Qi-Yong Liu

Chinese Center For Disease Control And Prevention | CDC · National Institute for Communicable Disease Control and Prevention

Although studies have reported the modification effect of air pollutants on heat-related health risk, little is known on the modification effect among various particulate matter with different particle size on mortality. We aimed to investigate whether the associations of hot temperatures with daily mortality were modified by different air pollutan...

Background Flea bites could trigger a series of complex molecular responses in the host. However, our understanding of the responses at the molecular level is still relatively limited. This study quantifies the changes in gene expression in mice after flea bites by RNA sequencing (RNA-seq) from their spleens, revealing the potential biological effe...

Background Mosquito-borne viruses cause various infectious diseases in humans and animals. Oya virus (OYAV) and Ebinur Lake virus (EBIV), belonging to the genus Orthobunyavirus within the family Peribunyaviridae, are recognized as neglected viruses with the potential to pose threats to animal or public health. The evaluation of vector competence is...

The commensal microbiota of the mosquito gut plays a complex role in determining the vector competence for arboviruses. In this study, we identified a bacterium from the gut of field Aedes albopictus mosquitoes named Rosenbergiella sp. YN46 ( Rosenbergiella_ YN46) that rendered mosquitoes refractory to infection with dengue and Zika viruses. Inocul...

Background Cardiovascular disease (CVD) has been found to be particularly vulnerable to climate change and temperature variability. This study aimed to assess the extent to which human-induced climate change contributes to future heat-related CVD burdens. Methods Daily data on CVD mortality and temperature were collected in 161 Chinese communities...

Background Culex pipiens pallens and Culex pipiens quinquefasciatus are the dominant species of Culex mosquitoes in China and important disease vectors. Long-term use of insecticides can cause mutations in the voltage-gated sodium channel ( vgsc ) gene of mosquitoes, but little is known about the current status and evolutionary origins of vgsc gene...

Rising temperatures can increase the risk of mental disorders. As climate change intensifies, the future disease burden due to mental disorders may be underestimated. Using data on the number of daily emergency department visits for mental disorders at 30 hospitals in Beijing, China during 2016–2018, the relationship between daily mean temperature...

Mosquito-borne viruses cause various infectious diseases in humans and animals. Tibet orbivirus (TIBOV), a newly identified arbovirus, efficiently replicates in different types of vertebrate and mosquito cells, with its neutralizing antibodies detected in cattle and goats. However, despite being isolated from Culicoides midges, Anopheles, and Culex...

Plague, as an ancient zoonotic disease caused by Yersinia pestis, has brought great disasters. The natural plague focus of Marmota himalayana in the Qinghai-Tibet Plateau is the largest, which has been constantly active and the leading source of human plague in China for decades. Understanding the population genetics of M. himalayana and relating t...

Background:Mosquito-borne viruses cause various infectious diseases in humans and animals. Oya virus (OYAV) and Ebinur lake virus (EBIV), belonging to the genus Orthobunyavirus within the Peribunyaviridae family, are recognized as neglected viruses with the potential to pose threats to animal or public health. The evaluation of vector competence is...

What is already known about this topic? Anopheles sinensis (An. sinensis) is the predominant malaria vector in China. The impact of S-methoprene on the emergence process of mosquito larvae suggests its potential as a control method for vector mosquitoes. However, the efficacy of S-methoprene in controlling An. sinensis has not yet been demonstrated...

Hemorrhagic fever with renal syndrome (HFRS) is a zoonotic disease caused by the rodent-transmitted orthohantaviruses (HVs), with China possessing the most cases globally. The virus hosts in China are Apodemus agrarius and Rattus norvegicus , and the disease spread is strongly influenced by global climate dynamics. To assess and predict the spatiot...

Rocky Mountain spotted fever is a tick-borne disease that is highly dangerous but often overlooked by the public. To prevent the spread of the disease, it is important to understand the distribution patterns of its vectors’ suitable areas. This study aims to explore the potential global suitability of areas for the vectors of Rocky Mountain spotted...

Parasite‐mediated selection is widely believed to play a crucial role in maintaining the diversity of the major histocompatibility complex (MHC) genes, which is thought to be maintained through heterozygote advantage, rare‐allele advantage, and fluctuating selection. However, the relationship between parasite pressure and MHC diversity has yielded...

Carrion’s disease is a vector-borne disease caused by Bartonella bacilliformis . The phlebotomine sand flies Lutzomyia peruensis and Lutzomyia verrucarum are the determined illness vectors. Some climate parameters, such as precipitation and temperature have affected the development and reproduction of sand flies. In addition, other climate related...

What is already known about this topic? An association between prenatal heatwave exposure and the risk of preterm birth was found. However, the disparities in heatwave-related preterm birth across different climate types have not been examined. What is added by this report? This nationwide case-crossover study investigated the association between...

Good practices: Co-producing integratedclimate, environment and health services The integration of climate and health sciences and services is vital to address growing health risks from climate extremes, variability, and change, as well as ecosystem changes. A 10-year strategy for advancing integrated climate and health science and services develop...

With growing health risks from climate change and a trend of increasing carbon emissions from coal, it is time for China to take action. The rising frequency and severity of extreme weather events in China, such as record-high temperatures, low rainfall, severe droughts, and floods in many regions (along with the compound and ripple effects of thes...

Background Strengthening the mosquito control measures undertaken by residents of an area where dengue fever is present can significantly decrease the spread of this disease. The aim of this study was to explore the effects of the source of information and knowledge of dengue fever on the mosquito control behavior of residents of areas at high risk...

Background: The current prevention and control strategy for Aedes albopictus heavily relies on comprehensive management, such as environmental management and chemical control. However, the wide application of pyrethroids has facilitated the development of insecticide resistance, primarily via mutations in the voltage-gated sodium channel (VGSC) ge...

Leveraging climate actions for healthy ageingWenjia Cai1†, Chi Zhang2†, Shihui Zhang1†, Yuqi Bai1, Max Callaghan3, Nan Chang4, Bin Chen5,Huiqi Chen6, Liangliang Cheng6, Xueqin Cui1, Hancheng Dai7, Bawuerjiang Danna8,Wenxuan Dong9,10, Weicheng Fan9,10, Xiaoyi Fang11, Tong Gao12, Yang Geng13, Dabo Guan1,Yixin Hu14, Junyi Hua15, Cunrui Huang16, Hong H...

Dengue fever is the most common arboviral infection of humans, responsible for a substantial disease burden to the world. Lately, an innovative technology has been approved to suppress natural mosquitoes by releasing Wolbachia-carrying male mosquitoes. To depict the transmission of dengue virus among mosquito and human populations, we respectively...

Importance: Associations between heat waves and preterm birth (PTB) have been reported. However, associations of daytime-only, nighttime-only, and compound heat waves with PTB have yet to be explored at a national level. Furthermore, possible heterogeneity across urban-rural communities with different socioeconomic statuses needs to be explored....

The incidence of plague has rebounded in the Americas, Asia, and Africa alongside rapid globalization and climate change. Previous studies have shown local climate to have significant nonlinear effects on plague dynamics among rodent communities. We analyzed an 18-year database of plague, spanning 1998 to 2015, in the foci of Mongolia and China to...

Background: The major histocompatibility complex (MHC) plays a key role in the adaptive immune response to pathogens due to its extraordinary polymorphism. However, the spatial patterns of MHC variation in the striped hamster remain unclear, particularly regarding the relative contribution of the balancing selection in shaping MHC spatial variatio...

Background: Gut microbiota have a complex role on the survivability, digestive physiology, production, and growth performance in animals. Recent studies have emphasized the effects of prebiotics therapy on the gut disease, but the relationship between elephant gut-related diseases and prebiotics remains elusive. Here, a case study was undertaken t...

The purpose of this study was to investigate tick species around Mount Fanjing and analyze bacterial communities in two species – Rhipicephalus microplus and Haemaphysalis longicornis – parasitizing cattle in Tongren, Guizhou province, Southwest China, using high-throughput sequencing methods. In April 2019, ticks were collected from five sites in...

Seizing the window of opportunity to mitigate the impact of climate change on the health of Chinese residents The health threats posed by climate change in China are increasing rapidly. Each province faces different health risks. Without a timely and adequate response, climate change will impact lives and livelihoods at an accelerated rate and even...

Background: We have limited knowledge on the impact of hydrometeorological conditions on dengue incidence in China and its associated disease burden in a future with a changed climate. This study projects the excess risk of dengue caused by climate change-induced hydrometeorological conditions across mainland China. Methods: In this modelling st...

Background Global connectivity and environmental change pose continuous threats to dengue invasions from worldwide to China. However, the intrinsic relationship on introduction and outbreak risks of dengue driven by the landscape features are still unknown. This study aimed to map the patterns on source-sink relation of dengue cases and assess the...

Background: Studies on the associations between temperature and osteoporotic fractures (OF) hospitalizations are limited. This study aimed to assess the short-term effect of apparent temperature (AT) on the risk of OF hospitalizations. Methods: This retrospective observational study was conducted in Beijing Jishuitan Hospital from 2004 to 2021....

Objectives The objective of this study was to construct a novel strategy for the mutation detection of knockdown resistance(kdr)gene in Aedes albopictus using multiplex PCR-mass spectrometry minisequencing technique (mPCR-MS minisequencing). Methods Based on the single-base mass probe extension of multiplex PCR amplification products in wild and m...

Background Aedes albopictus, commonly known as the tiger mosquito, has attracted global attention because its bite can transmit several viruses, such as dengue virus. With the absence of an effective therapy and vaccine, mosquito control is the sole method for dengue fever control. However, Ae. albopictus has developed resistance to most insecticid...

Increases in ambient temperatures and the frequency of extreme heat events constitute important burdens on global public health. However, evidence on their effects on public health is limited and inconclusive in China. In this study, data on daily deaths recorded in 33 Chinese cities from 2007 to 2013 was used to evaluate the effect of heat on mort...

Introduction Numerous studies have reported the modification of particulate matters (PMs) on the association between cold temperature and health. However, it remains uncertain whether the modification effect may vary by size of PMs, especially in Shandong Province, China where the disease burdens associated with cold temperature and PMs are both su...

Background Peromyscopsylla hesperomys and Orchopeas sexdentatus are regarded to be representative plague vectors in the United States. The incidence of plague is rising globally, possibly due to climate change and environmental damage. Environmental factors such as temperature and precipitation have a significant impact on the temporal and spatial...

Importance Dengue fever is a climate-sensitive infectious disease. However, its association with local hydrological conditions and the role of city development remain unclear. Objective To quantify the association between hydrological conditions and dengue fever incidence in China and to explore the modification role of city development in this as...

Background Evidence concerning effects of air pollution on influenza-like illness (ILI) from multi-center is limited and little is known about how regional factors might modify this relationship. Methods In this ecological study, ILI cases defined as outpatients with temperature ≥38 °C, accompanied by cough or sore throat, were collected from Nati...

Background Overseas imported dengue fever is an important factor in local outbreaks of this disease in the mainland of China. To better prevent and control such local outbreaks, the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in provincial-level administrative divisions (PLADs) where den...

Background: Previous studies have revealed the relationship between cold spells and morbidity and mortality due to respiratory diseases, while the detrimental effects of cold spells on the length of hospital stay and hospitalization expenses remain largely unknown. Methods: We collected hospitalization data for respiratory diseases in 11 cities...

Climate change affects ecosystems and human health in multiple dimensions. With the acceleration of climate change, climate-sensitive vector-borne diseases (VBDs) pose an increasing threat to public health. This paper summaries 10 publications on the impacts of climate change on ecosystems and human health; then it synthesizes the other existing li...

BACKGROUND Ectoparasites of rodents play significant roles in disease transmission to humans. Conventional poisoning potentially reduces the population densities of rodents, however, they may increase the ectoparasite loads on the surviving hosts. EP‐1 has been shown to have anti‐fertility effects on many rodent species, while ivermectin is effecti...

Background: Scrub typhus (ST) is a climate-sensitive infectious disease. However, the nonlinear relationship between important meteorological factors and ST incidence is not clear. The present study identified the quantitative relationship between ST incidence and meteorological factors in southern China. Methods: The weekly number of ST cases and...

Background Limited evidence is available about the association between tropical cyclones and dengue incidence. This study aimed to examine the effects of tropical cyclones on the incidence of dengue and to explore the vulnerable populations in Guangzhou, China. Methods Weekly dengue case data, tropical cyclone and meteorological data during the tr...

Objective: To explore the intraseasonal variation in mortality risk from cold temperature exposure in Shandong Province. Methods: Mortality data in Shandong province from 2013 to 2018 were collected from the cause of death surveillance system of Shandong Center for Disease Control and Prevention. The basic information mainly included the date of de...

A health-friendly, climate resilient, and carbon-neutral pathway would deliver major benefits to people's health and wellbeing in China, especially for older populations, while simultaneously promoting high-quality development in the long run. This report is the third China Lancet Countdown report, led by the Lancet Countdown Regional Centre based...

What is already known about this topic?: Numerous epidemiological studies have documented the association between ambient nitrogen dioxide (NO2) and mortality and morbidity of respiratory diseases, however, research on the effect of NO2 on the length of hospital stay (LOS) and hospitalization expenditure is limited. What is added by this report?:...

Studies have shown that the main pathway for tick host localization and perception of mating information may be chemosensory. However, chemical communication in ticks is poorly understood, especially in those other than the Ixodes ticks. Niemann–Pick C2 (NPC2) protein and ionotropic receptors (IRs) are considered to be closely related to the percep...

IPCC Working Group II has recently released the Sixth Assessment Report (AR6) of “Climate Change 2022: Impacts, Adaptation and Vulnerability”, in which Chapter 7 “Health, wellbeing and the changing structure of communities” assessed the current impacts, and projected future risks of climate change for health and wellbeing, taking into consideration...

Background: Climate change, environmental change, and globalization affect the geographical distribution of vector-borne diseases. Temperate regions should be prepared for emerging diseases and learn from each other's experiences. Objectives: The vector-borne disease preparedness in two regions, Beijing and the Netherlands, were compared in orde...

Introduction: There is a large body of epidemiological evidence showing significantly increased mortality risks from air pollution and temperature. However, findings on the modification of the association between air pollution and mortality by temperature are mixed. Methods: We used a varying coefficient distributed lag model to assess the compl...

Until now, we have no thorough understanding the role of absolute humidity on influenza activity, especially in tropical and subtropical areas. In this study, we investigated the relationship between absolute humidity and influenza activity in seven municipalities/provinces covering different climatic zones in China. Weekly meteorological data and...

New taxonomic and nomenclatural data are provided for Chinese species of Sarcophaga Meigen, 1824. Eight new synonyms are proposed: two at the genus level, Magnicauda Wei, 2005 syn. nov. = Sarcophaga Meigen, 1824 and Leigongshanophaga Lehrer & Wei, 2010 syn. nov. = Sarcophaga Meigen, 1824, two at the subgenus level, Magnicauda Wei, 2005 syn. nov. =...

The host-seeking activity of hematophagous arthropods is essential for arboviral transmission. Here, we demonstrate that mosquito-transmitted flaviviruses can manipulate host skin microbiota to produce a scent that attracts mosquitoes. We observed that Aedes mosquitoes preferred to seek and feed on mice infected by dengue and Zika viruses. Acetophe...

Background: Dengue fever has been a significant public health challenge in China. This will be particularly important in the context of global warming, frequent international travels, and urbanization with increasing city size and population movement. In order to design relevant prevention and control strategies and allocate health resources reaso...

Ornithoica aequisenta Maa 1966 (Diptera: Hippoboscidae) is recorded for the first time from a rodent from China. An updated checklist of louse flies including 21 genera and 52 species of Hippoboscoidea (Hippoboscidae, Nycteribiidae, and Streblidae) is presented for mainland China and Taiwan, including collection records and host species.

Dengue fever occurs throughout mainland China, except in the Tibet Autonomous Region. During 2005–2020, there were 12,701 imported cases and 81,653 indigenous cases recorded. The indigenous cases were mainly clustered in Guangdong (74.0%) and Yunnan provinces (13.7%). Indigenous dengue fever is a seasonal illness in mainland China, manifesting pred...

Executive Summary Climate-related illnesses, premature deaths, malnutrition in all its forms, and threats to mental health and well-being are increasing (very high confidence1 ). Climate hazards are a growing driver of involuntary migration and displacement (high confidence) and are a contributing factor to violent conflict (high confidence). Thes...

Severe fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. This virus is transmitted by the Asian longhorned tick (Haemaphysalis longicornis), which has parthenogenetically and sexually reproducing populations. Parthenogenetic populations were found in ≥15 provinces in China and strongly correlated with the distribution...

Ixodes scapularis is a vector of tick-borne diseases. Climate change is frequently invoked as an important cause of geographic expansions of tick-borne diseases. Environmental variables such as temperature and precipitation have an important impact on the geographical distribution of disease vectors. We used the maximum entropy model to project the...

Pomacea canaliculata is one of the 100 worst invasive alien species in the world, which has significant effects and harm to native species, ecological environment, human health, and social economy. Climate change is one of the major causes of species range shifts. With recent climate change, the distribution of P. canaliculata has shifted northward...

Background Ambient sulfur dioxide (SO2) has been associated with morbidity and mortality of respiratory diseases, however, its effect on length of hospital stays (LOS) and cost for these diagnoses remain unclear. Methods We collected hospital admission information for respiratory diseases from all 11 cities in the Shanxi Province of China during 2...

Introduction Dengue has become a more serious human health concern in China, with increased incidence and expanded outbreak regions. The knowledge of the cross-sectional and longitudinal epidemiological characteristics and the evolutionary dynamics of dengue in high-risk areas of China is limited. Methods Records of dengue cases from 2013 to 2016...

The impact of temperature and rainfall on the occurrence of typhoid/paratyphoid fever are not fully understood. This study aimed to characterize the effect of daily ambient temperature and total rainfall on the incidence of typhoid/paratyphoid in a sub-tropical climate city of China and to identify the vulnerable groups for disease prevention. Dail...

Background Anopheles gambiae (An. gambiae) is considered the most effective malaria vector worldwide and is widely distributed in Africa. The purpose of this study is to determine the potential impact of climate change on An. gambiae and predict the present and future potential suitable habitat globally. Methods In this study, environmental variab...

Hematophagous arthropods, such as mosquitoes, naturally carry and transmit hundreds of arboviruses to humans. Blood meal is a predominant physical interface that shapes cross-species communications among humans, bloodsuckers, and arboviruses. Here, we identify a human-blood-derived microRNA, hsa-miR-150-5p, that interferes with a mosquito antiviral...

Glossina morsitans is a vector for Human African Trypanosomiasis (HAT), which is mainly distributed in sub-Saharan Africa at present. Our objective was to project the historical and future potentially suitable areas globally and explore the influence of climatic factors. The maximum entropy model (MaxEnt) was utilized to evaluate the contribution r...

Background In the context of ongoing climate change, temperature variability (TV) has been considered as an important trigger of death. However, evidence of association between mortality and hourly temperature variability (HTV) is scarce at the multi-city level, and the time window of health effects of HTV is lack of investigation. This study aims...

Severe fever with thrombocytopenia syndrome virus (SFTSV) is spreading rapidly in Asia. It is transmitted by Haemaphysalis longicornis (Asian longhorned tick, ALT), which has both parthenogenetically and sexually reproducing populations. Parthenogenetic populations were found in at least 15 provinces in China and strongly correlated with the distri...

Background Dengue is a prioritized public health concern in China. Because of the larger scale, more frequent and wider spatial distribution, the challenge for dengue prevention and control has increased in recent years. While land use and land cover (LULC) change was suggested to be associated with dengue, relevant research has been quite limited....

Amblyomma americanum (the lone star tick) is a pathogen vector, mainly from eastern North America, that bites humans. With global integration and climate change, some ticks that are currently confined to a certain place may begin to spread out; some reports have shown that they are undergoing rapid range expansion. The difference in the potential g...

Background: Anopheles philippinensis and Anopheles nivipes are morphologically similar and are considered to be effective vectors of malaria transmission in northeastern India. Environmental factors such as temperature and rainfall have a significant impact on the temporal and spatial distribution of disease vectors driven by future climate change...

The second COVID-19 outbreak in Beijing was controlled by non-pharmaceutical interventions, which avoided a second pandemic. Until mass vaccination achieves herd immunity, cities are at risk of similar outbreaks. It is vital to quantify and simulate Beijing's non-pharmaceutical interventions to find effective intervention policies for the second ou...

(1) Background: Overseas imported dengue fever is an important factor in the local epidemic of dengue fever in mainland China. Therefore, in order to effectively prevent and control the local epidemic of dengue fever in mainland China, the epidemiological characteristics and temporal-spatial distribution of overseas imported dengue fever cases in p...

Background Studies have shown that tropical cyclones are associated with several infectious diseases, while very few evidence has demonstrated the relationship between tropical cyclones and dengue fever. This study aimed to examine the potential impact of tropical cyclones on dengue fever incidence in the Pearl River Delta, China. Methods Data on...