous solvent evaporation method using ethanol/ liquid paraffin system. In vivo antiulcer activity was performed in albino rats in order to investigate the signi...

To investigate the hepatoprotective potential of Solanum xanthocarpum (Solanaceae) (S. xanthocarpum) in experimental rats to validate its traditional claim. 50% ethanolic fruit extract of S. xanthocarpum (SXE, 100, 200 or 400 mg/kg body weight) was administered daily for 14 days in experimental animals. Liver injury was induced chemically, by CCl(4...

This study was conducted to (1) see the histopathological distribution of different subtypes in steroid resistant nephrotic syndrome (SRNS) and (2) compare the clinical, biochemical parameters and outcome between Minimal Change Disease (MCD) with non-MCD subtypes in response to immunosuppressive therapy. A retrospective analysis was done of data on...