Paweł Siudem

Paweł Siudem
Medical University of Warsaw · Department of Organic and Physcial Chemistry

PhD

About

24
Publications
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182
Citations

Publications

Publications (24)
Article
Full-text available
Aronia (chokeberry, Aronia melanocarpa) is a valuable fruit that combines the health benefits of green tea and red wine and is gaining popularity worldwide. Aronia has a unique chemical composition with strong antioxidant properties, including anthocyanins and chlorogenic acids (CGAs). However, it remains unclear which specific compounds or groups...
Article
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The high content of bioactive compounds in Aronia melanocarpa fruit offers health benefits. In this study, the anti-atherosclerotic effect of Aronia extracts was assessed. The impact on the level of adhesion molecules and the inflammatory response of human umbilical vein endothelial cells (HUVECs) was shown in relation to the chemical composition a...
Article
Background. Vegetable oils play an important role in the food, pharmaceutical and cosmetic indus tries. They are not only a source of nutrients, but also a carrier of bioactive substances as an ingredient of creams or emulsions. Some oils, like extra virgin olive oil or argan oil, due to high consumer demand and high prices, may be subject to adult...
Article
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Natural products are the precursors of many medicinal substances. Peppers (Piper, Capsicum, Pimienta) are a rich source of compounds with potential multidirectional biological activity. One of the studied directions is antitumor activity. Little research has been carried out so far on the ability of the compounds contained in peppers to inhibit the...
Article
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Turmeric is a traditional Indian spice that has recently become very popular worldwide because it contains a powerful ingredient called curcumin, which has strong anti-inflammatory properties. Hence, dietary supplements containing extracts rich in curcumin have gained great popularity. The main problems related to curcumin-containing dietary supple...
Article
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Turmeric is a strong-taste component of spices characteristic of Indian cuisine. It is obtained from the turmeric rhizome (Curcumae longae rhizoma) and has been used for thousands of years not only for culinary purposes, but also for medicinal purposes. It contains a group of organic compounds called curcuminoids. Curcumin is the main representativ...
Article
Hemp oil is widely used in the food industry, and also in many other industries. It is characterized by a high content of unsaturated fatty acids with the optimal ratio of ω-6 to ω-3 fatty acids (3:1). Such composition means that this oil is often used in the food, pharmaceutical and cosmetic industries. Due to the popularity of hemp oil and its hi...
Article
The fatty acid composition is a parameter that determines the quality and origin of vegetable oils. The standard method used in the analysis of fatty acid composition is gas chromatography (GC). In the last 20 years, however, the ¹H NMR method has become more important in the analysis of fatty acids. Thanks to no need of special sample preparation,...
Article
Energy drinks (EDs) are widely consumed to stimulate psychomotor functions and improve the efficiency of the human body. They typically contain caffeine, taurine, sugars or sweeteners, vitamins and organic acids. EDs were selected for the study in terms of composition diversity, reflecting the variety of products available on the Polish market. The...
Article
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The problem of the SARS-Cov-2 coronavirus pandemic currently affects all people on earth. Numerous scientific studies focus on the possibilities of inhibiting the development of the disease, alleviating its course and modifying the immune response. The pro-inflammatory cytokines produced in the body in the course of the disease play an important ro...
Article
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Two new spirostanol sapogenins (5β-spirost-25(27)-en-1β,2β,3β,5β-tetrol 3 and its 25,27-dihydro derivative, (25S)-spirostan-1β,2β,3β,5β-tetrol 4) and four new saponins were isolated from the roots and rhizomes of Convallaria majalis L. together with known sapogenins (isolated from Lilia-ceae): 5β-spirost-25(27)-en-1β,3β-diol 1, (25S)-spirostan-1β,3...
Article
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Autism is a spectrum of neurodevelopmental disorders. Manifestations of autism include behavior problems (hyperactivity, self-harm, aggression), sleep and eating disorders. Etiology of autism is poorly understood. Oxidative stress can participate in biochemical mechanisms of autism. Evidence indicates beneficial effects of treatment with plant diet...
Article
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Przyprawy stanowią istotny składnik diety. Ostra papryka jest powszechnie używana jako przyprawa kuchenna. Korzyści z jej stosowania wiążą się nie tylko z walorami smakowymi, ale także z pozytywnym wpływem prozdrowotnym. Jest to związane ze związkami polifenolowymi oraz innymi związkami o właściwościach przeciwutleniających zawartymi w owocach ostr...
Article
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The TRPV1 receptor (transient receptor potential cation channel subfamily V member 1) is a non-selective cationic channel activated by vanilloids like capsaicin. Therefore, TRPV1 is also called a capsaicin’s receptor, which is a spicy substance found in chili peppers. The receptor is located in sensory nerve fibers and non-neuronal cells, for examp...
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Aronia melanocarpa (Michx.) Elliott's (chokeberry) besides anthocyanins contains significant amounts of hydroxycinnamic acids: Chlorogenic and its isomer neochlorogenic acid. They exhibit antioxidant, anti-inflammatory, antidiabetic, and antibacterial activities, thus they can have a significant impact on the health-promoting properties of Aronia....
Article
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Capsaicinoids are alkaloid type capsaicin analogs with prospective pharmacological activity. However their solid state conformations have not been studied yet. As part of the study, cross polarization (CP) magic angle spinning (MAS) solid state 13 C and 15 N NMR spectra of dihydrocapsaicin (DHCAP) and nonivamide (NVA) were recorded. Solid state che...
Article
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Ostropest plamisty (Silybum marianum) jest rośliną leczniczą, która tradycyjnie wykorzystywana była w choro-bach wątroby. Początkowo spożywano sproszkowane owoce roślinne lub sporządzano z nich napary. W obecnych czasach leki roślinne są standaryzowane na zawartość kompleksu flawonolignanów sylimaryny. Zastosowanie medyczne potwierdza Farmakopea Po...
Article
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Papryka, zwana inaczej pieprzowcem rocznym (Capsicum annuum) jest warzywem cenionym przez konsumentów ze względu na właściwości biologiczne i specyficzny, ostry smak. Jest ona ważnym źródłem witaminy C, E i prowitaminy A, ponadto zawiera witaminy z grupy B, szczególnie B1 i B2 oraz PP, białko, kwasy organiczne i znaczną ilość cukrów. Pieprzowiec ro...
Article
Since Cannabis species include psychoactive varieties containing high levels of Δ9-tetrahydrocannabinol (THC), psychotropic properties could be wrongly attributed to hemp-seed oil obtained from Cannabis sativa. Hemp oil does not exert any psychotic effect; on the contrary, it may provide significant health benefits, because it has an optimum propor...
Article
SUMMARY Introduction. Because of high concentration of monounsaturated and polyunsaturated fatty acids plant oils are increasingly popular ingredient of daily diet. Polyunsaturated fatty acids, which are not synthetized in the human body, are particularly important, because they are necessary for regular functioning of nervous and cardiovascular sy...
Article
Capsaicin produced by plants from genus Capsicum exerts multiple pharmacological effects and has found applications in food and pharmaceutical industry. The alkaloid was studied by a combined approach: solid-state NMR, GA conformational search and GIAO DFT methods. The ¹³C CPMAS NMR spectra were recorded using variable contact time and dipolar deph...
Article
Bisphenol A (BPA) acts as an endocrine-disrupting compound even at a low concentration. Degradation of BPA could lead to the formation of toxic products. In this study, we compare the toxicity of BPA and seven intermediate products of its degradation. The accuracy of three molecular docking programs (Surflex, Autodock, and Autodock Vina) in predict...
Article
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Aktualnie obserwuje się duży nacisk opinii społecznej na legalizację medycznych zastosowań marihuany, czyli szczytowych części roślin bogatych w tetrahydrokannabinol (THC). Tymczasem, w konopiach Cannabis sativa L zidentyfikowano ponad 500 związków, w tym ponad 80 różnych kannabinoidów, między innymi kannabidiolu (CBD). Bardzo obiecujące są potencj...

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