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24
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Introduction
Skills and Expertise
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January 1991 - present
Publications
Publications (24)
Background/aim:
To evaluate the effectiveness of curative (chemo)radiotherapy in patients with nasopharyngeal carcinoma and to identify prognostic factors influencing treatment outcomes.
Patients and methods:
We conducted a retrospective study of 73 consecutive patients, treated with definitive (chemo)radiotherapy from 2002 to 2019 (median stage...
Endocrine therapy (ET) for the treatment of patients with hormone receptor-positive/human epidermal growth factor receptor 2-negative (HR-positive/HER2-negative) metastatic breast cancer (MBC) has changed markedly over recent years with the emergence of new ETs and the use of molecularly targeted agents. Cytotoxic chemotherapy continues, however, t...
Background and aims:
Metastases are a severe complication in cancer patients and biomarkers predicting their progression are still lacking for specific groups of patients. HER2 positive breast cancer (HER2 BC) patients on trastuzumab therapy are at risk of the development of unpredictable and often fatal central nervous system (CNS) metastases and...
Breast cancer care is organised independently (screening and diagnosis by radiologists; cancer treatment by oncologists in accredited Comprehensive Cancer Centers) in the Czech Republic. All experts cooperate closely and are members of multidisciplinary team. Central authorities (Ministry of Health, in cooperation with local, regional and national...
Introduction: We performed a prospective study of advanced HER2-positive breast cancer (HER2-aBC) patients in palliative Trastuzumab therapy. We studied the presence of circulating tumor cells in the peripheral blood and matrix metalloproteinase 2 (MMP-2), matrix metalloproteinase 9 (MMP-9) and vascular endothelial growth factor (VEGF) levels in th...
Background and aims:
Activation of RAGE due to its increased expression in cancer cells or its stimulation by multiple ligands (AGEs, HMGB1, S100 proteins, etc.) may contribute to the proliferation, invasiveness of tumor cells and formation of distant metastases and also to the resistance of cancer to treatment. RAGE ligands could thus become both...
Breast cancer is the leading cause of death among women, and its incidence increases with age. The average age at diagnosis is 61 years, and the majority of deaths occurs after the age of 65 years. Optimal approach to elderly women with breast cancer is still a major challenge. Elderly patients with cancer should have at least a brief geriatric ass...
Renal anomalies are quite a common medical condition thought to be genetically influenced. The subject of this work was to conduct molecular genetic analysis of two human renal agenesis causing candidate genes encoding the RET receptor thyrosin kinase and GDNF neutrophic factor. The mutational analysis of twenty RET exons and three GDNF exons in tw...
ABSTRACT Aim: To determine the impact of educational materials (EMs) on the treatment compliance of postmenopausal women with hormone receptor-positive (HR(+)) early-stage breast cancer.
Patients (n = 2757) were randomized to standard aromatase inhibitors (AI) alone (group A) or with EMs (group B) in a global, real-world setting.
The 2-year results...
Unlabelled:
Simultaneous detection of disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) was shown to be associated with an especially poor prognosis and increased incidence of disease-related deaths in non-metastatic breast cancer patients. We analyzed the occurance of DTCs and CTCs in patients with primary breast cancer and evalu...
Unlabelled:
Circulating tumor cells (CTCs) are an independent prognostic factor for patients with metastatic breast cancer (MBC). However, the role of CTCs in early breast cancer management is not yet clearly defined. The aim of this study was to assess the CTC-positivity rate in patients undergoing chemotherapy depending on breast cancer stage in...
Introduction:
Circulating tumor cells (CTCs) detection prior to and during therapy is considered as an independent and strong prognostic marker. The present study was designed to isolate and characterize CTCs in peripheral blood of an early breast cancer (BC) patient as a biomarker for monitoring treatments efficacy.
Materials and methods:
In to...
Background:
On the whole, most European and international guidelines recommend prophylactic use of granulocyte-colony stimulating factors (G-CSFs) when the risk of chemotherapy-induced febrile neutropenia (FN) in cancer patients exceeds 20%. In patients treated with intermediate-risk chemotherapy regimens the recent EORTC guidelines recommend to c...
Anti-VEGF therapy dramatically improved the outcome of patients with renal cancer and other advanced malignancies, but may be complicated by proteinuria and hypertension. VEGF is indispensable for the normal development of glomerulus and preservation of glomerular filtration barrier. Interference with its action may result in damage to glomerular e...
Breast cancer risk increases with age and about a third of female breast cancers are diagnosed in patients aged older than 70. Breast cancer in the elderly has, however, poorer outcome with lower survival rate compared to younger subjects. This may be partly explained by the delay in diagnosis and the ‘under-treatment’ of elderly breast cancer pati...
Metastatic spread of the primary tumour is responsible for the vast majority of cancer-related deaths. Detection of disseminated tumour cells in the bone marrow and circulating tumour cells in the peripheral blood is correlated with early metastatic relapse in breast cancer. Positive detection of disseminated tumour cells was associated with poor o...
The new millennium has been marked by the advent of biological targeted therapy in the treatment for breast cancer, which has gradually worked its way from a treatment for metastatic disease to adjuvant and, most recently, neoadjuvant indications. It meets the demands for individualization of treatment as it is intended for a small, well-defined gr...
The advancement in the systemic treatment of hepatocellular carcinoma (HCC) has improved prospects for the overall survival rate in patients with the advanced form of the tumour. In this overview, the new targeted therapy is set in the context of both traditional and the latest therapeutical methods, which include - besides liver transplant, partia...
The G-CSF was given to three patients, who were suffering from advanced generalised testicular tumors to accelerate the reparation of granulocytopenia induced by high dose myelotoxic chemotherapy. No side effects were noticed and the effect of G-CSF on the normalisation of the peripheral blood granulocytes count was significant. It has to be pointe...
