Nilay Cöplü

Kastamonu University, School of Medicine, Kastamonu, Turkey. · Department of Microbiology

Background Herbaspirillum species are nonfermenting, aerobic, helical or curved, Gram-negative bacteria belonging to the class Betaproteobacteria, order Burkholderiales. To date, only a few studies have reported on the epidemiology, clinical symptoms, antibiotic susceptibility profiles, treatment and outcomes of Herbaspirillum huttiense -related in...

Introduction: Our aim was to determine the change in antibody response against COVID-19 over time and estimate the duration required for it to decrease to the threshold of the ELISA test in patients with a positive COVID-19 RT-PCR test. The purpose was to present data for epidemiological measures related to the risk of reinfection or the need for b...

Introduction: Carbapenem resistance generally emerges from carbapenemase production in Acinetobacter baumannii isolates. It is known that prognosis is adversely affected, and mortality rate increases in infections caused by Metallo-beta-lactamase (MBL) type carbapenemase-producing isolates. This study aimed to investigate MBL production in carbapen...

Aim: This study purposed to determine anti-spike IgG levels at the fourth week after the second dose in healthcare workers (HCWs) who had two doses of the CoronaVac vaccine (Sinovac Life Sciences, Beijing, China). The second purpose of the study was to evaluate several factors that may affect antibody levels. Material and Method: The study was perf...

Objective: The aim of this study was to monitor the time-dependent change by evaluating the antibody levels at the 4th, 7th, 10th, 13th, and 16th weeks after the second dose of the CoronaVac vaccine. Methods: The study group (n=65) were between 21 and 60 years old and received two doses of the CoronaVac vaccine. Blood samples were collected afte...

Nosocomial infections occur 48-72 hours after hospitalization, especially caused by bacteria, and pose a high risk for patients in intensive care units (ICUs), including COVID-ICUs. This study aimed to reveal bacteria distribution and antibiotic susceptibility profiles isolated from various clinical samples of non-COVID-ICU and COVID-ICU patients....

Introduction COVID-19 infection develops neurologic symptoms such as smell and taste loss. We aimed to determine the volumetric changes in the brain and correlation of possible related biochemical parameters and endocannabinoid levels after COVID-19 recovery. Methods Brain magnetic resonance images of recovered COVID-19 patients and healthy volunt...

Aim In this study it was aimed to evaluate the prognostic factors for the geriatric patients with confirmed COVID-19 in a tertiary-care hospital at Kastamonu region of Turkey. Method Patients (≥65-year-old) who had PCR positivity for COVID-19 between March 2020 and April 2020 in our center were recorded retrospectively. A p value less than 0.05 wa...

Introduction: Detecting Pseudomonas aeruginosa strains producing extended-spectrum beta-lactamase (ESBL) in the hospital setting and taking necessary precautions against them is important for infection control and public health. This study aimed to investigate PER-1 and OXA-10-like ESBLs production frequency in ceftazidime-resistant P. aeruginosa o...

The Coronavirus-19 pandemic continues at full speed, and the number of patients who die from Covıd-19 is increasing. It was aimed to evaluate the demographic information and laboratory findings of 86 patients who died while being followed up in our hospital with a pre-diagnosis of Covıd-19. Identifying these characteristics of deceased patients wil...

Introduction: Nontuberculous Mycobacteria (NTM) infections have recently increased significantly in the world. Especially, lung diseases caused by various NTM are noteworthy. Susceptibility to antimicrobials can vary greatly by species, geographic region and time for NTMs. In this study, it was aimed to determine the resistance percentages of antim...

Aim: Today, increasing antibiotic resistance has focused the science world on the discovery of new antimicrobial molecules or the development of alternative methods of struggle. One of the alternative methods is thought to be inhibition of bacterial quorum sensing (QS). Because the QS system performs a crucial part in the synthesis of virulence fac...

Objective: Antimicrobial resistance is a growing problem worldwide, and to combat with this problem some measures should be taken. One of them is analysis of current situation and National Antimicrobial Resistance Surveillance System (NAMRSS) was established for this purpose. The quality of the data depends on the participating laboratories perform...

Objective: Infections of the urinary tract are included among the most common infections globally, and the most frequently seen pathogen is Escherichia coli. Nitrofurantoin, trimethoprim-sulfamethoxasole and fosfomycin are recommended as the first choice antibiotics for urinary system infections according to the guideline prepared by Infectious Dis...

Objective: National Antimicrobial Resistance Surveillance System (NAMRSS) was established aiming to determine and track the percentage of antimicrobial resistance in Turkey, and in order to assure the reliability of the system, an external quality assurance laboratory proficiency assessment was performed in September 2011, for the first time. Metho...

Establishment of sustainable and evidence-based surveillance systems are recommended for prevention of microbial resistance by the World Health Organization (WHO). As a necessity of these surveillance systems, participants are recommended to implement an external quality assessment (EQA) program. In this scope, National Antimicrobial Resistance Sur...

Establishment of sustainable and evidence-based surveillance systems are recommended for prevention of microbial resistance by the World Health Organization (WHO). As a necessity of these surveillance systems, participants are recommended to implement an external quality assessment (EQA) program. In this scope, National Antimicrobial Resistance Sur...

stablishment of sustainable and evidence-based surveillance systems are recommended for prevention of microbial resistance by the World Health Organization (WHO). As a necessity of these surveillance systems, participants are recommended to implement an external quality assessment (EQA) program. In this scope, National Antimicrobial Resistance Surv...

Pertussis continues to cause significant mortality and morbidity in many countries despite high vaccine coverage, especially among young infants. The aim of the study was to determine pertussis antibody levels in paired maternal and cord blood samples, to evaluate the placental transfer of these antibodies, and to assess whether newborn infants hav...

Pertussis is a vaccine-preventable disease that is transmitted from infected to susceptible individuals by respiratory route. Bordetella pertussis infection may occur at any age as neither vaccine nor natural infection induced immunity lasts life-long. This study was planned to demonstrate the serological evidence of infection among adults, to rais...

Carbapenems are the choice of treatment in infections caused by multidrug resistant Enterobacteriaceae. In recent years carbapenem-resistant Enterobacteriaceae isolates due to carbapenemases have been increasingly reported worldwide. Multicenter studies on carbapenemases are scarce in Turkey. The aim of this study was to determine the distribution...

Objective: Due to the increase in of the antimicrobial resistance problem, in our country, the studies to establish National Antimicrobial Resistance Surveillance System (NAMRSS) was started. It is important to provide reliable data for the laboratories those will be included in NAMRSS. For this purpose, a questionnaire was applied to evaluate the...

Pertussis is a life-threatening, vaccine-preventable infection. Adults who can be asymptomatic may infect infants. The aim of this study is to determine the IgG antibody levels against pertussis toxin (PT) and filamentous hemagglutinin from 6 months to ≥60 years in Izmir, Turkey. A cluster sample design developed by Expanded Programme on Immunizati...

OBJECTIVE[|]This study aims to investigate the conditions and the factors affecting clinicians in prescription of antibiotic medicines. In this way, some of the policies to combat with the development of antibiotic resistance will be appointed and the measurement of the efficiency of the measures would be possible.[¤]METHODS[|]For the study, 8 prov...

Bu çalışmada, S.B. Dışkapı Yıldırım Beyazıt Eğitim ve Araştırma Hastanesi Klinik Mikrobiyoloji Laboratuvarı’na Ağustos 2010-Mart 2011 tarihleri arasında farklı kliniklerden gönderilen örneklerden izole edilen 199 enterokok cinsi bakteri tür tayini ve antibiyotik duyarlılıkları yönünden değerlendirilmiştir. Enterokokların identifikasyonu ve antibiyo...

The aim of this study was to determine whether vancomycin resistant Staphylococcus aureus (VRSA) and vancomycin intermediate susceptible S.aureus (VISA) strains were present among methicillin-resistant S.aureus (MRSA) strains isolated from patients hospitalised at intensive care units (ICU) of hospitals located at different regions of Turkey and to...

The aim of this study was to investigate the presence of extended spectrum beta-lactamase (ESBL), KPC-type carbapenemase and plasmid-mediated AmpC beta-lactamase (pAmpC) which have increased in incidence in recent years in Escherichia coli and Klebsiella pneumoniae strains isolated from the blood samples causing serious infections. Ninety nine E.co...

Pertussis is a respiratory infection caused by Bordetella pertussis. It attacks all age groups. It has significantly higher mortality and morbidity among newborns and children. Adolescents and adults with symptomatic but unrecognized pertussis are often the source of the infection for pediatric cases. Therefore, it is suggested to perform laborator...

Lyme disease or lyme borreliosis is a zoonosis caused by Borrelia burgdorferi transmitted by ticks, especially Ixodes species. Lyme borreliosis is a multi-systemic disease that invades the skin, musculoskeletal, cardiovascular and central nervous systems. Tick-borne encephalitis (TBE) is an important arboviral infection caused by tick-borne encepha...

Aim: The Haemophilus influenzae type b (Hib) vaccine was introduced into the routine immunization schedule in Turkey on January 1, 2007. This study investigates the immunity to Hib prior to the introduction of the vaccine. Materials and methods: Serum samples were collected from healthy volunteers between the ages of 6 months and 50 + years of age,...

Objectives: The aim of this study was to evaluate the seropositivity of rickettsial infections (rickettsioses) and to as-sess risky behaviors for rickettsioses in North Anatolia, which have dense tick population. Materials and methods: Blood samples of 409 voluntary participants were collected in a cross-sectional seroprevalence research in Samsun...

Serological methods are widely used for the laboratory diagnosis of syphilis or for screening purposes. The aim of this study was to determine an algorithm for the application of laboratory tests that will provide accurate diagnosis of syphilis in a cheap, fast and practical way. A total of 162 serum samples were evaluated by the following tests: V...

The aim of this community-based seroepidemiological survey was to assess the immune status against pertussis among the healthy population in three selected provinces with different geographical and socioeconomical status (Antalya, Diyarbakir and Samsun, located at Mediterrenean, Southeast Anatolia and Black Sea regions of Turkey, respectively) in r...

The aim of this study was to evaluate the existence and the rate of pertussis infection in December 2002 among the symptomatic contacts in Konurhaciobasi village of Kirikkale province (placed in middle Anatolia, Turkey, with a population of 500 people), where a laboratory-confirmed pertussis case was defined by culture positivity. Sixty contacts wi...

Older children, adolescents and adults with prolonged cough should be screened for pertussis, because they can be a major source of transmission for infants who are not yet fully immunized. This study aimed to estimate the incidence of pertussis among schoolchildren of 6-14 years old with prolonged cough attending two government primary schools in...

In coproparasitological examination, there is need to perform concentration methods in order to increase the probability of finding helminth eggs and protozoa cysts in addition to the widely used direct examination, especially when they are low in number. In this study, seven concentration methods were investigated on 134 fecal specimens as to thei...

The treatment of multidrug resistant tuberculosis (MDR-TB) requires the use of minor antituberculosis drugs, thus susceptibilities against these minor drugs should be performed. The aim of this study was to establish and standardize the susceptibility testing methods for minor antituberculosis drugs in this laboratory and to obtain data about the r...

Immune response against pertussis can be induced by infection and/or vaccination and vaccine induced immunity is known to wane within the decade following vaccination. Our aim was to assess the pertussis immune response among adolescent girls in the province of Edirne in Turkey. In addition we determined the relationship between the immune response...

Seroepidemiological studies need sensitive, practicle and cost-effective methods. For pertussis serosurveillance, an in-house ELISA for antipertussis-toxin (PT) and anti-filamentous-hemagglutinin (FHA) were established in our laboratory and compared by a Ball-ELISA which had been reported to be reliable previously. Sixty sera with various antibody...

We conducted a cross-sectional survey in a cellulose plant among 109 reed workers, exposed to reed dust and 78 unexposed office workers, to investigate respiratory health effects of reed dust exposure. Investigations included dust measurements, serum total IgE, skin prick test, pulmonary function testing and questionnaire on respiratory symptoms. T...

H. influenzae is a fastidious bacteria, so the selection of a reliable method for in-vitro susceptibility tests is particularly important. The E-test is a practical method for detecting in-vitro antimicrobial susceptibility of antibiotics by MIC values. This study was performed using the E-test for direct patient management and in order to obtain e...

Using a broth microtiter dilution method, the minimum inhibitory concentrations of antipseudomonal antibiotics were determined against 19 P. aeruginosa isolates. Two different concentration of inoculum, 10(5) and 10(8), were used to show the inoculum concentration effect of in vitro antibiotic susceptibility tests. On the basis of the MIC values an...