Mohammad Adil

Aligarh Muslim University | AMU · Department of Dermatology

Palmoplantar keratoderma (PPK) is a broad entity comprising wide range of hereditary and acquired disorders. Herein, we present a case of 18-year-old female who presented with complaints of palmoplantar thickening since birth and progressive constriction bands around digits for 3 years. On examination, diffuse transgradient honeycomb type of PPK wa...

Morphea and Related Disorders is a comprehensive reference on morphea. The book covers the subject in 20 chapters. The book starts with a detailed introduction and history of the morphea and its various classifications systems. Next, the book progresses into epidemiology, predisposing factors and pathogenic mechanisms, followed by histopathology fo...

Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the apocrine glands characterized clinically by recurrent nodules, abscesses, and discharging sinuses which heal with a bridge or rope-like scars in the axilla, groin, and perineum. HS is seen to be associated with several other autoimmune and pilosebaceous structural disorders. We...

Background: Alopecia areata (AA) is an autoimmune disorder and exhibits non scarring alopecia. Currently, there is no definitive cure, platelet rich plasma (PRP) has emerged as a newer modality for non-cicatricial alopecias such as AA. This study was conducted to compare the efficacy and adverse effects of topical mometasone with PRP versus topical...

Background: Androgenetic Alopecia is a hereditary androgen-dependent disorder characterized by a gradual conversion of terminal hair into miniaturized hair with typical bitemporal recession and balding vertex and is considered the most common type of baldness characterized by progressive hair loss. This study evaluated the hormonal profile in males...

Isolated involvement of external ear is rare in Hansen's disease. Ear involvement may present as infiltration, nodule formation, rat-bitten or cauliflower ear, mega lobule or as perichondritis. Herein, we present a case of a 65-year-old female who was being treated for infective perichondritis due to erythema and oedema over the right ear for two m...

Background: Dermatophytosis is a common dermatological problem. Recent studies have reported an increase in the prevalence of the disease. Management of dermatophytosis thus has become challenging for both dermatologists and patients due to their resistance to treatment and their refractory nature. Currently the management of dermatophytic infectio...

Background: Both extrinsic as well as intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate the disease activity and markers of coagulation cascade in patients of CSU. Methods: A hospital-based, cross-sectional, descriptive study was carried out in 100 patients of chronic u...

ABSTRACT Degos-like lesions (DLL) have been associated with connective tissue diseases. Till date only twelve cases of systemic lupus erythematosus (SLE) with DLL have been published. We describe a rare case of SLE with leg ulcers and DLL. A 23-year-old male presented with malar rash, photosensitivity, leg ulcers, joint pain, oral ulcers , altered...

Black hairy tongue is an asymptomatic and benign condition presenting with black-to-brownish discoloration of the dorsum of the tongue with elongated filiform papillae. Several medications, particularly antibiotics, are implicated in its causation. Xerostomia, abnormal desquamation of the tongue, use of oxidizing mouthwashes, excessive intake of ni...

Milia are benign keratinous cysts that present as small, firm, dome-shaped papules. Leprosy is a chronic granulomatous disease caused by M leprae. It is well known to damage skin adnexa, including eccrine glands, due to infiltration of inflammatory cells or by pressure from granuloma formation followed by their subsequent repair. We report a 12-yea...

Cysticercus cellulosae is the larval form of the pork tapeworm, Taenia solium. It can be transmitted to humans through food and water contaminated with eggs. The cysticerci formed are spread through the intestinal wall and are carried by the blood stream to muscles, brain, and subcutaneous tissues, leading to clinical manifestations. Rarely, dissem...

Griscelli syndrome is a rare autosomal recessive disorder characterized by hypopigmentation of skin and hair. Griscelli syndrome type 2, one of the three subtypes of Griscelli syndrome, is characterized by recurrent infections, in addition to pigmentary abnormalities. We present the case of a 15-year-old girl with late onset of Griscelli syndrome t...

Background: Vitiligo is a chronic pigmentary disorder resulting in hypopigmentary areas which progressively become amelanotic. The onset of vitiligo in childhood leads to severe psychological trauma to both patients and their parents. Aim: The aim was to study the clinical profile of childhood vitiligo (<18 years) and its association with other aut...

Corticosteroids are one of the most common drugs to be used and abused in the field of medicine and surgery. It can be used as topical, oral, intravenous, intra-articular and intralesional forms. Intralesional route of administration have the advantage of achieving high concentration of drug locally with minimal systemic absorption and side effects...

Children with hereditary sensory and autonomic neuropathy (HSAN) Type IV present with loss of pain and temperature sensation and anhidrosis. They may sometimes exhibit aggressive and self-mutilating behavior. We present here the case of a 5-year-old male child who presented with a history of self-mutilating behavior leading to ulcers over knees, el...

Background: Vitiligo is a chronic disease of great cosmetic concern presenting with depigmented macules and patches. It is often recalcitrant to medical treatment. Aim: The aim of the study was to study the efficacy and safety of topical 5% 5-fluorouracil with needling versus topical 5% 5-fluorouracil alone in stable vitiligo. Materials and Methods...

Lipedematous scalp and lipedematous alopecia are a rare cutaneous disorders of unknown etiology characterised by thickening of subcutaneous fat layer presenting with thick, boggy scalp of spongy consistency. In addition to changes in texture of skin, varying degree of hair loss are seen in patients of lipedematous alopecia. It was first described b...

Morphea en coup de sabre is a type of linear localized scleroderma, characterized by a sclerotic skin band in the forehaead and frontoparietal scalp area. It can cause cicatricial alopecia, when affecting the scalp. The disease is mostly unilateral and may be associated with neurological complications and eye defects. Herein, we present a case of b...

Generalized eruptive histiocytosis (GEH) is a rare histiocytosis of the skin that presents in adults as multiple asymptomatic skin colored papules and nodules on the face, trunk and proximal upper limbs in a symmetrical manner. The lesions occur in crops and regress on their own. Clinical and histopathological examination differentiates this condit...

Extragenital involvement in lichen sclerosus is uncommon. Involvement of the palms and soles is very rare, with lichen sclerosus almost always showing elsewhere on the body. We describe the case of a female child with a linear hyperpigmented plaque on the right sole studded with keratotic papules. Dermoscopy showed scales and keratin plugs with sur...

Letter to the Editor Sir, "Spiny keratoderma" is a rare dermatosis characterized by fine keratotic projections over palms soles, or other areas of body. The other names for this disorder are filiform, spiked, minute, digitate, minute aggregate, and music box keratoderma. Spiny keratoderma usually involves the palms and soles in a diffuse fashion as...

Background: Vitiligo is a chronic disease of great cosmetic concern presenting with depigmented macules and patches. It is often recalcitrant to medical treatment. Aim: The aim of the study was to study the efficacy and safety of topical 5% 5-fluorouracil with needling versus topical 5% 5-fluorouracil alone in stable vitiligo. Materials and met...

Hutchinson-Gilford progeria syndrome is an extremely rare genetic disorder characterized by premature ageing involving the skin, bones, heart, and blood vessels. The incidence is 1 in several million births. It occurs sporadically and is probably an autosomal dominant syndrome. The diagnosis is essentially clinical and the manifestations become mor...

Donovanosis or granuloma inguinale is a mildly infectious, progressive ulceration of the genital area caused by the Gram-negative bacillus, Klebsiella granulomatis.Human immunodeficiency virus (HIV) infection alters the clinical picture of the disease and prolongs healing time. We discuss a case of donovanosis which was found to be HIV positive, a...

Background/objectives: Dermatophytosis can have a significant effect on patient's psychosocial and economic life. Despite this, knowledge on the quality of life (QoL) in patients with dermatophytosis is limited. The objective of the present study was to assess the quality of life in patients with dermatophytosis. Methods: This was a cross-sectio...

Background: Seborrheic keratosis is a benign skin tumour. None of the common therapies is satisfactory. This study compared the efficacy of 30% hydrogen peroxide versus 50% trichloroacetic acid in treatment of seborrheic keratoses. Methods: This unblinded, comparative interventional study was conducted on 85 patients of seborrheic keratosis. Les...

Background: Onychopathies or nail disorders are associated with social stigma and causes limitation of daily activities by hampering the function of both fingers and toes. Aim: To evaluate the impact of onychopathies on quality of life (QoL) and compare the severity of impact on QoL in various nail disorders. Materials and Methods: A hospital‑based...

Cutaneous warts are particularly difficult to treat with conventional treatment on sites such as the palms, soles, and periungual region. Immunotherapy boosts the host immune response and helps clear warts with less chance of recurrence. Vitamin D plays an important role in proliferation and differentiation of keratinocytes. The aim of this observa...

Conradi-Hunermann-Happle Syndrome is a rare type of chondrodysplasia punctata that presents with ichthyosis, asymmetry of limbs, short stature, and less frequently cataracts, ichthyosiform erythroderma, epiphyseal stippling and craniofacial defects. It is X linked dominant disorder with mutation in the gene emopamil binding protein (EBP) located on...

Lipoid proteinosis (LP) is a rare progressive autosomal recessive disorder caused by mutations in the extracellular matrix protein 1 gene present on chromosome 1q21. It is characterized by infiltration of hyaline material into the skin, mucosae, and internal organs. Patients present with a classical history of repeated blistering, skin scarring, be...

Hypomelanosis of Ito is also known as Incontinentia pigmenti achromians because the distribution of depigmented lesions is the negative image of hyperpigmented streaks of Incontinentia pigmenti. We report an infant of 9 months with hypopigmented macules along blaschkoid lines, developmental delay, macrocephaly and seizures. MRI brain revealed white...

Background and Aims: Involvement of the gastrointestinal tract is common in systemic sclerosis. The aim of this study was to identify the frequency and severity of dyspeptic symptoms in systemic sclerosis patients and to identify the common patterns of upper gastrointestinal endoscopic pathology from Kashmir valley, the study being first of its kin...

Background Hand eczema is a common distressing condition aggravated by a number of endogenous and exogenous factors. Various morphological patterns of hand eczema have been described. Aims To study the morphological patterns of hand eczema and identification of contact sensitizers of hand eczema by patch test. Methods Hundred consecutive patients o...

Sclerema neonatorum (SN) is a rare clinical condition usually seen during the 1st week of life. It presents as hardening of the skin and has a high mortality rate. It is usually associated with congenital anomalies, hypothermia, respiratory illnesses, and sepsis. Defective lipolytic enzymes, a high melting point, and resultant low solidification po...

Linear atrophoderma of Moulin (LAM) is a rare clinical entity characterized by hyperpigmented, depressed band‑like skin lesions following blaschko lines (BL). Since its first description by Moulin et al., several authors have presented cases with variable clinical and histopathological features and have diagnosed them as LAM. Whether all those case...

Erythematous scaly papules on the palms and soles are a common manifestation of secondary syphilis. We report a case of 19-year-old male who presented with erythematous, scaly, psoriasiform lesions over the palms and glans penis. The papules over the palms showed tenderness on blunt vertical pressure. There was a history of sexual contact and ulcer...

Background: Alopecia areata is one of the common causes of nonscarring hair loss with autoimmune etiology. This study was designed to evaluate any added benefit of topical calcipotriol when combined with topical mometasone in the treatment of alopecia areata. To the best of our knowledge, no such study has been conducted in the past. Materials an...

Introduction: Leprosy is a chronic disease caused by Mycobacterium leprae. Despite being eliminated from India in 2005, there are still a considerable number of leprosy cases. Methods: A prospective hospital-based study involving all leprosy patients attending the leprosy clinic at the Department of Dermatology from January 2015 to December 2016. R...

Background: Omega-3 fatty acids have been reported to reduce disease severity in psoriasis in various studies. This study aims to study the effects of omega-3 fatty acid supplementation on the quality of life in psoriasis. Methods: This open, non blinded interventional study divided patients of psoriasis with affected body surface area of less tha...

Norwegian scabies is a rare type of scabies characterised by hyperkeratotic and crusted plaques and is usually seen in immunologically and neurologically impaired patients. An elderly female presented to us with erythema and scaling over the body along with thick plaques covered with yellow crusts over the flexor aspects of the wrists and forearm....

Background: Topical corticosteroids are one of the most widely prescribed class of topical drugs. They have been abused in developing countries as they provide rapid symptomatic relief in inflammatory dermatoses. Aims: This study was done to find the risk factors related to topical corticosteroids abuse and consequences thereof. Methods: A hospital...

Objective: Androgenetic alopecia is the commonest cause of hair loss in males and has been associated with coronary heart disease. This study aims to find relationship between andro- genetic alopecia and metabolic syndrome. Materials and Methods: This hospital based case-control study was conducted on 50 clinically diagnosed male patients of early...

Introduction: Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by immune-mediated activation of tissue fibroblasts and consequent fibrosis, vascular abnormalities, and inflammation. The skin and esophagus are the two most frequently involved organs in this disease. Data regarding the correlation between the severity...

Pellagra is a state of niacin deficiency, a vitamin required for various metabolic processes, cell signaling and DNA repair. It is characterized by diarrhea, dermatitis and dementia that can ultimately lead to death. The disease can occur due to dietary deficiency or due to interference of metabolism or absorption of niacin as in alcoholism, drug i...

Tufted Angioma is a benign vascular anomaly. Histopathologically it is characterized by multiple "tufts" of capillaries infiltrating the dermis in a "cannon ball" distribution.

p class="abstract"> Background: Leprosy was eliminated as a public health problem in India in 2005. Yet, more than 60% of all new cases of leprosy are reported from India. Methods: A retrospective analysis of the records of patients attending the leprosy clinic of the Dermatology Out Patient Department was done for a period of one year from May 201...

Alopecia areata is a common inflammatory disease of the hair characterized by nonscarring hair loss.1 Herein, we present a case of alopecia areata with an unusual annular pattern of hair loss over the scalp.

Disorders of reticulate dyschromia can be diagnosed on the basis of the distribution and type of pigmentation in association with coexisting abnormalities. We describe a 4‑year‑old male child with reticulate dyschromia of the dorsal aspects of hands and feet and over the axillae, buttocks, and groins. The child had near complete absence of hair ove...

N-acetylcysteine is a mucolytic drug which is commonly used as an antidote for acetaminophen toxicity. It is a thiol compound, which acts as a donor of cysteine, leading to replenishment of glutathione and thus acts as an antioxidant. It also has anti-inflammatory effects, alters the levels of neurotransmitters, inhibits proliferation of fibroblast...

Introduction. The management of refractory warts continues to be a challenging task for the dermatologist. There are recent trends towards the use of intralesional immunotherapy by different antigens as they boost the cell-mediated immunity against human papilloma virus. Objective. To evaluate the efficacy of intralesional MMR (measles, mumps, rube...

Context Vitiligo is a psychosocial problem which significantly affects quality of life in Indian scenario. Aims The purpose of this study was to compare the changes in quality of life in patients of vitiligo before and after treatment with narrowband ultraviolet B (NBUVB) phototherapy. Subjects and Methods A total of 54 patients had completed the...

Leprosy is a chronic infectious disease caused by Mycobacterium leprae, characterized by varied clinical presentation. The various clinical manifestations in leprosy are the results of the variations in the tissue response of the host to the leprosy bacilli in the body in genetically susceptible persons. After entering in the body the bacteria are...

The management of psoriatic arthritis (PsA) is complex and early intervention is needed to prevent or delay the progression of the disease. The severity of PsA and response to medication should guide the proper treatment modality, as per the recent EULAR and GRAPPA recommendations. Conventional treatment options include non-steroidal anti-inflammat...

Morphea and lichen sclerosus et atrophicus (LSA) are two diseases that show considerable clinical and histopathological similarity and have been known to coexist in the same patient. Whether the two conditions are different entities or part of the same spectrum has been a topic of debate. This article describes a very rare and interesting case of c...

Introduction: Morphea is an uncommon disease that presents with skin induration and sclerosis. The disease is common in Caucasians and there are few studies describing the clinico-epidemiological profile of these patients from the Indian subcontinent. Methods: This prospective study was conducted during a three year period from June 2014 to May...

Pachyonychia congenita (PC) is a very rare group of autosomal dominant genodermatoses caused by mutations in one of the genes that encode for nail keratin [1]. It has traditionally been classi ed into four types, with type 1 (Jadassohn-Lewandowsky type) and type 2 (Jackson-Lawler type) being the most common variants. We present here a case of PC ty...

Progressive facial hemiatrophy (PFH), or Parry- Romberg syndrome, is a rare disease characterised by atrophy of the craniofacial tissues seen in the dis- tribution of one or more divisions of the trigeminal nerve with minimal epidermal involvement, while en coup de sabre (ECDS) manifests as a paramedian de- pression of the scalp and forehead, with...

Lupus vulgaris, the commonest form of tuberculosis of the skin, presents with a plaque that enlarges slowly with advancing edges while showing atrophy at other areas. It may be acquired by the blood stream, via lymph, by contiguous spread or from external inoculation. We describe a case of lupus vulgaris with a large erythematous-scaly plaque of 44...

Congenital atrichia with papular lesions (APL) is a disease characterized by the complete absence of hair from the whole body occurring within a few months of birth and the presence of papules distributed over the body. A 9-year-old boy presented with sparse hair over his body and with a history of losing his hair soon after birth. Multiple skin-co...

A 60-year-old healthy female presented with gradually increasing, spiky projections on both palms for 5 years. On examination, multiple, discrete, firmly adherent, keratotic papules of the size 1–2 mm were noted over both the palms. Rest of the cutaneous and systemic examination was unremarkable. Wet contact dermoscopy showed normal skin markings w...

A 52‑year‑old uncircumcised male with no significant past medical history presented with 1‑year history of gradually enlarging raised skin lesion over the glans penis. Local examination revealed a large yellow to light brown plaque of size 4–5 cm, woody in consistency, involving the whole glans penis, prepuce, and coronal sulcus [Figure 1]. Regiona...

Silymarin is a plant‑derived flavonoid which is extracted from the fruits and seeds of milk thistle (Silybum marianum L. Gaertn.), which belongs to the family Asteraceae. The extract of milk thistle has been used as a general medicinal herb used to treat the disorders of the spleen, liver, and gallbladder since as early as the 4th century BC, and w...

Objective This study aimed to find the prevalence of the most common antibodies in patients of systemic sclerosis and to ascertain their prevalence with the limited and diffuse cutaneous variants of systemic sclerosis. Methods Thirty-four patients of systemic sclerosis, attending the dermatology department, diagnosed as per the American Rheumatolog...

Erythema annulare centrifugum (EAC) is a rare condition characterized by annular, polycyclic, erythematous plaques with a trailing scale. The disease has been known to be precipitated by various infections, neoplasia, drugs and other autoimmune conditions.1 We describe a case of EAC after trauma, an association never before reported in literature.

Hyper-IgE syndrome (HIES), also referred to as Job’s syndrome, is a rare immunodeficiency disorder characterized by eczema, recurrent infections and elevated IgE. It is usually inherited in an autosomal dominant pattern, but a distinct subset with autosomal recessive inheritance has been observed. We present a rare case of autosomal recessive HIES...

We describe 25 cases of erythromelanosis follicularis faciei et colli from India. The male:female ratio was 5.25:1 and the average age of onset was 12.3 years. The cheeks, preauricular area, and submandibular region were the sites most commonly affected. Keratosis pilaris was seen in 22 (88%) of the patients.

Linear scleroderma is a rare form of morphea which mainly affects children, with 67% of patients diagnosed before 18 years of age. Linear scleroder-ma may involve the forehead and fronto-parietal area of the scalp, where it is called linear scleroder-ma en coup de sabre because the appearance of skin lesions simulates the stroke of a saber [1]. Co-...

Psoriasis is a chronic inflammatory disease marked by remissions and exacerbations. The exact etiology is not clear but a mix of genetic and environmental factors is proposed as the cause. The disease is associated with obesity and metabolic syndrome. In these contexts, diet assumes an important role in psoriasis patients. This review aims to discu...

Dear Editor, Nicolau's syndrome, also called embolia cutis medicamentosa or livedoid dermatitis, is a rare injection site reaction characterized by immediate intense pain at the injection site followed by erythema and a hemorrhagic patch with a livedoid reticular pattern after injections of non-steroidal anti-inflammatory drugs (NSAIDS), antiepilep...

Inherited punctate palmoplantar keratoderma is a rare disease characterized by multiple, small, asymptomatic, keratotic papules on the palms and soles. Punctate keratoderma has rarely been reported in a linear fashion. We found only three reports of unilateral linear type of punctate palmoplantar keratoderma described till now. We present a unique...

Introduction. Omega-3 fatty acids are largely derived from fish oils and are known to decrease inflammation. There have been a few small studies showing the beneficial effect of omega-3 fatty acids in psoriasis. Objective. To evaluate the efficacy of omega-3 fatty acids in conjunction with emollients in patients with mild to moderate chronic plaqu...

Late onset bilateral angioma serpiginosum involving upper limbs in a male: a rare presentation Rzadki przypadek naczyniaka pełzakowatego o późnym początku z obustronnym zajęciem kończyn górnych u pacjenta płci męskiej Angioma serpiginosum (AS) is a rare vascular disorder characterized by punctate red macules in a nevoid distribution arranged in gro...

Clouston syndrome, also called hidrotic ectodermal dysplasia (HED), is an autosomal dominant ectodermal dysplasia characterized by a clinical triad of onychodystrophy, generalized hypotrichosis, and palmoplantar keratoderma. Herein we report the case of a 24-year-old male with the distinctive clinical triad associated with multiple epidermoid cysts...

Idiopathic atrophoderma of Pasini and Pierini (IAPP) is a disease characterized by well-defined skin patches with a “cliffdrop” border that show no signs of sclerosis and induration . Idiopathic atrophoderma of Pasini and Pierini can be distinguished from linear atrophoderma of Moulin (LAM) by the latter’s earlier onset, nonprogressive course, blas...

neurofibromatosis-1 (NF-1), or von Recklinghausen’s disease is an autosomal dominantly inherited genodermatosis that presents with multisystem involvement predominantly the skin, eyes, brain and bone. About half of the cases occur due to sporadic mutations. NF-1 is associated with several pigmented cutaneous anomalies like café-au-lait macules, axi...