Pandurang appana Dalavi

Yenepoya University · Yenepoya Research Centre

Due to the limitations of the current treatment approaches of allograft and autograft techniques, treating bone disorders is a significant challenge. To address these shortcomings, a novel biomaterial composite is required. This study presents the preparation and fabrication of a novel biomaterial composite scaffold that combines poly (D, L-lactide...

Glioblastoma is the most common lethal form of malignant tumor that arises from the central nervous system. The present-day therapeutic strategies possess their own pros and cons. Hence, there is a need to look back into the traditional medicines that could be potential agents to treat glioblastoma. One of the potential approaches in anticancer the...

Dental caries is a common problem in adolescents, leading to permanent loss of teeth or cavitation. Caries is a continuous process wherein demineralization and remineralization occur regularly. Hydroxyapatite (HA) is one of the most biocompatible and bioactive materials, as it closely resembles the mineral composition of teeth. The present study de...

Biomimetic materials for better bone graft substitutes are a thrust area of research among researchers and clinicians. Autografts, allografts, and synthetic grafts are often utilized to repair and regenerate bone defects. Autografts are still considered the gold-standard method/material to treat bone-related issues with satisfactory outcomes. It is...

Defects and disorders of the bone due to disease, trauma, or abnormalities substantially affect a person's life quality. Research in bone tissue engineering is motivated to address these clinical needs. The present study demonstrates casein-mediated liquid exfoliation of molybdenum disulfide (MoS2) and its coupling with alginate to create microsphe...

Nanoparticles play a significant role in the development of pharmaceuticals. In the present study, gold nanoparticles (AuNPs) were synthesized using the microwave irradiation method and evaluated their cytocompatibility and antioxidant properties. Saussurea obvallata plant extract was used as a reducing agent to prepare AuNPs. The UV–visible spectr...

Significant development has been achieved in searching the biocompatible biomaterials for various biological and biomedical applications. For example, Chitooligosacchairdes (COS), the derivative of chitosan, is a water-soluble natural cationic biopolymer that has been extensively used for biological, tissue engineering, and drug delivery applicatio...

Tissue engineering has recently gained much attention in developing artificial tissue to repair and replace defective or diseased tissue/organs. Materials, cells, and growth factors play an important role in constructing artificial tissue. Materials can be derived through synthetic as well as the natural source, which can act as an extracellular ma...

In recent years, enormous research has been carried out on the utilization of polysaccharides-based nanoparticles for biomedical applications including biosensors, drug delivery, wound healing, and tissue engineering. These polysaccharides nanoparticles include chitosan, alginate, and starch that are gaining much attention due to abundant, biocompa...

About 2.2 million bone graft operations are performed per year worldwide to treat bone defects caused by motor defects, congenital disabilities, bone tumors, and other causes. Autografts, allografts, and synthetic grafts are widely used for bone graft substitutes. Even though autograft is the gold standard for treating bone defects, there is a prob...

Clinically, implant-related bone infections are a serious concern as they reduce the success rate of grafting techniques and increases the risk of morbidity. Clinicians use antibiotics to treat bone grafts. Silver-based components are gaining popularity for their exceptional antimicrobial activity. The current review provides the preparative proced...

Finding a novel bioactive bone graft substitute is an emerging area of research for all the time to overcome the traditional bone graft procedures. Bone graft substitute, which induces osteogenesis, is considered suitable graft material in orthopedic clinical practice. Different kinds of biomaterials are used to develop bone grafts using polymers,...

Silver nanoparticles (AgNPs) have gained much attention in the treatment of dental caries due to their excellent antimicrobial activities. In this study, we have biosynthesised chitooligosaccharide coated silver nanoparticles (COS-AgNPs) using a rapid microwave-assisted method. The physical and chemical characterisations of biosynthesised COS-AgNPs...

Drug delivery system (DDS) has the ability to enhance the efficiency of the conventional drugs which are commonly suffers in lower bioavailability in human body. Recently, marine polysaccharides such as alginate and chitosan are gaining much attention in DDS due to their unique properties such as biocompatible, biodegradable, non-toxic, pH sensitiv...

Scaffolding system plays an important role in the development of artificial bone for treatment of defective or diseased bone tissue. In the present work, we have developed microspheres (COS-Ag-Alg-HA) containing chitooligosaccharide (COS) coated silver nanoparticles (Ag NPs) with alginate (Alg) and hydroxyapatite (HA) as bone graft substitutes. The...