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Publications (55)
The surge in multidrug-resistant pathogens worldwide has jeopardized the clinical efficiency of many current antibiotics. This problem steered many researchers in their quest to discover new effective antimicrobial agents from natural origins including plants or their residing endophytes. In this work, we aimed to identify the endophytic fungi deri...
l -asparaginase is an antileukemic enzyme that hydrolyzes l -asparagine into l -aspartic acid and ammonia, causing cell starvation and apoptosis in susceptible leukemic cell populations. Currently, l -asparaginase obtained from bacterial sources is constrained by several issues, including lesser productivity, stability, selectivity, and higher toxi...
L-asparaginase is an antileukemic enzyme that hydrolyzes L-asparagine into L-aspartic acid and ammonia, causing leukemia cell starvation and apoptosis in susceptible leukemic cell populations. Currently, L-asparaginase obtained from bacterial sources is constrained by several issues, including lesser productivity, stability, selectivity, and higher...
Drought is among the most common abiotic stresses that significantly influence plants’ growth and metabolic activities. In this study, Eriocephalus africanus L. (Asteraceae) was exposed to three levels of drought stress (irrigation with 75, 50, and 25% field capacity), together with foliar spraying of a plant hormone, salicylic acid (1, 2, and 3 mM...
Culex pipiens mosquitoes are vectors to many viruses and can transmit diseases such as filariasis and avian malaria. The present study evaluated the larvicidal activity of marine-derived endophytic fungi Aspergillus nomius and Aspergillus flavus from the soft coral Sarcophyton ehrenbergi along with two known cyclodepsipeptide compounds, scopularide...
Brassicaceae comprises various species representing an economically important source of industrial or pharmaceutical crops. The present study aimed to identify glucosinolates (GSLs) and volatile compounds in six Brassicaceae seeds cultivated in Egypt. An (High Performance Liquid Chromatography-Photodiode Array) HPLC–PDA analysis of GSLs in the alco...
Ammi majus L., an indigenous plant in Egypt, is widely used in traditional medicine due to its various pharmacological properties. We aimed to evaluate the anticancer properties of Ammi majus fruit methanol extract (AME) against liver cancer and to elucidate the active compound(s) and their mechanisms of action. Three fractions from AME (Hexane, CH...
Simple Summary: There is a rising demand for food security in the face of threats posed by a growing human population. Bees as an insect play a crucial role in crop pollination alongside other animal pollinators such as bats, birds, beetles, moths, hoverflies, wasps, thrips, and butterflies and other vectors such as wind and water. Bees contribute...
Background:
Khella (Ammi visnaga Lam.) fruits (Apiaceae) are rich in furanochromones, mainly khellin and visnagin, and are thus incorporated in several pharmaceutical products used mainly for treatment of renal stones.
Methods:
The objective of this study was to compare the yield of khellin and visnagin obtained using different conventional solv...
The main aim of this study was to differentiate among four Netherlands' genotypes of parsley (Moskurl 2 Petra, Moskurl 2 KRA USA, Gewone Dai 3 Rial 10 and Bravour) grown under Middle Egypt conditions in clay soil for the first time based on vegetative growth and oil composition. Gewone Dai 3 Rial 10 genotype is non-curly leafed, while the others ar...
The main aim of this study was to differentiate among four Netherlands' genotypes of parsley (Moskurl 2 Petra, Moskurl 2 KRA USA, Gewone Dai 3 Rial 10 and Bravour) grown under Middle Egypt conditions in clay soil for the first time based on vegetative growth and oil composition. Gewone Dai 3 Rial 10 genotype is non-curly leafed, while the others ar...
Prickly pear fruit peel constitutes a high-percentage of the fruit which could be a natural, economic agro-industrial waste in the nutraceutical industry. This study aimed to isolate and characterize the main constituents, and evaluate its antibacterial activity. A methanol extract was successively fractionated using hexane, chloroform & ethyl acet...
Ammi visnaga L. (Visnaga daucoides Gaertn., Family Apiaceae), also known as Khella Baldi or toothpick weed, is an annual or biennial herb indigenous to the Mediterranean region of North Africa, Asia, and Europe. The plant is known to have been used in traditional medicine a long time ago. Nowadays, it is used in modern medicine to treat many alimen...
One of the most widely distributed soft coral species, found especially in shallow waters of the Indo-Pacific region, Red Sea, Mediterranean Sea, and also the Arctic, is genus Sacrophyton. The total number of species belonging to it was estimated to be 40. Sarcophyton species are considered to be a reservoir of bioactive natural metabolites. Second...
Ammi majus L.; Family Apiaceae; is a plant indigenous to Egypt. Its fruits contain bioactive compounds such as furanocoumarins and flavonoids of important biological activities. An endophytic fungus was isolated from the fruits and identified as Aspergillus amstelodami (MK215708) by morphology, microscopical characterization, and molecular identifi...
The present study was conducted to evaluate the impact of drought stress and foliar spraying of salicylic acid (SA) on the secondary metabolites particularly the γ-pyrones and total polyphenolic content in the different organs of Ammi visnaga L. plant. The following were measured: different growth parameters, γ-pyrones, total polyphenolic content (...
The aim of this work is to characterize the active constituents present in the ethyl acetate fraction of Senna tora, L. Roxb. seeds. Due to the fact that the main biological activity of S. tora, L seeds is attributed to its phenolic compounds which are mainly isolated from Ethyl acetate fraction, to avoid repetition of work and to save time, it was...
Thymus vulgaris, (Lamiaceae), essential oils composition and yield, were found to be greatly influenced by water stress and growth enhancers. Therefore, three controlled cultivation conditions were applied to achieve the highest essential oil productivity of T. vulgaris. The essential oils obtained by hydro-distillation of the aerial parts were ana...
Extraction with supercritical fluid technique has proved to be effective in many applications including extraction and separation of various active principals from medicinal plants. It was used due to its advantages especially safety, specificity, selectivity and ease of component recovery.
Ammi visnaga, L. belongs to the family Apiaceae. The fruit...
Gas chromatographic mass spectrometric analysis using head space was carried out on the roots, stems and leaves of three different species of Mint grown in Egypt. This study was carried out aiming to investigate the chemical composition of the essential oils obtained from roots, stem and leaves of Mentha piperita L, Mentha spicata Var. crispa L. an...
Fifteen pyrrole alkaloids were isolated from the Red Sea marine sponge Stylissa carteri and investigated
for their biological activities. Four of them were dibrominated [(+) dibromophakelline, Z-3-bromohymenialdisine, (±) ageliferin and 3,4-dibromo-1H-pyrrole-2-carbamide], nine compounds were monobrominated [(−) clathramide C, agelongine, (+) manza...
Polyphenolic compounds are considered valuable secondary plant metabolites owing to the myriad of biological activities they exert. This study aimed to investigate the effect of applying various concentrations of the plant growth regulator, salicylic acid (SA), on Thymus vulgaris L. while subjecting the plant to decreasing amounts of irrigation wat...
A rapid and accurate UFLC method was developed for determination of scopolamine, hyoscyamine and lobeline in herbal cough mixture found in herbal product (BN) purchased from local market. Reversed phase chromatographic analyses was carried out under gradient conditions using column ACE, C18 (150 x 4.6 mm); packed with 5 µm diameter particles. The m...
A rapid and accurate HPLC method was developed for determination of both Khellin and Visnagin in Ammi visnaga L. extracts. The calibration curve of Khellin was linear with correlation coefficient (r 2) = 0.9990; over a concentration range of 53.60 – 355.00 mg/l; with a retention time of 9.19 minutes. While the calibration curve of Visnagin was line...
The genus Tribulus belongs to family Zygophyllaceae comprises approximately 25 species which grow as prostrate hairy herbs in tropical and warm regions. In this review, the literature data on phytochemical investigations of the Tribulus terrestris are compiled. The well-recognized groups of secondary metabolites were sterols, alkaloids, flavonoids,...
Gas chromatographic analysis was applied for the quantitative estimation of the essential oil(s) present in some carminative syrups in the Egyptian market. Depending on the fact that each essential oil has its unique component(s);the unique component was used as a marker compound in the quantitative determination of such oil. A calibration curve fo...
A 71-year-old female patient underwent urgent laparotomy due to severe right lower quadrant abdominal pain and fever. Macroscopically duplex coecal and transverse colon cancer as well as a sigmoid or left ovarian cancer were suspected. Pathological findings revealed synchronous left ovarian and transverse colonic neoplasms. Both primaries metastati...
The Egyptian cultivars of Mangifera indica L., have a great distinct difference in their aroma and fragrance, and due to the importance of the aroma (essential oils) in pharmaceutical, food, cosmetics and perfumes industries, it was necessary to investigate the composition of the essential oil of these cultivars. Gas chromatography Mass spectrometr...
In the present study the total and the defatted alcoholic extracts of seeds of Cassia tora Linn. (Leguminosae) were screened for hepatoprotective activity using adult Wister albino rats (120-170 g) as the experimental animals. Hepatic injury caused by carbon tetra chloride, was analyzed through estimation of AST, ALT, ALB and platelets in blood sam...
The present study was carried out to establish the pharmacognostical characters of stem of Tribulus terrestris L. No reports are available on the pharmacognostical studies of the stem; hence, the present study was carried out to help in identification of this plant for the future references. The microscopical studies of stem revealed the presence o...
The gastroprotective effect of the different fractions of Tribulusterrestris L. was investigated in the indomethacin-induced gastric ulcer in rats at dose of 30 mg/kg body weight. The petroleum ether and aqueous fractions hada significant gastroprotective activity, while the chloroform and ethyl acetate fractions hada moderate gastroprotective acti...
Tribulus terrestris L. (family Zygophyllaceae) is a prostrate branched herb. The stems have monopodial
branching and carry opposite compound paripinnate leaves and yellow simple flowers. The fruit is
schizocarpic. The present paper deals with comprehensive pharmacognostical studies on flower part of
this plant, including macroscopical and microscop...
Tribulus terrestris L. is an annual, prostrate, branched herb Zygophyllaceae family. In traditional medicine, hot water extract of the root is taken orally as an aphrodisiac. Therefore, in this context the detailed pharmacognostic study of root has been carried out with the aim to establish its pharmacognostical standards. The microscopical studies...
Tribulus terrestris L. (family Zygophyllaceae) is a prostrate branched herb. The stems have monopodial branching and carry opposite compound paripinnate leaves and yellow simple flowers. The fruit is schizocarpic. The present paper deals with comprehensive pharmacognostical studies on leaf part of this plant, including macroscopical and microscopic...
From the aerial parts of Tribulus terrestris, a new steroidal saponin, Diosgenin 3-O-[{a-L-rhamnopyranosyl-(1"3)} {a-L-rhamnopyranosyl-(1"4)}]-b-D-glucopyranosyl-(1"4)-b-D-glucopyranoside namely tribulin has been isolated together with six known compounds; scoparon, campesterol, stigmasterol, β-sitosterol, Diosgenin 3-O-[{a-L-rhamnopyranosyl-(1"4)-...
Four samples of different fennel fruit cultivars (F 1-F 4), obtained from El-Fayoum, Egypt (F 1), El-Menia, Egypt (F 2), Sudan, El-Khartoum (F 3), and Germany (F 4) were cultivated in MEPACO's Farm (Arab Co. for Pharm. and Med. Plants, Cairo, Egypt) and the obtained fruits were subjected to macro- and micromorphological stereomicroscopic examinatio...
Pollen grains are good sources of vitamins, minerals and amino acids with a high nutritional value that can be used as human food supplement. Date palm pollens are used in the Middle East especially Egypt in herbal mixtures as a folk medicine remedy for curing male infertility and promoting fertility in women .The raw materials purchased from the m...
Introduction Based on currently accepted scientific view, personalized therapy has been conquering more and more territories in oncology. Related to our case report, we propose the results and the consequencies of the molecular biological diagnostic process. Methods HER2, EGFR and ER/PR proteins of neoplastic tissues were investigated with immunohi...
Phytochemical and biological investigation of the roots of the wild Daucus carota ssp. carota afforded three new and four known compounds, including four sesquiterpenes daucane esters (1-3 [new], and 4), one polyacetylene (5), one sesquiterpene coumarin (6), and sitosterol glucoside. The structures of the new compounds were determined by comprehens...
One high-performance liquid chromatographic (HPLC) and two thin-layer chromatographic (TLC) methods are proposed for the determination of colchicine in crude drugs and pharmaceutical preparations. The TLC scanner method is based on measurement of the absorbance of the separated colchicine spot; alternatively, after scraping the spot from the plate...
