Praneetha Palasuberniam

Universiti Malaysia Sabah (UMS) | ums · Biomedical Sciences

Background: The Malayan blue coral snake, Calliophis bivirgata flaviceps, is a medically important venomous snake in Southeast Asia. However, the complexity and diversity of its venom genes remain little explored. Methods: To address this, we applied high-throughput next-generation sequencing to profile the venom gland cDNA libraries of C. bivir...

Plant pathogens with their abundance are harmful and cause huge damage to different agricultural crops and economy of a country as well as lead towards the shortage of food for humans. For their management, the utilization of entomopathogenic fungi is an eco-friendly technique, sustainable to the environment, safe for humans and has promising effec...

Diabetes is a chronic disease for which a significant amount of naturally occurring plant-based products is frequently used as a therapy source. One of the plants that has been traditionally used to treat diabetes is Annona squamosa L. It is a fruit tree belonging to the family Annonaceae and is widely found in tropical and subtropical regions. The...

MALAYSIAN SOCIETY ON TOXINOLOGY NEWSLETTER DUO EDITION 2021-2022

Background Philippine Cobra Antivenom (PCAV) is the only snake antivenom manufactured in the Philippines. It is used clinically to treat envenoming caused by the Philippine Spitting Cobra (Naja philippinensis). While PCAV is effective pharmacologically, it is crucial to ensure the safety profile of this biologic that is derived from animal plasma....

Objective: The aim of this study was to investigate the effects of CaM antagonist, PTZ, and TFP on cell proliferation and migration of colon cancer cells and its impact on POPDC protein expression. Methods: The 50% inhibitory concentration (IC50) of PTZ and TFP in SW1116, SW480, HCT-15, and COLO205 colon cancer cell lines are measured using MTT....

The Samar Cobra, Naja samarensis, is endemic to the southern Philippines and is a WHO-listed Category 1 venomous snake species of medical importance. Envenomation caused by N. samarensis results in neurotoxicity, while there is no species-specific antivenom available for its treatment. The composition and neutralization of N. samarensis venom remai...

Snakebite envenomation is a serious neglected tropical disease, and its management is often complicated by the diversity of snake venoms. In Asia, pit vipers of the Ovophis species complex are medically important venomous snakes whose venom properties have not been investigated in depth. This study characterized the venom proteomes of Ovophis convi...

Introduction: The Malayan blue coral snake, Calliophis bivirgata flaviceps (C. bivirgata flaviceps), is a medically important venomous snake widely distributed in the subcontinent region of Southeast Asia. It is an elapid species of the Old World coral snakes, and snakebite envenomation caused by this species can result in clinical toxicity. Howeve...

Background: The Philippine cobra (Naja philippinensis) and Samar cobra (Naja samarensis) are two WHO Category 1 medically important venomous snakes in the Philippines. Philippine cobra antivenom (PCAV) is the only antivenom available in the country, but its neutralization capacity against the venoms of N. philippinensis and hetero-specific N. sama...

Malaysia has high prevalence of general and central obesity which can be signified by measurements of BMI and waist circumference respectively. Both parameters are established risk factors and predictors for non-communicable diseases including diabetes and hypertension. A health screening programme was conducted in a rural district of Sabah, Malays...

Prompt restoration of lost fluids and salts is the primary goal of cholera treatment. Oral rehydration therapy (ORT) with high-osmolarity mixture of glucose and salts has been recommended by the World Health Organization (WHO) and proved to be safe and effective in treating and preventing dehydration in cholera patient. The standard WHO-oral rehydr...

The Emergency Department (ED) provides treatment for acutely ill patients in need of urgent medical attention. Despite the availability of the primary care unit 'Klinik Kesihatan', where non urgent patients should be treated, Malaysia's public hospitals still need to deal with overcrowding of non-urgent patients in ED. The main aim of the study was...