Mohammad Farid Rahman

Brawijaya University · Department of Chemistry

The main structure of novel bromoalkyl-1,4-benzoquinones is quinoid ring that can be modified to increase the bioavailability as a drug candidate. In this research, the modifications were carried out as 2-(4-bromobutyl)-3.5-dimethyl-1,4-benzoquinone (C4), 2-(7-bromoheptyl)-3,5-dimethyl-1,4-benzoquinone (C7), and 2-(10-bromodecyl)-3.5-dimethyl-1,4-b...

Caesalpinia sappan, commonly known as secang in Indonesia, has been used in traditional medicine to treat inflammation, microbial infection, diabetes, and cancer. In this study, the chromatographic separation of the ethyl acetate fraction of C. sappan was carried out. It resulted in the isolation of 2′,5,6-trimethoxyflavone (TM) and cirsimaritin (C...

Cellulose is one of the renewable natural resource materials that can be found in Indonesia. Cellulose can be synthesized from various parts of plants, such as pine trees. Pinewood waste is also known for its high amount of cellulose content. Thus, cellulose can be isolated from its pinewood waste. The necessary process in isolation is the removal...

Sponge Halichondriidae sp. obtained from the Kangean Islands belongs to the Demospongiae class, which has much potential in drug development, especially to treat cancer. The study aims to extract the Halichondriidae sponge with various solvents n-hexane, EtOAc, n-BuOH, and MeOH. Each extract was tested for its anti-cancer activity, including toxici...

The content of active compounds in plants can be analyzed by phytochemical tests. One of the herbal plants that is widely consumed is secang (Caesalpinia sappan). Secang is usually stored in the form of herbal tea and brewed with hot water then drunk to reduce throat inflammation or any other symtompts. To introduce simple research activities in sc...

Pine rosin of Pinus merkusii Jung at de Vriese is produced industrially from a distillation process of pine sap. The high total Indonesian production leads the primary derivatization strategy into several derivates to fulfill the market demand. Abietic acid (AA) is a major compound in pine rosin, used as the object of observation in this study. The...

The wide therapeutic effect of quinone-based drugs has received considerable interest for a long time. In this research, Friedel-Crafts performed a facile synthesis of quinone derivatives using the mixture of Brønsted acid. Reflux of 2,3-dimethylhydroquinone (1), isopropanol, glacial acetic acid, and H2SO4 for 15 minutes gave yellow oil product of...

The purpose of this research were to determine the effect of alkaloid jellyfish compounds on kidney histopathology and to know the best doses to the Relative Percent Survival (RPS) of tiger grouper. The method of this research was descriptive and treatment with Completely randomized design. The treatment of active alkaloid compound on feed was give...

Sponge Clionidae sp. is a multicellular animal that has active secondary metabolites that are used for survival. Sponge has cytotoxic, anticancer and antitumor properties and can be used in the pharmaceutical field, but the toxicity and antioxidant levels must be done to determine the uses level. Toxicity levels of sponge Clionidae sp. against Arte...

The solubility of the compound is a crucial task for new drug design. Quinone is a promising candidate to develop as a new drug. In this research, the synthesis of 1,4-benzoquinone derivatives, that is, 2-(5-bromoamyl)-3,5-dimethyl-1,4-benzoquinone (2a) and 2-(5-bromoamyl)-5-methyl-1,4-benzoquinone (2b) were carried out by decarboxylation and inser...

A bio-cellulose isolated from pinecone flower waste has been isolated by two type procedures. The first method is commonly used in industrial protocol. It is undergone via delignification and bleaching processes. In the delignification process provide a black-liquid of lignin waste, meanwhile the bleaching process afford neutralized clear liquid. T...

Eugenol or 4-allyl-2-methoxyphenol is the main component in clove oil which can be used as a starting material in organic synthesis. One of the example is synthesis of organonitrogen compound through the Ritter reaction. Eugenol as a carbocation precursor is reacted with acetonitrile, in the presence of a strong acid catalyst H 2 SO 4 , to form org...

Biomass as a renewable material became a prospective precursor for the development of alternative energy. It contains cellulose, hemicellulose, and lignin. The decomposition of lignin gives phenolic derivatives, which represent a major fraction of bio-oil after catalytic hydrodeoxygenation (HDO) treating. Here, an attempt to get hydrocarbon based-f...

The purposes of this research were to determine the effect of alkaloid jellyfish compounds on intestinal histopathology of tiger grouper and to determine the best doses to the relative percent survival (RPS) of tiger grouper. The method of this research was descriptive with completely randomized design. The treatment of active alkaloid compound on...

Proapoptotic activity of ester eugenol,1-(3-methoxy-4-hydroxy)phenyl-2-propylmethanoat, which synthesized from eugenol is reported. Eugenol as starting material in the synthesis of ester eugenol was obtained from fractional distillation of clove oil with the yield of 70.66%. Synthesis of ester eugenol was camed out by addition-esterification reacti...

The paper report antibacterial activity of flower extract from Pinus merkusii Jungh Et De Vriese and its mixture with copper nanoparticle on Staphylococcus aureus. This finding revealed the potency of pine forestry waste to overcome a bacterial-resistance problem on some commercially antibiotics. The extract was prepared by hot water extraction of...

Influence of water and acidic protic solvent on hydrodeoxygenation (HDO) of the furfural-acetone adduct (FAA) over Ni/Al2O3-ZrO2 (NiAZ) catalysts were investigated. The HDO of FAA was carried out in a batch reactor at 150°C for 8 hours. The NiAZ catalysts were home-made catalysts which were prepared by wet impregnation method with 10 and 20% nickel...

TiO 2 - zeolite photocatalyst has been prepared by impregnation of TiO 2 onto acid -activated natural zeolite. The XRD data confirmed that natural zeolite used in this work is predominated with mordenite and clinoplitolite types, whereas anatase type can be attributed to TiO 2. The highest performance of TiO 2 – zeolite, which is indicated by surfa...

Catalytic oxidation of alpha-pinene was investigated using potassium permanganate as an oxidant. The reaction consumed catalyst following stoichiometric amount instead of the catalytic one. The keto-carboxylate compound 2 was afforded as the oxidation product. Further study of its complex compound with copper(II) and zinc(II) was also reported incl...

Catalytic oxidation of alpha-pinene was investigated using potassium permanganate as an oxidant. The reaction consumed catalyst following stoichiometric amount instead of the catalytic one. The keto-carboxylate compound 2 was afforded as the oxidation product. Further study of its complex compound with copper(II) and zinc(II) was also reported incl...

Alpha-pinene was isolated in high purity from turpentine oil harvested from Pinus merkusii plantation. The recent investigation on selective oxidation of alpha-pinene using potassium permanganate was undertaken under acidic conditions. The result taught the selective oxidation of alpha-pinene in acidic using potassium permanganate lead to the forma...

Hydrogenation of furfurylidene acetone has been carried out using Ni/γ−Al2O3 and Cu/γ−Al2O3 catalyst in the presence of isopropanol in autoclave batch reactor. The hydrogenation using Cu/γ−Al2O3 at 120oC for 6h gives main formation of 1,5-bis-(furan-2-yl)-pentan-3-one. Reaction at higher temperature at 140oC for 8h using Ni/γ−Al2O3 leads to 1,5-bis...

Indonesia has abundance source of alpha-pinene, and mainly can be isolated from turpuntine oils. This oils itself, was harvested from pine tree (Pinus merkusii Junh. & de Vr). This paper reveals the recent investigation on oxidation of α-pinena using hydrogen peroxide catalyzed by iron(III) chloride. Meanwhile the end objective of this study basica...

Indonesia has abundance source of alpha-pinene, and mainly can be isolated from turpentine oils. This oils itself, was harvested from pine tree (Pinus merkusii Junh. & de Vr). This paper reveals the recent investigation on oxidation of α-pinena using hydrogen peroxide catalyzed by iron(III) chloride. Meanwhile the end objective of this study basica...

White turmeric (Curcuma zedoaria (Christm.) Roscoe) has been used as traditional medicine by Indonesian people. The chemical constituents of essential oil of white turmeric were collected in 5 hours of the steam-distillation, and then were investigated by GC-MS. Furthermore, the essential oils were fractionated every hour of 5 hours distillation an...

A qualitative and quantitative analysis of the turpuntine oils was undertaken by means of gas chromatography and mass spectroscopy. Two types of sample was analyzed, one was bought from local market in Malang and a sample originally from local producer. Analysis was conducted directly from raw sample after drying over magnesium sulfate anhydrate an...

The α-linolenic acid (9,12,15-octadecatrieonic acid) is omega-3 fatty acid that more active than other fatty acids to inhibit cell membrane damages, formation and growth of brain functions, antiinflamatory and prevent several cronic deseases like lung desease and arthrytis. Some research explain that geometri of omega-3 fatty acids had effect on it...

Patchouli oil contains a compound with biological activities to human body called the patchouli alcohol that can be further developed in medical field. This research aimed to synthesize organonitrogen compound from patchouli alcohol through Ritter reaction with acetonitrile and discover its toxicity towards Artemia salina Leach. The isolation of pa...

The synthesis of 1,3-dimethyl-6,7-dimethoxy-3,4-dihydroisoquinoline from methyleugenol with application of Ritter reaction for directly cyclization was presented. This research was carried out in 2 steps : (1) Determination of intermediate stability that undergo in the reaction by using hyperchem version 6 with AM 1 semi empirical method, and (2) S...

Kedondong laut (Polyscias fruticosa) is one of medical plants which is useful to increase poultry immune system, antiviral, antibacterial, antidisentry and for curing diuretic and gardiasis. The research purpose is to find out the kind of triteipenoides comiound in kedondong laut root bark. ln the pre-experiment has indicated positive for Lieberman...