Orysya Svystun

University of Alberta | UAlberta

Purpose: CT colonography (CTC) has been accepted as an optical colonoscopy (OC) alternative for colorectal cancer (CRC) screening by some guidelines, while others maintain that the data is insufficient. CTC’s less invasive nature may improve compliance; however, cost and need for colonoscopy, if lesions are detected, remain an obstacle for implemen...

Objectives The sensitivity and specificity of computerized tomographic colonography (CTC) has approached that of (OC). This has led to the acceptance of CTC as an alternative for colorectal cancer screening by some guidelines. CTC’s less invasive nature and lower risk of complications may improve compliance and in turn patient outcomes; however, co...

Objectives: To describe indications for injection augmentation (IA), endoscopic repair (ER) and conservative methods for the management of type 1 laryngeal cleft (LC1) and propose a management algorithm. We also aimed to compare success of IA and ER and determine independent predictors of treatment failure. Methods: Retrospective study of patien...

Background: The function of the Ras association domain family 1 (RASSF1)/modulator of apoptosis 1 (MOAP-1) molecular tumor suppressor pathway is often perturbed in many solid and blood cancers by epigenetic loss of RASSF1A via promoter specific methylation. However, a detailed analysis of expression and stability of MOAP-1 as well as effect on cell...

Objective: The function of the Ras association domain family 1 (RASSF1)/modulator of apoptosis 1 (MOAP-1) molecular tumor suppressor pathway is often perturbed in many solid and blood cancers by epigenetic loss of RASSF1A via promoter specific methylation. However, a detailed analysis of expression and stability of MOAP-1 as well as effect on cellu...

Acute pancreatitis is an increasingly common condition and can result in significant morbidity and mortality. Contrast enhanced computed tomography (CECT) is the primary initial imaging modality in the characterization of acute pancreatitis. In this article, we provide sample CECT technical acquisition parameters for pancreatic imaging. We also rev...

Background and objectives: Remediation in residency is expensive; however, most research has focused on general approaches to remediation, with minimal investigation into whether there are patterns to the competencies or rotations that are most difficult for residents. Acquiring this information may improve future physician training and potentiall...

MOAP-1 is a pro-apoptotic tumor suppressor molecule with a growing set of known interacting partners. We have demonstrated that during death receptor-dependent apoptosis, MOAP-1 is recruited to TNF-R1 or TRAIL-R1, followed by RASSF1A and Bax association. MOAP-1/Bax association promotes Bax conformational change resulting in the translocation of Bax...

Objective Whereas the literature is replete with reports on complex children with dysphagia (DP), the parameters characterizing non-neurologically impaired (NNI) children have been underreported, leaving a substantial knowledge gap. We set to characterize a consecutive cohort of NNI children, their management, and outcomes. Methods We undertook a...

Background: MOAP-1 is a pro-apoptotic protein. Results: MOAP-1 expression is reduced in cancers and high expression correlated with increased patient survival. MOAP-1 can associate with tubulin and modulate tubulin stability. Furthermore, loss of the BH3 domain of MOAP-1 resulted in lack of tumor suppressor function. Conclusion: MOAP-1 is a highly...