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Introduction
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Publications
Publications (55)
( Am J Obstet Gynecol. 2023;228:569.e1–569.e24)
Pre-eclampsia, a complex and multisystemic disorder affecting a significant percentage of pregnancies worldwide, is a leading cause of preterm birth and maternal mortality. This condition is not uniform and can be classified into different subtypes based on gestational age and underlying pathophysiolo...
Objectives
To compare longitudinal changes in cervical length (CL) and mean cervical shear wave elastography (CSWE) scores between women with singleton and twin pregnancies who experience spontaneous preterm birth (sPTB) and those who have term births (TB).
Methods
This was a prospective longitudinal study of 1264 unselected women with singleton (...
Objectives:
To determine whether first trimester biomarkers of placental function can be used to screen for spontaneous preterm birth (sPTB) and develop prediction models with maternal factors, obstetric history and biomarkers of placental function at 11-13 weeks for the calculation of patient-specific risks for sPTB.
Methods:
This was a retrosp...
Objectives:
To assess whether pregnancy associated plasma protein-A (PAPP-A) improves or provides equivalent screening performance as placental growth factor (PlGF) when screening for preterm preeclampsia (PE) at 11-13 weeks METHODS: This is a secondary analysis of a non-intervention screening study of 6546 singleton pregnancies prospectively scre...
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( Acta Obstet Gynecol Scand . 2021;100:170–177)
Umbilical cord prolapse is an emergency with risk for significant complications, including prematurity and birth asphyxia. As cord compression and umbilical arterial vasospasm can lead to fetal hypoxia and birth asphyxia, rapid delivery is required to prevent fetal brain injury, cerebral palsy and dea...
Objective:
To objectively assess the degree of fetal head elevation by different maneuvers, including wedging the maternal buttocks, knee chest position, Trendelenburg position and filling up the maternal urinary bladder.
Methods:
This was a prospective observational study on 20 pregnant women at term before elective Cesarean delivery. A baselin...
Objective:
To investigate the risk factors associated the loss of the co-twin after selective fetal reduction in monochorionic (MC) multiple pregnancies using radiofrequency ablation (RFA) performed before 16 gestational weeks and thereafter.
Methods:
This was a single-center retrospective analysis of 63 consecutive RFA indicated for twin revers...
Objective data:
Preconception or early administration of low-dose aspirin might improve endometrial growth, placental vascularization, and organogenesis. Most studies have evaluated the potential benefit of preconception or early administration of low-dose aspirin in women with a history of recurrent pregnancy loss, women who have undergone in vit...
Objective To evaluate Sylvian fissure development by assessing Sylvian fissure angles in fetuses with malformation of cortical development (MCD).
Methods Thiswasaretrospectivestudyof22fetuseswith MCD. Cases with a stored three-dimensional (3D) brain volume acquired at 18 + 0 to 30 + 6 weeks of gestation at an ultrasound-based research clinic betwee...
Background:
The diagnosis of labor dystocia generally is determined by the deviation of labor progress, which is assessed by the use of a partogram. Recently, intrapartum transperineal ultrasound for the assessment of fetal head descent has been introduced to assess labor progress in the first stage of labor in a more objective and noninvasive way...
Background:
The traditional approach to the assessment of labor progress is by digital vaginal examination; however, it is subjective and imprecise. Recent studies have investigated the role of transperineal ultrasonographic assessment of fetal head descent by measuring the angle of progression and head-perineum distance.
Objective:
The objectiv...
Objective:
To (i) evaluate the normal development of the Sylvian fissures in the anterior coronal view of the fetal brain at 18-30 weeks' gestation by transvaginal 3D ultrasound; (ii) develop reference ranges of measurements of the right and left Sylvian fissure angles during normal pregnancy at 18-30 weeks' gestation; and (iii) examine the intra-...
Objective:
To examine (1) the concordance of manual and automated para-symphyseal angle of progression (psAOP) measurements, (2) the repeatability of psAOP, head-symphysis distance, head-perineum distance, and sonographic cervical dilatation, and (3) the value of transperineal ultrasound (TPU) in predicting induction of labor (IOL) outcome.
Metho...
Objective: To assess the association between body mass index (BMI) and adverse pregnancy outcomes.
Materials and methods: A multicentre retrospective cohort study was conducted in three hospitals in Hong Kong including 67 248 women with singleton pregnancy at 11–13 weeks between 2010–2016. The relationship between maternal BMI and [1] miscarriage o...
Objective:
The objectives of this study were to 1) define the protocol for the first-trimester assessment of the uterine artery pulsatility index (UtA-PI) using the new transverse technique, 2) evaluate UtA-PI measured by the transverse approach versus that obtained by the conventional sagittal approach, and 3) determine if accelerated onsite trai...
The study aimed to identify the simplest protocol for the measurement of mean arterial pressure (MAP) across 10-40. weeks' gestation. 2726 women with uncomplicated singleton pregnancy attending for their routine hospital visit between 10 and 40. weeks' gestation were recruited prospectively. The blood pressure (BP) was measured according to the Nat...
Proteomics data used in the analyses presented in this study.
Protein abundance data for each sample (rows) and each of the 1125 proteins is given in this table. ID: anonymized identifier indicator of the patient, GA: gestational age at sample, LatePE: is 1 for late preeclampsia and 0 for normal pregnancy. Protein symbol and names provide by Somalo...
Summary of differential abundance analysis between late-onset preeclampsia and normal pregnancy in five intervals of gestation.
Thirty-six proteins that were significant (Sig.) (q<0.25 and fold change >1.1) in at least one interval are shown. Adjustment was performed for BMI, maternal age, parity and smoking. FC: linear fold change, with negative v...
Objective: To determine inter-sonographer, intersampling site pulsatility index differences in the ascending branch of the uterine artery (UtA-PI) and their effect on detection rates (DR) for early onset preeclampsia (PE).
Methods: A prospective observational study was conducted including 52 women with singleton viable pregnancy at 11–13 weeks’ ges...
Objective: To demonstrate prevalence of sexually transmitted infections (STIs) and pregnancy outcomes in Thai
pregnant women without antenatal care (ANC) who delivered at Siriraj Hospital.
Methods: Medical charts of pregnant women without ANC who delivered at Siriraj Hospital during 2010-2014
were reviewed. Data of all deliveries during the same ti...
Preterm premature rupture of membranes (PPROM) is the leading identifiable cause of preterm birth with ~ 40% of preterm births being associated with PPROM and occurs in 1% - 2% of all pregnancies. We hypothesized that multiple rare variants in fetal genes involved in extracellular matrix synthesis would associate with PPROM, based on the assumption...
Comparison of neonatal ancestry between cases and controls in the initial WES.
Neonatal case (n = 49) and control (n = 20) samples were compared for European and West-African ancestry proportions. Values represent mean genetic ancestry estimates generated using two-way model of admixture following maximum likelihood method with SD in parentheses (T...
COL2A1 mRNA expression in amnion sample from normal term pregnancy.
RT-PCR gel image for COL2A1 (100 bp) using 1 μg RNA from amnion tissue sample (lane 3) obtained from normal term pregnancy (gestational age > 37 weeks) showing mRNA expression of the COL2A1 gene in the amnion. RNA from primary cultures of human ear chondrocytes (provided by Dr. Bar...
Background:
Failure of physiologic transformation of spiral arteries has been reported in preeclampsia, fetal growth restriction, fetal death, and spontaneous preterm labor with intact or ruptured membranes. Spiral arteries with failure of physiologic transformation are prone to develop atherosclerotic-like lesions of atherosis. There are striking...
Inflammasomes are cytosolic signaling platforms that regulate the activation of caspase (CASP)-1, which induces the maturation of interleukin (IL)-1β and IL-18. Herein, we determined whether the chorioamniotic membranes from women in spontaneous labor at term with acute histologic chorioamnionitis express major inflammasome components and whether t...
Background:
Midkine (MDK) and pleiotrophin (PTN) are heparin-binding growth factors that, in rodents, are highly expressed in early life and decrease to undetectable levels by adulthood. The potential roles of MDK and PTN in human growth and development are not completely elucidated.
Method and findings:
To delineate the role of MDK and PTN in h...
Parallelism between the standard curve and serially diluted samples of the MDK ELISA.
A plasma sample was diluted 2, 10, 50, and 100 fold into assay buffer (TBSTA) and then assayed for MDK. Black bars, measured MDK concentrations; patterned gray bars, measured value multiplied by the dilution factor. Data are presented as mean ± SEM.
(DOCX)
Comparison of MDK concentrations in plasma collected in polypropylene vs. glass tubes.
Plasma in the tissue bank had been collected in glass citrate tubes, centrifuged promptly, and stored at -80°C in polypropylene tubes. To determine whether MDK adhered to the glass tubes (Hando et al., 2008), freshly obtained blood samples (n = 5) from pregnant w...
A & B. Parallelism between the standard curve and serially diluted amniotic fluid washout samples.
An amniotic fluid sample was diluted 100, 200, and 400 fold into assay buffer for MDK measurement (Panel A) and 25, 50, and 100 fold for PTN measurement (Panel B). The assays showed good parallelism between the standard curve and serially diluted AF w...
A & B. Comparison of MDK and PTN concentrations in AF collected in polypropylene vs. glass tubes.
AF in the tissue bank had been centrifuged in glass tubes. To determine whether MDK or PTN adheres to the glass (Hando et al., 2008), freshly collected AF (n = 5) was placed in either polypropylene or glass tubes, stored at room temperature for 2 hours...
