Monica Hancianu

Universitatea de Medicina si Farmacie Grigore T. Popa Iasi | UMF Iasi · Department of Pharmacognosy

This review study explores the complex methods involved in the extraction and purification of polyphenols, specifically catechins, prominent compounds that are bioactive and found in plant-based extracts and foods like tea. This study also addresses the challenges that may arise from the complex chemical structure of catechins and their inherent va...

Healthy dietary patterns during pregnancy are crucial for ensuring maternal and foetal health outcomes. Numerous methodologies exist for assessing the diet of pregnant women, including dietary patterns and various appraisal tools of diet quality. This study aimed to assess the dietary patterns and diet quality of pregnant women and to investigate t...

The memory-enhancing activity of Matricaria chamomilla hydroalcoholic extract (MCE) is already being investigated by behavioral and biochemical assays in scopolamine-induced amnesia rat models, while the effects of scopolamine (Sco) on cerebral glucose metabolism are examined as well. Nevertheless, the study of the metabolic profile determined by a...

This study explores the complexities involved in the extraction and purification of catechins, prominent bioactive compounds found in plant extracts and tea. It addresses challenges arising from the intricate molecular structure of catechins and their inherent variability across botanical sources. Despite these obstacles, catechins present signific...

Tribulus terrestris L. (Tt) has been recently gaining attention for its pharmacological value, including its neuroprotective activities. In this study, we explore the neuroprotective effects of a Tribulus terrestris extract in a zebrafish (Danio rerio) model of scopolamine (SCOP)-induced memory impairment and brain oxidative stress. SCOP, an antich...

Diabetes mellitus (DM) is a long-standing and non-transmissible endocrine disease that generates significant clinical issues and currently affects approximately 400 million people worldwide. The aim of the present review was to analyze the most relevant and recent studies that focused on the potential application of plant extracts and phytocompound...

(1) Background: This study aimed to outline the antioxidant, antitumoral, and cytotoxic proprieties of various types of Perilla frutescens extracts obtained from the leaves of the species. (2) Methods: We determined total polyphenols, flavonoids and anthocyanins contents, as well as the in vitro antioxidant, antitumoral, and cytotoxic actions in th...

(1) Background: This study aimed to outline the antitumoral, antioxidant, and cytotoxic proprie-ties of various types of Perilla frutescens extracts obtained from the leaves of the species; (2) Methods: We determined total polyphenols, flavonoids and anthocyanins contents, as well as the in vitro antioxidant, antitumoral, and cytotoxic actions in 3...

Metal nanoparticles (NPs) have garnered considerable attention, due to their unique physicochemical properties, that render them promising candidates for various applications in medicine and industry. This article offers a comprehensive overview of the most recent advancements in the manufacturing, characterization, and biomedical utilization of me...

Black-eyed Susan (Rudbeckia hirta L.), a flowering plant with various traditional medicinal uses, has recently garnered interest for its therapeutic properties. However, little is known about the potential therapeutic activities of the plant species. The current study focused on conducting a comprehensive investigation into the chemical composition...

Essential oil from Coriandrum sativum has been demonstrated to provide various pharmacological properties, such as antioxidant, antimicrobial, antibacterial, antifungal, antidiabetic, anticonvulsive, anxiolytic-antidepressant, and anti-aging properties. This study investigated the mechanism of Coriandrum sativum var. microcarpum essential oil (CSEO...

The aim of the study was to evaluate the antibacterial activity and surface hardness of a light-activated microhybrid composite resin modified with green silver nanoparticles (AgNPs). AgNPs were synthesized using an Equisetum sylvaticum extract and characterized through different methods such as UV-Vis, EDX, and FTIR. The obtained AgNPs were mixed...

The limited antifungal drugs available and the rise of multidrug-resistant Candida species have made the efforts to improve antifungal therapies paramount. To this end, our research focused on the effect of a combined treatment between chemical and photodynamic therapy (PDT) towards a fluconazole-resistant clinical Candida albicans strain. The co-t...

(1) Background: Chronic renal disorders (CRD) are associated with significant comorbidities and necessitate complex therapeutic management. As time passed, Perilla frutescens (PF) became a promising therapeutic option for CRD. The aim of this systematic review and meta-analysis was to outline the therapeutic effects of PF extracts on various models...

Obstructive sleep apnea (OSA) is associated with increased cardiovascular risk, sedentarism, depression, anxiety and impaired quality of life. The long-term effectiveness of positive airway pressure (PAP) is insufficiently studied and limited by poor patient compliance. The aim of this pilot prospective cohort study was to evaluate long-term adhere...

1) Background: Acute heart failure (HF) represents a complex clinical syndrome burdened by increased mortality and a high rate of systemic complications. Although natriuretic pep-tides (e.g., NT-proBNP) currently represent the diagnostic and prognostic gold standard in acute HF, those molecules do not accurately reflect all the pathophysiological m...

Individualized gastric cancer (GC) treatment aims at providing targeted therapies that translate the latest research into improved management strategies. Extracellular vesicle microRNAs have been proposed as biomarkers for GC prognosis. Helicobacter pylori infection influences the therapeutic response to and the drivers of malignant changes in chro...

(1) Background: Perilla frutescens (L.) Britt. is an important pharmaceutical crop that remains a focus point for researchers worldwide due to its complex phytochemical constituents, medicinal effects, and nutraceutical properties. The literature data are based on animal and cell culture studies, so the clinical evidence for the therapeutic effects...

Y. schidigera contains a number of unusual polyphenols, derivatives of resveratrol and naringenin, called spiro-flavostilbenoids, which have potent in vitro anti-inflammatory, antioxidant, and moderate cholinesterase inhibitory activities. To date, these compounds have not been tested in vivo for the treatment of neurodegenerative diseases. The aim...

Guiera senegalensis JF Gmel. (Combretaceae) (GS) is a plant used in traditional medicine in West Africa for the treatment of several diseases, such as epilepsy and depression. However, its potential benefits in improving scopolamine (Sco)-induced memory impairment and brain oxidative stress in zebrafish have been investigated. In the present study,...

The purpose of the current review is to bring up to date some studies and data about the effects of hypoglycemic oral drugs in combination with DPP-4 inhibitors. As the medicine and pharmaceutical industry are revolutionary in type 2 diabetes protocols, scientists made a close research on patients that have combined metformin plus sulfonyurea and m...

The present study reports an eco-friendly synthesis method of silver nanoparticles (AgNPs) using two different extracts (aqueous and ethanolic) of Tagetes erecta flowers. When exposed to different biocompounds found in the plant, silver ions are reduced, thus, resulting in the green synthesis of nanoparticles. After performing the optimization of s...

In the field of oncology, the plant kingdom has an inexhaustible supply of bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This has brought Helleborus to the attention of medical researchers. H. purpurascens is a plant characteristic of the Carpathian area, know...

The ethanolic extracts of three Equisetum species (E. pratense Ehrh., E. sylvaticum L. and E. telmateia Ehrh.) were used to reduce silver ions to silver nanoparticles (AgNPs). The synthesized AgNPs were characterized using UV-Vis spectrophotometry, Fourier Transform Infrared Spectroscopy (FTIR), Energy Dispersive X-ray (EDX), Transmission Electron...

Citation: Batir-Marin, D.; Boev, M.; Cioanca, O.; Mircea, C.; Burlec, A.F.; Beppe, G.J.; Spac, A.; Corciova, A.; Hritcu, L.; Hancianu, M. Neuroprotective and Antioxidant Enhancing Properties of Selective Equisetum Extracts. Molecules 2021, 26, 2565. https://doi.org/10.3390/ molecules26092565 Academic Editor: Simona Rapposelli

The sterile stems belonging to the Equisetum species are often used in traditional medicine of various nations, including Romanians. They are highly efficient in treating urinary tract infections, cardiovascular diseases, respiratory tract infections, and medical skin conditions due to their content of polyphenolic derivatives that have been isolat...

Conyza canadensis is a plant widely used in traditional medicine in Morocco for the treatment of varied health challenges. However, to the best of our knowledge, there is no scientific study justifying the traditional use of Conyza extract as an anxiolytic and antidepressant agent. Moreover, data regarding the polyphenolic fraction is limited. Ther...

Tagetes erecta L. is a popular ornamental plant of the Asteraceae family, which is widely cultivated not only for its decorative use, but also for the extraction of lutein. Besides carotenoid representatives, which have been extensively studied, other important classes of secondary metabolites present in the plant, such as polyphenols, could exhibi...

Background: Albizia adianthifolia (Schumach.) W. Wright (Fabaceae) is a traditional herb largely used in the African traditional medicine as analgesic, purgative, anti-inflammatory, antioxidant, antimicrobial and memory-enhancer drug. This study was undertaken in order to evaluate the possible cognitive-enhancing and antioxidative effects of the aq...

Bay leaf (Laurus nobilis L.) has been shown to possesses various biological activities such as wound healing activity, antioxidant activity, antibacterial activity, antiviral activity, immunostimulant activity, anticholinergic activity, antifungal activity, insect repellant activity, anticonvulsant activity, antimutagenic activity, and analgesic an...

Essential oils or volatile oils are natural products that have a large series of uses in the food and cosmetic sectors. According to their intended use, essential oils are subjected to various European guidelines that aim to protect the health and safety of consumers. Volatile oils present important biological activities, some of the most known bei...

The present study was designed to investigate the level of six heavy metals (arsenic, cadmium, cooper, iron, mercury and lead) in both wild-growing and packaged samples from twelve commonly used medicinal plants and spices in Romania. The concentrations of all heavy metals, except mercury and lead, were within permissible limits in the analysed p...

Background This study was designed as a continuation of a complex investigation about the phytochemical composition and biological activity of chamomile, parsley and celery extracts against A375 human melanoma and dendritic cells. Objective The main aim was the evaluation of the antimicrobial potential of selected extracts as well as the in vitro...

The incidence of oncological diseases has become very high in the last decade, whether we refer to more or less developed countries. The incidence of the oncologic disease continue to increases in spite of substantial progress in the development of medicine and medical technologies. At the same time, an efficient treatment depends on an accurate an...

Teucrium is a genus that belongs to Lamiaceae family, but the endemic plants from our country have not been studied before. Therefore, the aim of this study was to provide evidence and specific characteristics with taxonomic value. Material and methods: we collected the plants (Teucrium chamaedrys L., T. montanum L. and T. polium L.) from the wild...

The present study investigated the capability of an essential oil mix (MO: 1% and 3%) in ameliorating amnesia and brain oxidative stress in a rat model of scopolamine (Sco) and tried to explore the underlying mechanism. The MO was administered by inhalation to rats once daily for 21 days, while Sco (0.7 mg/kg) treatment was delivered 30 min before...

The present study aimed to characterize the phenolic extracts obtained from fruits of Pimpinella anisum L., Carum carvi L. and Coriandrum sativum L. (Apiaceae), and to assess their antifungal activity against main etiological agents involved in onychomycosis and other dermatomycoses (Trichophyton rubrum, T. mentagrophytes, Microsporum canis, M. gyp...

Positron emission tomography (PET) has become a widespread and indispensable tool for non-invasive oncological, cardiological and neurolog-ical diagnosis. With its increase use, there has been a surge in medical cyclotron facilities to answer this demand as well as a continuous research into novel radiopharmaceuticals. Although the high demand for...

The growing use of plant products among patients with cardiovascular pharmacotherapy raises the concerns about their potential interactions with conventional cardiovascular medicines. Plant products can influence pharmacokinetics or/and pharmacological activity of coadministered drugs and some of these interactions may lead to unexpected clinical o...

The Romanian coastlines of the Black Sea have abundant seaweed resources, but little effort has been done to investigate their biological potential. The aim of the present study was to assess the in vitro antioxidant and anti-proliferative effects of Cystoseira barbata (Stackhouse) C. Agardh (Sargassaceae), a brown alga inhabiting the Black Sea coa...

The objective of the current study is represented by the determination of silica and a phytochemical screening of phenolic derivates of some Equisetum species. The antioxidant and antimicrobial activity for Equisetum pratense Ehrh.,, Equisetum sylvaticum L. and Equisetum telmateia Ehrh. (sin. Equisetum maximum Lam.) were also investigated. The conc...

Zinnia elegans (syn. Zinnia violacea) is a common ornamental plant of the Asteraceae family, widely cultivated for the impressive range of flower colors and persistent bloom. Given its uncomplicated cultivation and high adaptability to harsh landscape conditions, we investigated the potential use of Z. elegans as a source of valuable secondary meta...

The most prevalent neurodegenerative disease is Alzheimer’s dementia. It is determined by the deposits of amyloid-beta peptide which leads to memory impairment, oxidative stress, and neurodegeneration. Aromatherapy by using essential oils could represent a natural treatment option for Alzheimer′s dementia. Therefore, this study aimed to identify th...

In the present study, we investigated the effects of the Matricaria chamomilla (chamomile) hydroalcoholic extract on anxiety and depression using a scopolamine rat model. Behavioural procedures for anxiety and depression were assessed in rats using elevated plus maze and forced swimming tests. The chamomile extract (25 and 75 mg/kg b.w.) was given...

Ephedra alata Decne. belongs to the Ephedraceae family. It is a species of Ephedra that grows mostly in the desert. Today, the main importance of Ephedra species in the medical field is due to the presence of the alkaloids derived from phenyl-alanine, which act on the sympathetic nervous system as a sympathomimetic. The aim of this study was to con...

Chamomile, parsley, and celery represent major botanical sources of apigenin, a well-known flavone with chemopreventive properties. The aim of this study was to assess the phytochemical composition, antioxidant, and anti-inflammatory potential of methanol extracts obtained from chamomile, parsley, and celery collected from Romania, as well as the b...

Background: Tetraclinis articulata is used in traditional medicine and has been reported to possess antibacterial, antifungal, cytotoxic, anti-inflammatory and antioxidant properties. Purpose: This study investigated the effects of T. articulata essential oil on memory and brain oxidative stress in amyloid-β peptide 1–42 (Aβ1-42)-induced an Alzheim...

The article presents the construction and characterization of selective membrane sensors based on electroactive material incorporated in PVC matrix for the determination of ranitidine, famotidine and nizatidine, which use their complexes with phosphomolybdic acid as their electroactive material. Ion-pair complexes have been synthesized and characte...

Biogenic amines are compounds produced by human metabolism which, in small concentrations, exert physiological roles. In high concentrations, biogenic amines can become toxic. In addition to the in vivo generation, biogenic amines result from technological processes for the preparation and preservation of food products. These amines reach the body...

Background: Matricaria chamomilla L. is a medicinal herb traditionally used as the anti-inflammatory, antimicrobial, antiviral, anxiolytic and antidepressant agent. Nevertheless, supporting evidence demonstrated its memory enhancing activity and antioxidant properties. Purpose: To investigate the effects of the hydroalcoholic extract of M. chamo...

This review summarizes the literature data regarding plant lectins and as novel drug sources in prevention or treatment of cancer. Moreover, such compounds have been described as natural toxins that possess different biological activities (cytotoxic, antitumor, antimutagenic and anticarcinogenic properties). This activity depends greatly on their s...

Background: Recent studies have shown that rutin present a heightened interest due to the plethora of biological activities. The major drawback for this phytocompound is the poor water solubility, parameter that limits its bioavailability. The study aimed to prepare and assess the inclusion complexes of rutin with β-cyclodextrin (BCD) and hydroxyp...

Mushrooms contain compounds with different biological properties such as vitamins, minerals, polyphenols and flavonoids. The aim of our study was to evaluate the capacity of some extracts from mushrooms to restore endogen antioxidant systems in experimentally induced diabetes in mice. Methanolic extracts from the following mushrooms have been used:...

Rutin, a polyphenolic natural compound is described in the literature for a wide range of biological activities. The study aims to test the antiproliferative potential and the antibacterial effect for pure rutin and its β cyclodextrin complexes. On one hand, the antiproliferative assays against A2780 (human ovarian cells), MDA-MB-231 (human breast...

Background Plants of the genus Markhamia have been traditionally used by different tribes in various parts of West African countries, including Cameroun. Markhamia tomentosa (Benth.) K. Schum. (Bignoniaceae) is used as an antimalarial, anti-inflammatory, analgesic, antioxidant and anti-Alzheimer agent. The current study was undertaken in order to i...

Anthocyanins are well known for their powerful antioxidative potential, however new insights are discovered every year regarding their health benefits. For the present study, we investigated several anthocyanin-rich extracts in terms of their antimicrobial synergistic effect with commonly used antibiotics in urinary tract infections (UTI). The sele...

Our aim was to evaluate the beneficial properties of the most important groups of compounds present in the leaves of Pelargonium hispidum, P grandiflorum and P. radens. Given the studied species have a high content of polyphenols, the biologic activity was assessed by determination of free radical scavenging capacity against DPPH, and the investiga...

Objective: This paper presents the results regarding the morphological characters, the content in total phenols, the metabolites profile and the antioxidant activity of outdoor cultivated Rudbeckia hirta var. Goldilocks and Tagetes erecta plants. Material and Methods: The plant material was represented by flower buds and fully bloomed inflorescence...

We investigated the neuropharmacological effects of the methanolic extract from Lactuca capensis Thunb. leaves (100 and 200 mg/kg) for 21 days on memory impairment in an Alzheimer's disease (AD) rat model produced by direct intraventricular delivery of amyloid-β1-42 (Aβ1-42). Behavioural assays such as Y-maze and radial arm maze test were used for...

The main aim of the present study was to characterize and asses the antioxidant and biological activities of hydrophilic and lipophilic extracts from Crocus sativus from Greece. The bioactive compounds were analysed using high performance liquid chromatography (HPLC), the most important identified compounds being kaempferol derivatives, safranal an...

The current study includes the correlation between the chemical composition and the biological activity of four Pelargonium species. The plant material is represented by the leaves of Pelargonium hispidum (P.h), P. grandiflorum (P.g), P. radens (P.r) and P. zonale (P.z). The total phenolic content was determinate on the methanolic extract of each s...

The current study is part of a broader research that evaluated the chemical and biological properties of some Pelargonium species cultivated in Romania. The selected samples, P. hispidum and P. radens, were obtained from the “Anastasie Fătu” Botanical Garden, Iași, Romania. Our aim was to evaluate the chemical profile of the essential oils and hydr...

Vitellaria paradoxa C.F. Gaertn (Sapotaceae) is a perennial three which naturally grows in the northern part of Cameroon. It has been traditionally used in the Cameroonian folk medicine for treating inflammation and pain. In the present study, we evaluate the possible anti-amnesic and antioxidative effects of the methanolic extract of V. paradoxa s...

This is the first Romanian investigation of oral candidosis in patients suffering of HIV-infection or type 1 diabetes mellitus (T1DM). Candida albicans was the dominant species in both types of isolates: n=14 (46.7%) in T1DM, n=60 (69.8%) in HIV. The most frequent non-albicans Candida spp. were Candida kefyr (n =6; 20%) in T1DM and Candida dublinie...

Used as a spice and to improve the palatability of different meat and vegetable dishes, common fennel, Foeniculum vulgare Mill. (Apiaceae), was a traditional remedy for the relief of spasms and colic due to gas accumulation, to stimulate gastrointestinal motility, to alleviate productive coughs as well as for the induction of menstruation and lacta...

Bisoprolol belongs to the selective beta-blockers class, initially used for the treatment of cardiac arrhythmias and later in patients with arterial hypertension. A simple and accurate method of high performance liquid chromatography (HPLC) was developed and validated for the determination of bisoprolol fumarate in tablets. The chromatographic anal...

Patients with metabolic syndrome have a higher risk of cardiovascular events than healthy subjects. Many studies proved that plasma lipoprotein levels represent predictive factors for coronary disease. Among lipoproteins, small low density lipoproteins (sLDL) particles have the highest atherogenic potential. For patients with metabolic syndrome, le...

The current study regards the correlation between the biologic activity of two Pelargonium species and the spectra of the most important compounds of the samples. Pelargonium zonale and P. hispidum were not intensely studied, that is why the aim of the study was to correlate the chemical composition - antioxidant activity (DPPH, ABTS, reducing powe...

AIM: Medical records from 2010-2014 were retrospectively reviewed and analyzed in view of determining the correlations between the clinical severity of atopic dermatitis (AD) and total IgE level, eosinophilia, place of residence, family history of atopy, type of birth, and natural or artificial feeding.

The aim of the present study was to characterize and assess the in vitro antioxidant and cytotoxic activities of various solvent extracts from red alga Phyllophora pseudoceranoides. Bioactive compounds were extracted using solvents of different polarities. Total phenolic, flavonoid and carotenoid contents were also determined. Algal extracts displa...

Our investigations refer to tea consumption habits, practices and attitudes for medicinal plants commonly used in the domestic environment in Romania. Therefore, we conducted a survey within pharmaceutical network on a representative sample of patients. Tilia cordata, Matricaria chamomilla, Achilea milefollium, Hypericum perforatum and Calendula of...

Chrysanthemum indicum L. (Dendranthema indicum (L.) Des Moul) became useful as herbs and curatives in different parts of the world. In the current study, the chemical profile of outdoor cultivated Chrysanthemum indicum 'Avalone Red' was investigated for polyphenolic acid derivatives, flavonoids, alantolactone and ursolic acid using thin layer chrom...

Piper nigrum L. (Piperaceae) is employed in traditional medicine of many countries as analgesic, antiinflammatory, anticonvulsant, antioxidant, antidepressant and cognitive-enhancing agent. This study was undertaken in order to evaluate the possible anxiolytic, antidepressant and antioxidant properties of the methanolic extract of Piper nigrum frui...

Although Juniperus communis L. is known as a traditional remedy, common juniper is used especially as food spice for food & beverage industry. In aromatherapy, juniper essential oil is recommended for anxiety, nervous tension, mental exhaustion and stress-related problems. In our study, we assessed the biological properties of inhaled Juniperi aeth...

Juniper volatile oil is extracted from Juniperus communis L., of the Cupressaceae family, also known as common juniper. Also, in aromatherapy the juniper volatile oil is used against anxiety, nervous tension and stress-related conditions. The present study analysed the possible anxiolytic, antidepressant and antioxidant properties of the juniper vo...

Curcumin, an active compound with multiple anti-cancer properties, is able to form organo-metallic complexes which exhibit superoxide dismutase like properties when complexed with manganese ions. The mitochondrial selectivity of a curcuminmanganese derivative in cancer cells could be accomplished by the addition of a triphenylphosphonium (TPP) radi...

The polyphenols and flavonoids from two edible mushrooms (Agaricus bisporus brown - 3 samples, Pleurotus ostreatus - 2 samples) and one un-edible mushroom (Fomes fomentarius - one sample) have been extracted with methanol. From each extract the quantity of these compounds has been determined by spectrophotometric methods. The antioxidant properties...

HYPOGLYCEMIA INDUCED BY ANTIDIABETIC SULFONYLUREAS (Abstract): Diabetes mellitus is a major health problem due to its increasing prevalence and life-threatening complications. Antidiabetic sulfonylureas represent the first-line drugs in type 2 diabetes even though the most common associated risk is pharmacologically-induced hypoglycemia. In the dev...

The immune chronic thrombocytopenic purpura is an illness characterized by peripheral thrombocytopenia occurred through a mechanism of early hyper destruction of blood platelets or by deficient platelet synthesis in the medulla. The chronic immune purpura can be primary, autoimmune in nature, thrombocytopenic idiopathic or secondary in the context...

Rudbeckia hirta L. is an ornamental plant of Asteraceae family, largely used in landscaping and prevention of soil erosion. The aim of the study was to extend the uses of this species, in relation to phenolic content. Two cultivars, 'Moreno' and 'Goldilocks', were studied. Height and plant diameter, number and diameter of inflorescences and total p...

Diabetes mellitus is an important public health problem because of its increased incidence and its devastating complications. In addition to this, it was observed an increase in prevalence for diabetes risk factors. The aim of this study was to evaluate the frequency of the pathophysiological and behavioral risk factors among patients treated with...

This study aims to assess the microbial load of some medicinal plants (Matricaria chamomilla, Achillea millefolium, Ocimum basilicum, Calendula officinalis, Tilia cordata, Hypericum perforatum) commonly used as medicinal teas. A total of 24 samples collected from the local market, as well as from the spontaneous flora of Galati County, were analyze...

Armillaria mellea, known as honey mushroom, has been used both as food and medicine. In this work, the ethanolic and hydromethanolic extracts from Armillaria mellea fruiting bodies were investigated for their phenolic content, antioxidant and antihyperglycemic effects (in vitro studies). The total phenolics were quantified using Folin-Ciocalteu ass...

The aim of the present study was to investigate the chemical composition and antioxidant activity of Satureja montana essential oil of Romanian origin (S. montana EO). The essential oil was obtained by hydrodistillation from dried aerial parts of cultivated plants in northeastern Romania. The chemical composition of S. montana EO was analysed by GC...

Arterial hypertension is a complex disease with many serious complications, representing a leading cause of mortality. Selective beta-blockers such as metoprolol and bisoprolol are frequently used in the management of hypertension. Numerous analytical methods have been developed for the determination of these substances in biological fluids, such a...

Hypertension is one of the most common causes of death, a complex and incompletely controlled disease for millions of patients. Metoprolol, bisoprolol, nebivolol and atenolol are selective beta-blockers frequently used in the management of arterial hypertension, alone or in fixed combination with other substances. This study presents the most used...