Prudence Lopez

John Hunter Hospital · Paediatric Endocrinology

Aim To determine the glycaemic impact of an increased insulin dose, split insulin dose and regular insulin for a high fat, high protein breakfast in people with type 1 diabetes using multiple daily injections (≥4/day). Methods In this cross‐over trial, participants received the same high fat, high protein breakfast (carbohydrate:30g, fat:40g, prot...

Aim: Postprandial hyperglycaemia is a challenge for people living with Type 1 diabetes. In addition to carbohydrate, dietary protein has been shown to contribute to postprandial glycaemic excursions with recommendations to consider protein when calculating mealtime insulin doses. The aim of this review is to identify and synthesize evidence about...

Aim To compare systematically the impact of two novel insulin‐dosing algorithms (the Pankowska Equation and the Food Insulin Index) with carbohydrate counting on postprandial glucose excursions following a high fat and a high protein meal. Methods A randomized, crossover trial at two Paediatric Diabetes centres was conducted. On each day, particip...

Aims: To determine the optimum combination bolus split to maintain postprandial glycaemia with a high-fat and high-protein meal in young people with Type 1 diabetes. Methods: A total of 19 young people (mean age 12.9 ± 6.7 years) participated in a randomized, repeated-measures trial comparing postprandial glycaemic control across six study condi...

Aim: To determine the glycaemic impact of increasing protein quantities when consumed with consistent amounts of carbohydrate in individuals with Type 1 diabetes on intensive insulin therapy. Methods: Participants with Type 1 diabetes [aged 10-40 years, HbA1c ≤ 64 mmol/mol (8%), BMI ≤ 91(st) percentile] received a 30-g carbohydrate (negligible f...

Background: Dietary protein increases postprandial glucose and insulin requirements in people with T1DM. Previously we demonstrated that 40g protein in a mixed macronutrient meal and >75g pure protein resulted in significant postprandial glycaemic excursions between 3-5hrs. The aim of this study is to determine the glycaemic impact of protein consu...

Session type Abstract submission Topic 10. Informatic s in the service of medicine; telemedicine, software and other technologies Presentation preference Oral Presentation Abstract title USING MODEL PREDICTION TO INCREASE THE EFFICIENCY OF TRANSLATING CLINICAL RESEARCH INTO CLINICAL PRACTICE FOR TYPE 1 DIABETES PATIENTS Background and Aims Cli...

Aim: To determine the effects of protein alone (independent of fat and carbohydrate) on postprandial glycaemia in individuals with Type 1 diabetes mellitus using intensive insulin therapy. Methods: Participants with Type 1 diabetes mellitus aged 7-40 years consumed six 150 ml whey isolate protein drinks [0 g (control), 12.5, 25, 50, 75 and 100]...

Oral presentation

Objective: Continuous glucose monitoring has demonstrated limitations in the current approach for mealtime insulin dosing, which is based primarily on carbohydrate counting. To overcome this, novel algorithms have been developed to account for the glycemic impact of fat and protein. The aim of this study was to compare three prandial insulin dosing...

Aim To determine the effects of protein alone (independent of fat and carbohydrate) on postprandial glycaemia in individuals with Type 1 diabetes mellitus using intensive insulin therapy. Methods Participants with Type 1 diabetes mellitus aged 7–40 years consumed six 150 ml whey isolate protein drinks [0 g (control), 12.5, 25, 50, 75 and 100] and t...

Bubble formation in insulin pump giving sets is a common problem. We studied change in temperature, change in atmospheric pressure, and vibration as potential mechanisms of bubble formation. 5 Animas 2020 pumps with 2 mL cartridges and Inset II infusion systems, 5 Medtronic Paradigm pumps with 1.8 mL cartridge and Quickset and 3 Roche Accu-chek pum...

Insulin pumps are able to deliver bolus insulin as a standard, extended or combination bolus. There is minimal research to determine which bolus is preferable in different settings. Anecdotally, many patients utilizes only the standard bolus (SB) due to uncertainty regarding when and how to program the different bolus types. We compared postprandia...

OBJECTIVE To determine the separate and combined effects of high-protein (HP) and high-fat (HF) meals, with the same carbohydrate content, on postprandial glycemia in children using intensive insulin therapy (IIT).RESEARCH DESIGN AND METHODS Thirty-three subjects aged 8-17 years were given 4 test breakfasts with the same carbohydrate amount but var...

Nutritional management is an important aspect of care for children and young people with type 1 diabetes using intensive insulin therapy. Research suggests that medical nutrition therapy should focus on interventions to ensure normal growth and development, promote lifelong healthy eating habits and maintain glycaemic control, as well as assisting...