Nemany Abdelhamid Nemany Hanafy

Nanoscience and Nanotechnology Institute, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt · Nano-medicine

Bee pollen extract (BPE)-based polymer nanoparticles (BPENP) were fabricated using bovine serum albumin (BSA) and targeted with folic acid and were further characterized. Mice groups are: Group 1 received saline, whereas Groups 2, 3, 4, 5, and 6 received a single dose of urethane, followed by weekly injections of butylated hydroxy-toluene (BHT). Af...

The objective of this study is to activate autophagy in hepatocellular carcinoma for the enhancement of its cellular degradation. Liposomes incorporated chitosan in the core used to improve the stability of lecithin and increase the niacin loading efficiency. Additionally, curcumin as a hydrophobic molecule entrapped into liposomal layers and used...

This study aimed to overcome the poor solubility of pterostilbene (PTS) by developing promising reconstituted proethoniosomes (PENs). The reconstituted PENs loaded with PTS were fabricated according to a 23 factorial design by Design-Expert® software. The prepared ethoniosomes were assessed for entrapment efciency (EE %) and % PTS released after 24...

The migratory process is a highly organized, differentiated, and polarized stage by which many signaling pathways are regulated to control cell migration. Since the significant evidence of migrating cells is the reorganization of the cytoskeleton. In the recent study, the cell migration model was assessed on the fact that any disruption obtained in...

Bee pollen extract (BPE)-based polymer nanoparticles (BPENP) were fabricated by using bovine serum albumin (BSA) and targeted with folic acid and were further characterized. Mice groups are : Group 1 received saline, whereas Groups 2, 3, 4, 5, and 6 received a single dose of urethane, followed by weekly injections of butylated hydroxy-toluene (BHT)...

As fluorescence parameters such as lifetime, quantum yield, anisotropy and polarisation quantum are extremely sensitive to fluorophores' microenvironmental changes, changes in the properties of the fluorescence probe have been widely used to study hydrophobic interactions in protein and membrane biology. The current study determines the critical mi...

To avoid the harmful side effects of cetuximab and improve its therapeutic efficacy, egg serum albumin (ESA) was used as a targeting drug carrier moiety for cancer therapy against Caco-2 colon cancer cells. The simple improved desolvation method was used to synthesize ESA nanoparticles (ESA-NPs) and cetuximab-loaded albumin nanoparticles (CET-ANPs)...

Carbon quantum dots (CQDs) derived from natural sources have obtained potential interest in biomedical imaging and therapy because of their excellent biocompatibility properties, which include water solubility, simple synthesis and low cytotoxicity. Here the cytotoxicity of ethylene‐diamine doped carbon quantum dots (N‐CQDs) delivered to breast can...

Bee pollen extract (BPE) based polymer nanoparticles (BPENP) were fabricated in the current study by using bovine serum albumin (BSA) and the complex was then coated by folic acid conjugated protamine to be targeted for cancer cells. Spectroscopic and microscopic methods were used to characterize the resultant nanoparticles. High flavonoid and poly...

Fungi have a great ability and a wide variety of mechanisms to endure the toxicity of current antifungal agents. Researchers are working to find new therapeutic agents to combat the resistance ability of fungi. Almost all commercial antifungal agents have a wide variety of side effects on human health. This study aims to introduce tea tree oil nano...

Curcumin (CUR) nanomicelles were developed by solvent-evaporation method using Poly (lactic acid) (PLA) for the first time with Pluronic F127 (PF127) to produce CUR@PLA@PF127 nanomicelles. The X-ray diffraction (XRD) spectra confirmed the encapsulation of CUR into the produced nanomicelles (CUR@PLA@PF127). Fourier transform infrared spectroscopy (F...

Non-small cell lung cancer (NSCLC) is an important sub-type of lung cancer associated with poor diagnosis and therapy. Innovative multi-functional systems are urgently needed to overcome the invasiveness of NSCLC. Carbon quantum dots (CQDs) derived from natural sources have received interest for their potential in medical bio-imaging due to their u...

Hepatic fibrosis (HF) is a major cause of liver-related disorders and together with cancer-associated fibroblasts can favor liver cancer development by modulating the tumor microenvironment. Advanced HF, characterized by an excess of extracellular matrix (ECM), is mediated by TGF-β1, that activates hepatic stellate cells (HSCs) and fibroblasts. A T...

Bisphenol A (BPA) is an xenoestrogenic chemical used extensively in the fabrication of baby bottles, reusable plastic water bottles and polycarbonate plastic containers. The current study aims to investigate the hepatoprotective activity of Moringa oleifera Lam leaf extract (MOLE) and hydrogel NPs made of starch-MOLE-Bovine Serum Albumin (BSA) agai...

Apigenin (Ap) is one of the most important natural flavonoids that has potent anticancer activity. This study was designed, for the first time, to load Ap into chitosan to improve its hydro-phobicity and then it was coated with albumin-folic acid to increase its stability and bioavailability and to target cancer cells. The newly developed encapsula...

Curcumin (CUR) is a natural hydrophobic compound, which is available in turmeric rhizome. It has several bioactivities including antioxidant, anti-obesity, anti-diabetic, cardioprotective, anti-inflammatory, antimicrobial, anticancer, and other activities. Despite its medical and biological benefits, it is using in limitations because of its hydrop...

Lung cancer is the most common cause of cancer death worldwide. Thereby, new treatment strategies as targeting nano-therapy present promising possibilities to control the aggressiveness of lung cancer. Dual CD44 and folate receptors targetable nanocapsule based on folic-polyethylene glycol-hyaluronic (FA-PEG-HA) were fabricated to improve the thera...

Respiratory infected by COVID-19 represents a major global health problem at moment even after recovery from virus corona. Since, the lung lesions for infected patients are still sufferings from acute respiratory distress syndrome including alveolar septal edema, pneumonia, hyperplasia, and hyaline membranes Therefore, there is an urgent need to id...

Many reports have been published recently confirmed the limitation of cargo molecules delivered into the heart. This failure is mostly associated with lymphatic or vascular channels washing or to the immune system recognition. Delivery of anthocyanins by encapsulation may augment it retention in the heart at early time points as the capsules are to...

The introduction of nanoparticles made of polymers, protein, and lipids as drug delivery systems has led to significant progress in modern medicine. Since the application of nanoparticles in medicine involves the use of biodegradable, nanosized materials to deliver a certain amount of chemotherapeutic agents into a tumor site, this leads to the acc...

Transforming growth factor-beta (TGFβ1) is considered as a master regulator for many intracellular signaling pathways, including proliferation, differentiation and death, both in health and disease. It further represents an oncogenic factor in advanced tumors allowing cancer cells to be more invasive and prone to move into the metastatic process. T...

Background Silver nanoparticles (AgNPs) have anti-cancer effects with fewer side effects than standard chemotherapeutic agents, however, they exert oxidative stress-based adverse effects on normal cells and so their applications have raised concern about possible health and environmental risks.Objective We evaluated whether green tea extract (GTE),...

Transforming Growth Factor (TGF-β1) is a multifunctional cytokine belonging to the Transforming Growth Factor superfamily. It can be secreted by many cell types and has main role in cell proliferation and differentiation. In this mini review, TGFβ1 was addressed.

Hydrogel-based polymers are represented by those hydrophilic polymers having functional groups in their chain such as amine (NH 2), hydroxyl [-OH], amide (-CONH- ,-CONH 2), and carboxyl [COOH]. These hydrophilic groups raise their potential to absorb fluids or aqueous solution more than their weights. This physicochemical mechanism leads to increas...

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Hydrogels are widely used materials which have many medical applications. Their ability to absorb aqueous solutions and biological fluids gives them innovative characterizations resulting in increased compatibility with biological activity. In this sense, they are used extensively for encapsulation of several targets such as biomolecules, viruses,...

Glucose consumption in many types of cancer cells, in particular hepatocellular carcinoma (HCC), was followed completely by over-expression of type II hexokinase (HKII). This evidence has been used in modern pharmacotherapy to discover therapeutic target against glycolysis in cancer cells. Bromopyruvate (BrPA) exhibits antagonist property against H...

Gold nanoparticles (AuNPs) have obtained interest of scientists for many years. Their features exhibit enhanced optical and electromagnetic properties. For this reason, they are mostly applied for biomedical diagnosis and imaging. Besides that, they are being functionalized as a drug delivery system due to their small size. Since, this size gives t...

Silver nanoparticles exhibit great potential applications as anti microbial agents due to their strong inhibition for microbial growth. However, they can be used with drug delivery system in limitation. Nicked silver nanoparticles can produce free radical causing later mitochondrial dysfunction allowing initialing apoptotic process. In this review,...

The modern nanotechnology has proven its ability to solve most issues associated with drug administrations. Encapsulated drugs can be reached the site of reaction with much controllable. Further, their circulation can be prolonged in blood stream with no dilution for their certain concentration. With these desirable characterizations, drug encapsul...

Transforming growth factors (TGF-β) as a multifunctional cytokine can control proliferation, cellular differentiation, and other functions in most cells. Although many therapeutic strategies had been developed, they are used in limitation related to their complications on healthy cells. Our aim was to encapsulate TGF-β blockers inside moieties of c...

Although curcumin has many biological activities like antioxidant, anti-inflammatory, anti-tumorigenic anti-coagulant, anti-bacterial and anti-carcinogenic agents it is not widely used for cancer treatment because of its poor aqueous solubility, low adsorption, rapid metabolism and finally it is very sensitive to light. A strategy to encapsulate it...

Micelles as colloidal suspension have attracted considerable attention due to their potential use for both cancer diagnosis and therapy. These structures have proven their ability to deliver poorly water-soluble anticancer drugs, improve drug stability, and have good penetration and site-specificity, leading to enhance therapeutic efficacy. Micelle...

The significant step in CaCO3 fabrication is to obtain homogenous population. There is a wide application in biomedical and industry market, since many reports have been investigated possible control of its diameter and shape during fabrication. Nowadays, CaCO3 template can be synthesised in diameter near or less than 120 nm. Control factors affect...

Physiological behavior of invasive hepatocellular carcinoma (HCC) is in the state of rapid division, aggressive growth and wide dispersion [1]. They are complicated with forming new blood vessels (angiogenesis) [2], separating from mother tumor (migration) and forming new tumor (metastasis)

bionanosensor

LY2157299 (LY), which is very small molecule bringing high cancer diffusion, is a pathway antagonist against TGFβ. LY dosage can be diluted by blood plasma, can be captured by immune system or it might be dissolved during digestion in gastrointestinal tract. The aim of our study is to optimize a "nano-elastic" carrier to avoid acidic pH of gastroin...

Sohag Cancer Institute invitation for 30 Min. power point presentation

Glucose consumption in many types of cancer cells, in particular hepatocellular carcinoma (HCC), was followed completely by over-expression of type II hexokinase (HKII). This evidence has been used in modern pharmacotherapy to discover therapeutic target against glycolysis in cancer cells. Bromopyruvate (BrPA) exhibits antagonist property against H...

TGFβ1 pathway antagonists have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Inhibiting peptides, as P-17 in this study, are bound to either TGFβ1 or its receptors, blocking signal transduction. However, for efficient use of these TGFβ1antagonist as target therapeutic tools, improvement in their delivery...

Advanced Workshop on Nanomedicine and Nanoscopy

Our current work is to fabricate and functionalize drug delivery systems starting from a selection of suitable templates until to obtain layered capsule. For this reason, homogenous colloidal calcium carbonate has been fabricated. Their diameter and shape were controlled by biodegradable polymers. Chitosan (CHI) as positively charged polymer and Po...

Development and production of multifunctional bio nano-engineered drug delivery systems loaded by TGFβ1 inhibitors for delivering into hepatocellular carcinoma cells.

TGFβ1 pathway antagonists have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Inhibiting peptides, as P-17 in this study, are bound to either TGFβ1 or its receptors, blocking signal transduction. However, for efficient use of these TGFβ1antagonist as target therapeutic tools, improvement in their delivery...

European Association for the Study of the Liver

I am looking currently for Post Doc. position at nano medicine . My aim is to fabricate biological smart drug delivery system loaded by blockers against cancer cells . I am welcoming for any post doc position in the same field thank you so much nemany

Halloysite is a nanostructured clay mineral with hollow tubular structure, which has recently found an important role as delivery system for drugs or other active molecules. One of these is curcumin, main constituent in the rhizome of the plant Curcuma Longa, with a series of useful pharmacological activities, hindered by its poor bioavalaibility a...

Bursary of EASL conference

The natural properties of chitosan (CHI), such as biocompatibility and biodegradability, have stimulated its use as drug delivery carrier in several applications, including layer-by-layer assembly and polymer self–assembly. In this work we have aimed at producing chitosan microtubes by using CaCO3 rods doped with poly allylamine hydrochloride (PAH)...

Fluoro-magnetic nanoparticles play an important role in biomedical applications since their size and concentration in tumors allow a very high resolution and an accurate mapping of lesions. Fluorescein isothiocyanate (FITC) has been entrapped inside crystals of magnetic nanoparticles (MNPs) during crystallization. This causes changes of nanoparticl...

TGFβ1 pathway antagonists, such as interference RNAs or inhibiting peptides, have been considered promising therapies to attenuate TGFβ downstream signals in cancer cells. Interference RNAs, transiently transfected into the cell as siRNAs, or stably incorporated to the DNA with a plasmid the complementary sequence of shDNA inhibit translation of TG...

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Fabrication of homogenous CaCO3 particles is a significant step in assembling polyelectrolyte capsules. It is crucial to control the dimensions, the shape and the charge of the calcium carbonate particles in order to have homogenously separated and charged templates as a final result. Recently, crystallization of CaCO3 was done by adding Poly (Sodi...

Fabrication of homogenous CaCO3 particles is a significant step in assembling polyelectrolyte capsules. It is crucial to control the dimensions, the shape and the charge of the calcium carbonate particles in order to have homogenously separated and charged templates as a final result. Recently, crystallization of CaCO3 was done by adding Poly (Sodi...

I would like please to invite all people to attend my seminar. It will be hold at Salento University, Physics Department, Room M8 Wednesday 18th December , 11 O’clock. Thank you so much for all. Nemany Hanafy

Fabrication and Characterization of ALK1fc-Loaded Fluoro-Magnetic Nanoparticles Rods for Inhibiting TGF β1 in HCC. Nemany A.Hanafy1, 3, Marzia Maria Ferraro1, Antonio Gaballo1, Luciana Dini2, Vittorianna Tasco1, Concetta Nobile1, Maria Luisa De Giorgi3, Sonia Carallo1, Ross Rinaldi3 and Stefano Leporatti1 1 CNR NANOTEC- Istituto di Nanotecnologia L...

Green tea extract exhibits several beneficial activities for the human body. In the present work, we explored the healing effect of a novel bio-nano particle named ‘Chitosan nano-encapsulated green tea extract’ at the ultrastructural level by performing experiments on rat hepatocytes. A fixed volume of Chitosan nano-encapsulated green tea extract s...

The present study examined the effect of Green Tea Extract (GTE) encapsulated into Chitosan Nanoparticles (CS-NPs) on hepatic fibrosis in rat model as determined by atomic force microscopy (AFM). The bioactive compounds in GTE encapsulated into CS-NPs were determined using LCMS/MS method. Additionally, the uptake of GTE-CS NPs in HepG2 cells showed...

Fabrication of homogenous CaCO3 particles is a significant step in assembling polyelectrolyte capsules. It is crucial to control the dimensions, the shape and the charge of the calcium carbonate particles in order to have homogenously separated and charged templates as final result. For this reason, previously. hey have been deeply investigated. Re...

The aim of the present study was to investigate the hepatoprotective effect of green tea extract (GTE) against the hepatic fibrosis induced by carbon tetrachloride (CCl4), ethanol, and dual exposure to CCl4 plus ethanol in rats. In particular, an investigation of the three-dimensional architecture was conducted using scanning electron microscopy. V...

Our aim is to prevent HCC invasiveness by inhibition of glycolysis and to protect normal cell from side effect of drug. To achieve this purpose, bromopyruvic acid was encapsulated in carrier coated by two specific molecule, BSA as specific target for liver and Folic acid as specific target for foliate receptor

Compared to normal cells, cancer cells exhibit a unique dependence on glycolysis as a possible mean to enhance their survival in a hypoxic tumour environment. However, the increased glucose consumption is followed by over-expression of type II HexoKinase (HK) in many type of cancer cells (Macchioni, et al., 2011) particular in Hepatocellular carcin...

Compared to normal cells, cancer cells exhibit a unique dependence on glycolysis as a possible mean to enhance their survival in a hypoxic tumour environment. However, the increased glucose consumption is followed by over-expression of type II HexoKinase (HK) in many type of cancer cells (Macchioni, et al., 2011) particular in Hepatocellular carcin...

Why cancer cells resist conventional chemotherapy Tumour cells are more rapid proliferation than normal cells creating a population of cells distant from blood vessels. With oxygen and nutrient limitation. This a process is exacerbated by a poorly organized vascular architecture and irregular blood flow forming hypoxia. Resultant hypoxia, increase...

Trapping multiple drugs into a single delivery system has got many interest especially in cancer research for last years. This happened not only for avoiding medical side effects and cancer drug resistance issues but also for the opportunity of delivering multiple drugs to the same location at a controlled relevant concentration (Cui, Jing et al.,2...

Hepatic fibrosis constitutes a serious insult to the liver, with a substantial negative impact on the quality of life of such patients worldwide. It is a consequence of severe liver damage and occurs as the result of several factors. Chronic alcoholism is the most common cause. Fibrosis also results from chronic viral hepatitis and autoimmune hepat...