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Publications (9)
Basal renal Pi excretion in the fetus is very low compared to that in older children and in adults. Studies have demonstrated that the fetal kidney responds to stimuli known to effect renal tubule Pi reabsorption in the adult, and thus, developmental immaturity is not a factor in renal Pi handling in early life. Preliminary studies in fetal lambs s...
Calcium requirements for growth and for skeletal mineralization during fetal life and in early postnatal development are substantial. During fetal life, significant active transfer of calcium occurs from mother to fetus via the placenta.1 At birth, the connection between mother, placenta, and infant is severed and the intestinal tract becomes the m...
In vivo study of H control of CRG was done in ewes and their twin fetal lambs (FL) at 100-140 d gestation. In 9 controls, fetus A (FA) was removed by cesarean section and fetus B (FB) was then removed either 30, 60, 90, or 180 min later. Both kidneys in each fetus were removed and total DNA/RNA content or the rate of 14C-choline incorporation (14C-...
Compensatory renal hypertrophy was studied in fetal lambs during midgestation. Functional adaptation was correlated with anatomica and biochemical changes by measuring glomerular filtration and clearance of para-amino hippurate (PAH). Normal intrauterine body growth and kidney growth by changes in RNA and DNA over a 72-hr period were studied in twi...
Postnatal response to unilateral nephrectomy (UN) is age related and is greater in the young. We studied CRH in fetal lambs at 85-95 days gestation (term-150). RNA and DNA content in renal cortical slices (C) was measured in fetal kidneys from twin pregnancies, single fetuses after UN, and fetuses after maternal UN. Control studies were in 6 sets o...
The effect of rapid extracellular fluid expansion with saline was studied in 9 fetal lambs with intact umbilical circulation between 100-120 days gestation. After control measurements of UV, UNaV, GFR, % TNa, CH2O, serum total protein (T.P.), Hct and [Na+], 0.45 N NaCl was infused rapidly into the fetus until the increase in UV was stable. After ex...
Three children presented in renal failure (RF) during a relapse of the nephrotic syndrome (NS). The etiology of NS in each case was felt to be minimal change glomerular disease. The episodes of RF were anteceded by infectious diseases which presented with fever and anorexia in all cases; recurrent emesis in 2. Clinical signs of circulatory hypovole...
Pediatric Research (1974) 8, 458–458; doi:10.1203/00006450-197404000-00711
