Philip-John Lamey

Queen's University Belfast | QUB · Faculty of Medicine, Health and Life Sciences

This study investigated the association between satisfaction with the dentition and dental prostheses and personality profiles among patients who received implant-supported prostheses. Patients seeking dental implant therapy were recruited for this study. A Dental Impact on Daily Living questionnaire was used to assess dental satisfaction and the e...

This study aimed to evaluate the reliability of a new CAD-CAM Laser scanning machine in detection of incisal tooth wear through a 6-month period and to compare the accuracy of using this new machine against measuring tooth wear using tool maker microscope and conventional tooth wear index. Twenty participants (11 males and 9 females, mean age=22.7...

A modified Carlsson-Crittenden cup was used to collect three consecutive 0.5 ml samples of stimulated saliva from the parotid glands of 14 individuals with no known salivary disease and 14 patients with Sjögren's syndrome. Microbiological culture yielded bacteria from 30 of the 42 samples from healthy individuals and all 33 specimens obtained from...

Aesthetics and function of the orofacial region are very important aspects of human life which may be affected by tooth loss and impact on the quality of life. The aim of this study was to identify the effects of anterior tooth loss on patients' quality of life and satisfaction with their dentition. Fifty partially edentulous patients with missing...

The purpose of this study was to compare absolute and proportional electromyography (EMG) levels in the masseter and temporalis muscles during performance of a variety of oral functions for migraineurs and age- and sex-matched controls. Both groups consisted of nine women and one man, with a mean age of 43 years (range, 29 to 51 years). Absolute re...

To determine the distribution of the NPY Y1 receptor in carious and noncarious human dental pulp tissue using immunohistochemistry. A subsidiary aim was to confirm the presence of the NPY Y1 protein product in membrane fractions of dental pulp tissue from carious and noncarious teeth using western blotting. Twenty two dental pulp samples were colle...

To investigate the possibility that ozone may have an adverse effect on the bond strength of orthodontic brackets and to determine the area of residual adhesive on teeth after the debonding of brackets. 60 extracted premolars teeth were used in this study. Resin coated APC brackets (3M) were bonded according to the manufacturers' instructions. Bond...

The antioxidant status of an individual is thought to be important in the development of potentially malignant oral lesions (PMOL) and oral squamous cell carcinoma (OSCC). To date, little detailed information on mucosal antioxidant status is available in a United Kingdom population and neither has the relationship between smoking and mucosal antiox...

Oral surgery and stress can trigger and/or increase asymptomatic shedding of herpes simplex virus type-1 (HSV-1) into human saliva. In this investigation we examined the frequency of HSV-1 shedding in 32 patients undergoing an oral surgery procedure compared with 40 control patients attending for noninvasive treatment. Control patients comprised 18...

Infrared thermography technique (IRT) is utilized by a growing number of disciplines within medicine and dentistry. However, IRT has not been employed in the evaluation of salivary gland dysfunction. The purpose of this study was to examine the feasibility of using thermographic imaging in the evaluation of minor labial salivary gland function in s...

The purpose of this study was to evaluate 3-dimensionally the changes on tooth surfaces after debonding orthodontic brackets and after removing residual adhesive and finishing. Sixty premolars were randomly divided into 2 groups, and brackets were bonded according to the manufacturers' instructions. Two types of orthodontic adhesives were used: res...

This study was undertaken to identify whether personality traits had any relationship with patients' satisfaction with their dentition in tooth wear cases. One hundred tooth wear patients and one hundred controls were recruited into the study. A Dental Impact on Daily Living questionnaire was used to assess impact of tooth wear on day to day life a...

The aim of this study was to identify the effects of tooth wear on patients' quality of life and satisfaction with their dentition. Seventy-six tooth wear patients and 76 control subjects were recruited for the study. A Dental Impact on Daily Living questionnaire was used to assess the affect of tooth wear on daily living and satisfaction with the...

To quantitatively measure VIP levels and to qualitatively study the distribution of VIP fibres and demonstrate the presence of the VPAC1 receptor in human dental pulp from carious and non-carious adult human teeth. Dental pulp samples were collected from non-carious, moderately carious and grossly carious adult human teeth. VIP levels were determin...

Sialorrhoea, the symptom of apparent excessive secretion of saliva is a relatively uncommon complaint. Some authors consider that in the absence of clinical findings, then these patients have a psychiatric disorder masquerading as a physical illness. However, there is little evidence in the literature to support this conclusion and a detailed psych...

Recent evidence suggests that the sympathetic nervous system may have a role in modulating neurogenic inflammation and bone remodelling. Neuropeptide Y (NPY) is a well-characterized neuropeptide transmitter in the peripheral sympathetic nervous system. NPY is known to be present in human dental pulp; however, quantitative data on NPY levels in pulp...

Numbers of Langerhans ceils (LC) expressing the common thymocyte antigen (T6/CD1) are similar in oral lichen planus (LP) and in normal oral epithelium: however, expression of class II major histocompatibility antigens (HLA-DR/Ia) by Langerhans cells is greater in lichen planus than in normal epithelium, a phenomenon believed to be associated with a...

To evaluate clinical procedures and chair time required to seat and adjust hard, heat-cured acrylic occlusal splints and an alternative laminated appliance developed to simplify construction of migraine prevention appliances. Single-centre study in the Oral Medicine Clinic, The Royal Hospitals, Belfast, Northern Ireland. Questionnaires were distrib...

The study was designed to determine the efficacy of OraDisc (active component 2 mg amlexanox) on the prevention of aphthous ulcers treated at the prodromal stage. Thermographic imaging was used to confirm the presence of a prodromal ulcer. Fifty-two patients were randomized to receive OraDisc (N = 26) or vehicle patches (N = 26). Patches were appli...

Recurrent minor aphthous ulceration (RAU) is a common condition which is multifactorial in origin. This study, firstly, aimed to treat the prodromal stage of RAU with Aphtheal (5% amlexanox paste) to determine if ulcer development could be prevented. A second arm of the study investigated treatment of RAU with Aphtheal once ulceration had developed...

The role of antimicrobial peptides is particularly important in the oral cavity where there is constant challenge by microorganisms. The alpha-defensins are a group of cationic peptides that comprise 30-50% of the total protein in azurophilic granules of human neutrophils. They include the human neutrophil peptides (HNP) 1, 2 and 3 which have almos...

To investigate if burning mouth syndrome (BMS) patients have differing health perceptions, medication, and life experiences compared with controls and to examine the role of vulnerability factors and differentiate them from the presenting symptomology in patients with BMS. A nonprobability convenience sample of patients presenting with BMS and age-...

To date, little attention has been paid to the possible role of alpha-defensins (human neutrophil peptides 1-3), HNP-1, HNP-2 and HNP-3 in innate host defence against tumour invasion. In the current study, using a single-dimensional high pressure liquid chromatography (HPLC) method for peptide separation, followed by mass spectrometry and amino aci...

Primary and Secondary Sjögren's syndrome are disease complexes characterized by periductal inflammatory cell infiltration of the salivary and lacrimal glands and manifest as dry mouth and dry eyes. Secondary Sjögren's syndrome may be associated with a connective tissue disorder. Additional extraglandular features in Sjögren's syndrome include a gen...

We examined clinical parameters of patients from Northern Ireland with potentially malignant lesions (PML) to determine association with development of intraoral squamous cell carcinoma (SCC). retrospective, cross-sectional, population-based, clinically validated, laboratory-verified. All patients who had more than one incisional oral mucosal biops...

The measurement of neuropeptides in complex biological tissue samples requires efficient and appropriate extraction methods so that immunoreactivity is retained for subsequent radioimmunoassay detection. Since neuropeptides differ in their molecular mass, charge and hydrophobicity, no single method will suffice for the optimal extraction of various...

To evaluate the role of the anti-inflammatory neuropeptide vasoactive intestinal peptide (VIP) in periodontal health and disease and to determine the effects of periodontal treatment, resulting in a return to periodontal health, on the levels of VIP in gingival crevicular fluid (GCF). At baseline, 10 subjects with periodontitis (nine females, one m...

The aim of this study was to investigate the presence of substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) in the gingival crevicular fluid of teeth diagnosed with pain of pulpal origin compared with clinically healthy teeth, and to detect any changes in the levels of these neuropeptides in gingival crevicular fluid af...

In the preparation of osseointegrated dental implant sites, the use of bone drilling with conventional external irrigation has been shown to be thermally non-injurious to bovine bone, when employed as a model for dental implantology. The use of internal irrigation drilling systems is promoted on the basis of improved delivery of coolant to the bone...

No good predictive marker for the malignant transformation of potentially malignant oral lesions (PMOLs) is currently available. This study re-evaluated the value of p53 immunoexpression to predict malignant transformation of PMOLs after discounting possible confounding factors. PMOLs from 18 patients who showed progression to carcinoma, 16 of the...

The purpose of this study was to investigate the levels of substance P (SP), neurokinin A (NKA) and calcitonin gene-related peptide (CGRP) in painful and healthy human dental pulps. Forty-six samples of pulp tissue were collected from extracted or endodontically treated painful teeth and 20 from clinically healthy teeth extracted for orthodontic re...

The protein components of GCF can be separated by reverse-phase microbore HPLC on a C18 column with detection on the basis of 214 nm absorbance. A single major symmetrical protein peak eluting with a retention time of 26 min (50% acetonitrile) was evident in gingival crevicular fluid (GCF) from periodontitis patients but not in healthy GCF. This pr...

Background: The study of periodontitis provides a unique model for assessing the involvement of neuropeptides in inflammatory disease. Aim: To investigate the effects of periodontal treatment, resulting in a return to periodontal health, on the levels of substance P (SP) and neurokinin A (NKA) in gingival crevicular fluid (GCF). Method: We complete...

To assess the influence of psychological factors on the acceptance of complete dentures in a population wearing dentures judged to be clinically satisfactory. Subjects were asked to complete personality profiles and also to rate their dentures using a denture satisfaction questionnaire. The survey was conducted in the prosthetics clinic of a teachi...

This study investigated the influence of nystatin and fluconazole on virulence properties of Candida albicans. A total of 108 diabetic patients participated in the study. Eighty-eight patients had clinical oral candidosis. Drug therapy was given at 6 hourly intervals for nystatin or daily with fluconazole for a maximum of 2 weeks. Adhesion of C alb...

Burning mouth syndrome (BMS) is known to have multiple precipitating factors and exists in various clinical subtypes. If salivary gland function was compromised in BMS it could help explain the link with diverse precipitating factors. This study quantified stimulated right and left parotid flow rates (SPFR) in 114 patients with BMS. It also attempt...

To examine the incidence and severity of post-operative pain and use of analgesics following biopsy of oral mucosal lesions. A patient survey using a self-completed pain diary. Seventy-six patients attending an oral medicine clinic for investigation of oral mucosal disease recorded overall and worst pain experiences and analgesic usage over 7 post-...

The purpose of this investigation was to compare the masticatory muscle volume, bite force, and craniofacial morphology of migrainous subjects with age- and sex-matched controls. Ten adult dentate migraineurs were matched with 10 dentate age- and sex-matched controls. The groups consisted of nine women and one man (mean age, 43 years; range, 29 to...

We studied 45 patients with malar fractures who had some degree of infraorbital nerve deficit. Thermographic facial images failed to show any substantial changes in the temperature profiles of the affected and the normal control sides in relation to reco very of their facial sensation. Although some patients who had thermography on the day of injur...

The purpose of the study was to analyse how the protein composition of the inflammatory exudate associated with chronic periodontitis differed from the exudate in periodontal health. Gingival crevicular fluid (GCF) was collected from sites with chronic periodontal inflammation and from non-diseased sites in healthy control subjects. Microbore HPLC...

To observe the thermographic appearance of teeth and to develop a suitable protocol for imaging teeth in human subjects using modern thermographic imaging (TI) equipment in a thermologically controlled environment. The emissivity of enamel was investigated using an extracted incisor tooth. A total of 12 unrestored maxillary lateral incisors in six...

To investigate the rewarming pattern and rewarming rate of clinically healthy teeth following a controlled cold stimulus using TI techniques. A controlled cold stimulus was developed using an air stream at 20 degrees C. Gingival and incisal sites on 12 healthy maxillary lateral incisors in six patients were imaged under rubber dam following 20 s co...

To examine, for the first time Bcl-2 expression in sequential (autogenous) oral mucosal biopsies taken from the same sites in a gender, risk-factor matched, Caucasoid sample, over a 21-year period. Retrospective immunocytochemical longitudinal study of archival serial biopsies. Computer records were used to identify biopsy specimens derived from 12...

This study was designed to use two methods of temperature measurement to analyse and quantify the in vitro root surface temperature changes during the initial stage of the continuous wave technique of obturation of 17 single-rooted premolar teeth with standard canal preparations. A model was designed to allow simultaneous temperature measurement wi...

Metabolism by peptidases plays an important rôle in modulating the levels of biologically-active neuropeptides. The metabolism of the anti-inflammatory neuropeptide calcitonin gene-related peptide (GCRP), but not the pro-inflammatory neuropeptides substance P (SP) and neurokinin A (NKA) by components of the gingival crevicular fluid (GCF), could po...

The study of periodontitis provides a unique model for assessing the involvement of neuropeptides in inflammatory disease. To investigate the effects of periodontal treatment, resulting in a return to periodontal health, on the levels of substance P (SP) and neurokinin A (NKA) in gingival crevicular fluid (GCF). We completed a cause of non-surgical...

This study investigated the effects of iron replacement on the incidence of recurrent herpes labialis and serum ferritin levels in patients with sideropenia. Ten patients with diagnosed sideropenia and a history of recrudescent herpes labialis were prescribed ferrous sulphate for a period of 3 months. Patients were questioned on the number of episo...

This study investigated the influence of the carbon source of the growth medium, strains of Candida albicans and source of epithelial cells, and the influence of smoking and gender, on the adhesion of C. albicans to epithelial cells from insulin-using diabetic patients. Adhesion was determined by an autologous adhesion assay with exfoliated buccal...

The identification of the novel candidal species, C. dubliniensis, from oral swab studies of HIV-seropositive and -seronegative individuals has led to speculation that such a species may also reside in the oral cavity of other patient groups. In this study involvement of the newly described species, C. dubliniensis, was investigated in oral carriag...

Measuring neuropeptides in biological tissues by radioimmunoassay requires efficient extraction that maintains their immunoreactivity. Many different methods for extraction have been described, but there is little information on optimal extraction methods for individual neuropeptides from human dental pulp tissue. The aim was therefore to identify...

This paper examines patients with atypical facial pain. This condition forms part of the subject of oral medicine with patients being referred for pain relief. For the most part patients are unwilling to entertain the idea that their pain could have a psychological causation and it could be said that they are fixed to the physical nature of their c...

The antioxidant status of an individual is thought to be important in the development of potentially malignant oral lesions (PMOL) and oral squamous cell carcinoma (OSCC). To date, little detailed information on mucosal antioxidant status is available in a United Kingdom population and neither has the relationship between smoking and mucosal antiox...

To evaluate candidal load and carriage of candidal species in 414 insulin-treated diabetes mellitus patients with and without clinical signs of infection. Host factors that could influence candidal load in diabetic patients with oral candidosis were also investigated. Candidal species were recovered from 414 insulin-treated diabetes mellitus patien...

Tetracycline staining of teeth during tooth development is well documented. We report here the rarer condition of tetracycline staining of adult teeth. This occurrence appears to involve enamel surface demineralization/remineralization and can produce staining clinically indistinguishable from that occurring during tooth development.

This study used modern thermal imaging techniques to investigate the temperature rise induced at the pulpal well during thermal debonding of ceramic brackets. Ceramic brackets were debonded from vertically sectioned premolar teeth using an electrothermal debonding unit. Ten teeth were debonded at the end of a single 3-second heating cycle. For a fu...

The aims of the present study were to investigate whether calcitonin gene-related peptide (CGRP) was present in gingival crevicular fluid in both periodontal health and disease and to study the relationship with periodontal inflammation. Gingival crevicular fluid (GCF) was collected from a healthy, a gingivitis and a periodontitis site in 18 subjec...

This study describes the results of a survey undertaken to assess the management of potentially malignant oral mucosal lesions by oral medicine practitioners and compares their approach with that of oral & maxillofacial surgeons that we have previously described. Significant differences were noted between the two groups in the use of photography to...

Burning mouth syndrome is a fairly common condition. Contrary to popular belief, its management is successful in about 70% of cases--provided a structured protocol based on scientific evidence is adopted. Specialist advice must be sought in some cases, but many patients can be successfully treated in the primary care environment.

Four patients, three women and one man, with a mean age of 32 years, presented with a history of recurrent parotid swelling. In the women the swelling was unilateral. All had previously undergone sialography using a hand injection technique and no structural abnormality was demonstrated. Sialography was repeated using a continuous-infusion pressure...

Early treatment of recrudescent herpes labialis over the symptomatic area has been claimed to inhibit the clinical signs of recrudescent herpes labialis. Electronic infrared thermography can both recognise the prodromal phase and identify the area requiring drug therapy. Our objective was to use infrared thermography to identify prodromal herpes an...

White sponge naevus is a rare benign inherited disorder of the mucous membranes, principally the oral mucosa. Although the condition is painless, patients are often symptomatic, complaining of an altered texture of the mucosa or that the lesions are unaesthetic. No standard treatment for the condition exists although numerous treatments have been t...

The purpose of the study was to determine the prevalence of burning mouth (BM) in a population of Parkinson's Disease (PD) sufferers and also to assess the use of pain profiles in identifying the type of burning sensation experienced. Subjects were surveyed by means of a one shot postal questionnaire for which ethical approval had previously been g...

Christie SN, McCaughey C, Marley J J, Coyle PV, Scott DA, Lamey P-J: Recrudescent herpes simplex infection mimicking primary herpetic gingivostomatitis. We report six cases of recrudescent intraoral herpes simplex infection clinically indistinguishable from primary herpetic gingivostomatitis. All infections occurred in healthy children or young adu...

Herpes simplex virus type 1 (HSV-1) and, to a lesser extent, type 2 (HSV-2) are the aetiological agents of recrudescent herpes labialis (RHL). The available literature on patterns of HSV-1 shedding into the oral cavity at the prodromal stage of disease, during recrudescences and also during asymptomatic periods, is reviewed, as are the potential so...

Recrudescent herpes labialis (RHL) is a disease caused by herpes simplex virus (HSV), predominantly type 1 (HSV-1). We have monitored HSV-1 shedding in the oral cavity by polymerase chain reaction (PCR) and enzyme-linked immunosorbent assays (ELISA) using digoxigenin-labeled primers designed to amplify a 278 bp segment of the HSV-1 UL 42 region. Pr...

The mechanical preparation of a post space in a root filled tooth is commonly carried out using rotating instruments in a slow handpiece. This procedure creates frictional heat which may be transferred to the root surface. In this investigation, the temperature changes on the root surface of 12 root filled, extracted human premolar teeth during pre...

The temperature changes on the root surface of 30 extracted human premolar teeth during thermomechanical root canal obturation with gutta-percha were determined using an infrared thermal imaging camera. Three handpiece rotational speeds of 8, 12 and 16 x 10(3) r.p.m. were used, in conjunction with a Gutta Condensor. On completion of the procedure,...

Buccal epithelial cells (BEC) from 12 patients with diabetes mellitus and 12 age- and sex-matched non-diabetic subjects were tested in vitro for adhesion of Candida albicans following exposure to nystatin both in vitro and in vivo. Adhesion was significantly reduced (P < 0.002) to cells from both the diabetic and non-diabetic subjects after in vitr...

Numbers of Langerhans cells (LC) expressing the common thymocyte antigen (T6/CD1) are similar in oral lichen planus (LP) and in normal oral epithelium; however, expression of class II major histocompatibility antigens (HLA-DR/Ia) by Langerhans cells is greater in lichen planus than in normal epithelium, a phenomenon believed to be associated with a...

This study was to investigate the potential role of salivary glycoproteins in burning mouth syndrome. This study compared major parotid glycoproteins in a group of patients with burning mouth syndrome and age-, sex-, race-matched healthy controls. By use of a glycoprotein detection kit, saliva from both patients and controls exhibited three major p...

This in-vitro study aimed to examine the change in surface temperature induced by the actions of drills for the placement of dentine pins. Ten decoronated extracted premolar teeth were embedded by the apical tip of their roots in orthoresin. They were held in a bench vice and allowed to reach the ambient temperature of 24 degrees C. A thermal imagi...

A rare case of candidal infection of the lips is presented. Predisposing factors appeared to be intra-oral candidal carriage, actinic lip damage and Sjögren's syndrome. Systemic antifungal therapy with fluconazole resolved the initial infection and a subsequent recurrence.

Twenty subjects with burning mouth syndrome (BMS) and 20 control subjects were tested for oral size perception. Blindfolded subjects assessed the size of holes (2.38-12.70 mm diameter) presented to the tongue, using their fingers to select a matching hole from a comparator series of 31 holes (0.76-15.87 mm diameter) using first static then phasic t...

The purpose of this study was to ascertain how accurate the general public was at diagnosing the condition of recrudescent herpes labialis. An advertisement was placed in a local newspaper inviting patients to attend the Oral Medicine Clinic as soon as they thought they developed the clinically evident stage of herpes labialis. At the clinic, patie...

Harmartomas of the head and neck are common lesions, often taking the form of melanocytic nevi or vascular malformations such as hemangiomas and lymphangiomas. Hamartomas composed of other tissue types are much rarer and within the oral cavity are usually located on the tongue near the foramen cecum or on the anterior hard palate near the incisive...

This study evaluated the efficacy of bioadhesive hydrogel patches, made of a pharmaceutical grade cellulose derivative, in the control of pain and as an aid to healing of aphthous ulceration. Patients kept a twice daily ulcer diary to record their pain level on a visual analogue scale. The sensitivity of the test ulcer was assessed by a challenge w...

Anxiety and salivary cortisol were measured in two groups of patients with recurrent aphthous ulceration. One group of patients had persistent aphthae (Group 1) and the others had been relieved of their aphthae following correction of detected haematinic deficiency states (Group 2). Anxiety was measured using the Hospital Anxiety and Depression sca...

The use of infrared thermography in dentistry has been minimal, principally due to technological inadequacies of previous thermal imaging systems. However, with the ever-developing advancement in technology, current systems are capable of producing real-time, highly sensitive digitized thermal images. This development has led to an increased use of...

Changes in bone temperature during the sequence of drilling for implant site preparation using the Branemark technique were monitored using infra-red thermography. Bovine mandibles were used to provide cortical bone of a similar quality to human mandibular bone. To ensure the consistency in the drilling procedure, one operator used a conventional d...

In this study the presence of mandibular tori was related to conditions associated with parafunctional activity. Parafunction in the form of tooth clenching or grinding has been associated with temporomandibular disorders (TMD) and recently migraine. Patients attending a facial pain clinic in Belfast were assessed for the presence of tori and resul...

Burning mouth syndrome is a common condition particularly affecting elderly women. Numerous precipitating factors are recognized that lead to a burning sensation in clinically normal mucosa. By taking each precipitating factor into account, a favorable treatment outcome usually can be achieved. This article highlights the significance of precipitat...

The various components of saliva, namely mixed saliva, parotid saliva, submandibular saliva, crevicular fluid and minor (labial) gland secretions, were collected from 63 known HIV antibody seropositive patients. A commercial test system, Wellcozyme HIV 1+2, and an antibody capture ELISA (GACELISA), were compared for sensitivity against all componen...

Electronic infrared thermography is an imaging modality for the accurate quantification of surface temperature. It has been used in medicine since the 1960s but its use in dentistry has been limited. Its use in dentistry could, however, be very useful, for example in objectively quantifying post-surgical inflammation and studying the effects of tre...

This study aimed to evaluate the relationship between the nocturnal wearing of an acrylic appliance of 2 mm thickness covering all occlusal surfaces of the teeth and the frequency of attacks of migraine. Nineteen patients were studied and all fulfilled accepted criteria for migraine with or without aura. Two appliance designs were employed, one cov...

This paper describes the results of a recent survey carried out under the auspices of the Professional Education and Evaluation Subgroup of the UK Working Group on Screening for Oral Cancer and Precancer. The aim of this survey was to assimilate information regarding currently used management options of potentially malignant oral lesions as a basis...

To use the technique of infrared thermography for non-invasive monitoring of temperature changes during polymerization of resin composite by measuring the infra-red emission from the surfaces of resin composite restorations during photocuring. In this study 10 patient volunteers had resin composite restorations placed in upper incisor teeth and dur...

To obtain baseline information on the prevalence of oral problems and disease in institutionalized elderly in a Scottish hospital. A cross-sectional clinical investigation with complementary microbiological studies as appropriate. A cohort of 147 elderly in five long-term care wards; collection of demographic data; clinical examination to determine...

Two cases of adult linear IgA disease (LAD) with oral and colonic involvement are presented. Oral findings, for both patients, were of widespread painful ulceration present for two to three months and diagnosis was confirmed by biopsy and direct immunofluorescence. Colonic symptoms preceded oral symptoms in both cases and a number of investigations...

We present a case of recurrent herpes labialis treated with acyclovir. The patient attended within 3 h of the onset of prodrome of the condition, when he appeared clinically normal. Electron infra-fred thermography of the face and lips was undertaken and demonstrated a significant sub-clinical local elevation in temperature of 1.7 degrees C at the...

This study investigated 84 patients with burning mouth syndrome (BMS), who were asked to complete a hospital anxiety and depression (HAD) scale questionnaire. A control group of 69 patients was also included. All patients were interviewed regarding parafunctional habits and were subjectively examined for signs of occlusal wear of the natural teeth...

The purpose of this study was to ascertain the applicability of infrared thermography to study the natural history of herpes labialis lesions. Since thermography is capable of detecting changes not visible to the naked eye, then it may be of value in complementing clinical examination of the various stages of herpes labialis. In addition, thermogra...

A prospective study was undertaken to assess the relationship between recrudescent herpes labialis and host iron status. Forty-one patients with recrudescent herpes labialis, proven by herpes simplex virus isolation, were studied along with an equal number of age-and-sex matched control subjects. The iron status of patients and controls were assess...

The recovery of proteolytic activity from human saliva was investigated using the Salivette system. Comparison of activity measurements with those obtained from whole saliva indicated that the Salivette system allowed increased recovery of proteolytic activity suggesting minimal enzyme binding to the cotton roll. The significance of these results i...

We report 12 cases of contact sensitivity to the flavouring agents menthol and peppermint oil in patients presenting with intra-oral symptoms in association with burning mouth syndrome, recurrent oral ulceration or a lichenoid reaction. The patients were referred from the Glasgow Dental Hospital over a 4-year period for assessment of the possible c...

One hundred sixty-one patients with a clinical diagnosis of an oral lichenoid reaction were evaluated serologically for circulating autoantibodies toward basal cell membrane components. The study group comprised 119 women and 42 men with a median age of 59 and 55 years, respectively. Most patients (n = 144) had an oral mucosal biopsy undertaken. Se...

Multiple mucoceles are an extremely rare condition in the oral cavity. We report a case which responded entirely to systemic gamma-linolenic acid but which recurred several months following discontinuation of therapy. Spontaneous resolution of the condition seems unlikely and it would appear that gamma-linolenic acid could have an effect on minor s...