Mohammad Bostanudin

Al Ain University · College of Pharmacy

The optimization of respiratory health is important, and one avenue for achieving this is through the application of both Pulmonary Drug Delivery System (PDDS) and Intranasal Delivery (IND). PDDS offers immediate delivery of medication to the respiratory system, providing advantages, such as sustained regional drug concentration, tunable drug relea...

Cytarabine, an antimetabolite antineoplastic agent, has been utilized to treat various cancers. However, because of its short half-life, low stability, and limited bioavailability, achieving an optimal plasma concentration requires continuous intravenous administration, which can lead to toxicity in normal cells and tissues. Addressing these limita...

Background: Enteric coating films in acidic labile tablets protect the drug molecule from the acidic environment of the stomach. However, variations in the excipients used in the coating formulation may affect their ability to provide adequate protection. This study is the first to investigate the potential effects of coating materials on the prote...

PurposeCytarabine, an antimetabolite antineoplastic agent, has been used to treat acute myeloid leukemia. However, due to its short half-life, maintaining an optimal plasma concentration necessitates continuous intravenous administration, which may result in toxicity to healthy cells and tissues. The purpose of the current investigation was to desi...

Nanomaterials manufactured of amphiphilically‐altered polysaccharides have sparked a great deal of interest due to their capability to elevate drug transport across the skin. The study presents the fabrication of alkylated chitosan through 2‐tert‐butoxymethyloxirane alteration (alkylation degree 29.7%), that was typified by spectroscopic, chromatog...

Introduction: This study aims to assess the impacts of COVID-19 pandemics among university students in Malaysia, by identifying the prevalence of depression, anxiety and stress among them and their respective predictors. Methodology: An online cross-sectional study was conducted via non-probabilistic convenience sampling. Data were collected on...

The aim of the current study was to enhance the oral bioavailability of Acyclovir (ACV) based on the papain-functionalized self-emulsifying drug delivery systems (SEDDS). The optimum control SEDDS formulation comprised of kolliphore (40%), transcutol (30%), propylene glycol (20%) and oleoyl chloride (10%). However, in the targeted SEDDS formulation...

The study aims to formulate and characterize nanoformulations produced from amphipathically‐modified pectin containing fusidic acid, making clear the importance of nanocarrier amphipathicity in boosting drug permeation through the skin. For this purpose, the amphipathically‐modified pectin (GBE‐PEC) fabrication was achieved following glycidol butyl...

Background and aim: The learning experience, satisfaction, attitude (ESA), and challenges are important in the evaluation of distance education courses. Materials and method: A cross-sectional study was conducted amongst students from April to May 2020. A total of 251 students were approached to participate in this study. The questionnaire was vali...

Hydrogels constructed of amphiphilically modified polysaccharides have attracted a lot of interest because of their potential to augment drug diffusion over the skin. This research describes the synthesis of amphiphilic alkylated pectin via glycidyl tert-butyl ether modification (alkylation degree 15.7%), which was characterized using spectroscopic...

Diltiazem hydrochloride is a calcium channel blocker, which belongs to the family of benzothiazepines. It is commonly used to treat hypertension and atrial fibrillation. Even though the drug has high solubility, its high permeability and rapid metabolism in the liver can limit the bioavailability and increase the dose frequencies for up to four tim...

Polymeric colloidal nanocarriers formulated from hydrophobically grafted carbohydrates have been the subject of intensive research due to their potential to increase the percutaneous penetration of hydrophilic actives. To this goal, a series of hydrophobically grafted pullulan (BMO-PUL) derivatives with varying degree of grafting (5-64%) was prepar...

Nano-colloidal systems formulated from amphiphilically-modified polysaccharides (degree of modification 16.6 %) are focus of prominent study due to their potential to augment active penetration across the skin. Here we report the synthesis of amphiphilically-modified guar gum (GBE-GG) prepared by grafting with glycidol butyl ether (GBE), which were...

Toward the development of colloidal systems that can enhance transdermal permeation of hydrophilic actives, a material combining the non‐toxic of dextran with alkylglycerols permeation enhancing property has been designed. To this purpose, a range of amphiphilic butylglyceryl dextrans (DEX‐OX4) was synthesized via modification with n‐butylglycidyl...

Background and purpose: There has been a long-standing belief that generic drugs are of lower value in comparison to their branded name counterparts. They are in particular under scrutiny due to their low market price. Even though the reduction in costs is largely based on skipping expensive preclinical studies and clinical trials for generic drug...

Product authentication using a DNA-based technology method, Polymerase Chain Reaction (PCR), is very crucial in determining halal status and preventing any fraud or contamination. Pharmaceutical products contain excipients which are highly processed materials, thus the DNA is present in small fragments and extraction process may render it undetecta...

ABSTRACT Background: Headache is one of the most common nervous system disorders that aff ecting people worldwide and has been frequently investigated in research studies due to high prevalence. Although unfavourably underestimated among student population, it has been associated with signifi cant negative outcomes including quality of life deteriora...

Colloidal systems prepared from carbohydrates are subject of intense research due to their potential to enhance drug permeability through biological membranes, however their characteristics and performance are never compared directly. Here we report the results of a comparative investigation of a series of butylglyceryl-modified polysaccharides (ch...

Background: Headache is one of the most common nervous system disorders that affecting people worldwide and has been frequently investigated in research studies due to high prevalence.Although unfavourably underestimated among student population, it has been associated with significant negative outcomes including quality of life deterioration and f...

Pectin is a polysaccharide with very good gel forming properties that traditionally has found important applications in foods and pharmaceutical industries. Although less studied, chemical modifications of pectin leading to a decrease in its hydrophilicity can be useful for the development of novel drug carriers. To this aim, butylglyceryl pectins...

Background: The United Arab Emirates (UAE) has a high coverage of childhood vaccination, however since it is highly affected by the knowledge and attitude of parents, it is crucial to assess these in a rapidly developing and changing society of Abu Dhabi, UAE. Methods: The study will utilize cross-sectional survey method and the potential sample wi...

The objective of this study was to compare α-glucosidase inhibitory activity of Phaleria macrocarpa extracts using subcritical carbon dioxide (subCO2) soxhlet extraction method with sonication and solvent extraction methods. The extraction was performed by subCO2 soxlet using carbon dioxide and the conventional organic solvent-based sonication usin...

Abstract Background This study was aimed to evaluate antioxidant and α-glucosidase inhibitory activity, with a subsequent analysis of total phenolic and total flavonoid content of methanol extract and its derived fractions from Clinacanthus nutans accompanied by comprehensive phytochemical profiling. Methods Liquid-liquid partition chromatography w...

In the present study, development of salbutamol sulphate nanoparticles that adhere to gastric mucus was investigated. Salbutamol sulphate has low bioavailability due to short transit time in gastric. It also has a positive surface charge that provides hurdles to be encapsulated by the positively strong mucoadhesive polymer of chitosan. To overcome...