Nesrin Sharif

Johannes Gutenberg-Universität Mainz | JGU

Spontaneous neuronal replacement is almost absent in the postnatal mammalian nervous system. However, several studies have shown that both early postnatal and adult astroglia can be reprogrammed in vitro or in vivo by forced expression of proneural transcription factors, such as Neurogenin-2 or Achaete-scute homolog 1 (Ascl1), to acquire a neuronal...

The transactivator of transcription protein, HIV‐1 Tat, is linked to neuroAIDS, where degeneration of dopamine neurons occurs. Using a mouse model expressing GFAP‐driven Tat protein under doxycycline (Dox) regulation, we investigated microglial‐neuronal interactions in the rostral substantia nigra pars compacta (SNc). Immunohistochemistry for micro...