Nandhini Gunasekaran

SRM Institute of Science and Technology | SRM · Department of Oral Pathology

Oral cancer is the most prevalent head and neck cancer. Although tumor markers have been investigated for detecting the progression and prognosis of oral cancer, no reliable marker has been identified. We investigated the expression of ATP binding cassette subfamily B member 5 (ABCB5) positive stem cells in oral squamous cell carcinoma (OSCC) and i...

A neurofibroma is a benign peripheral nerve sheath tumor. They occur in combination with neurofibromatosis or as a solitary mass. Intraoral neurofibromas pose diagnostic difficulties, suggesting the appropriate use of diagnostic markers and clinical knowledge. Here, we report a case of intraoral neurofibroma in a 57-year-old female who reported wit...

Objective: To evaluate the anticancer activity of Cassia auriculata leaf extract on Oral Squamous Cell Carcinoma cell lines. Material and methods: Biopsy of oral cancer tissues samples were taken, processed and cell lines were developed. Active component of Cassia auriculata was identified and the cell lines were treated with active component at 25...

Objective: To evaluate the anti-carcinogenic effect of Centella Asiatica on to evaluate the Anti-Carcinogenic Effect of Centella Asiatica on Oral Cancer Cell Line oral cancer cell line. Materials and methods: Oral Cancer cell line and normal oral keratinocyte cell line were procured.Centella asiatica extract was prepared. The cells were then sub...

Oral melanoma is a rare malignancy with poor prognosis because of its invasive and metastasizing tendencies. It is derived from the melanocytes and is clinically asymptomatic initially but in later stages may show ulceration, pain, bleeding, tooth mobility, and parasthesia. Because of its silent progression, diagnosis is often delayed leading to po...

Background: The exact etiology of non-tobacco associated oral squamous cell carcinoma (NT-OSCC) is still unknown. The lack of established biomarkers for oral NT-OSCC has resulted in less effective management and poor prognosis. Here, we report for the first time a panel of potential markers identified from the quantitative proteomic analysis of NT...

Background: Oral submucous fibrosis (OSMF) in recent times has been recognized as a potentially malignant disorder (PMD) with an increased risk of developing oral squamous cell carcinoma with malignant transformation rates that vary from 0.6% to 36%. Alpha-L-fucosidase (AFU) is a lysosomal enzyme that is involved in maintaining the homeostasis of...

Aim: To assess the expression of PGC1-α and PGC1-β in Oral squamous cell carcinoma in the presence and absence of hyperglycemia. Materials and methods: Fresh tissue samples were collected from 14 well differentiated OSCC patients with hyperglycemia, 14 OSCC patients without hyperglycemia and 14 healthy controls and subjected to quantitative real...

Objective: Oral submucous fibrosis (OSMF) is a debilitating chronic disease of the oral cavity with a high potential for malignant transformation. The main etiological agent attributed to the development of OSMF is the use of smokeless tobacco products like areca nut. There is no known cure for the disease. Current modalities of treatment do not p...

Oral lesions are often the first tell-tale sign for human immunodeficiency virus infections (HIV). Numerous oral lesions have been associated with HIV infections, some lesions such as candidiasis being more common than others. Regular oral screening can aid in identifying such lesions allowing for the early diagnosis of HIV and help in monitoring t...

Adenoid cystic carcinoma (AdCC) is an aggressive neoplasm that often carries a poor prognosis due to its high recurrence rate. Due to its indolent growth, it is often overlooked by the patients and early diagnosis is often challenging due to its deceptively benign clinical course. We report a case of AdCC in the lower lip and buccal mucosa of a pat...

Introduction: Liquid-based cytology (LBC) is a new monolayer slide preparation method introduced to overcome the limitations of conventional Papanicolaou (PAP) smears which is used in cancer screening. The study was aimed to compare the efficacy of modified technique, centrifuged LBC (CLBC) with that of conventional brush cytology in normal oral mu...

Glandular odontogenic cyst (GOC) is a rare cyst occurring in the jaw bone having an uncertain and aggressive behavior with high recurrence rate. The diagnosis of this lesion is trying as it can be confused with other jaw cysts and malignant lesions. Treatment methods vary from conservative surgical treatment to jaw resection. This article presents...

Ameloblastoma is a true benign neoplasm of odontogenic epithelial origin mostly seen in the mandible. After odontoma, it is the second most commonly seen odontogenic neoplasm. Ameloblastoma comprises of several clinical, radiological and histological varieties, making it the most significant odontogenic neoplasm. Among these, the unicystic type is...

Ameloblastomas are the second most common tumor that originates from the odontogenic epithelium. The common age of occurrence is usually the third decade of life, with majority of the cases involving the mandible. Unicystic ameloblastoma accounts for about 5%–15% of all ameloblastic lesions with no tendency to metastasize. It is a slow-growing tumo...

Neurofibroma is a benign, slow-growing, peripheral nerve neoplasm. It presents as a solitary tumor or component of neurofibromatosis (NF) and von Recklinghausen's disease. The occurrence of solitary neurofibromas in the oral cavity is less frequent, and those in the palate are reported in less numbers. This report describes an unusual case of solit...

Haemangiomas and venous malformations are formed due to disturbances during the developmental period of an embryo. Changes in blood flow dynamics within a haemangioma may induce thrombus formation and phleboliths. Inflammation, trauma, debris acting as nidus and vascular lesions have been attributed as principal causes for occurrence of calcificati...

Pemphigus vulgaris (PV) is a chronic, autoimmune, intraepidermal blistering disease of the skin and mucous membranes. The initial clinical manifestation is frequently the development of intraoral lesions, and later, the lesions involve the other mucous membranes and skin. The etiology of this disease still remains obscure although the presence of a...

Molluscum contagiosum (MC) is an infection of the skin and mucous membrane caused by a DNA virus from the poxvirus family. It usually affects any part of the body and presents as pearly, flesh colored dome shaped nodule with a central umbilication. Clinical diagnosis can be supplemented with histopathology for the confirmed diagnosis of MC. This ar...

Forensic odontology analyzes dental evidence for human identification. Teeth form an excellent material for anthropological, genetic, odontologic and forensic investigations, as their characteristics remain unchanged even after long periods of stay in extreme environments. Determining the sex is one of the most important steps in the process of hum...

Background: Odontogenic cysts are distinct entities and a quite common occurrence in the jaw bones. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. Various molecules have been implicated to play a role in the pathogenesis of these lesions ranging from cell cycle perturbations to mutations...

Tuberculous lymphadenitis occurring in the cervical region is the most common cause of extra-pulmonary tuberculosis (TB). Isolated form of tuberculous cervical lymphadenitis is rare and is described in patients without evidence of previous or ongoing TB anywhere in the body. This type yields inconsistent physical and laboratory findings, and final...

Aim: The aim of this study is to evaluate the levels of malondialdehyde (MDA) and nitric oxide (NO) in serum and saliva of patients with oral lichen planus (OLP) and to compare the levels. Materials and Methods: The study included 10 cases of OLP patients which formed the study group and 10 cases of healthy individuals, which formed the controls. T...

Objective: To evaluate the clinical utility of salivary interleukin 8 (IL-8) in the differential diagnosis of potentially malignant lesions (PMLs) and oral squamous cell carcinoma (OSCC) in a region with high oral cancer prevalence. Study design: Saliva and blood samples were collected from 100 participants in each group (OSCC, PMLs, and healthy...

Objectives To evaluate the clinical utility of salivary interleukin (IL)-8 in differential diagnosis of potentially malignant lesion (PML) and oral squamous cell carcinoma (OSCC) under high oral cancer prevalent region. Study design Saliva and blood samples were collected from 100 subjects in each group of OSCC, PML and healthy control subjects. S...

Cytokines are nonstructural proteins, which act as molecular messengers in the movement of various inflammatory cells, as well as in inducing growth and regeneration in the surrounding microenvironment. The inflammatory cytokine network, which influences growth, proliferation, and differentiation of cells in normal health and healing has also been...

CYFRA 21-1, a constituent of the intermediate filament proteins of epithelial cells is known to be elevated in many cancers. This study was designed to estimate the levels of salivary and serum CYFRA 21-1 in oral precancer and oral squamous cell carcinoma (OSCC) patients and compare them with healthy controls. Each group comprised of 100 subjects....