Mohamed Mahdy

South Valley University & King Salman International University · Department of Anatomy & Embryology

Skeletal muscle regenerates efficiently following injuries and diseases. However, muscle regeneration is compromised in several conditions by adipocyte infiltration and excessive collagen deposition. Adipocyte infiltration is a characteristic feature of sarcopenia, diabetes, cachexia, muscular dystrophies, and advanced cases of Duchenne muscular dy...

Extracellular matrix (ECM) is an essential component of skeletal muscle. It provides a framework structure that hold myofibers, and blood capillaries and nerves supplying the muscle. In addition, it has a principal role in force transmission, maintenance and repair of muscle fibers. Excessive accumulation of ECM components, especially collagens, ei...

The Nile fox (Vulpes vulpes aegyptica) is the largest Egyptian fox being distributed in different geographical regions in Egypt. The current study aims to investigate the three-dimensional features of the lingual papillae and their connective tissue cores in the Nile fox by using scanning electron microscopy (SEM). Five types of lingual papillae we...

The present study investigated the morphology of the palate of rabbit (Oryctolagus cuniculus). Samples from twelve healthy adult rabbits were examined by gross observation, morphometry, scanning electron and light microscopy. The hard palate was elongated and narrowed rostrally. The incisive papilla appeared as a diamond-shaped prominence flanked o...

Many universities and colleges worldwide suspended classroom teaching due to the novel coronavirus pandemic and switched to online teaching. The current cross-sectional study was carried out to analyze the impact of COVID-19 lockdown on the academic performance of veterinary medical students and researchers. Veterinary medical students and research...

The present study focused on the histogenesis of the crop in quail embryos. The developmental sequence was recorded from day 10 of incubation to the hatching day (17th day) by gross anatomy, morphometric analysis, and by using light and scanning electron microscope (SEM). Grossly, the crop was distinguished as an enlarged pouch of the cervical esop...

The present study was designed to provide a comprehensive analysis of the anatomical aspects of arterial blood vasculature in the water buffalo brains. Fifty cranial cavities of adult water buffaloes were opened via both the dorsal and ventral approaches and the arteries were exposed and photographed. The buffalo rostral epidural rete mirabile gene...

The present study was carried out to study the morphology of the goat's soft palate and palatine tonsil by gross anatomy, morphometry, light and scanning electron microscopy (SEM). Twelve heads of normal adult (18–24 months) apparently healthy goats of both sexes were collected from local commercial slaughterhouses in Qena Governorate, Egypt. The o...

Di(n-butyl) phthalate (DBP) is considered a substance of serious concern because of its reproductive toxicity and endocrine-disrupting properties. Exposure to DBP causes morphological and functional changes in the male reproductive system of birds and mammals. However, there are no detailed reports on the effects of DBP on the Sertoli cell and the...

Osteoarthritis (OA) is a condition that manifests as cartilage deterioration and subchondral bone sclerosis in the joint tissues. The weight-bearing joint is most severely impacted by OA. According to some research, consuming foods high in copper albumin complex (cu-albumin complex) can help with OA-related joint degeneration and pain relief. The c...

Apoptosis of germ cells is an important feature of spermatogenesis, as this process allows the removal of excess germ cells from testicular tissue. This is crucial to control the number of germ cells that can be supported and nourished by the Sertoli cells. It has been established that up to 75 % of germ cells are lost during the development of sp...

This study investigated the developmental changes in the adherens junctions, gap junctions, as well as tight junctions forming the blood-testis barrier (BTB) in Japanese quail (Coturnix coturnix japonica) testis. Testicular tissue from pre-pubertal, pubertal, adult, and aged Japanese quail were examined by immunohistochemistry and transmission elec...

Introduction Chitosan and curcumin are natural products that have a wide range of beneficial effects including wound healing. However, their high molecular weight and poor water solubility limit their applications. Aims Therefore, the current study aims to evaluate the effects of chitosan (Cs) and curcumin (Cn) nanoparticles (NPs) on fibrosis and...

The Egyptian red fox (Vulpes vulpes aegyptiaca) and Egyptian Baladi dog (Canis familiaris) are two members of the Family Canidae that are widely distributed in Egypt. The skulls of different Canid species vary greatly in their size and shape; therefore, they can be used as a tool to study the evolution and evolutionary history of these animals. The...

The testicular excurrent duct system undergoes several physiological and morphological changes during the reproductive stage or breeding season in mammals, birds and reptiles. Studies on normal age-related histomorphological changes in the excurrent duct system of Japanese quails (Coturnix japonica) remain unreported, despite the extensive use of s...

The sudden shift of veterinary anatomy teaching from traditional to online mode during the coronavirus disease 2019 (Covid‐19) pandemic lockdown was a major challenge used for the first time in Egyptian veterinary medical schools. This study aimed to evaluate the students' perspectives regarding the shift of veterinary anatomy teaching to online mo...

Purpose: The present study assessed the shift to remote teaching of veterinary anatomy during the COVID‐19 pandemic based on students’ perspectives. Methods: Participants were invited to answer an anonymous online Google Form questionnaire using the snowball sampling method. Only students who studied anatomy online during the COVID-19 lockdown peri...

Exposure to dibutyl phthalate (DBP) induces testicular damage in mammals. However,studies on the effects of DBP on spermatogenic cells in birds are grossly lacking.Therefore, this study was designed to determine the effects of the pre-pubertalexposure to DBP on the histology and ultrastructure of spermatogenic cells in the testisof adult Japanese q...

The current work aimed to study the anatomical features of the guinea pig’s head by two medical imaging techniques: computed tomography (CT) and magnetic resonance imaging (MRI), and their correlation with the anatomical cross-sectional images. Six adult healthy guinea pigs were used in the present study. Two heads were imaged by CT scanner and the...

The present study investigated the morphological, as well as the histological features of the Egyptian red fox’s palate, in addition to the three-dimensional characteristics of the connective tissue papillae (CTP) of the palate by scanning electron microscopy (SEM). The hard palate was narrow rostrally and its width increased caudally. The maximum...

Prepared sections from pre-pubertal, pubertal, adult, and aged Japanese quail testes were examined by light microscopy and transmission electron microscopy (TEM) and measurements of seminiferous tubular diameter (STD), luminal diameter (SLD), epithelial height (SEH) and cross-sectional area of the seminiferous tubules (AST) were taken using an imag...

Although anatomists worldwide have rapidly shifted to emergency remote learning in the COVID-19 crisis, the sudden transition has forced traditional anatomists in developing countries to shift into virtual mode without planning or training. Moreover, practical training was missing. Aim: It is important to evaluate the shift to explain how we can re...

Purpose: The present study assessed the shift to remote teaching of veterinary anatomy during the COVID‐19 pandemic based on students’ perspectives. Methods: Participants were invited to answer an anonymous online Google Form questionnaire using the snowball sampling method. Only students who studied anatomy online during the COVID-19 lockdown peri...

The morphology of different lingual papillae of the Egyptian goats was studied by gross observation, scanning electron microscopy, and light microscopy. According to function, two types of papillae were present; mechanical (filiform, conical and lenticular papillae) and gustatory papillae (fungiform and vallate papillae). Two types of filiform papi...

The current study compared the morphological features of the oropharyngeal floor of squabs and adult domestic pigeons (Columba livia domestica). Samples from the oropharyngeal floor of both squabs and adult pigeons were collected directly after slaughtering. The collected samples were examined grossly, morphometrically and by scanning electron micr...

A novel coronavirus has been reported as the causative pathogen of the Coronavirus disease 2019 (COVID-19) outbreak in Wuhan city, China in December 2019. Due to the rapid spread of the virus worldwide, it has been announced as a pandemic by the World Health Organization (WHO). Hospitalized patients in Wuhan were associated with the Huanan seafood...

The red fox (Vulpes vulpes) is a universally widespread wild carnivore in the world. It has an important impact on human interests and plays a vital role in conservation biology. There is no report to describe computed tomography (CT) of the red fox head and its correlation with gross anatomy. Therefore, the intent of the present study was to docum...

The current study was done to provide comprehensive information on the anatomical features of the lips and cheeks of the goat by gross examination and morphometric analysis in addition to scanning electron microscope (SEM). Samples from twelve normal healthy adult goat’s heads of both sexes were collected directly after slaughtering. The lips and c...

The present study aims to compare the morphology of the oropharyngeal roof of young and adult domestic pigeon (Columba livia domestica) by gross observation, morphometric measurements, and scanning electron microscopy (SEM). The oropharyngeal roof was divided into the palate and pharyngeal roof. The palate was narrow triangular in shape and concave...

Many universities and colleges worldwide suspended classroom teaching due to the novel coronavirus pandemic and switched to online teaching. The current cross-sectional study was carried out to analyze the impact of lockdown due to coronavirus disease 2019 (COVID-19) pandemic on the academic performance of veterinary medical students and researcher...

The current cross-sectional study was carried out to analyze the impact of COVID-19 lockdown on the academic performance of veterinary medical students and researchers. An online google form questionnaire was used to invite veterinary students and researchers to answer the questionnaire. A total of 807 participants were from 86 different countries...

Recently, we have shown that glycerol induces early fibrosis in rat muscles which persists up to two weeks after injury. The current study aims to determine the possible factor associated with fibrosis of rat muscle following glycerol injury. Eight-week-old male Wistar rats received either glycerol only (as a control) or a co-treatment of neutraliz...

Skeletal muscles are characterized by their unique regenerative capacity following injury due to the presence of muscle precursor cells, satellite cells. This characteristic allows researchers to study muscle regeneration using experimental injury models. These injury models should be stable and reproducible. Variety of injury models have been used...

Glycerol has been recently used to induce muscle adiposity in mice. However, its effects on the rat muscles have not been investigated previously. Therefore, we investigated the regeneration outcomes of rat muscles following glycerol-induced injury at different time points. Glycerol injection induces myofiber degeneration with extensive inflammator...

The aim of this study was to investigate the morphology of the goat hard palate by light and scanning electron microscopy (SEM), in addition to gross and morphometric analysis. A total of twelve goat heads, from normal adult and apparently healthy goats of both sexes, were collected from local slaughterhouses in Qena province, Egypt. Samples were s...

Transforming growth factor (TGF)-β1 is associated with fibrosis in many organs. Recent studies demonstrated that delivery of TGF-β1 into chemically-injured muscle enhances fibrosis. In this study, we investigated the effects of exogenous TGF-β1 on muscle regeneration and adipogenesis in glycerol-injured muscle of normal mice. Tibialis anterior (TA)...

In this study, we investigated the early changes of skeletal muscle damage in response to injuries induced by cardiotoxin (CTX) and glycerol by using both light microscopy and transmission electron microscopy. Normal, non-dystrophic, adult male mice were used in this study. Tibialis anterior (TA) muscles were injected either with CTX or glycerol. S...

: Fibrosis and adipogenesis are characteristic features of several muscle diseases such as muscle dystrophies, inflammatory myopathies and sarcopenia, they negatively affect muscle function. Chemically-induced injuries provide good models to study the mechanism of muscular dystrophies and consequently to develop new therapies for treatment. Recentl...

Osteoblast activating peptide (OBAP) was previously reported to be expressed in the rat stomach and to have a vital role in osteogenesis, but its distribution in rat stomach has not been determined. Thus, the aim of the present study was to identify the cell types expressing OBAP in the rat stomach. The stomachs of twelve 10-to-11-week-old male Jc1...

Fibrosis and adipogenesis are characteristic features of several muscle diseases such as muscle dystrophies, inflammatory myopathies and sarcopenia, they negatively affect muscle function. Chemically-induced injuries provide good models to study the mechanism of muscular dystrophies and consequently to develop new therapies for treatment. However, t...

In the present study, we examined muscle regeneration following two types of chemical injuries, cardiotoxin (CTX) and glycerol, in order to compare their effect on the morphological characteristics during muscle regeneration, in addition we studied the structural changes of the intramuscular connective tissue (IMCT) during the regeneration process,...

To study muscle regeneration several animal models had been used. However, time course of regeneration differs depending on the type of injury. Therefore, our study aims to compare muscle regeneration in two chemically-injured models, cardiotoxin (CTX) and glycerol. Tibialis anterior (TA) muscles of adult male mice were injected either with CTX or...

Experimental studies of skeletal muscle regeneration used several animal species. However, different species showed different reactions to the same injury during regeneration. The aim of the study is to compare muscle regeneration in mice and rats in response to glycerol injury. Left tibialis anterior (TA) muscles of mice and rats were injected wit...

The present study was carried out to investigate the structure of the sublingual caruncles of the goat. Specimens were studied by gross anatomy, morphometery, light and scanning electron microscopy. Results show that the sublingual floor of the oral cavity consisted of a rostral prefrenular part and two lateral sublingual recesses. The sublingual c...