Nazim Uddin EmonUniversity of Arkansas | U of A · Cell and Molecular Biology
Nazim Uddin Emon
Doctor of Philosophy
About
52
Publications
26,853
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
652
Citations
Introduction
"Failure is not falling down, but an advanced step to being an equipped warrior with wining vision", so dare to fail and get up every morning to win a vision.
The efficient recipes of being a dynamics fellow,(like a super Porsche) are focusing and hard working mind. I wish to be the latest version of a Porsche. Yes, the most recent version of Porsche of my generation.
(Social: https://www.instagram.com/nazimemonlaam/)
-Nazim Uddin Emon
Education
August 2015 - November 2019
Publications
Publications (52)
Lygodium microphyllum Cav. (Family: Lygodiaceae) is a perennial, snake fern and an invasive weed in Florida and also known as old world climbing fern. This study is intended to evaluate the antipyretic, analgesic, anti-inflammatory, antidiarrheal and anthelmintic activity of methanol extract of Lygodium microphyllum Cav. leaves (MELM) by in vivo, i...
Bauhinia scandens L. (Family, Fabaceae) is a medicinal plant used for conventional and societal medication in Ayurveda. The present study has been conducted to screen the chemical, pharmacological and biochemical potentiality of the methanol extracts of B. scandens stems (MEBS) along with its related fractions including carbon tetrachloride (CTBS),...
Bauhinia scandens L. (Family: Fabaceae) is commonly used to treat cholera, diarrhea, asthma, and diabetes disorder in integrative medicine. This study aimed to screen the presence of phytochemicals (preliminary and UPLC-QTOF–M.S. analysis) and to examine the pharmacological activities of Bauhinia scandens L. stems (MEBS) stem extracts. Besides, in...
This study constructed the phytochemical profiles of Adenostemma lavenia (L) methanol extract (MEAL) and investigated its anti-nociceptive, anti-diarrheal, antipyretic, thrombolytic and anthelmintic effects. The GC-MS characterized MEAL had undergone an in vivo antipyretic effect assayed on Swiss albino mice adopting the yeast-induced pyrexia model...
As the incidence of neurodegeneration and cancer fatalities remains high, researchers are focusing their efforts on discovering and developing effective medications, especially plant-based drugs, against these diseases. Hence, this research aimed to investigate the neuropharmacological potentials of aerial parts of Tetrastigma leucostaphyllum, empl...
Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these natural substances are renowned, and initiatives are being taken to extract the flavonoids. Apigenin...
Crinum asiaticum L. (Amaryllidaceae) is a perennial bulbous herb, locally utilized for possessing multifaceted pharmacological properties including anticancer, immune-stimulating, analgesic, antiviral, antimalarial, antibacterial and antifungal, in addition to its popularity as an aesthetic plant. Separation of MeOH extract of C. asiaticum leaves y...
Since the first case of coronavirus disease (COVID-19) was reported in December 2019, it has become a pandemic, which is one of the most severe global health crises. In 2022, more than 100 million people in around 210 countries have been reported to be infected and about two million people have been reported to have died because of COVID-19. Then,...
Crinum asiaticum L. (Amaryllidaceae) is a perennial bulbous herb, locally utilized for possessing multifaceted pharmacological properties including anticancer, immune-stimulating, analgesic, antiviral, antimalarial, antibacterial, and antifungal, in addition to their popularity as an aesthetic plant. Separation of MeOH extract of C. asiaticum leave...
The pharmacological actions of benzylisoquinoline alkaloids are quite substantial, and have recently attracted much attention. One of the principle benzylisoquinoline alkaloids has been found in the unripe seed capsules of Papaver somniferum L. Although it lacks analgesic effects and is unrelated to the compounds in the morphine class, it is a peri...
Diabetes mellitus is a life-threatening disorder affecting people of all ages and adversely disrupts their daily functions. Despite the availability of numerous synthetic-antidiabetic medications and insulin, the demand for the development of novel antidiabetic medications is increasing due to the adverse effects and growth of resistance to commerc...
Ganoderma lucidum is known as lingzhi mushroom, which is said to have medicinal properties by the local residents. This research was focused to assess the antidepressant, anxiolytic, and sedative activities of the mentioned mushroom extracts by means of in vivo and in silico approaches. The antidepressant, anxiolytic, and sedative properties of the...
The natural spread of various harmful organisms into the environment has resulted in a wide range of diseases worldwide, including in Bangladesh. In December 2019, the world was exposed to a new virus-mediated sickness known as coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which has mostly a...
Plants are serving the mankind with important bioactive phytochemicals from the very ancient ages to develop novel therapeutics against different disease states. Glycosmis cyanocarpa (Blume) Spreng is a plant from the Rutaceae family and a very less explored species from the Glycosmis genus. Thus, this present study was intended to present the chem...
Blumea lacera (Burm.f.) DC., popular for its traditional use in di erent diseases, was employed in phytochemical and biological investigations. e chemical studies led to the isolation of acyclic diterpene-phytol (1) along with two fatty acids-linolenic acid (2) and oleic acid (3). All the structures were determined by 1 H NMR spectroscopic analysis...
Autism spectrum disorder (ASD) is a neurological disorder that affects normal brain development. The recent finding of the microbiota–gut–brain axis indicates the bidirectional connection between our gut and brain, demonstrating that gut microbiota can influence many neurological disorders such as autism. Most autistic patients suffer from gastroin...
Dillenia pentagyna Roxb. is traditionally used to treat cancer, wound healing, diabetes, and diarrhea in local tribes. This study was designed to evaluate the pharmacological potentiality of this plant. In vivo analgesic, anti-inflammatory, and antipyretic studies of the methanol extracts of D. pentagyna (MEDP) leaves were performed by using acetic...
Focusing on traditional knowledge, this study sought to evaluate the neuropharmacological and anti-cancer potential (cell lines) of several TLA plant extracts. Wherein, n-hexane fraction was picturesque the noteworthy antidepressant and anxiolytic effects with aiming lowest IC 50 value (14.3 μg/mL) in U-251 cell line. Thereafter, GC-MS technique wa...
This study intends to evaluate the development, importance, pre-clinical and clinical study evaluation of stem cell therapy for the treatment of cardiovascular disease. Cardiovascular disease is one of the main causes of fatality in the whole world. Though there are great progressions in the pharmacological and other interventional treatment option...
Gynura nepalensis D.C. (family: Asteraceae) has abundant uses in the alternative medicinal practice, and this species is commonly used in the treatment of diabetes, rheumatism, cuts or wounds, asthma, kidney stones, cough, urinary tract bleeding, gall bladder stones, hepatitis, diarrhea , hemorrhoids, constipation, vomiting, fertility problems, blo...
Steam inhalation therapy can be a contemporary approach for COVID-19 affected patients of all age groups to manage respiratory conditions, though it presently lacks the scientific backing to establish itself as a befitting practice. The age of COVID-19 has facilitated this traditional home remedy to resurface among the general mass as a helpful app...
This study was undertaken to evaluate the appearance of phytochemicals and anti-oxidant activity of seven wild mushrooms of the University of Chittagong campus. Phytochemical screening was performed using standard methods, whereas DPPH radical scavenging assay was used to elucidate the antioxidant effect. Besides, in silico studies were implemented...
This study was designed to evaluate the cytotoxic and analgesic potential of methanol extracts of five wild mushrooms available in the University of Chittagong, Bangladesh. The acetic acid-induced writhing method was used for the analgesic activity, while cytotoxicity was tested using brine shrimp lethality bioassay. In silico molecular docking and...
This research was designed to evaluate the CNS depressant, anxiolytic, and analgesic action of aqueous and ethanol extract of Ganoderma applanatum, a valuable medicinal fungus used in multiple disorders belongs to Ganodermataceae family. Two extracts of G. applanatum were prepared using distilled water and ethanol as solvents and named AEGA and EEG...
Dillenia pentagyna Roxb., a deciduous and medium sized tree, is an ethnobotanically important species of several Asian countries including Bangladesh, Srilanka, and India. Various parts of this endangered tree including leaf, bark, root etc. are used in folkloric medicine systems for a very long time. It is locally used in the treatment of pain, wo...
The present study sought to evaluate the central nervous system (CNS) depressant, antioxidant, and cytotoxicity activity of methanol and aqueous extract of Trametes versicolor (METV and AETV). The CNS activity was assessed by the open field, hole-cross, forced swimming, thiopental sodium-induced sleeping time, hole-board, and rotarod tests in Swiss...
This study was undertaken to evaluate the antidiabetic, hypolipidemic, and hepatoprotective
effects of methanol and aqueous extracts of Ganoderma applanatum
(MEGA, AEGA) in alloxan-induced
diabetic rats. The antidiabetic study was implemented
by the induction of alloxan to the rats. The analysis of the hypolipidemic
and liver-protective
effects of...
Background
COVID-19 has mutation capability, and there are no specific drug therapies that are available to fight or inhibit the proteins of this virus. The present study aims to investigate the binding affinity of the bioactive and synthetic compounds with the main protease (Mpro) enzymes and angiotensin-converting enzyme 2 (ACE 2) by computationa...
Caesalpinia digyna (Rottl.) (Family: Fabaceae) is well known for its numerous medicinal values against several human disorders including fever, senile pruritis, diarrhea, tuberculosis, tonic disorder, diabetes, etc. The current study is intended to investigate the in vivo antipyretic activity of the methanol extract of C. digyna leaves (MECD) and i...
Background
Colocasia gigantea , locally named as kochu is well-known due to its various healing power. This research is to investigate the antidiarrheal, antimicrobial and antioxidant possibilities of the methanol soluble extract of Colocasia gigantea .
Methods
The antidiarrheal investigation was performed by using in vivo castor oil-induced diarr...
A B S T R A C T
Caesalpinia digyna (Rottl.) (Family: Fabaceae) is an essential medicinal plant for it's conventional uses against a kind of human disorders. This research aims to investigate the antidiarrheal, antibacterial and antifungal properties of the methanol extract of the stems extracts of the C. digyna (MECD). The in vivo antidiarrheal ac...
Piper nigrum L. also called black pepper is popular for its numerous uses. The present research is designed to investigate the pharmacological potential of methanol extract of Piper nigrum (MEPN). The antidepressant investigation was performed by using both in vivo forced swimming test (FST) and tail suspension test (TST) methods while the anxiolyt...
Millettia peguensis, popular for its ethnopharmacological uses, was employed to evaluate its different pharmacological properties in this study. The analgesic studies of the plant have been performed by acetic acid-induced writhing and formalin-induced licking tests respectively, whereas the antidiarrheal experiment was done by castor oil-induced d...
Tetrastigma leucostaphylum (Family: Vitaceae) is popular for its medicinal value in Bangladeshi tribal communities. This study aims to investigate several pharmacological values of methanol extract of T. leucostaphylum (METL). In vivo analgesic and anti-inflammatory researches have been implemented by using acetic acid-induced writhing and formalin...
Achyranthes aspera L. (Prickly Chaff flower) is an imperative Asian herb that has been known for numerous healing powers. The aim of this research is to investigate the pharmacological i.e., antidepressant and anxiolytic properties of the methanol extract of aerial part of A. aspera (MEAA) by in vivo and in silico approaches. Additionally, thrombol...
Tetrastigma leucostaphylum (TL) is an important ethnic medicine of Bangladesh used
to treat diarrhea and dysentery. Hence, current study has been designed to characterize the
antidiarrheal (in vivo) and cytotoxic (in vitro) e�ects of T. leucostaphylum. A crude extract was
prepared with methanol (MTL) and further partitioned into n-hexane (NTL), dic...
Tetrastigma leucostaphylum (TL) is an important ethnic medicine of Bangladesh used to treat diarrhea and dysentery. Hence, current study has been designed to characterize the antidiarrheal (in vivo) and cytotoxic (in vitro) effects of T. leucostaphylum. A crude extract was prepared with methanol (MTL) and further partitioned into n-hexane (NTL), di...
Aims
With a large number of fatalities, coronavirus disease-2019 (COVID-19) has greatly affected human health worldwide. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the virus that causes COVID-19. The World Health Organization has declared a global pandemic of this contagious disease. Researchers across the world are collaborati...
As of July 21, the mean Rt and growth factor is 1.32 and 1.02, respectively.
Each phase of nation-wide lockdown has contributed to the decline of effective reproduction number (Rt) for Bangladesh by 28.44%, and 26.70%, respectively, implying moderate effectiveness of the epidemic response strategies.
The Rt of Bangladesh was below 1 for onl...
1. According to the Logistic curve fitting analysis, the inflection point of the COVID-19
pandemic has recently passed, which was approximately between May 28, 2020, to May 30,
2020.
2. It is estimated that the total number of confirmed cases will be around 187-193 thousand at
the end of the epidemic. We expect that the actual number will most like...
ABSTRACT: Tetrastigma leucostaphylum (Family: Vitaceae) is popular for its medicinal value in
Bangladeshi tribal communities. This study aims to investigate several pharmacological values of
methanol extract of T. leucostaphylum (METL). In vivo analgesic and anti-inflammatory researches have
been implemented by using acetic acid-induced writhing...
The study was intended to compare and evaluate the in vitro thrombolytic activity and in vivo anxiolytic activities of methanol extracts of Piper nigrum fruits (MEPNF) and Sesamum indicum seeds (MESIS). An in vitro thrombolytic activity was employed by investigating the clot lysis effect of MEPNF, MESIS, and their combinations. In vivo anxiolytic a...
Background Colocasia gigantea is locally named as kochu and also better known due to its various healing power. This research is to investigate the antidiarrheal, antimicrobial, and antioxidant possibilities of the methanol soluble extract of Colocasia gigantea.
Methods Antidiarrheal investigation was performed by using in vivo castor oil induced...
Running title: de novo vaccine design against SARS-CoV-2
Currently, with a large number of fatality rates, coronavirus disease-2019 (COVID-19) has emerged as a potential threat to human health worldwide. It has been well-known that severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) is responsible for COVID-19 and World Health Organization (WHO) proclaimed the contagious disease as a global pand...
Objectives: Bauhinia scandens Linn,and Senna sophera has been locally known as monkey ladders and Kalkasunda in Bangladesh. They have several significant traditional uses as a source of the medicinal agent. This study is to implement the thrombolytic and cytotoxic activity of n-Hexane fraction of Bauhinia scandensstems and Senna sopherastems (NHBS,...
The present study was planned to determine phytochemicals, antioxidants, and anxiogenic (anti-psychotic) activity of methanol extract of Amomum aromaticum roxb. Leaves (MEAA) in the laboratory using both in vitro and in vivo methods. In vitro antioxidant investigation was implemented by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, FeCl...
The present study was planned to determine phytochemicals, antioxidants, and
anxiogenic (anti-psychotic) activity of methanol extract of Amomum aromaticum roxb. Leaves
(MEAA) in the laboratory using both in vitro and in vivo methods. In vitro antioxidant
investigation was implemented by 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging,
F...
The study aimed to report in vitro thrombolytic and in vivo anti-nociceptive activity of methanolic extract of Caesalpinia digyna (MECD) followed by in silico PASS prediction, ADME analysis with toxicity and molecular docking study of antinociception (Cox-1, Cox-2) and thrombolytic (Tissue plasminogen activator). The clot lysis of human blood for t...
https://link.springer.com/article/10.1007/s13596-020-00429-7
The present study was meant to explore the thrombolytic action of methanol extract of Senna sophera stems (MESS) and Caesalpinia digyna stems (MECD) alongside streptokinase as positive control and saline water as negative control. In the In vitro thrombolytic model, the MESS stems and MECD stems has been indicated 32.79±4.51% and 9.19±0.80% clot ly...
Questions
Questions (5)
Rationale of the research required with the answer
Young children do not seem to be particularly badly affected by the virus, which they say is peculiar considering their susceptibility to flu, but it is not clear why...?
We became to know that the spike proteins are susceptible to ACE 2 receptor and there are numerous ACE 2 blockers are already in market. As existing, why not we suggest ACE 2 blockers in SAR-CoV-2 inhibition.?
I have searched on PDB but I didn't succeed in retrieve ACE 2 from PDB. Does there any option to obtain this Enzyme.?
PDB IDs are 3KBH for HCoV-NL63 S1-CTD, 4F5C for PRCV S1-CTD, 2AJF for SARS-CoV S1-CTD, 4KR0 for MERS-CoV S1-CTD, 3R4D for MHV S1-NTD, 4H14 for BCoV S1-NTD, 2IEQ for HCoV-NL63 HRs, 1WYY for SARS-CoV HRs, 4NJL for MERS-CoV HRs, and 1WDF for MHV HRs. HCoV-NL63 and other alpha-coronaviruses recognize different receptors: other alpha-coronaviruses such as TGEV, PEDV, and PRCV recognize another zinc peptidase, aminopeptidase N (APN) (22–25). Similarly, SARS-CoV and other beta-coronaviruses recognize different receptors: MERS-CoV and HKU4 recognize a serine peptidase, dipeptidyl peptidase 4 (DPP4) (26, 27); MHV recognizes a cell adhesion molecule, carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) (28, 29); BCoV and OC43 recognize sugar (30). The alpha-coronaviruses TGEV and PEDV and the gammacoronavirus IBV also use sugar as receptors or coreceptors.
